Los ntawm Reddit & Quora: 12 Cov Lus Nug (Debated Debated) Txog NMN - AASraw
AASraw ua rau Cannabidiol (CBD) hmoov thiab Hemp Roj tseem ceeb hauv qhov ntau!

Nicotinamide Mononucleotide NMN

 

  1. NMN Hmoov yog dab tsi?
  2. NAD+ Ua Dab Tsi Nrog NMN?
  3. Puas yog NMN Hmoov Zoo Ntxiv?
  4. Cov txiaj ntsig dab tsi tuaj yeem NMN Hmoov Tuaj Rau Kuv Lub Cev?
  5. Kuv Puas Tau Txais NMN Txaus Los Ntawm Zaub Mov Los Tiv Thaiv Kev laus?
  6. Yuav Siv Li Cas NMN Hmoov?
  7. Kuv puas yuav tsum noj lwm yam tshuaj ntxiv nrog NMN ua ke?
  8. Puas yog NMN pab tau zoo rau tiv thaiv COVID-2019?
  9. NMN VS. NR: Qhov Twg Zoo Tshaj?
  10. Kuv Yuav Pom Li Cas NMN Hmoov Zoo?
  11. Yuav Ua Li Cas Khaws NMN Hmoov?
  12. Puas Muaj Kev Txheeb Xyuas Tiag tiag ntawm NMN Hmoov?
  13. Ntsiab lus

 

Raws li peb txhua tus paub, Cov khoom tiv thaiv kev laus yog lub ntsiab lus ruaj khov thiab ntau tus tib neeg kawm txoj haujlwm no ntev, Thaum xyoo 2018, muaj cov tshuaj tshiab los tiv thaiv kev laus thiab nws ua rau muaj kev npau taws rau cov khoom lag luam tiv thaiv kev laus, cov khoom tshiab no hu ua " NMN "ua. NMN (β-Nicotinamide Mononucleotide) raws li hom tshiab ntawm cov tshuaj tiv thaiv kev laus yog nrov heev. Noj NMN tshuaj ntxiv lossis ntxiv qee cov NMN hmoov rau noj tshais yog qhov pom ntau heev txij li xyoo 2020. Cov ntaub ntawv twg peb yuav tsum paub txog NMN thiab yuav yuav NMN hmoov online li cas, txhua lo lus nug muaj kev txhawj xeeb los ntawm cov neeg feem coob uas npaj siv NMN hmoov lossis tshuaj ntxiv. Hnub no, peb tau sau cov ncauj lus sib tham feem ntau online los ntawm reddit thiab quora ntawm NMN, vam tias cov lus teb no tuaj yeem pab koj kom paub NMN thiab yuav cov hmoov NMN tiag hauv online.

 

NMN Hmoov yog dab tsi? 

NMN luv rau nicotinamide mononucleotide (CAS: 1094-61-7), ib txwm muaj tshwm sim hauv lub cev muaj nyob hauv txhua hom tsiaj. Ntawm qib molecular, nws yog ribonucleotide, chav tsim qauv yooj yim ntawm nucleic acid RNA. Hauv daim ntawv nws suav nrog pawg nicotinamide, ribose thiab pawg phosphate. NMN yog Vitamin B3 (niacin) derivative. Nws tshwm sim ib txwm muaj thiab tuaj yeem tsim los ntawm kev noj zaub mov zoo xws li txiv hmab txiv ntoo, mis, thiab zaub. Hauv lub cev, NMN yog siv los tsim nicotinamide adenine dinucleotide (NAD+), lub zog loj thiab tseem ceeb uas muaj nyob hauv txhua lub cell ntawm lub cev. Yog li, Noj NMN hmoov yog ib txoj hauv kev uas NAD+ qib hauv cell tuaj yeem nce ntxiv, tom qab ua tiav lub hom phiaj ntawm kev tiv thaiv kev laus.

Txog tam sim no, muaj ntau txoj hauv kev los tsim NMN cov khoom siv raw hauv lub hoobkas, tseem hu ua NMN hmoov. Raws li kuv paub, Kuv tau paub 2 txoj hauv kev los ntawm lub Hoobkas uas tsim cov hmoov NMN:

Txoj Kev 1 rau kev tsim cov hmoov NMN: Catalyst method (Industrial Grade)

Cov khoom lag luam tsim no tsuas yog siv rau tshuaj lom neeg siv tshuaj tiv thaiv, tsis haum rau tib neeg, lawv yuav tsis xav tau txhawm rau txheeb xyuas cov hlau hnyav, qhia txog microbiological sab hauv cov hmoov, nws yog qhov txaus ntshai.

Txoj Kev 2 rau kev tsim cov hmoov NMN: Enzymatic method (Zaub Mov Qib)

Los ntawm txoj kev no, NMN hmoov muaj kev nyab xeeb rau tib neeg siv, thiab tsis muaj Reagent seem, txawm siv txheej txheem txheej txheem sab nrauv los ntsuas qhov ua tau zoo, qhov tshwm sim tseem tsis muaj tsawg dua 98% kev ua kom huv. (muaj qee yam khoom yooj yim ua kom qhuav niam kom tau cov hmoov, thiab siv HPLC txoj hauv kev los ntsuas qhov huv, nws kuj tseem tsis tsawg dua 98%, tab sis thaum nws siv cov txheej txheem sab nraud los ntsuas, tom qab ntawd qhov sib txawv yuav pom tseeb .

AASraw yog lub chaw tsim khoom lag luam los tsim NMN hmoov hauv Suav teb thiab txoj hauv kev twg peb siv yog txheej txheem enzymatic, txhua pawg NMN hmoov yuav raug kuaj ua ntej muag tawm thiab qhov huv qhia tau 99% min, qhov zoo yog ruaj khov. Peb tau cog lus nrog ntau lub tuam txhab pabcuam loj thiab muab NMN hmoov rau lawv rau lub sijhawm ntev. Tsis muaj qhov tsis ntseeg tias Enzymatic txoj kev yog qhov kev xaiv zoo rau feem ntau ntawm cov chaw tsim khoom. Yog li, thov lees paub qhov no nrog koj tus neeg muab khoom ntawm NMN hmoov ua ntej koj yuav ntau NMN hmoov.

 

NAD+ Ua Dab Tsi Nrog NMN?

NAD sawv rau nicotinamide adenine dinucleotide. Los ntawm cov kab mob mus rau cov tsiaj txhu, nws yog ib qho ntawm cov muaj txiaj ntsig tshaj plaws thiab tseem ceeb hauv cov txheej txheem hauv cellular. Hauv lwm txoj hauv kev, txhua lub cev muaj NAD cov khoom, peb yuav zaum tuag hauv 30 vib nas this yam tsis muaj NAD+. Uas qhia peb NAD+ yog cov khoom tseem ceeb rau peb lub cev, nws tuaj yeem txhawb peb lub cev ua haujlwm li qub txhua hnub.

NAD+ ua haujlwm ua lub tsheb npav thauj neeg, xa cov hluav taws xob hla ib lub xovtooj ntawm tes mus rau lwm qhov. Cov txheej txheem no tseem ceeb heev.Nws lwm txoj haujlwm ntawm NAD+ suav nrog tswj kev pw tsaug zog/sawv ntxov. NAD+ tsav sirtuins los tswj cov metabolism thiab tswj cov chromosomes ruaj khov. Cov lwg me me tseem pab kho DNA puas.

