JW 642

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm kev gram kom loj txog kev txiav txim siab ntawm JW 642 (1416133-89-5), raws li CGMP kev tswj thiab kev tswj xyuas qhov system.

Endocannabinoids xws li 2-arachidonoyl glycerol (2-AG) thiab arachidonoyl ethanolamide yog cov lipids biologically uas koom nrog ntau cov txheej txheem synaptic nrog kev ua kom cov kab mob cannabinoid. JW 642 yog ib lub hwj chim inhibitor ntawm monoacylglycerol lipase (MAGL) uas qhia txog qhov tseem ceeb ntawm 50, 7.6, thiab 14 nM forinhibition ntawm MAGL hauv nas, nas, thiab lub paj hlwb, feem ntau. JW3.7is selective rau MAGL, yuav tsum tau muaj ntau dua cov kev ua kom muaj zog hauv kev ua kom tsis muaj rog (amphitheater) (IC642s = 50, 31, thiab 14 μM rau nas, nas, thiab mob siab rau lub paj hlwb).

Hauj lwm yam khoom

JW 642 video


I.JW 642 theem pib:

Lub npe: JW 642
CAS: 1416133-89-5
Molecular Formula: C21H20F6N2O3
Molecular phaus: 462.4
Melt Point:
Cia Temp: tom-20 ° C 3 xyoo hmoov
xim: Dawb khoom


II. JW 642 lub voj voog

1. Npe:

Tshuaj Npe:
4 - [(3-Phenoxyphenyl) methyl] -1-piperazinecarboxylic acid 2,2,2-trifluoro-1- (trifluoromethyl) ethyl ester
txhais:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

2. JW 642 Siv:

Hauv cov txheej txheem kuaj, rau qhov ntev cia, peb xav hais tias JW 642be muab pov thawj ntawm -20 ℃. Nws yuav tsum ruaj khov rau tsawg kawg ib xyoos.
JW 642 yog khoom nkag ua cov tshuaj methyl acetate. Txhawm kom hloov cov hnyav, tsuas ntab cov methyl acetate hauv qab kwj deg ntawm nitrogen thiab ua ntxiv qhov hnyav ntawm qhov kev xaiv. Cov khoom siv xws li asethanol, DMSO, thiab dimethyl formamide purged nrog cov roj hauv inert yuav siv tau. Lub solubility ntawm JW 642 nyob rau hauv cov kuab tshuaj yog kwv yees 13,5, thiab 11mg / ml, feem.
JW 642 yog cov tshuaj tua tau zoo nyob hauv cov dej ciav hlau. Rau cov kev daws teeb meem siab tshaj hauv aqueousbuffers, ethanolic kua ntawm JW 642should yuav diluted nrog lub aqueous tsis hnov ​​qab. JW 642 muaj ib qho kev txhawj xeeb ntawm 0.3 mg / ml hauv 1: 2 tov ethanol: PBS (pH 7.2) siv hom no. Peb tsis tuaj yeem pom zoo cia khaws cov kua dej rau ntau tshaj ib hnub.

3.Dab tsi ntau npaum li cas ntawm JW 642?

DMSO rau 100 mM
Ethanol rau 100 mM
Stability and Solubility Advice: Qee cov kev daws teeb meem tau yooj yim kom tau thiab muaj peev xwm beencouraged los ntawm ceev nrawm, sonication los yog ua kom sov siab (hauv 45-60 ° C dej da dej). Cov ntaub ntawv hais txog khoom ruaj khov, tshwj xeeb tshaj yog kev daws teeb meem, tsis tshua muaj kev tshaj tawm thiab feem ntau peb tsuas yog muab cov kev qhia dav dav xwb. Peb cov txheej txheem tawm tswv yim yog: SOLIDS: Muab khaws cia raws li tau teev nyob rau ntawm daim ntawv lo thiab cov vial tseem khaws cia ruaj khov, cov khoom yuav khaws cia rau 6 lub hlis txij li hnub tau txais. SOLUTIONS: Peb pom zoo kom npaj cov ntsiab lus, npaj ib zaug, muab khaws cia rau hauv lub vialsat ceev nruj-20 ° C los yog hauv qab thiab siv nyob rau hauv 1 lub hlis.Txawm qhov kev tsim nyog yuav tsum tau ua thiab siv tib hnub.

4.How JW 642 ua haujlwm dabtsi?

JW 642 yog ib qho muaj zog thiab cov xim monoacylglycerol lipase (MAGL) inhibitor (IC = 3.7 nM). Qhia txog> 1000-fold selectivity rau MAGL ntau dua fatty acid amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) isa serine hydrolase lub luag hauj lwm rau lub hydrolysis ntawm 2-AG rau arachidonic acid thiab glycerol, yog li nws qhov kev ua haujlwm lom. Tshuaj Tawv Nqaij Teeb Nqa tuaj yeem tshwm sim rau hauv qab no: Methyl Acetate - Cov ntaub ntawv toxicity: Qhov ncauj LD50 (nas):> 5,000 mg / kg; Qhov Ncauj LD50 (luav): 3,705 mg / kg; Daim tawv nqaij LD50 (luav):> 5,000 mg / kg; Inhalation TCLO (tib neeg): 15,000 mg / m3; Methyl Acetate - Cov Ntawv Xaj Ntsws: Daim tawv nqaij (luav): 500 mg (24h) me me; Ob lub qhov muag (luav): 100 mg (24h) mob me ntsis.

