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Txhua yam hais txog Entecavir hydrate hmoov

1.Hydralazine HCL-CAS: 304-20-1
2.Hydralazine HCL mechanism ntawm kev ua
3. Yuav siv li cas Hydralazine HCL?
4.How kuv yuav tsum tau noj hydralazine HCL (Apresoline)?
5. Hydralazine HCL Dosage
6.Hydralazine-qhov ncauj
7. Hydralazine HCL phiv tshuaj
8.How mus khaws hydralazine HCL (304-20-1)?


Hydralazine hydrochloride hmoov yees duab


I. Hydralazine HCL hmoov theem pib:

Lub npe: Hydralazine hydrochloride hmoov
CAS: 304-20-1
Molecular Formula: C8H9ClN4
Molecular phaus: 196.64
Melt Point: 280-282 ° C
Cia Temp: tub yees
xim: Dawb los yog tua dawb Crystalline hmoov


1. Hydralazine HCL-CAS: 304-20-1Piv txwv

Hydralazine HCL yog siv los kho ntshav siab (ntshav siab). Nws kuj siv los tswj cov ntshav siab nyob rau hauv ib leej niam thaum cev xeeb tub (pre-eclampsia lossis eclampsia) lossis thaum muaj xwm ceev thaum muaj ntshav siab heev (hypertensive ntsoog).
Ntshav siab ntxiv rau txoj haujlwm ntawm lub plawv thiab cov hlab ntsha. Yog tias nws tseem mus ntev, lub plawv thiab cov hlab ntsha tuaj yeem ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau cov hlab ntsha hauv lub hlwb, lub plawv, thiab ob lub raum, ua rau mob hlab ntsha, lub plawv tsis ua mob, lossis lub raum tsis ua haujlwm. Kev txo cov ntshav siab tuaj yeem ua rau lub plawv nres thiab muaj cwj pwm txawv.
Hydralazine HCL ua haujlwm los ntawm relaxing cov hlab ntsha thiab nce cov ntshav thiab oxygen rau lub plawv thaum txo nws txoj haujlwm. Qhov tshuaj no tsuas muaj nrog koj tus kws kho mob cov tshuaj.

Hydralazine HCL (304-20-1): Haujlwm & Txwv & Qhov Teebmeem ntawm AASraw


2. Hydralazine HCL mechanism ntawm kev txiav tximPiv txwv

Hydralazine HCL (304-20-1) yog ib lub voj voog ntawm peripheral; nws ua rau lub cev muaj zog ntawm cov leeg leeg ntawm cov leeg mob ntawm ib qho kev siv nyiaj ncaj. Txawm hais tias stimulation ntawm sympathetic lub paj hlwb yog txuam nrog hydralazine HCL kev tswj hwm, qhov no yog ib lo lus teb rau cov lus teb thiab tsis muaj feem ntawm nws cov mechanism. Cov ntsiab lus piav qhia ntawm hydralazine HCL lub tswv yim tsis nkag siab; Txawm li cas los xij, zoo ib yam li cov organic nitrates thiab nitroprusside, nws xav tias hydralazine HCL cuam tshuam nrog cov calcium mov hauv vascular smooth nqaij uas yog lub luag hauj lwm rau kev pib thiab tswj kev cog lus hauv lub xeev. Hauv kev sib piv rau cov organic nitrates thiab sodium nitroprusside, li cas los xij, hydralazine HCL yog xaiv rau cov leeg arterioles.

Lub vas sab perodheral vasodilating ntawm hydralazine HCL ua rau cov ntshav siab tsis haum (diastolic ntau dua systolic) thiab peripheral vascular ua haujlwm. Ntxiv mus, qhov hydralazine HCL-induced reflex autonomic teb nce lub plawv dhia, qhov ntim mob hlab ntsha, lub plawv nres, thiab sab laug voos phais. Qhov tshwj xeeb tshaj tawm ntawm arterioles, raws li muab piv rau cov leeg, minimizes hydrosazine postural hydralazine HCL thiab txhawb nqa qhov kev nce rau hauv lub plawv nres txawm tias hydralazine HCL teebmeem ntawm hydralazine HCL yog txo qis me ntsis los ntawm qhov kev nce hauv kev tawm dag zog. Muaj cov pov thawj pom tias hydralazine HCL siv cov kev cuam tshuam zoo los ntawm kev ua rau cov neeg tsis ua hauj lwm.