Nicotinamide Mononucleotide 04

 

Yog li, nws yog qhov tseem ceeb heev kom NAD+ qib ntawm peb lub cev. Qhov ntawd tseem hais rau peb tias peb tau hluas dua los ntawm kev nce qib NAD+, pab peb tawm tsam kev laus. Tom qab ntawv dab tsi peb yuav tsum nce peb qib NAD+?

Raws li cov kws tshawb fawb tau hais, muaj peb txoj hauv kev nce NAD+ qib:

Kho kev noj zaub mov noj. Kev noj zaub mov muaj roj ntau thiab muaj carbohydrates tsawg, xws li keto lossis Atkins-style diet, txhawb lub xeev ketosis. Thaum koj lub cev nyob hauv ketosis, koj siv cov rog rau lub zog tsis yog piam thaj. Cov txheej txheem no nce qhov sib piv ntawm NAD+ rau NADH, yog li tiv thaiv koj lub cev los ntawm oxidation.

NAD+ Ntxiv. Koj lub cev muaj peev xwm kawg los tsim NAD+, yog li nrhiav cov khoom ntxiv los ntawm cov tuam txhab tsim khoom muaj npe uas muaj kev lees paub kev dawb huv yog txoj hauv kev tsis mob los txhawb cov qib no hauv koj lub cev. Cov tshuaj ntxiv no suav nrog nicotinamide, nicotinic acid, nicotinamide mononucleotide (NMN), thiab nicotinamide riboside (NR). 【Nicotinic acid hloov mus rau NAD+ los ntawm peb qib. Hauv thawj kauj ruam, enzyme NAPRT hloov pauv nicotinic acid mus rau nicotinic acid mononucleotide (NAMN). Hauv qib thib ob, enzyme, NMNAT, hloov NAMN mus rau nicotinic acid adenine dinucleotide (NAAD). Cov enzyme, NAD+ synthetase (NADS) tom qab ntawd hloov NAAD rau NAD+. NAD+ biosynthesis nyob rau hauv txoj kev khaws cia cuam tshuam nrog nicotinamide hloov pauv mus rau NMN ntawm cov enzyme, phosphoribosyltransferase, NMNAT. Cov enzyme hloov NMN rau NAD+.】

Xyaum yoo mov tsis tu ncua. Txawm hais tias txwv tsis pub muaj calorie ntau lossis ntev ntawm kev yoo mov tsis pom zoo rau cov neeg laus feem ntau, kev yoo mov luv lossis tsis tu ncua tuaj yeem pom cov txiaj ntsig zoo ib yam. Kev yoo mov tsis tu ncua yog txoj hauv kev muaj txiaj ntsig zoo ntawm kev qhia koj lub cev rau lub sijhawm ntev dua yam tsis tau noj mov, nce koj qib NAD+ ntau ntau ib yam nkaus li ketosis.

Hmoov tsis zoo, kev noj zaub mov muaj roj ntau yuav tsis pom zoo yog tias koj muaj ntshav qab zib, mob plawv, lossis nce LDL cov roj cholesterol. Ib yam li ntawd, kev yoo mov yuav tsis pom zoo rau cov uas muaj mob thiab feem ntau nyuaj rau txuas ntxiv mus raws sijhawm. Yog li, ntxiv nrog NMN hmoov lossis lwm yam NAD ntxiv feem ntau yog txoj hauv kev nyab xeeb tshaj plaws thiab yooj yim tshaj plaws los txhawb kev tsim NAD.

Tom qab peb paub NAD+ thiab nws ua haujlwm li cas, kuv kwv yees tias koj yuav tsum paub yog vim li cas peb thiaj xav tau NMN hmoov? Nws ua haujlwm li cas thaum NMN hmoov nkag rau hauv peb lub cev. Hauv txoj hauv kev yooj yim, NMN yog tus ua ntej ntawm NAD+ ua ntej nkag mus rau peb lub cev. Noj cov hmoov NMN tuaj yeem nce qib NAD+ thiab pab peb tuav qhov nrawm ntawm kev laus.

 

Puas yog NMN Hmoov Zoo Ntxiv? 

Feem ntau ntawm cov ntaub ntawv kom deb li deb tau los ntawm tsiaj, uas tsis tau qhia tias muaj kev phiv. Kev tshawb fawb cov nas mus ntev kuj tseem tsis pom muaj tshuaj lom, muaj kev phom sij loj, lossis nce tus neeg tuag nyob thoob plaws 12 lub hlis kev cuam tshuam. Raws li peb paub, Tib neeg tau sim tsis ntev los no tawm ntawm Nyij Pooj. Lub hom phiaj ntawm kev sim yog los txiav txim siab tias NMN hmoov tau nyab xeeb. NMN tau ua rau 10 tus txiv neej noj qab nyob zoo. Cov koob tshuaj ntawm 100, 250, thiab 500 mg NMN tau muab. Kev tswj hwm qhov ncauj ib leeg ntawm NMN tsis ua rau muaj cov tsos mob tseem ceeb lossis hloov pauv hauv lub cim tseem ceeb xws li lub plawv dhia, ntshav siab, oxygen txaus, thiab lub cev kub. Kev sim sim pab kom paub tseeb tias, feem ntau, NMN hmoov muaj kev nyab xeeb thiab ua tau zoo; txog qhov kawg, kev sim tuaj yeem suav tias yog kev ua tiav. Txoj kev tshawb fawb no tseem ntsuas kev pw tsaug zog zoo, thiab pom tsis muaj qhov sib txawv ua ntej thiab tom qab NMN noj.

Vim tias muaj pes tsawg tus tib neeg raug sim, cov kws tshawb fawb tseem tab tom tshawb fawb txog cov kev mob tshwm sim ntawm NMN, siv zog kom tau txais cov ntaub ntawv kho mob ntau ntxiv los ntawm tib neeg kev sim, txhawm rau kom ntseeg tau tias cov khoom lag luam tshiab tiv thaiv kev laus no tau pib ua haujlwm.

Nyob rau tib lub sijhawm, peb yuav tsum tham txog Dr. David Sinclair uas yog ib ntawm 100 tus neeg muaj peev xwm tshaj plaws hauv ntiaj teb los ntawm Time Magazine, tau noj NMN cov tshuaj ntxiv rau ntau xyoo nrog cov phooj ywg hauv kev lag luam laus. Nws qhia qhov kev paub nrog peb tom qab nws noj NMN hmoov ntev. Nws hais tias: "Kuv ib txwm noj 1 gram ntawm NMN txhua hnub, nrog rau lwm yam tshuaj ntxiv suav nrog resveratrol, metformin, thiab tshuaj aspirin. Kuv tsis tau ntsib dua lwm yam tshaj li mob plab heev txog tam sim no. " Nws kuj tseem nco txog tias peb yuav tsum khaws NMN hmoov hauv huab cua txias lossis zoo tshaj hauv lub tub yees, vim tias NMN degrades rau Nicotinamide lom koj lub cev thaum NMN khaws cia hauv qhov kub/sov.

