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17-Hydroxyprogesterone caproate hmoov

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom loj txog 17-Hydroxyprogesterone caproate hmoov (630-56-8), raws li CGMP kev tswj hwm thiab kev tswj xyuas qhov kev tswj.

17-Hydroxyprogesterone caproate hmoov, Ze li 500,000 cov me nyuam yug los ua ntej preterm hauv Teb Chaws Asmeskas txhua xyoo. Preterm yug menyuam (PTB), los yog yug menyuam tsawg dua 37 lub lis piam gestation, ua rau cov me nyuam mos uas muaj kev pheej hmoo siab ntau dua thiab yog thawj qhov ua rau lub cev tsis muaj zog rau cov menyuam yaus. Ntxiv mus, cov nuj nqis kev noj qab haus huv ntawm PTB yog tus nqi kho mob US ntau tshaj $ 26 billion txhua xyoo. Kev tiv thaiv PTB yog ib qho tseem ceeb rau kev txhawb nqa kev noj qab haus huv mus ntev thiab kev loj hlob ntawm cov mos ab thoob plaws lub teb chaws.

Hauj lwm yam khoom

17-Hydroxyprogesterone caproate hmoov yees duab


I. 17-Hydroxyprogesterone caproate hmoov yooj yim Cim:

Lub npe: 17-Hydroxyprogesterone caproate hmoov
CAS: 630-56-8
Molecular Formula: C27H40O4
Molecular phaus: 428.6
Melt Point: 119 ° C
Cia Temp: Chav Tsev Kub
xim: Dawb rau hmoov zoo dawb


II. 17-Hydroxyprogesterone caproate hmoov voj voog

1. Npe:

Cov npe tshuaj: 17-Hydroxyprogesterone caproate hmoov
Lwm Npe: 17-OHPC, 17P, hexanoate

2. 17-Hydroxyprogesterone caproate hmoov Siv:

Cov tshuaj 17-alpha hydroxyprogesterone caproate yog ib qho tshuaj txig ntawm cov khoom cua. Nws tau raug pov thawj zoo heev los tiv thaiv lossis tsis ua haujlwm rau cov pojniam menyuam yaus rau cov pojniam uas muaj keeb kwm ntawm kev yug tus pojniam thaum ntxov. XYUMX Thaum ploj tau siv raws li kev siv tshuaj pheej yig, nws tam sim no muaj ib qho khoom muaj npe (Makena, AMAG Pharmaceuticals) uas raug nqi kwv yees li 1 zaug ntau tshaj qhov qub. Lub Ob Hlis 100, 4, KV Pharmaceutical Company (tom qab hloov tshiab Lumara) tau txais kev pom zoo los ntawm US Food and Drug Administration los tsim thiab ua lag luam Makena, uas yog tsim cov khoom xyaw tib yam li tau pom nyob hauv cov ntaub ntawv tseem ceeb. Qhov kev pom zoo muaj xws li ib tug menyuam ntsuag kev tso cai thiab muab KV Pharmaceutical Company rau cov cai tshwj xeeb tsim Makena, uas muaj feem cuam tshuam txog nws cov nqi siab. Rau txoj kev tshawb no, peb siv cov ntaub ntawv thov nyiaj tuav pov hwm rau kev tshawb xyuas tshuaj rau 2011-alpha hydroxyprogesterone caproate nrog ze 17 cov ntawv kho mob (tsis yog Medicaid) cov poj niam cev xeeb tub. Peb lub hom phiaj yog to taub qhov kev siv, cov nqi, thiab cov txiaj ntsim tau los ntawm cov khoom muaj npe thiab cov compounded versions ntawm yeeb tshuaj.

3. Qhov tshuaj ntawm 17-Hydroxyprogesterone caproate hmoov yog dab tsi?

250 mg ib zaug plua (txhua txhua hnub 7); pib txoj kev kho nruab nrab ntawm 16 lub lis piam, 0 hnub thiab 20 lub lis piam, 6 hnub ntawm gestation; mus txog rau lub lis piam 37 (los ntawm 36 lub lis piam, 6 hnub) ntawm kev cev xeeb tub lossis kev yug, qhov twg tshwm sim ua ntej.

