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Bortezomib hmoov (179324-69-7)

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5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 179324-69-7. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom loj txog Bortezomib hmoov (179324-69-7), raws li CGMP kev tswj thiab kev tswj xyuas qhov system zoo.

Bortezomib yog kev siv tshuaj tua kabmob thiab cov thawj cov tshuaj hu ua proteasome inhibitor los siv rau tib neeg. Proteasomes yog cellular complexes uas ua txhaum cov nqaijrog. Hauv qee cov qog nqaij hlav, cov proteins uas feem ntau tua cov qog nqaij hlav cancer tau tawg tuaj sai dhau. Bortezomib ncua kev ua hauj lwm no thiab cia cov proteins uas tua cov kabmob hlwb. Nws tau kev pom zoo hauv Tebchaws Meskas thiab cov tebchaws Europe los kho tus mob ieloma ntau dua thiab cov kabmob kua nplaum (mantle cell lymphoma). Hauv ntau yam mob myeloma, cov lus teb tiav cov lus teb tau muab rau cov neeg mob uas muaj lwm yam kev mob los yog mob ceev ceev.

Hauj lwm yam khoom

Bortezomib hmoov video


Bortezomib hmoov theem pib

Lub npe: Bortezomib hmoov
CAS: 179324-69-7
Molecular Formula: C19H25BN4O4
Molecular phaus: 384.24
Melt Point: 122-124 ° C
Cia Temp: -20 ° C Freezer
xim: Dawb mus tua dawb Crystalline hmoov


Raw Bortezomib hmoov nyob rau hauv kev siv

npe

Boronic acid, Velcade, Neomib, Bortecad

Bortezomib hmoov pab

Bortezomib hmoov yog ib txoj kev siv tshuaj tua kab mob cancer thiab thawj cov tshuaj proteasome inhibitor siv rau tib neeg. Proteasomes yog cellular complexes uas ua txhaum cov nqaijrog. Hauv qee cov qog nqaij hlav, cov proteins uas feem ntau tua cov qog nqaij hlav cancer tau tawg tuaj sai dhau. Bortezomib hmoov cuam tshuam cov txheej txheem no thiab cia cov proteins tua cov kabmob hlwb. Nws tau kev pom zoo hauv Tebchaws Meskas thiab cov tebchaws Europe los kho tus mob ieloma ntau dua thiab cov kabmob kua nplaum (mantle cell lymphoma). Hauv ntau yam mob myeloma, cov lus teb tiav cov lus teb tau muab rau cov neeg mob uas muaj lwm yam kev mob los yog mob ceev ceev.

Lub boron atom hauv Bortezomib nyoos hmoov binds lub catalytic site ntawm 26S proteasome nrog affinity siab thiab tseem. Hauv cov qe ntshav, cov proteasome tswj cov protein ntau thiab kev ua haujlwm los ntawm degradation ntawm ubiquitylated proteins, thiab tseem ntxuav lub cell ntawm txawv txav lossis misfolded proteins. Clinical thiab preclinical cov ntaub ntawv txhawb lub luag hauj lwm hauv kev tswj cov tsis muaj phenotype ntawm myeloma hlwb, thiab ntawm tes-kab lis kev cai thiab xenograft cov ntaub ntawv txhawb ib txoj haujlwm zoo sib xws hauv cov nqaij hlav nqaij hlav. Thaum muaj ntau yam tswv yim ua rau kev koom tes, proteasome inhibition yuav tiv thaiv tau degradation ntawm pro-apoptotic yam, li no triggering programmed cell tuag hauv hlwb neoplastic. Tsis ntev tas los no, nws tau pom tias Bortezomib hmoov ua rau muaj kev sib txawv thiab ua txoj kev hloov hauv cov qib plaidas uas yog tsim los ntawm proteasome. [8] Qee lub pob peg dej tau pom tias yog biologically active, thiab yog li cov nyhuv ntawm Bortezomib nyoos hmoov cov theem ntawm cov pob peg puav hlwb yuav ua rau kom muaj kev lom neeg thiab / los yog phiv tshuaj.