Tsiaj thiab txwv cov tib neeg cov ntaub ntawv qhia tias nitric oxide (TSIS TAU) yuav raug tsim los ntawm hydralazine HCL uas kuj muaj tshuaj tua kab mob kom zoo ntxiv rau cov tshuaj nitrates thiab kom txo tau qhov ua siab ntev tiv ntawm mob nitrate. Cov tshuaj tua tau hws ntawm Hydrocarazine HCL tuaj yeem raug vim nws muaj peev xwm tiv thaiv oxidase tsim. Lub tsuj zuj zuj zuj ntawm oxidative dawb radicals tsim ib qho chaw uas qhov kev txo kom tsawg dua Tsis muaj bioavailability pab txhawb kev poob qab ntawm cov pob txha ntawm pob txha microvessels. Cov nyhuv no, tig mus, ua rau cov nqaij ntshiv tsis zoo nrog cov neeg mob siab zog. Cov kev tshawb fawb pom tau tias kev kho mob nrog hydralazine HCL muaj qhov cuam tshuam cov tshuaj oxidase uas ua lub luag hauj lwm hauv kev tswj cov bioactivity tsis muaj, tsim los yog endogenously los yog thaum siv exogenously.

Cov kab mob qoob tuag, coronary, splanchnic, thiab lub raum cov ntshav feem ntau nce tom qab kev saib xyuas ntawm hydralazine HCL, thaum cov kab mob urinary feem ntau tsis zoo. hydralazine HCL yuav ua rau cov kev ua haujlwm renin hauv plasma, txawm tias cov hlwb hauv lub cev tsis tshua muaj mob hauv cov lus teb rau cov kev xav ntawm lub paj hlwb; qhov nce hauv renin kev ua rau cov zus tau los ntawm angiotensin II, uas ua rau cov neeg tau txais kev ua si thiab kev noj tshuaj, thiab sodium reabsorption. Vim lub kua qis dua, cov ntshav nce ntxiv. Yog li ntawd, kev ua siab ntev tuaj yeem tsim tau, uas yuav suav tau tias tsis muaj kev txhim kho hauv qee tus neeg mob uas tau txais cov tshuaj rau lub sijhawm ntev.

Ua ib qho antihypertensive, hydralazine HCL tsis ua rau kev txhim kho hauv LVH. hydralazine HCL tej zaum yuav ua rau mob LVH, uas yog vim muaj cov pob txha mob ua kom tsis muaj zog thiab mob siab khov kho, uas yuav tiv thaiv cov txiaj ntsig ntawm kev txo qhov kev txo hwjchim.


3. Yuav siv li cas Hydralazine HCL?Piv txwv

Noj cov tshuaj no ntawm qhov ncauj los yog tsis muaj zaub mov noj, feem ntau 2 rau 4 zaug txhua hnub lossis raws li koj tus kws kho mob hais. Cov tshuaj noj raws li koj qhov mob thiab teb rau kev kho mob. Koj tus kws kho mob yuav pib koj ntawm tsawg dua thiab maj mam nce koj cov tshuaj. Ua raws li koj tus kws kho mob cov lus qhia kom zoo.
Siv cov tshuaj no tas li kom tau txais txiaj ntsim los ntawm nws. Pab kom koj nco qab, nqa tib lub sijhawm txhua hnub. Nws yog ib qho tseem ceeb uas koj yuav tau noj tshuaj ntxiv no txawm tias koj zoo lawm. Feem ntau cov neeg muaj ntshav siab tsis hnov ​​mob. Tej zaum nws yuav siv sij hawm li ob peb lub lis piam ua ntej koj tau txais cov txiaj ntsig kev pab ntawm cov tshuaj no.
Tsis txhob tsum noj cov tshuaj no yam tsis tau txais kev pabcuam koj tus kws kho mob. Qee qhov kev mob kuj yuav ua rau mob ntxiv thaum lub tshuaj nres tam sim ntawd. Koj qhov tshuaj noj yuav tsum tau qis qis dua.