 

Cov txiaj ntsig dab tsi tuaj yeem NMN Hmoov Tuaj Rau Kuv Lub Cev? 

NMN (Nicotinamide Mononuleotide) yog lub ntuj tsim ua ntej ntawm NAD+. NMN ntxiv kev txhawb nqa DAN+ rau kev noj qab haus huv tseem ceeb & kev nyob ntev ntawm kev muab lwm yam txiaj ntsig kev noj qab haus huv.NMN hmoov yog nyob rau theem pib ntawm tib neeg kev sim siab thiab tam sim no cov txiaj ntsig tau thov tau dhau los ntawm kev ua tiav ntawm kev tshawb fawb tsiaj. Txog rau hnub tim, tsis muaj pov thawj ntawm qhov cuam tshuam tsis zoo, txawm tias txhaj tshuaj ntau dhau nyob rau lub sijhawm ntev. Nws kuj tseem tau qhia txog txiaj ntsig kev noj qab haus huv hauv cov neeg mob Ntshav Qab Zib Hom II thiab Alzheimer Tus Kab Mob.Qhov hauv qab no yog 10 ntawm cov txiaj ntsig zoo tshaj ntawm NMN hmoov:

♦ Los tiv thaiv kev laus

♦ Ua kom txiv neej muaj zog ntxiv

♦ Txhim kho qhov muag & pom kev

♦ Lub zog txhawb zog

♦ Ua kom yooj yim kho cov kab DNA tawg

♦ Txhim kho lub raum ua haujlwm & ntshav ntws

♦ Txo cov roj cholesterol thiab triglycerides

♦ Txhim kho kev tiv thaiv kab mob ua haujlwm

♦ Txhawb kev noj qab haus huv lub plawv & ua haujlwm

♦ Txhim kho kev ua haujlwm mitochondrial los ntawm kev txo qis kev mob qog noj ntshav

 

Kuv Puas Tau Txais NMN Txaus Los Ntawm Zaub Mov Los Tiv Thaiv Kev laus? 

Cov lus teb yog "tau kawg tsis yog". Vim tias NMN pom muaj nyob hauv ntau cov zaub mov thiab koj tuaj yeem nrhiav tau yooj yim hauv peb lub neej.

▪ Broccoli

Zaub qhwv

▪ Dib

▪ Edamame

▪ Avocado

▪ Txiv lws suav

 

Nicotinamide Mononucleotide

Tam sim no, koj yuav tsum xav txog: "Yog tias pom NMN hauv cov zaub mov, kuv puas tuaj yeem nce kuv qib NAD+ los ntawm kev noj cov zaub mov ntau dua?" Yog lo lus nug zoo. Txawm li cas los xij, Kuv yuav tsum taw qhia tias yog tias koj xav thim rov qab nrog NMN, koj yuav tsum tau noj ntau ntawm txhua qhov ntawm cov zaub mov no. Hmoov tsis zoo, NMN hauv ob peb lub qia ntawm zaub paj tsis yooj yim txawm tias yuav pib txhawb NMN qib. Txawm hais tias NMN tshwm sim hauv cov zaub mov no, qhov sib xyaw tsawg dua 1 mg rau ib kg zaub mov. Hauv lwm lo lus, kom tau txais txog 1mg ntawm NMN, koj yuav tsum tau noj txog 1kg ntawm zaub paj! Nws tau pom tias txhawm rau txhawb qib NAD+ hauv tib neeg, qib NMN yuav tsum nyob rau ntau pua milligrams ib koob. Qhov no yog txoj hauv kev siab dua qhov peb tuaj yeem tau txais los ntawm peb cov zaub mov noj, tsis muaj teeb meem ntau npaum li cas zaub paj zaub peb noj. Yog li, peb yuav tsum txiav txim siab txog kev noj NMN hmoov ua tshuaj ntxiv rau kev tiv thaiv kev laus hauv peb lub neej, nws tuaj yeem pab peb lub cev nce NAD+ntau dua, tiv thaiv kev laus.

 

Yuav Siv Li Cas NMN Hmoov? 

Hauv lo lus nug kawg, peb tau hais txog Dr. David Sinclair uas tau noj 1g NMN txhua hnub. Tom qab ntawd 1g yog qhov ua tau zoo tshaj plaws rau peb kom tau txais txiaj ntsig ntawm NMN, puas yog? “Tsis yog!” Thaum ua haujlwm ntau npaum li cas koj yuav tsum tau noj, nws yog ib qho tseem ceeb los txiav txim siab li cas NMN raug tswj hwm thiab nws cov muaj nyob hauv. Dab tsi ntxiv, lub cev sib txawv nrog cov tshuaj tiv thaiv sib txawv. Peb xav tau tawm thaum nws zoo los noj NMN, yuav siv nws li cas thiab ntau npaum li cas peb yuav tsum noj thaum koj npaj noj NMN hmoov.

 

Cia peb tham thawj lo lus nug: Yuav Siv NMN hmoov li cas? 

NMN tau tswj hwm hauv plaub txoj kev xaiv uas yuav cuam tshuam ntau npaum li cas NMN ua rau nws nkag mus rau hauv koj cov ntshav: hmoov, sublingual hmoov, tshuaj ntsiav tshuaj txheem, thiab tshuaj tiv thaiv lub plab.

Txhawm rau nkag siab bioavailability, ib tus yuav tsum nkag siab First Pass Effect (nws hais txog ntau npaum li cas ntawm cov khoom raug rhuav tshem lossis ua tiav los ntawm lub siab ua ntej nws nkag mus rau hauv cov ntshav). Qhov no yog lub tswv yim nyuaj, kuv kwv yees qhov vis dis aus no tuaj yeem pab peb nkag siab tias nws ua haujlwm li cas thiab vim li cas nws thiaj tseem ceeb heev rau peb kom paub nws ua ntej noj NMN hmoov. Vim tias thawj-dhau cov metabolism, kev siv qhov ncauj ntawm NMN tsis muaj txiaj ntsig ntau dua li cov tshuaj sublingual lossis lub plab-tiv taus. Thaum NMN hmoov tau noj ntawm qhov ncauj (txawm yog thaum noj lossis sib xyaw nrog kua) feem ntau nws raug rhuav tshem los ntawm lub plab kua qaub. Qhov seem NMN tom qab ntawd yog metabolized los ntawm daim siab. Yuav ua li cas daim siab metabolizes NMN tuaj yeem muaj kev cuam tshuam loj heev rau kev noj qab haus huv. Nws yuav yog qhov tsuas yog ib feem ntawm NMN ua rau nws nkag rau hauv koj lub cev. Tsis tas li txhawm rau txhim kho koj li NAD+ qib, koj tuaj yeem coj ncua-tso NMN tsiav tshuaj nrog Sirtuin Activator xws li Resveratrol nrog cov rog tag nrho uas yog pab cov bioavailability ntawm Resveratrol.

