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Apixaban hmoov

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5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 503612-47-3. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom huab hwm coj ntawm Apixaban hmoov (503612-47-3), raws li CGMP kev tswj thiab kev tswj cov kev tswj qhov system.

Hauj lwm yam khoom

Apixaban hmoov video


Apixaban hmoov theem pib

Lub npe: Apixaban hmoov
CAS: 503612-47-3
Molecular Formula: C25H25N5O4
Molecular phaus: 459.50
Melt Point: 238-240 ° C
Cia Temp: 20 ° C rau 25 ° C
xim: Dawb kom daj ntseg daj


Apixaban hmoov hmoov hmoov

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Apixaban hmoov

Apixaban hmoov khib nyiab hmoov siv

Txo Cov Kev Hloov Ntxiv
Kev tswj hwm nrog ob chav neeg ua haujlwm ntawm CYP3A4 thiab P-gp

Yog hais tias noj> 2.5 PO BID, txo cov tshuaj los ntawm 50%
Yog tias noj 2.5 mg BID, tsis txhob muaj kev tswj hwm nrog cov khauj khaum ob leeg
Nonvalvular atrial fibrillation

Txo cov kab mob ntxiv rau 2.5 mg PO BID rau cov neeg mob uas muaj 2 ntawm cov yeeb yam nram no:
Muaj hnub nyoog ≥80 xyoo
Qhov hnyav ≤60 kg
Serum creatinine ≥1.5 mg / dL

  • Yuav txo tau qhov kev mob ntawm txoj hlab ntsha tawg / Muaj zog nyob rau hauv qhov tsis mob ntsws nyob hauv Nonivvular Atrial Fibrillation, 5 mg (Cov neeg laus) ib zaug ib hnub ob zaug; Cov 2 ntawm cov hauv qab no: hnub nyoog ≥80 yr, hnyav ≤60 kg, serum creatinine ≥1.5 mg / dL- 2.5 mg ob zaug ib hnub; Siv cov tshuaj tiv thaiv uas muaj zog tiv thaiv cov kab mob CYP3A4 thiab P-gp-2.5 mg ob zaug ib hnub; Yog tias tus neeg mob twb noj tshuaj 2.5 mg ob hnub, tsis txhob siv cov tshuaj tua kab mob.
  • Raum tsis zoo, HD- 5 mg (Cov neeg laus) ib hnub ob zaug; HD thiab hnub nyoog ≥80 xyoo los yog qhov hnyav ≤60 kg- 2.5 mg ob zaug ib hnub.
  • Kev Tiv Thaiv Sib Sib Nqus Ntawm Qhov Hniav Hloov Taws Xeeb Tom Qab Kev Hloov lossis Kev Hloov Cov Hloov Xws Los, 2.5 mg (Cov neeg laus) ib hnub ob zaug, pib 12-24 hr (thaum hemostasis ua tiav) txuas ntxiv rau 35 hnub tom qab hloov hlav los yog 12 hnub tom qab lub hauv caug hloov.
  • Kev kho mob ntawm DVT los yog PE, 10 mg (Cov neeg laus) ib hnub ob zaug rau 7 hnub, tom qab ntawd 5 mg ob zaug ib hnub.
  • Kev txo yog qhov uas yuav rov ua dua ntawm DVT lossis PE, 2.5 mg (Cov neeg laus) ib hnub ob zaug tom qab ≥6 mo ntawm kev kho mob ntawm DVT lossis PE.

Ceeb toom rau Apixaban hmoov hmoov hmoov

Cov kev mob tshwm sim feem ntau yog los ntshav thiab mob ntsws, qhia rau koj tus kws kho mob lossis nrhiav kev pab kho mob tam sim ntawd yog tias koj muaj ib qho ntawm cov tsos mob nram qab no uas muaj feem xyuam rau qhov muaj qhov tsis zoo heev:

  • Cov tsos mob ntawm kev fab tshuaj, xws li tawm tsam; khaus; khaus; liab, o, plab, los sis tawv nqaij los yog tsis ua npaws; hawb pob; nruj hauv lub hauv siab lossis caj pas; ua tsis taus pa, nqos, lossis hais lus; txawv txawv hoarseness; lossis o ntawm lub qhov ncauj, ntsej muag, di ncauj, nplaig, lossis caj pas.
  • Cov cim qhia ntawm kev ntshav xws li cuam tshuam cov ntshav los yog muab pov tseg uas zoo li kasfes; hnoos tau ntshav; ntshav hauv cov zis; dub, liab, los yog tso quav; los ntshav ntawm cov pos hniav; qhov chaw mos los ntshav tsis zoo li qub; nqaij doog tsis muaj vim li cas los yog loj dua; los yog cov ntshav los yog qhov tsis zoo los yog koj tsis tuaj yeem nres.
  • Kiv taub hau los sis lem tawm.
  • Mob leeg los yog o.
  • Mob siab lossis mob siab.
  • Hnov nkees lossis tsis muaj zog.
  • Xav tsis meej.
  • Mob taub hau.
  • Hawb pob.