Hydralazine HCL mechanism ntawm kev txiav txim thiab Yuav ua li cas khaws cov hydralazine HCL hmoov


4. Kuv yuav tsum siv cov tshuaj HCL (Apresoline) li cas?Piv txwv

Noj cov tshuaj no raws nraim li koj tus kws kho mob hais. Tsis txhob noj nws ntau dua lossis ntev tshaj li kev pom zoo. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj.
Kom paub tseeb tias cov tshuaj no pab koj tus mob thiab tsis ua rau muaj teebmeem tshwm sim, koj cov ntshav siab yuav tsum tau kuaj xyuas ntau zaus. Tej zaum koj tseem yuav tsum tau kuaj ntshav hauv lub cev. Txhob nco tsis tau teem caij li cas.
khaws siv hydralazine HCL raws li qhia, txawm tias koj xav zoo. Cov ntshav siab feem ntau tsis muaj tsos mob li cas, yog li koj tsis paub thaum koj cov ntshav siab siab. Tej zaum koj yuav tau siv tshuaj siv ntshav siab rau koj lub neej. Khw hydralazine HCL nyob rau hauv chav tsev kub tawm ntawm noo noo thiab cua sov.

(1) Yuav ua li cas yog tias kuv tsis nco qab noj tshuaj (Apresoline)?

Noj cov tshuaj tsis tuaj sai li sai tau thaum koj nco qab. Yog tias nws yuav luag rau koj cov koob tshuaj tom ntej no, tos kom txog thaum noj cov tshuaj thiab hla qhov tsis tuaj tshuaj. Tsis txhob noj tshuaj ntxiv los ua kom tsis txhob noj tshuaj.

(2) Yuav ua li cas yog tias kuv tsis dhau (Apresoline)?

Nrhiav kev khomob kub ntxhov yog tias koj xav tias koj tau siv ntau yam tshuaj no.
Cov tsos mob dhau lawm yuav muaj xws li mob taub hau, kiv taub hau, lub plawv dhia ceev nrooj, sov los yog tingling hauv koj lub tawv nqaij, mob hauv siab, lossis tsaus muag.

(3) Kuv yuav tsum zam dab tsi thaum kev siv hydralazine HCL (Apresoline)?

Tsis txhob ceev ceev los ntawm qhov chaw zaum los yog dag, los yog koj xav tias muaj kiv taub hau. Maj mam nce qeeb thiab khov kho koj tus kheej kom tsis txhob poob.


5. Hydralazine HCL DosagePiv txwv

Cov neeg laus

300 mg / hnub PO rau kev kub ntxhov. Cov tshuaj siv ntau dua tau siv los kho cov neeg mob uas mob plawv; txawm li cas los xij, koob tshuaj ntau dua 200-300 mg / hnub PO yog txuam nrog kev pheej hmoo siab dua ntawm kev siv tshuaj tua kab mob lupus erythematosus. Titrate IV thiab IM npaum li tsim nyog rau ntshav siab tswj.

♣ Geriatric

300 mg / hnub PO rau kev kub ntxhov. Cov tshuaj siv ntau dua tau siv los kho cov neeg mob uas mob plawv; txawm li cas los xij, koob tshuaj ntau dua 200-300 mg / hnub PO yog txuam nrog kev pheej hmoo siab dua ntawm kev siv tshuaj tua kab mob lupus erythematosus. Titrate IV thiab IM npaum li tsim nyog rau ntshav siab tswj.