Bortezomib hmoov yog txuam nrog peripheral neuropathy hauv 30% ntawm cov neeg mob; Qee zaus, nws tuaj yeem ua mob heev. Qhov no tuaj yeem mob heev dua rau cov neeg mob uas muaj cov kab mob ua ntej paj hlwb. Tsis tas li ntawd, myelosuppression ua rau cov kab mob neutropenia thiab thrombocytopenia kuj tuaj yeem tshwm sim thiab ua kom tsis txhob muaj kab mob. Txawm li cas los xij, cov kev mob tshwm sim no feem ntau me ntsis txhim kho cov pob txha pob txha thiab lwm yam kev kho mob rau cov neeg mob muaj kab mob siab. Bortezomib nyoos hmoov yog txuam nrog ib tug siab tus nqi ntawm shingles, tab sis prophylactic acyclovir yuav txo tau txoj kev pheej hmoo ntawm no. Kev mob ua rau tus neeg mob tau tus mob kuj tau qhia tawm.

Gastro-intestinal (GI) cov teebmeem thiab asthenia yog cov txheej txheem phais feem ntau.

Cov teebmeem anticancer ntawm Bortezomib nyoos hmoov raws li ib tus neeg sawv cev tau pom hais tias hauv xenograft qauv ntawm ntau yam mob myeloma, tus neeg laus T-cell leukemia, ntsws, lub mis, prostate, pancreatic, lub taub hau thiab lub caj dab, thiab cov nyuv cancer, thiab hauv melanoma. Qhov ncauj Bortezomib hmoov 1.0 mg / kg txhua hnub rau 18 hnub ua rau qog hlob qeeb, zoo li ib tug txo ntawm pes tsawg tus metastases hauv Lewis ntsws cancer cancer qauv. Bortezomib hmoov ntawm ib zaug ntawm kev mus txog 5 mg / kg hla qis qis dua ntawm cov qog nqaij hlav hauv lub hlwb. Bortezomib hmoov 1.0 mg / kg tswj txhua lub lim tiam rau 4 lub lis piam thiaj txo qis loj hlob los ntawm 60% hauv murine xenograft qauv ntawm prostate cancer. 1.0 mg / kg Bortezomib nyoos hmoov tshuaj rau 4 lub lim piam tau tshwm sim hauv 72% los yog 84% txo ntawm pancreatic cancer murine xenografts kev loj hlob, as Well as nce ntawm qog cell apoptosis. 1.0 mg / kg Bortezomib hmoov tshuaj tuaj yeem ua rau tib neeg plasmacytoma xenograft kev loj hlob, ua rau cov qog hlwb qoob loo thiab tag nrho cov ciaj sia tuaj yeem, thiab txo qis qog angiogenesis.

Ceeb toom rau Bortezomib nyoos hmoov

Kev txhim kho cov kabmob pathogen hauv ubiquitin-proteasome tau sawv raws li kev kho kom haum rau kev kho tus neeg mob cancer. Raws li cov kev tshawb fawb tau zoo thiab kev tshawb fawb, Bortezomib nyoos hmoov tom qab tau pom zoo rau kev siv tshuaj kho mob ua ntej kho kab mob tshiab rau cov neeg mob me me thiab cov kev kho mob rov thev / ntau dua ntawm cov tshuaj myeloma thiab mantle cell lymphoma, uas yog yeeb tshuaj dhau los ua qhov chaw khomob ntawm kev khomob. Kev pom zoo ntawm Bortezomib hmoov los ntawm US Food thiab Drug Administration (FDA) tuaj yeem sawv cev ib qho tseem ceeb tshaj plaws raws li thawj cov tshuaj proteasome inhibitor kom ua raws li kev kho mob ntawm tus kab mob malignant. Bortezomib cov hmoov nyoos tau pom tias muaj txiaj ntsim zoo los ntawm ib leeg los yog ib feem ntawm txoj kev kho kom haum rau induce chemo- / xov tooj cua-sensitization los yog kov cov tshuaj tiv thaiv. Yog ib lub tswv yim loj ntawm Bortezomib hmoov txuam nrog nws txoj haujlwm anticancer yog los ntawm upregulation ntawm NOXA, uas yog ib tug proapoptotic protein, thiab NOXA yuav cuam tshuam nrog cov anti-apoptotic proteins ntawm Bcl-2 subfamily Bcl-XL thiab Bcl-2, thiab qhov tshwm sim nyob rau hauv apoptotic cell tuag hauv malignant hlwb. Lwm cov tswv yim tseem ceeb ntawm Bortezomib nyoos hmoov yog los ntawm kev tiv thaiv ntawm NF-SB signaling chaw uas ua rau hauv kev tswj hwm ntawm nws cov lej anti-apoptotic noob. Txawm hais tias feem ntau ntawm txoj kev vam meej nrog Bortezomib hmoov twb tau nyob rau hauv hematological malignancies, nws cov nyhuv rau khoom hlav tau tsawg dua kev txhawb. Txuas ntxiv, txoj kev siv kab mob Bortezomib siv thoob plaws tseem raug hampered los ntawm cov tsos ntawm koob tshuaj-limiting toxicities, tshuaj-ua hauj thiab cuam tshuam los ntawm tej qhov ntuj tsim teb. Cov kev tshawb pom no yuav pab tau cov kws kho mob kom paub kho cov kab mob Bortezomib cov hmoov nyoos, thiab txhawb cov kws tshawb fawb los ua cov cim ntxiv ntawm cov tshuaj proteasome uas ua rau cov kab mob muaj zog ntxiv thiab ua rau cov neeg mob khees xaws ntau dua. Lwm cov ntawv thov rau kev siv cov tshuaj proteasome ua rau muaj kev tiv thaiv ntawm cov tshuaj tiv thaiv tshwj xeeb E3 ligases, uas ua rau cov kauj ruam ua ntej ntawm qhov chaw ubiquitin-proteasome pathway, thiab cov kev tshawb nrhiav ntawm cov tshuaj lom neeg tsis haum thiab tshiab proteasome inhibitors los ntawm cov khoom natural thiab traditional medicines tej zaum yuav muab cov neeg siv tshuaj tua kab mob ntau ntxiv rau kev mob khees-xaws thiab kev kho mob ntawm cov neeg mob khees-xaws yav tom ntej.

