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BMS-564929 hmoov

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5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 627530-84-1. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom kev loj hlob ntawm BMS-564929 hmoov (627530-84-1), raws li CGMP kev tswj thiab kev tswj xyuas qhov kev tiv thaiv.

BMS-564929 hmoov yog ib qho kev tshawb nrhiav kev xaiv thiab cov neeg ua haujlwm rau cov neeg ua haujlwm, uas yog raug tsim los ntawm Bristol-Myers Squibb rau kev kho mob ntawm cov hnub nyoog txog kev poob qis hauv cov txiv neej ("andropause"). Cov tsos mob no yuav muaj kev tso cai, kev mob pob ntseg thiab lub zog, txo qis hauv libido thiab osteoporosis. Raws li cov kev tshawb pom no, BBMS-564929 hmoov zoo nkaus li yog ib qho zoo nkauj anabolic SARM

Hauj lwm yam khoom

BMS-564929 hmoov video


I.BMS-564929 hmoov theem pib:

Lub npe: BMS-564929 hmoov
CAS: 627530-84-1
Molecular Formula: C14H12ClN3O3
Molecular phaus: 305.71638
Melt Point: 175-184 ° C
Cia Temp: Qhuav, tsaus nti thiab tom 0 - 4 ° C rau lub sij hawm luv luv (hnub rau lub lis piam) los yog -20 ° C mus ntev (hli mus rau xyoo)
xim: Dawb hmoov


BMS-564929 hmoov (627530-84-1) hauv lub cev tsim kho

BMS-564929 hmoov npe

BMS-564929 hmoov

Raw BMS-564929 hmoov pab

BMS-564929 hmoov yog ib co muaj zog, hais lus dhia, nonsteroidal cov ntaub so xaiv thiabrogen receptor (AR) modulator. BMS-564929 hmoov yog ib subnanomolar AR agonist hauv vitro, yog co xaiv rau AR thiab lwm yam steroid hormone receptors, thiab exhibits tsis muaj kev sib cuam tshuam nrog SHBG los yog aromatase. Cov kev tshawb fawb kev tshawb fawb hauv cov txiv neej uas muaj teeb meem pom tau tias BMS-564929 nyoos hmoov ntau zog tshaj li testosterone (T) hauv stimulating qhov kev loj hlob ntawm levator ani leeg, thiab tsis zoo li T, mas xaiv cov nqaij thiab prostate.

BMS-564,929 yog ib qho xws li muaj xws li hauv cov neeg mob thaum ntxov, uas yog ib lub ncauj lus, muaj zog thiab xaiv cov agonist rau androgen receptors (Xi 2.1nM, 20x cov kev xaiv ua kom cov nqaij ntawm prostate) thiab nyob rau hauv cov kev tshawb fawb ntawm castrated nas nws pom txo cov nqaij pob txha thaum lub sij hawm, thiab ntau dua kev noj cov leeg mob, tsis muaj kev cuam tshuam rau cov nqaij ntshiab pob txha.Yog li cas ho vastly txo luteinizing hormone ntau ntau, nws yog ib qho astonishing 33x ntau suppressive compound tshaj testosterone, uas tej zaum yuav muaj teeb meem rau tib neeg soj ntsuam kev siv.
BMS-564929 nyoos hmoov khi zoo rau lub androgen reseptor thiab tsis mus rau lwm yam tshuaj steroid receptors. BMS-564929 hmoov tsis muaj kev sib tshuam nrog SHBG thiab nws tsis inhibit aromatase. Kev ntsuam xyuas nrog cov nas muaj cov kev ua zoo dua anabolic ces testosterone propionate ntawm tib lub koob, thiab ib qho kev ua tsis tshua muaj androgenic. Cov tshuaj dej BMS-564929 ntau dua ua rau cov tshuaj hypothalamus thiab lub pituary thiab ua li no txo ​​qis ntawm LH thiab FSH.