♣ Adolescents

Kev nyab xeeb thiab kev ua ub ua no tsis tsim muaj; txawm li cas los xij, koob tshuaj 7.5 mg / kg / hnub PO lossis 200 mg / hnub PO, seb qhov twg tsawg, lossis 3.5 mg / kg / hnub IV lossis IM tau siv.

♣ Children

Kev nyab xeeb thiab kev ua ub ua no tsis tsim muaj; txawm li cas los xij, koob tshuaj 7.5 mg / kg / hnub PO lossis 200 mg / hnub PO, seb qhov twg tsawg, lossis 3.5 mg / kg / hnub IV lossis IM tau siv.

♣ Baby

Kev nyab xeeb thiab kev ua ub ua no tsis tsim muaj; txawm li cas los xij, koob tshuaj txhaj rau 7.5 mg / kg / hnub PO lossis 3.5 mg / kg / hnub IV lossis IM tau siv.

♣ Neonates

Kev nyab xeeb thiab kev ua ub ua no tsis tsim muaj; txawm li cas los xij, tau siv cov tshuaj 7.5 mg / kg / hnub PO lossis 0.6 mg / kg / IV IV.
Noj cov tshuaj no raws nraim li koj tus kws kho mob hais. Tsis txhob noj nws ntau dua lossis ntev tshaj li kev pom zoo. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj.
Kom paub tseeb tias cov tshuaj no pab koj tus mob thiab tsis ua rau muaj teebmeem tshwm sim, koj cov ntshav siab yuav tsum tau kuaj xyuas ntau zaus. Tej zaum koj tseem yuav tsum tau kuaj ntshav hauv lub cev. Txhob nco tsis tau teem caij li cas.
Siv cov hydralazine li qhia, txawm tias koj zoo. Cov ntshav siab feem ntau tsis muaj tsos mob li cas, yog li koj tsis paub thaum koj cov ntshav siab siab. Tej zaum koj yuav tau siv tshuaj siv ntshav siab rau koj lub neej.
Khw hydralazine tom chav tsev kub deb ntawm kev ya raws thiab cua sov. Nrhiav kev khomob kub ntxhov yog tias koj xav tias koj tau siv ntau yam tshuaj no. Cov tsos mob dhau lawm yuav muaj xws li mob taub hau, kiv taub hau, lub plawv dhia ceev nrooj, sov los yog tingling hauv koj lub tawv nqaij, mob hauv siab, lossis tsaus muag.
Noj cov tshuaj tsis tuaj sai li sai tau thaum koj nco qab. Yog tias nws yuav luag rau koj cov koob tshuaj tom ntej no, tos kom txog thaum noj cov tshuaj thiab hla qhov tsis tuaj tshuaj. Tsis txhob noj tshuaj ntxiv los ua kom tsis txhob noj tshuaj.


6. Hydralazine-qhov ncaujPiv txwv

(1) Qhov siv rau kev siv qhov ncauj li cas?

Hydralazine-qhov ncauj siv rau kev kho mob ntawm cov ntshav siab (ntshav siab), ib leeg los yog ua ke nrog lwm cov tshuaj tiv thaiv cov tshuaj tiv thaiv. Nws kuj yog siv los kho cov teebmeem hypertensive thiab kev mob plawv ntawm lub plawv.
Qhia rau koj tus kws kho mob yog tias koj tus mob tsis zoo (piv txwv li, koj cov ntshav siab nyeem ntawv nce qib).

(2) Qhov ntau npaum cas rau qhov ncauj tawm ntawm qhov ncauj?