Tab sis thaum NMN (lossis ib qho tshuaj lossis tshuaj ntxiv) raug noj sublingually, nws tau nqus thoob plaws cov hnoos qeev (hauv qab tus nplaig) thiab kis ncaj qha mus rau hauv cov ntshav. Los ntawm qhov ntawd nws taug kev ncaj nraim mus rau lub hlwb thiab lwm yam kabmob, hla "qhov ua tau zoo dhau los" los ntawm daim siab. Nws yog vim li no, uas peb ntseeg hais tias noj sublingual NMN lossis hauv lub plab-resistant capsule yog qhov ua tau zoo tshaj plaws thiab muaj txiaj ntsig zoo. Nws yuav xav tau koob tshuaj tsawg dua li noj NMN hmoov hais lus lossis hauv cov qauv tshuaj ntsiav.

  1. NMN Hmoov yog dab tsi?
  2. NAD+ Ua Dab Tsi Nrog NMN?
  3. Puas yog NMN Hmoov Zoo Ntxiv?
  4. Cov txiaj ntsig dab tsi tuaj yeem NMN Hmoov Tuaj Rau Kuv Lub Cev?
  5. Kuv Puas Tau Txais NMN Txaus Los Ntawm Zaub Mov Los Tiv Thaiv Kev laus?
  6. Yuav Siv Li Cas NMN Hmoov?
  7. Kuv puas yuav tsum noj lwm yam tshuaj ntxiv nrog NMN ua ke?
  8. Puas yog NMN pab tau zoo rau tiv thaiv COVID-2019?
  9. NMN VS. NR: Qhov Twg Zoo Tshaj?
  10. Kuv Yuav Pom Li Cas NMN Hmoov Zoo?
  11. Yuav Ua Li Cas Khaws NMN Hmoov?
  12. Puas Muaj Kev Txheeb Xyuas Tiag tiag ntawm NMN Hmoov?
  13. Ntsiab lus

 

Cov lus nug tom ntej: Thaum twg yog lub sijhawm zoo tshaj los noj NMN hmoov? 

Kev laus yog kab mob uas tuaj yeem tawm tsam nrog kev sib xyaw ua ke ntawm cov tshuaj ntxiv thiab tus cwj pwm, raws li kev tshawb fawb tshiab los ntawm University of Waterloo.Ua siv cov qauv lej ua lej, cov kws tshawb fawb tseem pom tias lub sijhawm zoo tshaj plaws rau ib tus neeg los noj cov tshuaj no yog nyob ntawm ntawm lawv hnub nyoog. Qee cov tshuaj tiv thaiv kev laus yuav tsum tau siv los ntawm cov tub ntxhais hluas thaum hmo ntuj, thaum cov neeg laus yuav tsum noj nws thaum nruab hnub kom muaj txiaj ntsig zoo tshaj plaws. cuam ​​tshuam rau koj lub cev, koj hnub nyoog li cas thiab koj nyob li cas, "Tus kws tshawb fawb Layton tau hais. "Tib neeg yuav tsum nco ntsoov thaum lawv noj mov thiab ua kom ntseeg tau tias nws sib xws nrog lwm yam hauv lawv ib puag ncig uas cuam tshuam rau lawv lub sijhawm pw/tsaug zog lossis lub cev moos.

Yog li, thaum nws yog lub sijhawm zoo tshaj los noj NMN hmoov? hnub nyoog yog qhov tseem ceeb ua ntej txiav txim siab ntau npaum li cas peb noj NMN hmoov. Piv txwv li, nws tau kawm tias NMN cov tshuaj pab tau zoo tshaj rau cov tub ntxhais hluas siv sijhawm rau teev tom qab sawv los. Ntawm qhov tsis sib xws, kev tshawb fawb qhia tias Resveratrol tshuaj ntxiv ua haujlwm tau zoo tshaj yog tias cov tub ntxhais hluas noj lawv thaum yav tav su. Rau cov neeg laus, nws yog ib qho tseem ceeb kom noj cov tshuaj no thaum yav tav su.

 

Lo lus nug kawg: Peb yuav tsum noj NMN npaum li cas? 

Tom qab peb nyeem cov lus nug saum toj no, peb yuav tsum paub tias txhua tus xav tau nrhiav tus kheej cov tshuaj rau NMN hmoov, tsis yog koob tshuaj raws li kev pom zoo. Tom qab ntawv peb tuaj yeem suav qhov NMN ntau npaum li cas rau peb tus kheej? Raws li kev tshawb fawb zaum kawg, nws cuam tshuam nrog peb qhov hnyav. Los ntawm txoj kev tshawb fawb: "Muab tias 100 mg/kg/hnub ntawm NMN tuaj yeem txo qis feem ntau cuam tshuam txog kev mob lub cev hauv cov nas, qhov sib npaug ntawm thaj tsam ntawm tib neeg yuav yog ~ 8 mg/kg/hnub, muab kev cia siab los txhais peb nrhiav tau rau tib neeg. " Raws li tus kws sau ntawv ntawm kev tshawb fawb tshawb fawb tsis ntev los no, yog kom noj yam tsawg kawg nkaus ntawm 8 mg ntawm NMN ib kg ntawm lub cev hnyav ib hnub. Yog tias txoj kev tshawb fawb raug, tom qab ntawd txhawm rau nrhiav ntau npaum li cas NMN koj xav tau ntawm qhov tsawg kawg, koj yuav tsum xub nrhiav koj qhov hnyav hauv kg, tom qab ntawd muab sib npaug los ntawm 8. Piv txwv li, yog tias koj qhov hnyav yog 50kg, cov tshuaj pom zoo yog txog 400mg.

Yog tias koj noj cov tshuaj zoo ntxiv nrog kev noj qab haus huv zoo, zoo li AASraw's NMN hmoov, tom qab ntawd peb pom zoo cov tshuaj hauv qab no uas yog raws li cov neeg siv khoom tawm tswv yim:

 

Nyhav Dosage Rau Siv (txhua hnub)
45kg 45kg * 8mg = 360mg
50kg 50kg * 8mg = 400mg
60kg 60kg * 8mg = 480mg
70kg 70kg * 8mg = 560mg
90kg 90kg * 8mg = 720mg
Cov tshuaj no tsuas yog ua kom rov zoo xwb. Koj yuav tsum tau npaum li cas? Nws nyob ntawm koj. Tab sis yog tias koj pom qhov kev tshawb fawb tshwj xeeb no ntseeg tau, koj yuav pib ua koj cov lej ntawm 8 mg ib kg ntawm lub cev hnyav ib hnub.

 

Kuv puas yuav tsum noj lwm yam tshuaj ntxiv nrog NMN ua ke? 

Yog tias koj yog tus neeg soj ntsuam zoo, koj yuav tsum tau pom tias Dr. David Sinclair noj tshuaj tiv thaiv kev laus txhua hnub, tsis yog tsuas yog NMN hmoov, tseem muaj lwm tus, xws li resveratrol, metformin, thiab tshuaj aspirin ... Puas yog qhov yuav tsum tau noj lwm yam tshuaj ntxiv nrog NMN hmoov ua ke? Vim li cas?