Xoo hluav taws xob ntawm BMS-564929 hmoov nrog lub LBD ntawm lub androgen reseptor pom muaj qee qhov sib txawv ntawm BMS-564929 nyoos hmoov thiab dihydrotestosterone hauv lawv cov kev sib raug zoo nrog LBD ntawm tus neeg tau txais kev pab. Cov kev txawv no zoo nkaus li kom loj txaus los pab kho qhov teebmeem anabolic hauv cov leeg thiab tsis yog qhov muaj zog thiab cov nyhav hauv prostate. Nws tseem tsis tau paub meej tias yuav piav tag nrho qhov txawv li cas.

BMS-564929 hmoov yog qhov ncauj lus thiab metabolic transformations yog qeeb qeeb ces hauv lub SARI tus proionamide. Qhov sij hawm half-life txawv ntawm 8 mus rau 14 cov xuab moos, thiab tsawg dua qhov ua tau.

Ceeb toom rau BMS-564929 hmoov

BMS-564929 hmoov yog ib qho kev tshawb nrhiav androgen receptor modulator (SARM) uas yog raug tsim los ntawm Bristol-Myers Squibb rau kev kho mob ntawm cov hnub nyoog txog kev poob qis hauv cov txiv neej ("andropause"). Cov tsos mob no muaj xws li kev nyuaj siab, kev mob pob ntseg thiab lub zog, txo qis hauv libido thiab osteoporosis. Kev kho mob nrog exogenous testosterone zoo tiv thaiv cov tsos mob no, tab sis yog txuam nrog ntau yam kev phiv, qhov loj tshaj plaws uas yog loj ntawm qog prostate, uas tuaj yeem ua rau benign prostatic hypertrophy thiab txawm prostate cancer. Qhov no txhais tau hais tias muaj ib qhov kev xav tau rau kev xaiv thiab txiav cov roj ntsha txav hauv lub cev, uas tsim cov teebmeem anabolic hauv qee cov nqaij xws li cov leeg thiab pob txha, tab sis tsis muaj tus kab mob androgen receptors stimulating hauv prostate.

Cov lus qhia ntxiv

BMS-564929 hmoov yog ib qho xim thiab androgen reseptor (AR) modulator nrog Ki nqi ntawm 2.11 ± 0.16 nM.
Tus AR yog hom nuclear receptor uas yog qhib los ntawm cov tshuaj hormones androgenic, testosterone, lossis dihydrotestosterone. Qhov tseem ceeb muaj nuj nqi yog tswj cov noob qhia.
BMS-564929 nyoos hmoov yog ib qho nqaij-tawv nqaij mob agonist rau AR nrog cov qauv bicyclic hydantoin. BMS-564929 hmoov yog hais txog 400-fold selective rau AR vs. PR thiab ntau tshaj 1000-quav xim rau AR thiab GR, MR thiab ERα thiab β. Hauv C2C12 myoblast cell kab, BMS-564929 nyoos hmoov qhia tau hais tias lub zog ntawm 0.44 ± 0.03 nM piv nrog 2.81 ± 0.48 nM ntsuas rau testosterone.
Hauv cov txiv neej cov nas dej, cov nqaij nyoos BMS-564929 hmoov ntau zog dua li testosterone (T) hauv kev txhawb kev loj hlob ntawm levator ani leeg, thiab muaj kev xaiv heev rau cov leeg nqaij thiab Prostate. Vim nws txoj hauv kev ua kom lub cev loj thiab cov ntaub so ntswg, BMS-564929 hmoov yuav tsum tuaj yeem ua pa khov kho hauv cov nqaij thiab lwm cov nqaij nrog txoj kev nyab xeeb tshaj plaws.

BMS-564929 Raw Hmoov

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nyiaj.

Nqaij BMS-564929 hmoov muag

Kom muab rau yav tom ntej tom ntej.


Yuav ua li cas yuav BMS-564929 hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


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COA

COA 627530-84-1 BMS-564929 hmoov AASRAW

HNMR

Peb yog BMS-564929 hmoov khoom, BMS-564929 hmoov rau muag, BMS-564929 hmoov (627530-84-1) hplc = 98% | AASraw R & D Reagents

Zaub mov txawv

BMS-564929 Raw Pluas Noj Cov Khoom Noj:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations

Tshiab SARMS Feem Cuam Tshuam Txhab BMS-564929 Hmoov Siv Online