N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

AASraw yog nrog cov khoom siv los ntawm cov grams kom loj hlob ntawm N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide hmoov (CAS 681136-29-8), raws li txoj cai CGMP thiab kev tswj xyuas qhov system zoo.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder yog ib tug piperazinyl phenyl urea uas nws qauv yog txawv los ntawm alkyl carbamates thiab alpha-keto heterocyclic tebchaw thiab yog ib tug muaj zog thiab xim inhibitor ntawm fatty acid amide hydrolase (FAAH) (IC50s = 34 thiab 33 nm nyob rau hauv nas thiab tib neeg, ntsig txog) hais tias yog muaj peev xwm kom hla cov ntshav-hlwb barrier.1 Thaum 20 mg / kg, cov kev sib raug zoo khi rau ntawm thaj chaw ntawm FAAH los ntawm kev sib cais ntawm cov urea functionality generating aniline thiab FAAH-poperazinyl carbamate.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

Lub npe: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Purity: ≥99% (HPLC)
txhais: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Molecular Formula: C19H19N5OS
Molecular phaus: 365.459
Melting point: 240.48
Kub taw tes: 559.69 ° C ntawm 760 mmHg
ceev: ~ 1.3 g / cm3
Cia Temp: Khw tom + 4 ° C
Dej Cev: DMSO: ≥28mg / mL
Refractive index: n20D 1.68
xim: Crystalline khoom
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
Qhov tseem ceeb hauv InChI: BHBOSTKQCZEAJM-UHFFFAOYSA-N


II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Hmoov siv nyob rau hauv lub voj voog:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid hmoov, JNJ 166101 hmoov

2.How yog qhov hauj lwm ntawm N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Hmoov siv?

FAAH ua ntej nrog JNJ-1661010 qhia txog kev cuam tshuam kev cuam tshuam ntawm kev sib koom tes ntawm JNJ1661010 thiab thaj chaw ua haujlwm, uas yog ceev dua ntawm qhov kub dua. JNJ-1661010 yog ib qho kev tswj, cov cuab yeej ua haujlwm raws li substrate inhibitor raws li kev soj ntsuam los ntawm LC-ESI-MS. JNJ-1661010 docks nrog lub phenylthiadiazole nyob rau hauv lub qhov dej hydrophobic thiab cov phenylurea hauv hydrophilic hnab tsho ntawm FAAH, JNJ-1661010 (20 mg / kg ip) ua rau FAAH los ntawm tsawg kawg 85% rau 4 h tom qab kev noj tshuaj, ua rau ntawm lub lipid ethanolamides hauv nas lub hlwb. JNJ-1661010 koob tshuaj-rov qab hloov cov tactile allodynia nrog rau ntau tshaj li ntawm 90% ntawm 30 min postdose rau ob qho tib si Nqaij Teeb Nqaij (MTI) nas thiab nas qauv. JNJ-1661010 (20 mg / kg) hloov cov tactile allodynia los ntawm 60.8% ntawm 30 min hauv nas spinal paj hlwb ligation raug mob. JNJ-1661010 (50 mg / kg ip) qhia tau hais tias qhov tseem ceeb ntawm qhov hyperrarthia ntawm 30 min postdose rau hauv cov phom carrageenan tus qauv ntawm qhov mob inflammatory.
Cov nas nyob nrog JNJ-1661010 (20 mg / kg IP) muaj cov ntshav Cmax ntawm 26.9 μM ntawm Tmax ntawm 0.75 h thiab Cmax nyob rau hauv lub hlwb ntawm 6.04 μM ntawm Tmax ntawm 2 h. JNJ-1661010 (20 mg / kg ip) inhibits hlwb FAAH thiab nce qib AEA qib hauv hlwb nqaij hauv nas.

3.Warning rau N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide hmoov

4.Xaiv cov lus qhia:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nyiaj.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Hmoov Noj Txwv:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid hmoov muag:

Kom muab rau yav tom ntej tom ntej.


III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide hmoov HNMR

Peb yog khoom noj khoom haus Aprepitant, Aprepitant hmoov muag, Raw Aprepitant hmoov (170729-80-3) hplc = 98% | AASraw R & D Reagents


IV. Yuav ua li cas yuav N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide hmoov los ntawm AASraw?

1.To tiv tauj peb ntawm peb tus emailnug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.


Twv koj nyiam cov khoom blog:

  Yuav ua li cas siv Clenbuterol rau qhov poob phaus Dab tsi yog nandrolone hmoov siv rau / nandrolone cov nyiaj pab yog dab tsi?


Ntau yam hais txog cov khoom muag,txais tos nias ntawm no.


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