Pib ntawm kev tshawb fawb los ntawm Dr. David Sinclair thiab nws pab neeg, noj NMN hmoov lwm yam tshuaj ntxiv yog qhov muaj txiaj ntsig zoo rau kev tiv thaiv kev laus. Txog tam sim no, Kuv yuav qhia 3 tshuaj ntxiv thaum peb noj NMN hmoov. 2 cov tshuaj ntxiv yog resveratrol thiab pterostilbene. Resveratrol yog stilbenoid pom nyob rau ntawm daim tawv nqaij ntawm cov txiv hmab hauv qhov tsawg. Cov kev tshawb fawb tau qhia tias resveratrol tuaj yeem txo qhov kev pheej hmoo ntawm mob plawv, mob qog noj ntshav thiab txhim kho kev tsim kho tshiab. David Sinclair ntseeg tias resveratrol ua haujlwm ua ke nrog NMN. Resveratrol xav tau los ua kom cov noob sirtuin (uas tiv thaiv peb cov DNA thiab epigenome), thaum NMN xav tau txhawm rau txhawm rau sirtuins.Yog li cas, resveratrol nyuaj rau nqus los ntawm lub plab, thiab me ntsis resveratrol uas xaus rau hauv lub cev tau tawg Yog li ntawd, pterostilbene yog lwm txoj hauv kev zoo dua. Pterostilbene yog cov qauv uas zoo ib yam li resveratrol, tab sis nws tau nqus tau zoo dua thiab muaj kev ruaj khov nyob hauv tib neeg lub cev.

Lwm qhov ntxiv yog trimethylglycine (TMG), thaum peb noj NMN hmoov rau lub sijhawm ntev, NMN depletes methyl pawg hauv peb lub cev, raws li kev ceev faj, nws tau xav tias yog qhov tseem ceeb kom noj TMG (cov amino acid hu ua betaine) los pub cov pab pawg methyl. Thaum NMN hloov mus rau hauv NAD+, nicotinamide (NAM) tau tsim. Qib siab ntawm nicotinamide tsis zoo rau peb lub cev thiab kom peb lub cev tshem tawm nicotinamide nws yuav tsum tau ua methylated rau hauv N-methyl nicotinamide uas tau tso tawm hauv peb cov zis. Txhawm rau ua kom methylate NAM, lub cev xav tau los ntawm peb cov peev txheej ntawm pawg methyl. Txoj kev xav yog tias ntau dua NMN koj coj, ntau pawg methyl xav tau kom tshem NAM.

Hauv podcast hauv qab no nrog Dr. Mercola, Dr. David Sinclair tau hais tias nws ua TMG raws li kev tiv thaiv kom tiv thaiv qhov no tshwm sim, peb tuaj yeem kawm paub ntau ntxiv los ntawm daim vis dis aus no ntawm Dr. David Sinclair:

Txawm hais tias feem ntau ntawm cov tshuaj ntxiv tau nyab xeeb thiab muaj txiaj ntsig zoo rau peb lub cev, nws yog qhov zoo tshaj los tshuaj xyuas nrog koj tus kws kho mob ua ntej pib noj nws, tshwj xeeb tshaj yog tias koj muaj mob thiab siv tshuaj kho mob ntev. Ib txwm ua raws li cov tshuaj pom zoo.

 

Puas yog NMN pab tau zoo rau tiv thaiv COVID-2019? 

Lub cev pib teb rau qhov kev hem thawj sib kis zoo li COVID-19, paub tias yog lub cev tiv thaiv kab mob, yog nyob ntawm NAD+. Kev kis tus kab mob ua tsis tiav NAD+ vim tias kev kis kab mob ua rau muaj kev tiv thaiv cellular uas ua rau nce NAD+ kev puas tsuaj los tiv thaiv tus kab mob los ntawm kev hla lub cell. Qhov txo qis NAD+ qhov kev nkag siab tau pom hauv COVID-19 thiab qee cov kws tshawb fawb xav tias qhov no yog qhov tseem ceeb vim li cas tus kab mob no thiaj li tuag taus, tshwj xeeb tshaj yog rau cov uas muaj NAD+ cia. Dr. Zhavoronkov tau hais qhia tias Kuaj cov tshuaj rapamycin qis tus kheej lossis ua ke nrog metformin, thiab NAD+ boosters xws li nicotinamide riboside (NR), lossis nicotinamide mononucleotide (NMN) tuaj yeem pab tiv thaiv cov neeg laus los ntawm kev kis tus kab mob gerolavic niaj hnub no thiab tseem tuaj yeem txhim kho kev lag luam rov qab thaum muaj kev sib kis thoob ntiaj teb.

Ib qho ntxiv, kev tshawb fawb tau qhia tias NAD+ tuaj yeem ua rau lub cev tiv thaiv kab mob tiv thaiv lub cev los ntawm tus kabmob coronavirus xws li COVID-19. Kev tshuaj xyuas luam tawm Lub Peb Hlis 23, 2020 los ntawm Isfahan University of Medical Sciences muab pov thawj tias qib qis NAD+ tuaj yeem cuam tshuam rau qhov hnyav thiab mob hnyav nyob rau hauv COVID-19 muaj thoob qhov txhia chaw. Raws li kev sim tshuaj kho mob, NMN cov tshuaj txhawb NAD+ rau cov hluas. Ua NAD+ cov qauv muaj rau SIRT1 cov noob txhim kho lawv lub peev xwm los tiv thaiv lub cev tiv thaiv kab mob thiab kev puas tsuaj. Raws li kev tshawb fawb ntau tab tom ua, cov kws tshawb fawb tau pom tias NAD+ tseem muaj lub luag haujlwm tseem ceeb los ua hauv kev tswj hwm peb lub cev tiv thaiv kab mob.

Lawv kuj tau pom tias macrophages (ib hom ntshav dawb uas noj cov neeg muaj peev xwm xws li cov kab mob, cov kab mob, cov cab, thiab kab mob) siv txoj hauv kev sib txuas los ntawm NAD+ kom ntseeg tau tias cov cell muaj sia nyob thiab tswj kev mob. Tag nrho txhua qhov, kev tshawb fawb tau qhia tias NMN thiab qib nce ntawm NAD+ tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev pab peb lub cev tiv thaiv kev kis mob thiab kab mob. Hauv lwm lo lus, nws muaj peev xwm txhawb peb lub cev tiv thaiv kab mob thiab pab lawv thaum lub sijhawm kis thiab mob.

Ib qhov kev tshawb fawb tau tshaj tawm thaum Lub Plaub Hlis 22, 2020 los ntawm Dr. Robert Huizenga MD ntawm University of Chicago piav qhia nws cov lus teb rau tus poj niam hnub nyoog 55 xyoos uas tau mus pw hauv tsev kho mob nrog COVID-19 thaum Lub Peb Hlis 16. Nws tus mob txuas ntxiv zuj zus thiab nyob rau ib hnub 13 nws muaj mob ntsws pom tseeb, cua daj cua dub cytokine thiab ua rau hsCRP nce siab heev, tus cim tshwj xeeb rau qhov mob o. Dr. Huizenga kho nws nrog qhov ncauj NMN, betaine thiab NaCl (paub tias txo IL-6) thiab txuas ntxiv cov zinc kho nws tau muab ua ntej. Txog hnub 15, nws kub taub hau tau zoo dua thiab cov tsos mob zoo dua qub. Txog hnub 17 nws tau tawm mus tsev. Txog hnub 23, nws tsis muaj tsos mob. Ob tus neeg laus laus tau kho nrog tib "dej cawv" thiab ob qho tib si tau zoo ib yam rov qab los.