Ntshav
Apixaban hmoov tuaj yeem ua kom muaj kev pheej hmoo ntawm txoj kev los ntshav uas yuav ua rau muaj mob loj thiab muaj peev xwm tuag taus. Siv cov tshuaj siv rau kev siv tshuaj tua kabmob hemostasis tuaj yeem ua rau kom muaj kev pheej hmoo. Qhov no suav cov tshuaj xws li lwm yam tshuaj anticoagulants, heparin, aspirin, tshuaj antiplatelet, serotonin reuptake selective inhibitors, serotonin norepinephrine reuptake inhibitors, thiab nonsteroidal anti-inflammatory drugs (NSAIDs).

Ib qho kev txhawj xeeb nrog kev siv cov Apixaban hmoov thiab lwm tus tshiab cov tshuaj anticoagulants yog qhov tsis muaj kev pom zoo tsim nyog rau kev hloov ntawm lawv qhov kev ua si (tsis muaj antidote). Qhov no yog ib qho tseem ceeb ntawm cov ntsig txog warfarin thaum muaj teeb meem los ntshav, lossis thaum tib neeg siv cov tshuaj yuav tsum tau phais kev kho mob thaum muaj xwm ceev.

Sab nrawm
Thaum siv cov tshuaj loog los yog siv cov tshuaj loog los yog siv cov tshuaj loog, cov neeg mob uas tau txais kev pabcuam los tiv thaiv cov tshuaj tua kab mob ntsws los ntawm kev tiv thaiv ntawm cov teeb meem tromboembolic yuav muaj teeb meem rau kev tsim muaj hematoma, uas yuav ua rau kom ntev mus ntev los yog ua rau tuag tes tuag taw. Txoj kev pheej hmoo ntawm qhov no yuav raug nce ntxiv los ntawm kev siv epidural los yog intrathecal catheters tom qab kev siv phais mob los yog los ntawm kev siv sib tw siv tshuaj kho mob uas cuam tshuam rau hemostasis.

Cov lus qhia ntxiv

Apixaban hmoov yog ib qho tshuaj tiv thaiv tus kabmob thiab ncaj qha rau tus kws kho mob uas yog siv los txo qhov kev pheej hmoo ntawm venous thromboses, systemic embolisation thiab mob hlab ntsha tawg hauv cov neeg mob uas muaj atrial fibrillation, thiab txo qhov kev sib sib zog nqus voos thrombosis thiab pulmonary embolus tom qab lub hauv caug lossis lub ntsws hloov phais . Apixaban hmoov tau txuas mus rau tus nqi qis ntawm serum aminotransferase elevations thaum lub sij hawm kho thiab tsawg zaus ntawm clinically pom daim siab raug mob.

Kev siv kab mob:
Apixaban hmoov yog qhia rau cov nram no:

Yuav txo qee txoj kev pheej hmoo ntawm cov hlab ntsha tawg thiab cov paj hlwb nyob hauv cov neeg mob uas muaj lub cev tsis tuaj yeem hlav tsis zoo hauv atrial fibrillation.
Kev sib sib zog nqus voos thrombosis (DVT) prophylaxis. DVTs yuav ua rau cov ntsig txog mob ntsav ntsiag (PE) hauv cov neeg mob hloov ntawm lub hauv caug lossis lub ntsws.
Kev kho mob ntawm DVT thiab PE.
Yuav kom txo tau txoj kev pheej yig dua ntawm DVT thiab PE tom qab pib kho.

Apixaban Raw Hmoov

Apixaban hmoov yog ib tug dawb dawb daj ntseg daj. Nyob ntawm tus kab mob physiological pH (1.2-6.8), Apixaban hmoov tsis ionize; nws cov aqueous solubility hla kev tawm dag zog ntawm physiological yog ~ 0.04 mg / mL.

ELIQUIS ntsiav tshuaj muaj nyob rau ntawm qhov ncauj ntawm 2.5 mg thiab 5 mg ntawm Apixaban hmoov nrog cov khoom xyaw nram qab no: anhydrous lactose, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, thiab magnesium stearate. Cov yeeb yaj kiab txheej muaj lactose monohydrate, hypromellose, titanium dioxide, triacetin, thiab hlau iron oxide (2.5 mg tablets) los yog liab hlau oxide (5 mg ntsiav tshuaj).

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nyiaj.

Apixaban hmoov muag

Kom muab rau yav tom ntej tom ntej.


Yuav ua li cas yuav Apixaban hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


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COA

HNMR

Apixaban hmoov (503612-47-3) hplc≥98% | AASraw HNML

Zaub mov txawv

Apixaban Nqaij Pluag Mov Noj:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations

Apixaban (Eliquis): siv, kev sib tshuam, kev phiv tshuaj, lus ceeb toom