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Canrenone hmoov (976-71-6)

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 976-71-6. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm gram kom loj npaum li cas ntawm Canrenone hmoov (976-71-6), raws li CGMP kev tswj thiab kev tswj xyuas qhov system zoo.

Canrenone hmoov tau muab tso rau hauv koob tshuaj 2 × 82 mg thiab 2 × 164 mg ib hnub dhau ib lub sijhawm ntawm 10 hnub rau cov neeg mob ntshav qab zib tsis muaj kev mob plawv, lub siab los yog lub raum kev koom tes. Aldosterone excretion thiab plasma aldosterone nce ntau me ntsis thaum lub sijhawm ob qho tib si.

Hauj lwm yam khoom

Canrenone hmoov yees duab


Canrenone hmoov theem pib

Lub npe: Canrenone hmoov
CAS: 4642-95-9
Molecular Formula: C18H20O2
Molecular phaus: 258.36
Melt Point: 138-141 ℃
Cia Temp: Chav Tsev Kub
xim: Dawb los yog daj daj Crystalline hmoov


Canrenone hmoov txhuam

npe

TSIS HOM (S): Canrenone hmoov
GENERIC NPE (S): Sib, Luvion, Phanurane, Spiroletan

Canrenone hmoov pab

Plasma theem ntawm Canrenone hmoov thiab 'tag nrho cov metabolites' tom qab lub hauv paus hydrolysis tau muab piv rau cov hluas thiab cov neeg laus laus tom qab ib zaug thiab ntau koob tshuaj spironolactone. Tom qab thawj zaug ntawm hnub 1, plasma theem ntawm Canrenone nyoos hmoov thiab 'tag nrho cov metabolites' tau siab dua rau cov menyuam hluas dua li cov neeg laus, thiab qhov txawv txav ntawm ob pawg hnub nyoog hauv cov AUC rau Canrenone hmoov thiab 'tag nrho metabolites '. Txawm li cas los xij, cov kev sib txawv ntawm ob lub hnub nyoog muaj kev tsis sib haum tom qab hnub 8, thiab cov tub yees ua ntej ntshav qab zib ntawm Canrenone nyoos hmoov thiab cov 'metabolites' tag nrho cov nyom dua hauv cov laus laus. Cov kab sib tsoo ntawm Canrenone hmoov thiab 'tag nrho cov metabolites' muaj yig dua hauv cov neeg laus dua hauv cov hluas. Ob lub Canrenone nyoos hmoov thiab canrenoic acid tau feem ntau ua rau cov kua qe ntshauv, tiam sis tsis muaj qhov sib txawv ntawm ob lub hnub nyoog hauv cov protein ntau. Cov kev sib txawv hauv plasma theem tom qab ib zaug thiab ntau ntau qhov sib xyaw ntawm cov tub ntxhais hluas thiab cov laus muaj peev xwm ua rau muaj ntau yam xws li kev hloov ntawm cov metabolism nrog lub hnub nyoog; tsis hnov ​​lus tsis zoo ntawm niam txiv; thiab / los yog hloov ntim ntawm kev faib cov tshuaj.

Qhov ntau npaum li cas ntawm Canrenone hmoov

Qhov ncauj, feem ntau, 50-200 mg ib hnub raws li kev noj tshuaj ib zaug los yog hauv ntau qhov chaw khiav dej num txaus.
Hauv cov mob hnyav tshaj plaws, thawj zaug yuav muab ntau ntxiv rau 300 mg los yog ntau dua, tom qab ntawd cov tshuaj kho kom haum rau cov lus teb thiab kuaj cov kab mob.

Ua li cas Canrenone hmoov ua haujlwm

HPLC spectrometric txoj kev loj hlob txoj kev loj hlob yog ua tiav ntawm TQ4 Quantum Discovery triple quadrupole huab hwm coj spectrometer nrog ib qho Aria CTC HPLC autosampler system. Nyob rau hauv txoj kev zoo ntawm txoj kev electrospray ionisation yog cov tshuaj protonated ions (M + H) + m / z 341 rau Canrenone hmoov. Alfaxalone (precursor ions m / z 333; 1 μg) yog siv tus txheej txheem sab hauv. Hauv kev sib tsoo ntawm kev sib tsoo, qhov tseem ceeb ntawm kev faib cov ions yog m / z 107.1 thiab 91.1 rau Canrenone nyoos hmoov thiab m / z 297.3 thiab 315.3 rau alfaxalone. Lub fragmentation ions tau siv raws li quantifier thiab qualifier ions feem ntau ntxiv qhov tseem ceeb rau kev sib tw. Qhov kev sib cais ntawm qhov kev sib tw tau ua tiav raws li siv ammonium acetate (5 mM) / methanol ntawm (60: 40, 0.3 ml / min) rau ntawm Waters C18 T3 Atlantis HPLC kem (3 μm; 100 × 2.1 mm) tom 25 ° C. Lub gradient nce ntawm 40 rau 90% methanol tau thov, nrog rau tag nrho cov sij hawm ntawm 8 feeb.