Cov lus qhia ntxiv

Bortezomib hmoov yog ib hom tshuaj uas inhibits mammalian 26S proteasome. Txoj kev ua rau ubiquitin-proteasome plays lub luag haujlwm tseem ceeb hauv kev tswj cov txheej txheem intracellular ntawm cov roj ntsha tshwj xeeb, yog li ua rau mob homeostasis hauv hlwb. Inhibition ntawm cov 26S proteasome tiv thaiv no cov hom phiaj proteolysis, uas tuaj yeem cuam tshuam ntau cov phiajcim tsis pub dhau lub cell. Txoj kev cuam tshuam txog kev tsis zoo ntawm cov tsev homeostatic yuav ua rau tuag taus ntawm tes. Cov kev sim tau pom tau tias Bortezomib nyoos hmoov yog cytotoxic rau ntau hom kab mob cancer cell hom nyob rau hauv vitro. Bortezomib nyoos hmoov ua rau qeeb hauv kev loj hlob hauv vivo hauv cov qauv qog nqaij hlav, nrog rau ntau yam mob myeloma. Qog hlwb, uas yog, faib cov qe ntshav sai sai, zoo li yuav nkag siab ntau dua rau cov neeg hu ua proteasome inhibition.

Bortezomib hmoov yog ib tug reversible inhibitor ntawm chymotrypsin zoo li kev ua si ntawm 26S proteasome hauv hlwb mammalian. 26S proteasome yog ib qho loj protein complex uas ua rau cov kua qos yaj ywm muaj kuab. Qhov chaw ntawm lub proteasome muaj chymotrypsin zoo li, trypsin zoo li, thiab postglutamyl peptide hydrolysis kev ua si. 26S proteasome degrades ntau cov proteins uas tseem ceeb rau kev mob cancer ntawm lub cev, xws li cyclins, qog suppressors, BCL-2, thiab cyclin-dependent kinase inhibitors. Inhibition ntawm cov degradations sensitizes hlwb kom apoptosis. Bortezomib nyoos hmoov yog lub hwj chim inhibitor ntawm 26S proteasome, uas ua rau muaj kev ua hauv kev faib ntau yam myeloma thiab leukemic hlwb, yog li inducing apoptosis. Tsis tas li, Bortezomib hmoov zoo nkaus li ua rau cov kabmob kheesxaws ntawm cov kabmob tshuaj (xws li, gemcitabine, cisplatin, paclitaxel, irinotecan, thiab hluav taws xob).

Bortezomib Raw Hmoov

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nyiaj.

Raw Bortezomib hmoov muag

Kom muab rau yav tom ntej tom ntej.


Yuav ua li cas yuav Bortezomib hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


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COA

HNMR

Bortezomib hmoov (179324-69-7) hplc = 98% | AASraw R & D Reagents

Zaub mov txawv

Bortezomib Raw Pluas Noj Zaub:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations

Nov Yog Txhua Yam Koj Yuav Tsum Paub Txog Bortezomib