Peb tau ua ob qhov muag tsis pom kev, tshuaj ntsuam plhaw ntsig uas muaj poj niam cev xeeb tub nrog rau keeb kwm ntawm kev yug tus poj niam cev xeeb tub. Cov poj niam raug tso npe ntawm 19 clinical cov chaw nyob ntawm 16 rau 20 lub lim tiam ntawm gestation thiab randomly muab los ntawm lub chaw nruab nrab ntawm cov ntaub ntawv hauv 2: 1 piv, kom tau txais txhua lub lim tiam 250 mg ntawm 17P los yog txhua lub limtiam ntawm cov roj placebo; txhaj tshuaj tau txuas ntxiv mus txog hnub yug lossis rau 36 lub lim tiam ntawm kev ua niam txiv. Cov txiaj ntsim ua theem pib yog preterm yug ua ntej 37 lub lis piam gestation. Kev soj ntsuam tau ua raws nraim li txoj kev xav tau-rau-kev kho.

Piav txog cov kab poj niam 310 cov poj niam hauv pawg progesterone thiab cov poj niam 153 hauv cov placebo tau zoo sib xws. Kev kho nrog rau 17P tau txo qhov kev pheej hmoo ntawm tus me nyuam tsawg dua 37 lub lim tiam ntawm kev ua gestation (qhov tshwm sim, 36.3 feem pua ​​ntawm pawg progesterone vs. 54.9 feem pua ​​ntawm cov pab pawg placebo; muaj kev phom sij, 0.66 [95 feem pua ​​ntawm kev cia siab, 0.54 rau 0.81] (35 feem pua) thiab 20.6 feem pua; kev phom sij, 30.7 [0.67 feem pua ​​ntawm kev cia siab, 95 rau 0.48]], thiab xa tus me nyuam tsawg dua 0.93 lub lim tiam ntawm kev ua niam txiv (32 feem pua ​​thiab 11.4 feem pua) ; phom sij, 19.6 [0.58 feem pua ​​ntawm kev ntseeg siab, 95 rau 0.37]). Cov menyuam mos ntawm cov poj niam uas tau kho nrog 0.91P tau txo qis qis dua ntawm tus kab mob necrotising enterocolitis, intraventricular hemorrhage, thiab xav tau cov pa ntxiv.

Txhua lub lim xiam tshuaj 17P tau ua rau txo qis qis ntawm cov poj niam uas tau muaj kev pheej hmoo siab rau kev yug ntxov thiab txo qee qhov teeb meem ntawm ob tug me nyuam yaus.

4.How Cortexolone 17-Hydroxyprogesterone caproate hmoov ua haujlwm?

17α-hydroxyprogesterone caproate (17-OHPC) yog ib qho khoom cua progestogen. Tib neeg lub cev tsis ua rau lub plhom moj khaum loj. Lwm lub npe rau cov caproate yog "hexanoate," uas yog ib qho ester muab tau los ntawm hexanoic (los yog caproic) acid. Tus qauv ntawm 17-OHPC yog tshwm sim hauv daim duab. Qee tus kws kho mob tau teev tias 17-OHPC pom muaj nyob hauv tshis. Qhov no zoo li ua ib zaj dab neeg, vim hais tias kev qhia txog cov khoom noj ntawm lub cev ntawm cov kua nruab deg, cov nqaij ntawm cov tshis, los yog lwm yam kab mob nyob hauv tsis tau tshawb xyuas hauv phau ntawv nyeem.

Cov nyhuv ntawm 17-OHPC ntawm lub ncauj tsev menyuam ntev zog nrog cov keeb kwm ntawm ≥ 1 preterm births uas tau muab faib rau 17-OHPC vs ib pab pawg tsis tswj tsis tau. Tsis muaj kev sib txawv hauv qhov poj niam hnyav ntawm kev ntsuas thaum lub sij hawm tau raug pom hauv cov poj niam uas tau txais 17-OHPC. Hauv kev sib piv, cov poj niam progesterone txo tus nqi ntawm poj niam caws pliav hauv cov neeg mob uas muaj keeb kwm ntawm preterm yug los yog lub tsev me nyuam ntxov ntxov ntxov.