Validation of quantitative parameters twb tau siv rau sab hauv kev sib tham - thiab cov kev sib tshuam ntawm kev sib tshuam. Cov khoom txig ntawm Canrenone hmoov thiab alfaxalone (106.2% (tus txheeb ze tus qauv sib txawv (RSD) 9.5%) thiab 102.2% (RSD 4.7%)) tau tiav tom qab ua kua dej kua extraction ntawm 25 μl plasma nrog ethyl acetate (1: 10). Cov kev txwv ntawm xaj yog 5 ng / ml thiab qhov txo qis ntawm cov quantitation yog 15 ng / ml. Kev ntsuam xyuas tau tawm (r = 0.9936) ntau dua ntawm ntau yam (5 ng / ml rau 5 μg / ml). Txoj kev ntsuam xyuas tau pom zoo rau cov yees ntawm Canrenone nyoos hmoov hauv ib pawg neeg mob uas tau txais ib 400 mg koob tshuaj, uas yog cov concentrations hauv ntshav tau pom muaj nyob rau hauv ntau 5-45 μmol / l.

Cov txiaj ntsig ntawm Canrenone hmoov

Canrenone hmoov yog lub ntsiab lub cev metabolite ntawm spironolactone. Los ntawm kev ua qauv zoo li, nws ua rau competitiveively nrog aldosterone los ntawm kev tawm ntawm nws los ntawm cov chaw hauv receptor nyob rau theem ntawm qhov distal feem ntawm lub raj tshuaj hla thiab ntawm cov ciav sau; qhov no tshwm sim nyob rau hauv ib qho kev nce hauv diuresis thiab natriuresis thiab txo qis ntawm kaliuresis. Piv rau spironolactone muaj qhov zoo ntawm qis qis dua. Ib yam li spironolactone, Txawm li cas los xij, nws tsis muaj kev txiav txim siab hauv kev tshawb fawb los sis hauv cov kev kawm uas tau txais tsawg los ntawm kev poob qaub zuaj.
Tom qab qhov ncauj siv tshuaj tua kab, cov hmoov nplej Canrenone ceev nrooj, ua siab tshaj plasma ntau npaum li cas hauv thawj ob xuab moos. Ib nrab ntawm lub neej yog hais txog 18 cov sij hawm thiab, tsis zoo li spironolactone, excreted unchanged, nyob rau hauv 72 cov xuab moos, nrog rau cov zis thiab quav raws li qhov sib npaug.
Canrenone hmoov tau qhia nyob rau hauv cov kev mob uas ua rau lub siab tshaj ntawm aldosterone tsim tawm cov dej thiab sodium thiab muaj cov kab mob caliuria. Nws yog tseem ceeb nyob rau hauv kev kho mob ntawm ascites nyob rau hauv cirrhosis ntawm daim siab, txawm tias hais tias qhov kev siv tshuaj tsis tu ncua mus rau lub teb nyob rau hauv ib tug neeg cov ntaub ntawv.

Canrenone hmoov

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Kev txiav txim loj dua tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nqi.

Canrenone nyoos hmoov ua lag luam

Kom muab rau yav tom ntej tom ntej.

Canrenone nyoos hmoov overview

Canrenone nyoos hmoov yog ib qho metabolite ntawm spironolactone, canrenoic acid, thiab potassium canrenoate, thiab yog xav tias yog ib feem xyuam rau lawv cov teebmeem. Nws tau raug pom los ntawm cov nyiaj kwv yees li 10 rau 25% ntawm cov kab mob spironolactone, uas yog lwm metabolite, 7α-thiomethylspironolactone (7α-TMS), tso nyiaj rau 80% ntawm cov potassium-sparing effect ntawm cov tshuaj.

Canrenone hmoov yog tshaj tawm tias muaj peev xwm ua kom muaj zog tshaj li muaj peev xwm ua rau muaj spironolactone, tab sis tsis tshua muaj zog thiab ua zoo li ib qho kev ua rog. Zoo sib xws rau spironolactone, Canrenone nyoos hmoov inhibits steroidogenic enzymes xws li 11β-hydroxylase, cholesterol-chain cleavage enzyme, 17α-hydroxylase, 17,20-lyase, thiab 21-hydroxylase, tab sis dua ib zaug, comparatively tsawg zog ua.


Yuav ua li cas yuav Canrenone hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

Zaub mov txawv

Canrenone nyoos hmoov qhob noj

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations