Comodo SSL Raw URB597 (546141-08-6) HPLC = 98% | AASraw xim inhibitor
Rau qee cov nplooj ntawv yog txhais los ntawm cov software thiab lawv tsis muaj tseeb txaus, thov koj sim xyuas cov en English lub zeem muag rau cov ntsiab lus zoo dua.

URB597

URB597, lub npe hu ua KDS-4103, yog ib qho muaj zog thiab xaiv lub hauv siab ntawm cov rog fatty-acid amide hydrolase (FAAH), ib qho chaw enzyme catalyzing cov hlab ntaws ntawm qhov kawg ntawm kev noj tshuaj, nrog qhov tseem ceeb ntawm 50% inhibition concentration IC50 ntawm 4.6 nM thiab 0.5 nM hauv lub paj hlwb cov paj ntaub thiab neeg lub siab microsomes feem. URB597 tuaj yeem ua rau lub cev tsis muaj zog, antidepressant, antinociceptive thiab analgesic cov teebmeem hauv vivo tsis muaj evoking lwm cov tsos mob nrog cov kab mob cannabinoid.

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Hauj lwm yam khoom

 

URB597 yees duab

 

 


 

IURB597 basic characters:

 

Lub npe: URB597
CAS: 546141-08-6
Purity: ≥99% (HPLC)
Molecular Formula: C20H22N2O3
Molecular phaus: 338.4
EINECS: 1312995-182-4
txhais: N-Cyclohexylcarbamic acid 3 '- (aminocarbonyl) [1,1'-biphenyl] -3-yl ester; 3'-CarbaMoyl- [1,1'-biphenyl] -3-yl cyclohexylcarbaMate; 3- (3-carbaMoylphenyl) phenyl N-cyclohexylcarbaMate (XMUMX'-biphenyl] -3-yl ester; KDS 1,1 N-Cyclohexylcarbamic acid 3 '- (aminocarbonyl) [4103'-biphenyl] -3-yl ester; ; N-Cyclohexylcarbamic acid 1,1 '- (aminocarbonyl) [3'-biphenyl] -3-yl ester URB 1,1 KDS 3; URB 597,> = 4103%; APD597 (URB98)
Melt Point: 155-157 ° C
Alpha: D + 5 ° (c = 0.437 hauv chloroform)
Cia Temp: 2-8 ° C
Txhuam DMSO: soluble2mg / mL, ntshiab (sov)
xim: Dawb khoom

 


 

II. Kev pab URB597 hauv lub voj voog:

 

1.Name:

URB597

 

2.How yog qhov haujlwm rau URB597?

Qhov kev txiav txim siab: Ib qho kev txhawj xeeb loj nrog kev siv cov cannabinoid receptor 1 (CB1) tib neeg laus yog tias cov tebchaw no ua rau haus cawv ntau dua thiab yeeb-tshuaj txog kev tsim txom. Raws li lwm txoj kev qhia, CB1-receptor-mediated activities yuav ua kom yooj yim los ntawm kev nce anandamide qib nrog kev siv hydrolase fatty acid amide hydrolase (FAAH). Lub Hom Phiaj: Siv qhov kev xaiv ntawm FAAH inhibitor URB597, peb tshawb xyuas seb qhov ua rau cov neeg laus laus laus hu ua Cannabinoid ua rau kom haus cawv ntau dua, xws li CB1 receptor direct agonists. Cov ntaub ntawv thiab cov hau kev: URB597 tau soj ntsuam ntawm cawv tswj kev haus dej hauv Wistar nas thiab ntawm homecage haus cawv haus hauv kev xaiv rau kev xaiv ntawm cov kabmob Marchigian Sardinian cawv-preferring (msP). Hauv Wistar nas, URB597 cov teebmeem ntawm kev ntxhov siab vim kev ntxhov siab vim thiab kev ntxhov siab -, yohimbine- thiab cue-ntxias rov qab los ntawm kev tshawb nrhiav cawv kuj raug soj ntsuam. Rau kev sib piv, cov nyhuv ntawm CB1 tus neeg ntxeev siab antagonist rimonabant ntawm ethanol self-administration kuj kuaj. Kev soj ntsuam: Hauv peb qhov kev sim, kev kho cov kab mob hauv IPR ntawm XRUMENTS (597, 0.0 thiab 0.3 mg / kg) tsis muaj ntau hom kev haus dej haus cawv haus hauv msP nas tsuag los yog tsis yooj yim piv rau 1.0 thiab cov cwj pwm khwv tau haus cwj pwm ntawm cov neeg tsis tsim nyog. Hauv cov kev xeem rov qab, qhov kev tsis txaus siab tsis muaj teebmeem rau kev cue-, footshock stress- thiab yohimbine induced relapse. Conversely, URB1 kiag li abolished anxiogenic teb ntsuas thaum tshem tawm tom qab tus kab mob IP tswj kev haus cawv (597 g / kg). Rimonabant (3.0, 0.0, 0.3 thiab 1.0 mg / kg) txo cov ethanol self-administration. Kev xaus: Cov kev tshwm sim qhia tau hais tias kev ua kom tiav ntawm endocannabinoid anandamide system los ntawm kev xaiv kev tiv thaiv ntawm FAAH tsis ua rau haus dej cawv ntau dua tiam sis tsis txo kev ntxhov siab vim haus dej cawv tawm. Peb thiaj li xav tias cov tshuaj raws li kev siv endocannabinoid system modulators xws li URB3.0 tej zaum yuav muaj kev zoo dua piv rau kev kho mob nrog CB597 tus neeg txais kev tso cai.

 

3.Is nyhuv URB597?

