Txhua yam hais txog Cetilistat hmoov

1. Khoom Lub Npe: Cetilistat
2. Tshuaj Khoom Ntawm Khoom
3. Yooj Yoo Piav Qhia ntawm Cetilistat hmoov
4. Action Mechanism ntawm Cetilistat hmoov
5. Siv Cetilistat
6. Cetilistat hmoov dosage
7. Cetilistat Side Effects
8. Cetilistat Precautions
8.1 Lus Qhia rau Cia
8.2 Yuav ua li cas Nyob rau hauv Case koj tsis nco ib koob
8.3 Dab Tsi Tshwm Sim Thaum Koj Dhau Lawm Ntawm Cetilistat Hmoov
8.4 Kev Siv Cetilistat rau Cov Menyuam

1. Khoom npe: CetilistatPiv txwv

IUPAC Lub Npe: 2-hexadecoxy-6-methyl-3,1-benzoxazin-4-ib

8 lus nug kom koj tus kheej ua ntej noj Cetilistat hmoov

2. Tshuaj Khoom Ntawm KhoomPiv txwv

Khoom Npe Tus Nqi Khoom
Suav Cov Npoo Thaj Teb 1
Isotope Atom suav 0
Cov Nyiaj Txiag Lo Lus Uas Tsis Tau Undefined 0
Cov Nyiaj Txiag Lo Lus Stereocenter 0
Cov Npe Atop Stereocenter Suav 0
Hais txog Atom Stereocenter Suav 0
Hnyav Atom hnyav 29
Lub Nqi Them 0
Compound Is Canonicalized muaj tseeb
XLogP3-AA 9.8
Loj Loj 401.293 g / mol
Monoisotopic pawg 401.293 g / mol
Topological Polar Deg Cheeb Tsam 47.9 IB ^ 2
complexity 477
Cov Nyiaj Txiaj Ntsim Uas Tshaj Tawm 16
Hydrogen Bond Acceptor Suav 4
Hydrogen Nyiaj Donor Suav 0
molecular Nyhav 401.591 Mol

3. Nqe lus piav qhia yooj yim ntawm Cetilistat hmoovPiv txwv

Cetilistat yog ib lub qhov ncauj noj tshuaj uas tau tsim los pab neeg rog phom. Nws yog cais nyob rau hauv benzozaxines, uas yog cov organic compounds uas muaj benzene tso ua ke rau hauv lub nplhaib oxizine. Lub nplhaib oxizine yog ib qho 6-membered aliphatic nplhaib nrog 1 nitrogen atom, 1 pa atom, thiab 4 carbon atoms.

Cov kev tshawb fawb txog tib neeg kev sim tau tsim tau tias tus cetilistat ua haujlwm zoo ib yam rau Orlistat (Xenical). Qhov no poob phaus Cov tshuaj no yeej tseem ua rau cov kab mob pancreatic lipase hlob, uas yog cov enzyme uas lov nram triglycerides hauv cov hnyuv. Qhov qhaj ntawv ntawm no enzyme tiv thaiv kom tsis txhob muaj kev tso dej ntawm triglycerides mus rau hauv cov dej uas muaj roj dawb. Qhov no pub rau lub triglycerides kom raug qis qis.

4. Action Mechanism ntawm Cetilistat hmoovPiv txwv

Ib yam li Orlistat, Cetilistat yog ib tug lipase inhibitor, uas txhais tau hais tias nws ua rau hauv txoj hnyuv tawm mus qeeb hauv lipases, uas yog cov enzymes lub luag hauj lwm rau kev ua txhaum ntawm kev noj haus cov nqaijrog. Nws lub peev xwm hamper lub neej thiab kev nqus ntawm kev noj haus cov rog ntawm lub plab, cov tshuaj pab txo qis thiab roj kom tsawg, thiaj li pab poob phaus.

5. Siv Cetilistat Piv txwv

Ib ntu ntawm Zaum II sim tau pom Cetilistat qhov ua tau zoo thiab kev nyab xeeb. Nyob rau hauv ib lub rooj sibtham 12 lub limtiam thiab nrog 612 obese diabetic cov neeg mob, tshawb nrhiav pom tias cov neeg mob uas siv 80 milligrams thiab 120 milligram ntawm Cetilistat hmoov tau txiav txim siab yuag, tswj kev xNUMX kilograms thiab 3.85 kilograms feem. Qhov no yog piv rau 4.32 kilograms uas tau ploj los ntawm cov neeg mob uas tau muab cov placebo.