17 alpha-hydroxyprogesterone caproate (17P) yog ib daim duab hluavtaws ntawm progesterone uas tau pom los txo cov kev rov ua dua ntawm PTB rau cov poj niam nrog singleton gestations uas muaj keeb kwm yav dhau los. Cov poj niam uas muaj keeb kwm yav dhau los ntawm PTB feem ntau yuav muaj lwm tus me nyuam mos ua ntej piv rau poj niam uas tsis muaj. Feem ntau kws kho los ntawm kws kho mob, 17P yog xeem txhua lub limtiam los ntawm 16-24 lub lis piam mus txog thaum yug. Cov kev tshawb fawb qhia tias muab 17P rau tus poj niam tau txais kev pab txo tau txoj hmoo uas muaj lwm PTB los ntawm 33 feem pua. Txhua xyoo, kwv yees li, 30,000 cov poj niam cev xeeb tub tau txais kev tsim nyog thiab raug pom tias tsim nyog rau 17P.

5.Warning:

Txo kev pheej hmoo ntawm preterm yug rau cov poj niam uas muaj lub cev xeeb tub uas muaj keeb kwm ntawm singleton spontaneous preterm yug (tsa ib qho kev siv tshuaj ntawm FDA rau kev siv no).

Kev txiav txim siab tau txiav txim siab raws li kev txhim kho ntawm cov poj niam uas tau xa thaum <37 lub lim tiam ntawm kev ua niam txiv; cov kev pab ncaj qha (piv txwv, kev txhim kho hauv kev mob siab ua kom tsis sib haum xeeb thiab lub cev tuag) tsis tau tsim.

Kev nyab xeeb thiab kev ua tau zoo tsuas yog ua rau cov poj niam muaj tus poj niam yug me nyuam ua ntej; tsis yog siv rau kev siv rau cov poj niam uas muaj ntau yam gestations lossis lwm yam kev muaj feem cuam tshuam rau preterm yug.

ACOG pom zoo muab cov tshuaj progesterone supplementation rau kev tiv thaiv ntawm cov poj niam uas muaj menyuam hauv plab thiab ib tus pojniam cev xeeb tub thaum lub sijhawm <37 asthiv ntawm qhov kev qoj ib ce vim yog mob ntsws los ntawm kev ua haujlwm tsis zoo los yog kev tawg ntawm lub plab.

6.17-Hydroxyprogesterone caproate hmoov:

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Kev txiav txim loj dua tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nqi.

7.17-Hydroxyprogesterone caproate hmoov zaub mov txawv:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

8.17-Hydroxyprogesterone caproate hmoov Muag:

Kom muab rau yav tom ntej tom ntej.

9.Daug 17-Hydroxyprogesterone caproate hmoov Muaj Tej Teebmeem Nqa?

  • Synthetic progestin; tsim los ntawm esterification ntawm 17α-hydroxyprogesterone, ib txwm tshwm sim metabolite ntawm progesterone, nrog caproic acid.
  • Muaj cov kev ua haujlwm muaj zog progestogenic; tshwm los ua qhov ntev ntev thiab muaj peev xwm ua rau muaj peev xwm nyob rau ntawm qhov kawg ntawm qhov kev tsim cov tshuaj endometrium dua progesterone.
  • Nws tsis tuaj yeem tshwm sim thiab muaj cov tshuaj Andrrogenic, antiandrogenic, estrogenic, lossis glucocorticoid.

Mechanism ntawm kev txiav txim siab txo txoj kev pheej hmoo ntawm lub hnub nyoog yug ntxov tsis paub


III. 17-Hydroxyprogesterone caproate hmoov HNMR

Peb yog khoom noj khoom haus Aprepitant, Aprepitant hmoov muag, Raw Aprepitant hmoov (170729-80-3) hplc = 98% | AASraw R & D Reagents


IV. Yuav ua li cas yuav tau 17-Hydroxyprogesterone caproate hmoov los ntawm AASraw?

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.