 

NMN VS. NR: Qhov Twg Zoo Tshaj? 

Nicotinamide mononucleotide (NMN) thiab nicotinamide riboside (NR) yog biosynthetic ua ntej rau cov txheej txheem tseem ceeb rau cov metabolism - nicotinamide adenine dinucleotide (NAD+). Cov qauv txheej txheem ntawm NMN thiab NR zoo li qub, tshwj tsis yog NMN muaj cov pab pawg phosphate ntxiv. Cov pab pawg phosphate ntxiv no ua rau NMN muaj cov qauv loj dua li NR. NR (nicotinamide riboside) thiab NMN (nicotinamide mononucleotide) cov tshuaj ntxiv yog ob qho tib si feem ntau suav hais tias yog ob qho ntawm cov kev cia siab tshaj plaws los ua kom qeeb kev laus. Noj NR thiab NMN hmoov nce NAD+ qib. Qib NAD+ siab dua tiv thaiv peb cov epigenome thiab DNA. Kev nce qib NAD+ ua rau ntau cov txiaj ntsig kev noj qab haus huv ntawm ntau yam kabmob, xws li lub hlwb, kab mob plawv, thiab cov leeg.

Muab tias NR thiab NMN nce NAD+ qib, lawv feem ntau hu ua NAD boosters. Ntau qhov kev tshawb fawb qhia tias NR thiab NMN tuaj yeem txhim kho ntau yam kev ua rau lub hnub nyoog, zoo li tsis muaj kev cuam tshuam epigenome, DNA puas, cov protein ntau ntxiv, ua rau mob (ua rau cuam tshuam txog kev laus) thiab ntau yam kev ua haujlwm laus.

Tab sis lo lus nug loj yog: qhov twg yog qhov zoo dua, NMN hmoov lossis NR hmoov?

Tam sim no, tsis muaj kev tshawb fawb piv rau NMN thiab NR lub taub hau hais txog kev noj qab haus huv thiab cuam tshuam kev ua neej nyob. Cia peb sib piv NMN thiab NR:

NMN vs NRA

Kuv Yuav Pom Li Cas NMN Hmoov Zoo? 

Kuv ntseeg tias koj tau pom ntau tus neeg xa khoom thaum koj tso "NMN hmoov" hauv Google, yog li koj tsis paub tias qhov twg yog qhov zoo tshaj lossis haum rau koj tus kheej. Peb xav paub seb peb yuav tsum txheeb xyuas dab tsi thaum peb tham nrog NMN cov hmoov xa khoom. Rau kev ua haujlwm tawm qhov teeb meem no, Kuv tau tham nrog ntau tus neeg muag khoom ntawm NMN hmoov online thiab txheeb tawm cov npe rau siv:

 

(1) Kev tshawb nrhiav yooj yim

Koj xav tau txheeb xyuas lawv lub vev xaib lossis khw hauv online, nco ntsoov tias lawv yog tus muab kev ntseeg siab, tsis dag. Mus rau lawv lub vev xaib lossis khw, tham nrog lawv, nug cov lus nug yam koj xav tau. thaum lawv teb koj cov lus nug, koj tuaj yeem xav tias nws yog kev ntseeg siab, raws li peb txhua tus paub, kev ua siab ncaj yog lub hauv paus ntawm txhua txoj kev koom tes. Thaum koj nug lawv cov lus nug, koj tuaj yeem tham txog cov no: NMM hmoov tsim khoom, NMN daim ntawv pov thawj hmoov, muab peev xwm ntawm NMN hmoov….

 

(2)Kev Tu Siab Zoo

Qhov zoo tshaj plaws NMN hmoov yuav muaj 99% kev coj dawb huv lossis siab dua. Nws kuj tseem yuav tsis muaj cov khoom ntim los yog cov khoom tsim tawm xws li GMOs, mis nyuj, qe, kua zaub, gluten, tshuaj lom neeg, hlau hnyav, lossis cov kuab tshuaj siv hauv kev ua tiav ntawm cov khoom. Feem ntau cov hmoov NMN cuav siv cov tshuaj muab los yog cov tshuaj ua kom muaj ntau ntawm cov khoom. Qhov no tuaj yeem ua rau koj txoj kev noj qab haus huv muaj kev pheej hmoo loj vim tias koj tsis paub tias koj tab tom noj dab tsi. Yog tias koj tab tom yuav koj li NMN los ntawm lub tuam txhab uas tsuas yog muag NMN tsiav tshuaj, nws tuaj yeem yog dab tsi.

 

(3)Cov Ntaub Ntawv Muaj Feem Xeem - Kuaj Tshaj Qhia

Raws li NMN lub Hoobkas hmoov, cov ntaub ntawv cuam tshuam (COA, HPLC, HNMR, MS) yuav tawm tom qab lawv tsim cov khoom lag luam, lawv xav tau tshuaj xyuas nws qhov zoo, xa nws mus rau lab-thib peb kom kuaj (qhov no suav nrog kev ua kom huv, muaj kab mob sib kis, thiab hnyav hlau.), Ua kom ntseeg tau tias nws tau raws li tus qauv thiab tuaj yeem muag nws hauv khw. Koj tuaj yeem tshawb xyuas tus neeg muag khoom lub vev xaib rau cov ntaub ntawv ntsuas thib peb, lossis tiv toj lawv cov neeg siv khoom ncaj qha. Kev pov thawj ntawm kev tshuaj xyuas thib peb yog txoj hauv kev yooj yim kom ntseeg tau tias koj yuav los ntawm cov khoom muaj npe nrov. Txhua lub tuam txhab siv kev tshuaj xyuas thib peb yuav tsum zoo siab qhia cov ntaub ntawv ntawd nrog koj.

 

(4)Sib Piv Tus Nqi Ntawm Ntau Tus Neeg Muag Khoom

NMN Nqe yog lwm qhov ntsuas uas koj tuaj yeem siv los ntsuas cov khoom tsim nyog, los ntawm kev txheeb xyuas tus naj npawb ntawm NMN tus neeg xa khoom rau ob qho hmoov thiab tsiav tshuaj koj yuav tau txais lub tswv yim ntawm tus nqi nruab nrab ib gram.Yog koj tsuas xav txog tus nqi hauv khw, koj yuav tsum ua zoo dev tom ntawm cov hmoov NMN cuav, lossis cov khoom lag luam qis dua. Nws ib txwm ntxias kom xav txuag nyiaj txhua lub sijhawm koj tuaj yeem ua tau, tab sis nrog NMN tshwj xeeb, koj tau txais yam koj them rau. Tus nqi qis NMN yuav yog qib zaub mov, tsis yog qib tshuaj, uas txhais tau tias NMN cov txiaj ntsig tsis zoo ib yam.Qhov kev xaiv pheej yig dua ntawm NMN, uas tam sim no muaj nyob hauv khw, yog qib zaub mov thiab yuav muaj cov kab mob sib kis tau zoo. Qhov tseeb, muaj qee zaum tsawg dua 10% NMN hauv qib zaub mov NMN. Txhawm rau ntsuas qhov no, peb muaj qib zaub mov Qauv NMN kuaj thiab nws rov qab los nrog 8% NMN.Cons txiav txim siab koj cov peev nyiaj yog qhov tseem ceeb, tab sis koj yuav xaus them ntau dua nyob rau lub sijhawm ntev thaum xaiv rau cov nqi NMN qis dua cov khoom lag luam yog tias koj tsis pom muaj txiaj ntsig kev noj qab haus huv los ntawm lawv.