Cetilistat tsis tau tsuas yog ua kom tiav cov qib qis ntawm qhov poob qis li Orlistat, tab sis ob qho tib si yuag tshuaj kuj pom tau los ua cov ntsiab lus tseem ceeb HbA1c.

Thaum pib ntawm ib txoj kev tshawb fawb, cov neeg mob tau muaj lub cev kev hnyav ntawm 28 thiab 45 thiab tau muab metformin los tswj cov ntshav qab zib. Txawm hais tias cov neeg mob uas tau coj cetilistat poob ntau dua li cov neeg uas coj Orlistat, pawg neeg hauv cetilistat tau zam cov tshuaj zoo dua. Qhov kawg ntawm kev sim siab, nws tau tsim kom muaj kev siab ntev thiab kev nyab xeeb ntawm cov pej xeem cetilistat tseem ua tau raws li cov neeg tau pom hauv cov kev sib tw dhau los.

Cov nqi ntawm kev mob ua tsis tshua mob vim muaj cov teeb meem tshwm sim yog 2.5 feem pua, 5.0 feem pua ​​thiab 2.5 feem pua ​​rau cov tub ntxhais hluas 120, 80 milligrams thiab 40 milligrams. Qhov no piv rau 11.6 feem pua ​​rau Orlistat thiab 6.4 feem pua ​​rau cov placebo. Lub ntsiab yog vim li cas rau lub sij hawm luv siv tshuaj ntawm Orlistat yog txoj kev kho mob txoj kev mob siab rau txoj kev mob plaw.

8 lus nug kom koj tus kheej ua ntej noj Cetilistat hmoov

6. Cetilistat hmoov Piv txwv

Feem ntau, cov kws kho mob tau sau cov tshuaj cetilistat suav txij 60 cov milligrams mus rau 100 cov milligrams. Koj yuav tsum tau coj cetilistat raws nraim li koj tus kws kho mob sau tseg, thiab yuav tsum tsis pub tshaj cov tshuaj tsuas yog qhia tawm.

Yog tias koj noj cov tshuaj levothyroxine los yog cyclosporine, nco ntsoov siv cov tshuaj no 4-5 ua ntej los yog tom qab siv cetilistat.

7. Cetilistat Side EffectsPiv txwv

Raws li feem ntau (yog tsis yog txhua tus) poob phaus tshuaj, cetilistat muaj qee cov kev mob tshwm sim. Hom kab mob cetilistat phiv muaj xws li (tab sis tsis txwv rau):

  • Zawv plab
  • Kev sib cais
  • Mob plab lossis mob plab
  • Rog nyob hauv cov quav
  • Oily spotting
  • Flatus nrog paug
  • Plab hnyuv tso tawm
  • Cov quav muag

Yog tias koj muaj kev mob tshwm sim tom qab siv cetilistat, nws tseem ceeb heev kom nrhiav kev kho mob yam tsis muaj kev ncua.

8. Cetilistat Precautions

8.1 Lus Qhia rau CiaPiv txwv

  • Khaws cov ntsiav tshuaj nyob rau hauv chav tsev sov.
  • Khaws cia kom deb ntawm qhov ncaj ncaj los yog cua sov.
  • Txhob cia cov ntsiav tshuaj cetilistat.
  • Txav kom txhob muaj tsiaj txhu thiab menyuam yaus.
  • Tsis txhob nchuav cetilistat ntsiav tshuaj rau hauv cov kua los yog yaug tawm hauv lub qhov viv.

Yog xav paub ntxiv txog kev tshem tawm cov kab mob cetilistat, yuav tsum nrog koj tus kws muag tshuaj lossis tus kws kho mob tham.

8.2 Yuav ua li cas Nyob rau hauv Case koj tsis nco ib koobPiv txwv

Missed ib koob tshuaj? Nqa nws kom sai li sai tau. Yog tias nws yog lub sijhawm rau koj qhov tshuaj tivthaiv tom ntej, nco koj lub sijhawm tsis tuaj yeem thiab coj mus rau lwm hnub. Tsis txhob noj tshuaj ntxiv kom ua rau tus neeg tsis tuaj yeem. Tom qab cov koob tshuaj tom qab, cia li rov pib dua koj cov sijhawm noj raws li niaj zaus.

Tej zaum koj xav tsis thoob - ua li cas yog tias kuv tsis nco qab noj ib zaug? Zoo, nco ib qho tshuaj yuav txo qhov kev kho cov txiaj ntsim ntawm txoj kev kho thiab ua rau koj poob qhov kev poob phaus nce qib. Kev ploj zom ib zaug thaum nruab nrab kev kho yuav txo qhov kev ua tau zoo ntawm txoj kev kho mob. Qee cov neeg tuaj yeem tso cov cim thim tawm ntxov yog tias lawv pheej nco tshuaj.