Cov teebmeem ntawm URB 597 ib leeg thiab ua ke nrog anandamide raug tshawb xyuas hauv ib pawg ntawm cov liab (n = 4) uas muaj kev ntxub ntxaug Δ9-THC (0.1 mg-kg-1 iv) los ntawm tsheb, thiab lwm pab pawg (n = 5) tau txais mob xuabmoos (9 mg · kg-1 h-112 sc) uas muaj kev ntxub ntxaum cov kabmob tshuaj tiv thaiv kabmob (xNUMX mg-kg-1 iv).

 

4.Xaiv cov lus qhia:

URB 597 tau kho tus cwj pwm coj ntawm anandamide, tiam sis tsis yog lwm tus neeg CB1 agonists. Txawm li cas los xij, URB 597 tsis tau txhim khu lub zeem muag ntawm Δ9-THC thim tawm vim yog anandamide. Collectively, cov ntaub ntawv no qhia tias qhov kev pom zoo ntawm qhov tob hauv lub hlwb tsis nkag siab txog kev coj tus cwj pwm ntawm exogenously administered anandamide.

Muaj zog thiab xim fatty acid amide hydrolase (FAAH) inhibitor (IC50 qhov tseem ceeb yog 3 thiab 5 nM hauv tib neeg lub siab thiab lub paj hlwb, feem). Cov khoom pov thawj tsis muaj kev cuam tshuam dab tsi rau ntau yam ntawm cov neeg tau txais kev pabcuam, ion channels thiab enzymes, suav nrog cov neeg cannabinoid receptors thiab nas monoacylglycerol lipase. Qhia txog antiallodynic thiab antihyperalgesic kev ua si nyob rau hauv ib qho mob inflammatory qauv. Hauv vitro, KDS-4103 ua rau FAAH muaj kev ua haujlwm nrog cov tshuaj tiv thaiv nruab nrab ntawm nruab nrab (IC (50)) ntawm 5 nM rau hauv lub paj hlwb cov paj nruag thiab 3 nM hauv neeg lub siab microsomes. Nyob rau hauv vivo, KDS-4103 inhibits nas npav paj hlwb FAAH yam tom qab muab kev pabcuam intraperitoneal (ip) nrog lub cev tshuaj tiv thaiv kab mob (ID (50)) ntawm 0.15 mg / kg. Tus compound tsis sib raug zoo nrog lwm lub hom phiaj ntawm cov cannabinoid, nrog rau cov neeg ua haujlwm hauv cannabinoid thiab anandamide, los yog nrog sab nrauv ntawm cov neeg tuaj yeem, cov paib, cov tsheb thauj neeg thiab cov roj hmab. Los ntawm kev tswj hwm rau cov nas thiab cov nas tsuag KDS-4103 tseem ceeb heev, tsis pom zoo, zoo li cov tshuaj tiv thaiv antidepressant thiab analgesic, uas yog tiv thaiv los ntawm kev kho mob nrog CB1 tus neeg pleev kob antagonists. Ntawm kev sib piv, ntawm cov koob tshuaj uas tseem ceeb hauv FAAH kev ua haujlwm thiab ua tau nce lub hlwb anandamide ntau ntau, KDS-4103 tsis evoke cov kev ua haujlwm zoo li cannabinoid (xws li, catalepsy, hypothermia, hyperphagia), tsis ua rau qhov chaw nyiam, thiab tsis tsim kev sib txuas qhov kev ntxub ntxaug ntawm cov khoom muaj nyob rau hauv cannabis, Delta9-tetrahydrocannabinol (Delta9-THC). Cov kev tshawb pom no hais tias KDS-4103 ua los ntawm kev siv cov tshuaj tonic ntawm anandamide rau cov kab mob CB (1), uas feem ntau yuav ua rau tswj kev xav thiab mob. KDS-4103 yog lus muaj nyob hauv nas thiab cynomolgus liab. Cov kev rov qab soj ntsuam cov kab mob ncua ntev (1,500 mg / kg, rau cov os) hauv ob hom kabmob no tsis tau qhia txog kev mob toxicity. Ib yam li ntawd, tsis muaj tshuaj lom tau sau tseg hauv cov kab mob cytotoxicity tests hauv vitro thiab hauv Ames xeem. Tsis tas li ntawd, tsis muaj qhov tsis tau raug pom hauv cov nas tsuag ntawm qhov kev ntsuas ntawm rotarod tom qab mob ntsiav tshuaj tiv thaiv nrog KDS-4103 nyob rau ntawm 5 mg / kg los yog hauv lub cev muaj zog soj ntsuam tom qab txhaj tshuaj txog 1,500 mg / kg. Cov txiaj ntsim tau qhia tias KDS-4103 yuav muab ib txoj kev tshiab nrog rau lub qhov rooj kho kom haum rau kev kho mob ntawm kev ntxhov siab, kev nyuaj siab thiab kev mob.

 

5. URB597:

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nyiaj.

 

6. URB597 Recipes:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

 

7. URB597 Ua Hauj Lwm:

Kom muab rau yav tom ntej tom ntej.

 


 

III. URB597 HNMR

 

Peb yog khoom noj khoom haus Aprepitant, Aprepitant hmoov muag, Raw Aprepitant hmoov (170729-80-3) hplc = 98% | AASraw R & D Reagents

 


 

IV. Yuav ua li cas yuav URB597 ntawm AASraw?

 

1.To tiv tauj peb ntawm peb tus emailnug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

 


 

Twv koj nyiam cov khoom blog:

 

 Poj niam Viagra? Txhua yam hais txog kev sib deev Enhancing Flibanserin hmoov Yuav ua li cas siv Clenbuterol rau qhov poob phaus Dab tsi yog nandrolone hmoov siv rau / nandrolone cov nyiaj pab yog dab tsi?

 


 

Ntau yam hais txog cov khoom muag,txais tos nias ntawm no.


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