5.Warning:

I.Stability thiab reactivity

5.1 Reactivity

Ruaj raws li kev pom zoo lossis kev ceev cia.

5.2 Tshuaj stability

Nyob ruaj hauv pom zoo cia cov neeg mob.

5.3 Tau ntawm kev phom sij

Tej kev phom sij yuav tsis tshwm sim hauv qab kev thauj los yog cia khoom. Decomposition tej zaum yuav tshwm sim thaum muaj mob los yog cov ntaub ntawv teev hauv qab no.

5.4 Conditions kom tsis txhob tshav kub, ya raws.
5.5 Cov ntaub ntawv tsis txaus siab

Muaj cov acids / alkalis, muaj zog oxidising / txo cov neeg ua hauj lawm.

5.6 Cov khoom tsim kev puas tsuaj

Nyob rau hauv combustion tej zaum yuav tshem tawm cov pa phom. Tsis paub cov ntaub ntawv paub meej.

II.Hawm thiab khaws cia

5.1 Precautions kom muaj kev nyab xeeb

Siv nyob rau hauv ib qho tshuaj huas tshuaj, nrog cua nkag los ntawm kev ywj pheej. Tsis txhob nqhis, tiv tauj nrog rau qhov muag, tawv nqaij thiab
khaub ncaws. Tsis txhob ua kom muaj hmoov av thiab aerosols. Siv nyob rau hauv qhov chaw zoo. Txav deb ntawm qhov chaw tiv thaiv. Tsis txhob
lub sij hawm ntev los sis raug dua.

5.2 Cov lus rau kev ruaj ntseg cia, nrog rau txhua yam kev tsis sib haum xeeb.

Khaws rau hauv qhov chaw txias, qhov cua zoo. Txav deb ntawm kev tshav ntuj ncaj qha. Khaws kom ruaj ruaj ruaj ruaj kom txog thaum npaj txhij.
Pom zoo cia kub: Khaws ntawm-20 ° C

5.3 Siv kawg nkaus siv

Siv nyob rau hauv ib txoj kev kuaj qias hood qhov ua tau.

6.JW 642 Raw Hmoov:

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Kev txiav txim loj dua tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nqi.

7.JW 642 Raw Khoom Noj Cov Khoom Noj:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

8.JW 642 Kev Ua Lag Luam:

Kom muab rau yav tom ntej tom ntej.

9.Does JW 642 Puas Muaj Teeb Meem Los?

Cov khoom yuav ua rau txob mus rau ntawm cov xoos mucous thiab cov pa nqus tau pa; Tej zaum yuav tsim kev puas tsuaj los ntawm nqhis dej, hnoos, los sis tawv nqaij; Tej zaum yuav ua rau kev ntshai kev ntshai; Tej zaum yuav ua kom tawv nqaij lossis ua pa nyhav. Rov ua dua tuaj yeem ua rau lub plawv dhia lossis tawg.
Raug kev tswj / kev tiv thaiv tus kheej

9.1 Tswj tsis

Cheebtsam nrog kev txwv tsis pub ua haujlwm
Tsis muaj cov ntsiab lus nrog qhov muaj nqi ntawm kev ua haujlwm.

9.2 Raug kev tiv thaiv

Cov kev tswj xyuas yam tsim nyog
Siv nyob rau hauv ib lub fume hood qhov siv tau. Xyuas kom tag nrho cov qauv kev tsim kho hauv tshooj 7 ntawm SDS nyob hauv qhov chaw.
Xyuas kom paub meej yog ua kom muaj dej da dej thiab lub qhov muag chaw ntxuav muag.
Kev tiv thaiv koj tus kheej

Qhov muag / qhov muag tiv thaiv
Siv cov iav kom ruaj ntseg zoo.
Kev tiv thaiv ntawm daim tawv nqaij
Siv cov hnab looj cov khoom siv uas tsim nyog uas tsim nyog (qhov yuav tsum tau siv yam tsawg kawg hauv BS EN 374: 2003). Hnab looj tes yuav tsum
kuaj xyuas ua ntej siv. Ntxuav thiab qhuav tes kom huv si tom qab kov.
Lub cev tiv thaiv
Hnav cov khaub ncaws kom tsim nyog.
Kab mob kev tiv thaiv
Yog tias kev txheeb xyuas qhov kev xav tau hais tias tsim nyog, siv lub tshuab ua kom haum.

al nrog lwm tus


III. JW 642 HNMR

Peb yog khoom noj khoom haus Aprepitant, Aprepitant hmoov muag, Raw Aprepitant hmoov (170729-80-3) hplc = 98% | AASraw R & D Reagents


IV. Yuav ua li cas yuav JW 642 ntawm AASraw?

1.To tiv tauj peb ntawm peb tus emailnug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.


Twv koj nyiam cov khoom blog:

Yuav ua li cas siv Clenbuterol rau qhov poob phaus Dab tsi yog nandrolone hmoov siv rau / nandrolone cov nyiaj pab yog dab tsi?


Ntau yam hais txog cov khoom muag,txais tos nias ntawm no.


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