 

(5)Kev Pabcuam Uas Zoo Tshaj

Zoo NMN los ntawm cov khoom lag luam zoo, cov khoom lag luam txhim khu kev qha yuav tsum muaj kev pabcuam zoo rau cov neeg siv khoom. Thaum koj tham nrog cov neeg siv khoom sawv cev, xa txhua cov lus nug rau lawv thiab lawv yuav teb koj sai sai no. yuav taug qab koj tus kheej. Thov nco ntsoov tias kev pabcuam cov qhua tuaj noj mov zoo yog ib tus neeg uas zoo siab sib txuas lus nrog txhua lub sijhawm.

 

(6)Xyuas los ntawm Lwm Cov Neeg Siv Khoom

Raws li dav dav, peb tuaj yeem nrhiav qee qhov kev tshuaj xyuas txog lub tuam txhab ntawd yog tias lub tuam txhab tau muab NMN hmoov rau ntev, lossis lawv tuaj yeem muab qee cov lus tawm tswv yim los ntawm lwm tus neeg siv khoom. Tom qab tag nrho, peb tuaj yeem paub nws yog qhov tseeb tsuav lawv muaj cov ntaub ntawv muag khoom thiab tawm tswv yim tiag tiag ntawm cov neeg siv khoom. Yog lawm, peb yuav tsum paub tias kev tshuaj xyuas los ntawm lwm tus neeg siv tsuas yog siv thaum peb txiav txim siab yuav NMN hmoov, nws vam khom koj thaum kawg.

AASraw yog lub tuam txhab uas tau lees paub lub Hoobkas, tuaj yeem tsim cov hmoov NMN thiab lwm yam tshuaj tiv thaiv kev laus, cov khoom lag luam ruaj khov. Koj mus rau lawv lub vev xaib-www.aasraw.com txhua lub sijhawm thiab nug lawv li kev pabcuam cov neeg siv khoom, nug daim ntawv pov thawj zoo thiab ntawv tshuaj ntsuam xyuas hauv 3rd-lab, lees paub tias lawv cov hmoov NMN yog 99% kev ua kom huv huv qib tshuaj thiab nws yog ib qho saum toj kawg nkaus. Raws li kuv paub, lawv tuaj yeem xa cov khoom tawm uas koj tau xaj hauv 1-3 hnub ua haujlwm, txawm tias 12 teev tom qab tau lees paub qhov ua tiav, kev ua haujlwm tau zoo heev, Kuv yuav tsum muab lawv ntiv tes xoo rau qhov ntawd. Koj yuav tau txais NMN cov duab hmoov thiab tus lej taug qab los ntawm lawv tom qab kev txiav txim, tom qab ntawd koj tuaj yeem siv taug qab cov pob hauv online thiab paub tias nws nyob qhov twg, nyob deb deb ntawm koj lub tsev. Kawm paub ntau ntxiv txog AASraw tam sim no

Yuav Ua Li Cas Khaws NMN Hmoov? 

Nicotinamide riboside (NR) thiab nicotinamide mononucleotide (NMN), tau pom tias txhawm rau txhim kho cov kab mob muaj hnub nyoog cuam tshuam hauv tsiaj. Lawv tau ua siab ntev nyob rau hauv kev txhaj tshuaj siab thiab ua tau zoo nce NAD+ qib. Cov lwg me me no tsis yog lub txee ruaj khov ntawm qhov kub siab lossis nyob rau qhov xwm txheej ntawm cov av noo siab, txawm li cas los xij. Lawv ua kom sai sai rau hauv nicotinamide, uas tiv thaiv kev ua haujlwm ntawm sirtuins thiab PARP, DNA kho cov enzyme. Kom tau txais txiaj ntsig zoo tshaj plaws, NMN hmoov yuav tsum khaws cia hauv lawv lub ntim qub thiab nyob deb ntawm txhua qhov dej. NMN hmoov tsis noj rau 3 lub hlis lossis ntev dua tuaj yeem tso rau hauv tub yees kom ntseeg tau tias lawv tswj tau lub zog tag nrho. Raws li tus thawj coj thoob ntiaj teb, AASraw ib txwm muab qhov muaj txiaj ntsig zoo tshaj plaws thiab muaj txiaj ntsig zoo tshaj NAD+ thiab NMN hmoov muaj.

 

Puas Muaj Kev Txheeb Xyuas Tiag tiag ntawm NMN Hmoov? 

Tom los ntawm UK: Kuv tus poj niam thiab kuv tau pib noj NMN hmoov ntau lub hlis dhau los thiab peb xav tsis thoob tias kuv tsis tsaug zog thiab kuv tus poj niam cov teeb meem tawv nqaij pib ploj zuj zus! Peb tsuas yog xav paub meej meej ntawm lub siab kuj muaj zog ntau dua, kuv tsis tau noj tshuaj ntxiv uas kuv tau hnov ​​qhov tshwm sim rau kuv txhais tau tias koj noj ntau cov vitamins thiab tshuaj ntsuab ntxiv tab sis yeej tsis hnov ​​qhov txiaj ntsig! Qhov no yog qhov zoo tshaj plaws pab txiv neej zoo tau pom tseem thiab tsuas yog qhov ua tau ntawm kev rov kho ntau lab ntawm cov cell hauv tib neeg lub cev yog qhov kev tshawb pom zoo rau cov txheej txheem laus! Kuv xav tias txhua tus neeg yuav paub txog cov tshuaj no nyob rau yav tom ntej thiab kev tshawb fawb mob qog noj ntshav yuav tsum ceeb toom ib yam, peb nyob hauv 50 xyoo thiab tsis tuaj yeem hais txaus txog qhov txawv peb xav li cas! Leej twg yuav tsis xav kom muaj kev noj qab haus huv ntxiv qhov no rau koj cov tshuaj tiv thaiv kev laus ntxiv yuav hloov koj lub neej rau kev ntseeg zoo dua !!!

liMei los ntawm Tuam Tshoj: Kuv xaiv NMN hmoov vim kuv nyeem nws pab oxygenate cov ntshav thiab xa oxygen rau kuv lub cev nqaij daim tawv. Kuv lub cev tau hu rau cov khoom no, Kuv tau hnov ​​nkees thiab tsis tuaj yeem mloog zoo. Kuv tau lawm noj NMN hmoov rau ob lub lis piam tam sim no. Kuv tau pom kev nce lub zog, Kuv tuaj yeem koom nrog hauv qhov kev tawm dag zog cardio tom qab ua haujlwm tas hnub. Kuv cov kev xav tau meej, Kuv tsis hnov ​​tsaug zog hauv kev sib tham. Kuv zoo siab heev nrog NMN cov tshuaj ntxiv Kuv tau txais cov txiaj ntsig uas kuv tau nrhiav. Ib qho ntxiv, kuv yuav tsum hais tias: NMN tus nqi siab me ntsis rau kuv tab sis kuv xav hais kom noj, vim tias kuv xav ua hluas dua, haha ​​...