Kub siab nyob rau hauv cov neeg laus mob:
♦ Pib kho kom zoo dua qub thiab maj mam nce raws qhov kev mob ntawm tus neeg mob. Txoj kev cai lij choj raws li kev pom zoo pib yog 10 mg txhua txhua hnub plaub zaug rau thawj 2 rau 4 hnub, nce rau 25 mg plaub zaug txhua hnub rau qhov seem ntawm thawj lub lim tiam.
♦ Rau ob lub lim tiam thiab tom qab lub lis piam, muab qhov tshuaj ntxiv rau 50 mg plaub zaug txhua hnub (ntxiv cov koob tshuaj 10-25 mg / dose maj mam txhua hnub 2-5).
♦ Qhov ntau hnub uas siv hauv kev tshawb fawb soj ntsuam yog 300 mg.
Congestive plawv tsis ua hauj lwm:
♦ Thawj zaug rau kev kho lub plawv tsis ua hauj lwm yog 10 rau 25 mg lus 3 rau 4 zaug txhua hnub.
♦ Cov koob tshuaj niaj hnub yog 225 rau 300 mg txhua txhua hnub hauv 3 rau 4 faib koob.
♦ Kev kub nyhav rau cov menyuam muaj mob hnyav, qhov koob tshuaj yog 0.5 mg / Kg IV txhua xuab moos 4.

(3) Puas yog qhov kev mob hauv qhov ncauj los yog kuv tus menyuam tsis muaj menyuam?

Hydralazine-qhov ncauj yuav tsum tau siv rau thaum cev xeeb tub tsuas yog qhov txiaj ntsig zoo yuav tuaj yeem ua rau tus me nyuam muaj peev xwm ua rau tus me nyuam hauv plab. Hydralazine-lub qhov ncauj yog cais raws li FDA cev xeeb tub uas raug C (Cov tsiaj kev tshawb fawb tsiaj tau pom tias muaj kev cuam tshuam rau tus me nyuam hauv plab thiab tsis muaj kev tshawb fawb txog kev tsim nyog thiab tswj kav hauv tib neeg, tab sis cov txiaj ntsig zoo yuav siv tau cov tshuaj hauv cov poj niam cev xeeb tub txaus ntshai). Nws yog siv los kho cov ntshav siab thaum lub sijhawm cev xeeb tub.
Hydralazine-qhov ncauj tawm hauv niam mis. Hydralazine-qhov ncauj yuav tsum tau siv cautiously rau cov poj niam uas yog pub mis niam yog tias kev kho mob tsim nyog.


7. Hydralazine HCL phiv tshuajPiv txwv

Hydralazine qhov ncauj ntsiav tshuaj tsis ua rau nkees, tab sis nws tuaj yeem ua rau lwm cov kev mob tshwm sim.

(1) Cov kev mob tshwm sim ntau dua

Feem ntau cov kev mob tshwm sim uas tshwm sim nrog hydralazine muaj xws li:
· Mob taub hau
· Tsis qab los noj mov (anorexia)
· Xeev siab
· Ntuav
· Kev mob plab
· Lub plawv dhia ceev ceev
· Mob hauv siab
Yog tias cov teebmeem no tsis muaj teebmeem dabtsi, tej zaum lawv yuav ploj mus li ob peb hnub lossis ob peb lub asthiv. Yog tias lawv mob hnyav dua lossis tsis mus, nrog koj tus kws kho mob lossis kws muag tshuaj tham.

(2) Cov kev mob loj loj

Hu rau koj tus kws kho mob tam sim ntawd yog tias koj muaj kev phiv loj heev. Hu rau 911 yog tias koj cov tsos mob xav tias yuav ua rau koj tuag taus lossis koj xav tias koj muaj mob xwm txheej ceev. Cov kev mob tshwm sim loj heev thiab cov tsos mob muaj xws li cov hauv qab no:

♦ Cov tsos mob ntawm lub plawv, xws li:

· Tsis tshua muaj ntshav siab (hypotension)
· Lub plawv dhia ceev ceev
· Kiv taub hau lossis qaug zog
· Koj caj npab thiab txhais ceg

♦ Tej teeb meem paj hlwb. Cov tsos mob muaj xws li:

· Loog loog
· Tingling
· Chib los yog khaus ntawm koj cov tawv nqaij

♦ Kev nyuaj siab lossis kev ntxhov siab. Cov tsos mob muaj xws li:

· Xis nyob lossis tsis nyiam koj tus kheej
· Cov kev hloov hauv qab los noj mov
· Txhawj xeeb los yog ntug
· Tsis yog nyiam ua tej yam koj nyiam ua

