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Trilostane Hmoov (13647-35-3)

Rating: SKU: 13647-35-3. Qeb:

AASraw yog nrog kev sib txuas thiab kev tsim muaj peev xwm los ntawm gram mus rau ntau qhov kev txiav txim ntawm Trilostane Hmoov (13647-35-3), raws li CGMP kev tswj hwm thiab kev tswj xyuas tau zoo.

Hauj lwm yam khoom

Trilostane Hmoov (13647-35-3) video


Trilostane Hmoov (13647-35-3) Specification:

Tshuaj Txheem: khoom npe: Trilostane
Cas Tsis: 13647-35-3
molecular Formula: C20H27NO3
molecular Nyhav: 329.43
Standard: Hauv tsev
cia: Qhuav, tsaus nti thiab tom 0 - 4 C rau lub sijhawm luv (hnub rau lub limtiam) lossis-20 C rau cov sijhawm ntev (hli mus txog xyoo).
Cov ntaub ntawv (COA & HPLC thiab lwm yam): Qhov

Trilostane Hmoov (13647-35-3) Description:

Trilostane hmoov yog ib qho inhibitor ntawm 3β-hydroxysteroid dehydrogenase siv hauv kev kho mob ntawm Cushing's syndrome thiab thawj hyperaldosteronism. Cov no yog ob qho tib si cuam tshuam qhov twg ntau dhau ntawm corticosteroid hormones tsim nyob rau hauv lub cev. Corticosteroids yog qhov tseem ceeb rau lub cev kom ua kom tau txais kev siv cov carbohydrates, cov rog thiab cov nqaijrog thiab rau ib qho kev teb ntawm kev ntxhov siab. Lawv kuj yog qhov tsim nyog rau kev tswj hwm ntsev thiab dej sib npaug hauv lub cev. Trilostane hmoov pab tiv thaiv kev tsim tawm ntawm corticosteroids, tswj cov tsos mob cuam tshuam nrog cov kev cuam tshuam no.

Trilostane hmoov kuj tseem tuaj yeem pab tau zoo rau kev kho mob qog noj ntshav mis uas tau rov mob siab rau cov poj niam uas tau ploj mus lawm.

Nws tau pom zoo tsis ntev los no hauv 2008 rau kev kho mob Cushing's disease (hyperandrenocorticism) hauv dev. Nws tseem yog thawj cov tshuaj pom zoo los kho ob qho tib si pituitary- thiab adrenal-dependant Cushing hauv cov dev. Cov tshuaj no ua haujlwm los ntawm kev ua kom tsis txhob muaj cov cortisol hauv cov qog adrenal.

reference:

  • 1: M xwm JN, Drobatz KJ, Hess RS. Cortisol Concentrations hauv Cov Tsiaj Uas Zoo Tswjhwm Hyperadrenocorticism Kho Nrog Trilostane. J Vet Intern Med. 2015 Nov; 29 (6): 1529-33. doi: 10.1111 / jvim.13615. Epub 2015 Sep 16. PubMed PMID: 26374943.
  • 2: Fracassi F, Corradini S, Floriano D, Boari A, Aste G, Pietra M, Bergamini PF, Dondi F. Prognostic yam tseem ceeb rau kev muaj sia nyob hauv cov dev nrog pituitary-hyper hypercortisolism kho nrog trilostane. Vet Rec. 2015 Lub Ib Hlis 10; 176 (2): 49. doi: 10.1136 / vr.102546. Epub 2014 Aug 28. PubMed PMID: 25170036.
  • 3: Bonadio CM, Feldman EC, Cohen TA, Kass PH. Kev sib piv ntawm adrenocorticotropic hormone stimulation test tau pib 2 piv rau 4 teev tom qab kev saib xyuas trilostane hauv cov dev nrog kev tshwm sim hyperadrenocorticism. J Vet Intern Med. 2014 Lub Xya Hli-Lub Yim Hli; 28 (4): 1239-43. doi: 10.1111 / jvim.12357. Epub 2014 Lub Tsib Hlis 26. PubMed PMID: 24863172.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

References & cov khoom citations