Gary los ntawm Australia: Nov yog cov tshuaj tiv thaiv kev laus zoo. Kuv pom lub zog nce ntxiv, Kuv tsis ua rau kuv muaj 4 xyoos txias, thiab kuv tsis nkees li yooj yim. Hom zog kuv xav txawv ntawm caffeine siab. Kuv tsis hnov ​​ntxhov siab lossis txhawb siab, tsuas yog ceeb toom thiab tshiab. Txawm hais tias muaj kev ceeb toom, kuv pw tau zoo dua. Kuv yeej tsis tau muaj teeb meem pw tsaug zog, tab sis kuv tuaj yeem sawv ntau heev thaum hmo ntuj. Nrog NMN hmoov kuv tsaug zog ntev dua. Kuv xav tias NMN tau txais txiaj ntsig zoo rau kuv ntau txoj hauv kev thiab kuv tsuas yog tsis tuaj yeem hais lus txaus txog nws.

Steven los ntawm Asmeskas: Tom qab kawm paub txog NMN hmoov thiab nws muaj peev xwm ua tau los ntawm Harvard Txoj Haujlwm tshawb fawb los ntawm Dr. David Sinclair, Kuv txiav txim siab sim nws. Los ntawm thawj hnub kuv sim nws, Kuv pom qhov sib txawv ntawm kuv qib zog. Kuv muaj 57 xyoos, thiab kuv cov metabolism zoo li tau hloov pauv mus rau qhov zoo dua. Kuv tsis tau hloov kuv tus cwj pwm noj zaub mov, tab sis kuv poob phaus, 14 lbs hauv 4 lub lis piam. Lub sijhawm ntawd yog qhia txog kev poob tas mus li. Kuv tus poj niam tau poob 9 lbs, thiab nws raug kev txom nyem los ntawm qhov tsis tshua muaj teeb meem hu ua Erythromelalgia, uas ua rau cov ceg tau kub heev nrog mob neuropathic, thiab nws zoo ib yam. Niacin ib feem ntawm cov khoom sib xyaw, ntxiv rau nws cov tshuaj, tau ua rau qhov mob qis me ntsis, thiab ua kom muaj haujlwm ntau dua. Tom qab kuv khiav tawm thawj zaug - Kuv tau sim ib qho los ntawm lwm tus NMN cov khoom siv hmoov. Nws cov khoom sib txawv, thiab lub zog ploj mus. Tias yog vim li cas kuv thiaj rov qab los rau MAAC10, thiab tam sim no kuv rov qab taug qab. Koj paub, kuv txawm ntseeg qee qhov ntawm kuv cov plaub hau grey tau tsaus ntuj yam tsis muaj zas xim. Nws ua haujlwm Koj paub-Kuv tsis xav tias kuv saib 57 ntxiv lawm ib yam nkaus, txawm li cas los xij, ua tsaug rau qhov txuj ci tseem ceeb ntxiv-NMN hmoov thiab ua tsaug rau aasraw.

 

Ntsiab lus

Thaum Fountain of Youth tseem yog ib qho txuj ci tseem ceeb uas tsis zoo li yuav tshwm sim sai sai, kev tshawb fawb tom qab tshuaj tiv thaiv kev laus txuas ntxiv mus. Tej zaum muaj ib hnub, koj yuav muaj peev xwm noj tshuaj ua txuj ci tseem ceeb thiab ua lub neej raws li cov neeg hluas ib zaug ntxiv. Cov kev tshawb fawb hauv tsiaj tau qhia NMN qhov kev cia siab hauv NAD+-txhawb nqa thiab tiv thaiv kev laus. Tam sim no, Txawm hais tias cov kws tshawb fawb tab tom txav mus tom ntej nrog kev soj ntsuam kuaj mob txhawm rau tshuaj xyuas kev nyab xeeb thiab ua tau zoo ntawm cov txheej txheem hauv tib neeg. NAD thiab NMN ntxiv muab cov txiaj ntsig tiag los qeeb qhov cuam tshuam loj ntawm cell laus ntawm tib neeg lub cev. Kuv ntseeg tias nws yuav pab tau yog tias lawv tau txais txiaj ntsig zoo rau peb lub cev, Cia peb rov hluas dua ua ke.

 

reference

[1] Sab qaum teb, BJ, Rosenberg, MA, Jeganathan, KB, Hafner, AV, Michan, S., Dai, J.,… & van Deursen, JM (2014). SIRT2 induces lub kinase BubR1 txhawm rau ua kom lub neej muaj sia. EMBO phau ntawv xov xwm, e201386907.

[2] Hnia, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A.,… & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) txhawb nqa kev txhawb nqa neurovascular rejuvenation hauv cov nas uas muaj hnub nyoog: cov ntawv sau cia ntawm SIRT1 ua kom, tiv thaiv mitochondrial, tiv thaiv kev mob, thiab tiv thaiv apoptotic. GeroScience, 1-20.

[3] Grozio, A., Mills, KF, Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K.,… & Imai, SI (2019). Slc12a8 yog tus neeg thauj khoom nicotinamide mononucleotide. Xwm txheej metabolism, 1 (1), 47-57.

[4] Li, J., Bonkowski, MS, Moniot, S., Zhang, D., Hubbard, BP, Ling, AJ,… & Sinclair, DA (2017). Ib qho khaws cia NAD+ txoj hlua khi uas tswj hwm kev sib cuam tshuam nrog cov protein-protein thaum lub hnub nyoog laus. Kev Tshawb Fawb, 355 (6331), 1312-1317.

[5] Stipp D. Tshaj li Resveratrol: Anti-Aging NAD Fad. Kev Tshawb Fawb Asmeskas Blog Network. Peb Hlis 11, 2015.

[6] Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC. + Tsis kam. Cell Metabolism. Tsib Hlis 2018, 27 (5): 1081–1095.e10. PMC 5935140. PMID 29719225. doi: 10.1016/j.cmet.2018.03.016.

[7] Bogan KL, Brenner C. Nicotinic acid, nicotinamide, thiab nicotinamide riboside: kev tshuaj ntsuam xyuas molecular ntawm NAD+ cov vitamins ua ntej hauv tib neeg kev noj haus. Kev tshuaj xyuas ib xyoos ib zaug ntawm kev noj haus. 2008, 28: 115-30: kuv. PIB 18429699.

[8] Fletcher RS, Lavery GG (Lub Kaum Hli 2018). "Qhov tshwm sim ntawm nicotinamide riboside kinases hauv kev tswj hwm ntawm NAD+ cov metabolism". Phau ntawv Journal of Molecular Endocrinology. 61 (3): R107 – R121. doi: 10.1530/JME-18-0085. PMC 6145238. PMID 30307159.

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