♦ Cov tshuaj tsis haum. Cov tsos mob muaj xws li:

· Pob liab liab
· Khaus tawv nqaij
· Redness rau koj cov tawv nqaij
· Kub cev
· Ua daus no
· Qhov mob hauv koj cov pob txha
· Ua pa nyuaj
· Cem quav tawv
• Teeb meem tso zis

Raw Hydralazine HCL hmoov (304-20-1) hplc = 98% | AASraw hmoov

(3) Puas yog hydralazine HCL ua teeb meem?

Ua ke nrog lawv cov teebmeem, feem ntau cov tshuaj yuav ua rau tsis raug mob-txawm tias tsis yog txhua tus neeg paub txog lawv. Cov lus qhia hauv qab no muaj qee qhov feem ntau ntawm cov koom txoos hydralazine HCL. Qhov chaw zoo tshaj plaws los nrhiav cov npe ntawm cov kev mob tshwm sim uas tuaj yeem txuam nrog koj cov tshuaj, yog los ntawm cov ntaub ntawv luam tawm cov ntaub ntawv luam nrog cov tshuaj. Xwb, koj tuaj yeem nrhiav tau ib qho piv txwv ntawm cov ntaub ntawv tsim cov lus qhia hauv nqe lus nram qab no. Nrog koj tus kws kho mob lossis kws muag tshuaj tham yog tias ib qho ntawm cov hauv qab no tseem ua los yog ua teeb meem.

Ua hydralazine HCL ua teeb meem?
Feem ntau tshwm sim ntawm hydralazine (cov no muaj ntau dua 1 nyob rau hauv 10 cov neeg) Kuv yuav ua li cas yog tias kuv tau ua qhov no lawm?
Mob taub hau Haus dej kom ntau thiab nug koj tus kws muag tshuaj kom pom zoo rau tus kws kho mob uas tsim nyog. Yog hais tias mob taub hau ntxiv, nrog koj tus kws kho mob tham
Lub plawv dhia ceev nrooj, qhov kev xav ntawm lub siab ntsws '(plhuav) Yog tias koj muaj kev txhawj xeeb, nrog koj tus kws kho mob tham
Ntau hom kev tshwm sim ntawm hydralazine (cov no tshwm sim tsawg dua 1 hauv 10 cov neeg) Kuv yuav ua li cas yog tias kuv tau ua qhov no lawm?
Hnov flushed, o taw los yog pob taws, mob hauv siab Yog tias ib qho ntawm cov tsos mob no tseem ua los yog ua rau koj txhawj xeeb, nrog koj tus kws kho mob tham
Hnov kiv taub hau Yog tias qhov no tshwm sim, zaum rau ib ntus kom txog thaum koj hnov ​​zoo dua. Tsis txhob tsav tsheb thiab txhob siv cov cuab yeej lossis cav thaum tab tom raug teeb meem. Tsis txhob haus dej haus cawv
Hnov mob los yog mob (ntuav), raws plab Noj cov pluas noj yooj yim thiab haus dej kom ntau txaus los hloov cov kua dej
Ua ke lossis mob leeg Nrog koj tus kws kho mob tham txog qhov sai li sai tau. Tej zaum nws yuav yog ib qho kev qhia ntxov ntxov ntawm tus mob lupus erythematosus syndrome


Yog tias koj pom muaj lwm cov tsos mob uas koj xav tias yuav yog vim muaj qhov HCL hydralazine, thov nrog koj tus kws kho mob lossis kws muag tshuaj tham nrog kev pab tswv yim ntxiv.


8. Yuav ua li cas khaws cov hydralazine HCL (304-20-1)?Piv txwv

♦ Khaws tag nrho cov tshuaj tawm ntawm qhov pom thiab qhov mob ntawm cov menyuam yaus.
♦ Khaws hauv qhov chaw txias, qhuav, kom deb ntawm qhov sov so thiab taws.


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