Cov hauv qab no yog qee cov tswv yim zoo uas tuaj yeem tiv thaiv koj ntawm koj qhov kev txhaj tshuaj cetilistat:

  • Teem caij rau lub sijhawm, xws li txiav txim siab rau lub sijhawm pes tsawg lub sijhawm thaum koj tuaj yeem noj koj cov tshuaj. Nco ntsoov kho koj cov khoom noj txhua hnub rau koj kom yooj yim.
  • Yog tias koj muaj teebmeem nco tsis tau noj koj lub sijhawm, teem caij ceeb toom lossis ceeb toom rau ntawm koj lub xov tooj lossis saib.
  • Thov kom koj tsev neeg nco qab qhia koj.

8.3 Dab Tsi Tshwm Sim Thaum Koj Dhau Sij Hawm Cetilistat hmoovPiv txwv

Yog tias koj tsis ua tiav cov kev xav tau sai dua thaum koj xav tias, tsis txhob xav txog kev siv cov tshuaj nyob rau hauv ntau loj kom thiaj li ceev nrooj. Qhov no yog vim, txawm tias koj coj tus cetilistat loj dua los sis hauv cov sij hawm luv dua li tau sau tseg, koj yuav tsis poob ntau tshaj qhov nyhav, los yog tsis poob phaus sai dua. Xwb, koj yuav overdose rau cov tshuaj thiab xaus nrog qee cov teeb meem uas yuav ua rau tuag taus.

Yog tias koj tau mus pw saum cetilistat, nrhiav kev kho mob los ntawm chav kho mob ceev xwm ceev lossis chaw kho mob. Nws yog qhov tseem ceeb heev uas koj nqa daim ntawv lo, lub thawv, lossis lub thawv nrog koj kom cov kws kho mob tuaj yeem tau txais cov ntaub ntawv qhia txog kev siv tshuaj.

Ua ntej siv Cetilistat, nws yuav tsum tau mus ntsib koj tus kws muag tshuaj lossis tus kws kho mob txog kev siv tshuaj thiab yuav ua li cas thiaj xeeb tau noj. Ib yam li lwm cov yeeb tshuaj, Cetilistat yuav tsum tsis txhob sib koom. Qhov no txhais tau hais tias koj yuav tsum tsis txhob muab koj cov kab mob kws kho mob tso rau lwm tus, txawm tias nws muaj qhov teeb meem zoo li koj. Qhov no yog vim hais tias qhov tshuaj tsuas tau yog qhov zoo rau koj, tab sis nws kuj yog ib qho dhau lawm.

8.4 Siv Cetilistat nyob rau hauv Cov me nyuamPiv txwv

Cetilistat yuav tsum tsis txhob raug coj los ntawm cov menyuam yaus vim nws tuaj yeem cuam tshuam lawv txoj kev loj hlob. Nws yog, yog li ntawd, kev pom zoo kom ncua kev kho mob kom txog rau thaum 18 xyoo lossis txog thaum kev loj hlob tiav.

  • Siv hauv Menyuam

Cov me nyuam, tshwj xeeb tshaj yog thaum pub dawb, yuav tsis tau siv cov tshuaj no vim nws muaj peev xwm ua rau muaj kev phom sij rau lawv qhov siab thiab kev loj hlob. Kev kho, yog tias tsis ua cov txiaj ntsim tau, tuaj yeem qeeb mus txog thaum loj hlob tiav. [

  • xaus

Cov kev tshawb fawb pom tau tias Cetilistat hmoov yuav tsum muaj peev xwm ua tau ib qho kev soj ntsuam thiab clinically considerable poob phaus hauv rog thiab rog neeg. Dhau li ntawm poob phaus, cov neeg mob nrog lwm yam kev mob ntsig txog kev mob kuj muaj kev txhim kho ntau heev.

  • References

Yamada Y, Kato T, Paub H, Ashina S, Kato Ketetistat hmoov (ATL-962), ib tug tshiab pancreatic lipase inhibitor, ameliorates cev qhov hnyav nce thiab pab kho cov lipid profiles hauv nas. Horm Metab Res. 2008 Aug; 40 (8): 539-43. doi: 10.1055 / s-2008-1076699. Epub 2008 Tej zaum 21.

P Kopelman, A Bryson, R Hickling, Rissanen, S Rossner, S Toubro & P Valensi International Journal of Rog Ntoo 31, nplooj ntawv 494-499 (2007


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