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Dapoxetine HCL hmoov

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5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 129938-20-1. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm gram kom huab hwm coj ntawm Dapoxetine hydrochloride hmoov (129938-20-1), raws li CGMP kev tswj thiab kev tswj xyuas qhov kev tswj kom zoo.

Dapoxetine hydrochloride yog ib lub sijhawm luv luv ua xim serotonin reuptake inhibitor kev ua lag luam rau kev kho mob ntxov ntxov ejaculation hauv cov txiv neej. Ejaculation ntxov ntxov (PE) yog tus txiv neej feem ntau kev sib deev tsis zoo, kwv yees rau kev cuam tshuam rau 30% ntawm txiv neej. Dapoxetine hydrochloride yog ib qho kev ntsuas kev soj ntsuam uas yog categorized ua cov xim serotonin reuptake inhibitor. Nws muab kev txhim kho nyob rau hauv ntau yam tsis muaj feem xyuam rau ntxov ntxov ejaculation nyob rau hauv kev soj ntsuam hlw kom qis. Cov khoom no yog tsim los rau kev tshawb fawb thiab kev siv foos pub.

Hauj lwm yam khoom

Dapoxetine hydrochloride tshuaj loog siv yees duab


Raw Dapoxetine hydrochloride tshuaj loog yooj yim cim

Lub npe: Dapoxetine hydrochloride
CAS: 129938-20-1
Molecular Formula: C9H7ClN2O5
Molecular phaus: 258.62
Melt Point: 175-179 ° C
Cia Temp: -20 ° C Freezer
xim: Dawb crystalline hmoov


Dapoxetine yog ib qho organic compound ntawm cov chav kawm ntawm cov neeg ua rau cov neeg ua haujlwm kom tsis txhob muaj kev nyuab siab dua. Cov tshuaj no yog tsim los kho cov poj niam laus hauv caug thaum muaj hnub nyoog ntawm 18 thiab 64 uas ua tau raws li tag nrho cov hauv qab no:

1. Nruam los yog rov qab ejaculation ntawm chaw mos ua ntej, thaum lub sij hawm, lossis luv tom qab nkag mus rau hauv lub paum, thiab tsuas yog ua ntej kev tsis txaus siab ntawm kev sib deev;

2. Kev nyuaj siab ntxhov plawv los yog kev cuam tshuam ntawm tus kheej vim yog ntxov ntxov ejaculation (PE);

3. Muaj peev xwm tswj tsis tau tus kheej ejaculation.

Tshuaj lom neeg ntawm Dapoxetine

Dapoxetine hydrochloride ntsiav tshuaj yog ib hom yeeb yaj kiab-coated ntsiav tshuaj, uas yog dawb los yog dawb tom qab tshem tawm ntawm txheej.

Qhov tseem ceeb muaj: Dapoxetine hydrochloride.

IUPAC Name: (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine

Dapoxetine HCL hmoov tshuaj qauv

1. Qauv 2D:

2. 3D Conformer:

Cov roj formula: C21H23NO

Molecular phaus: 305.421 g / mol

CAS: 119356-77-3

Kev piav qhia yooj yim ntawm Dapoxetine

Tam sim no, tsis muaj ib qho kev tswj hwm rau kev kho tus txiv neej ntxov ntxov ejaculation nrog dapoxetine hydrochloride ntsiav tshuaj. Tsis muaj ib qho kev cai li cas los ntev npaum li cas cov tshuaj siv rau kev kho mob. Nws nyob ntawm qhov mob loj heev ntawm cov tsos mob ntawm ejaculation ntxov. Cov kev kho mob nyuaj yog txawv. Cov tshuaj no lub sijhawm tsis tuaj yeem pom dav dav. Txawm li cas los xij, cov tshuaj no tuaj yeem txhim kho cov tsos mob thaum ntxov ntxov, yog li cov neeg mob tau noj tshuaj raws li lawv cov tsos mob.

Dapoxetine feem ntau yog npaj rau kev kho mob ntawm 18 rau 64 xyoo laus txiv neej ejaculation (PE) cov neeg mob uas muaj tag nrho cov mob hauv qab no, nrog rau:

1. Qhov chaw mos yog qhov me me ua ntej, thaum lub sij hawm, los yog luv luv tom qab nkag mus rau hauv lub paum, thiab ua ntej kev sib deev siab. Kev hnov ​​mob ntawm kev sib deev yog tas mus li los yog rov qab ejaculation;

2. Kev nyuaj siab ntxhov plawv los yog kev cuam tshuam ntawm tus kheej vim yog ntxov ntxov ejaculation (PE);

3. Txuas kev tswj tsis tau cov ejaculation.

Dapoxetine twb tau txais kev pom zoo los ntawm cov kws kho mob nyob teb chaws Europe thiab hauv Teb Chaws Meskas raws li muaj kev ntxim siab rau kev kho mob ntxov ntxov ejaculation. Thaum noj dapoxetine, serotonin, ib yam khoom hauv lub hlwb, yog secreted. Qhov kev kuaj no yog tshuaj yeeb dawb ntawm lub hlwb los yog ua rau lub cev muaj zog. Qhov nro thiab excitement yog daws, cov nyhuv ntawm adrenaline kuj txo, kom ejaculation sij muaj peev xwm qeeb.

Dapoxetine hydrochloride tuaj yeem ua rau tsis zoo 5-HT rov ua dua thiab nce cov concentration ntawm 5-HT hauv lub zais hluav taws xob los ntawm qhov 5-HT carrier. Cov kev tshawb fawb pom tias dapoxetine centrally inhibits ejaculation reflex, thiab giant cell lateral nucleus yog ib qho tseem ceeb hauv lub hlwb. Thaum lub concentration ntawm dapoxetine yog siab, cov tshuaj monoamine protein thauj yuav raug inhibited, thiab lub reuptake ntawm dopamine kuj yog inhibited. Dapoxetine ua kom lub latency ntawm cov paj hlwb paj hlwb zoo nkauj thiab ua kom muaj kev sib deev.

Ntev npaum li cas nws yuav siv sij hawm rau dapoxetine hydrochloride ntsiav tshuaj kom zoo yog tsis generalized. Kev khomob yog nyob ntawm qhov mob loj heev ntawm cov tsos mob ntawm ejaculation ntxov. Qhov teeb meem ntawm kev kho mob yog txawv, thiab lub sijhawm noj cov tshuaj txawv.

Kev txiav txim siab ntawm Dapoxetine

Lub tswv yim ntawm kev txiav txim ntawm dapoxetine nyob rau hauv kev kho ntawm ejaculation ntxov ntxov yuav txheeb cov kev tiv thaiv ntawm reabsorption ntawm serotonin los ntawm neurons, li cuam tshuam qhov muaj peev xwm sib txawv ntawm neurotransmitters acting on receptors ua ntej thiab tom qab lub cell synapses.

Dapoxetine zoo rau kev ntxov ntxov ejaculation vim tias nws muaj cov nyhuv ntawm qhov ua rau cov concentration ntawm serotonin uas suppresses excitation hauv lub hlwb.

Serotonin feem ntau reabsorbed ntawm lub synapse, tab sis los ntawm kev noj cov tshuaj dapoxetine nws inhibits reabsorption thiab suppresses serotonin.

Serotonin suppresses dopamine uas ua kom muaj kev txaus siab, kev ntxhov siab, thiab adrenaline uas tawm los thaum koj poob siab, yog li koj tuaj yeem ua kom ntev ntev rau ejaculate.Dapoxetine zoo rau kev ntxov ntxov ejaculation vim tias nws muaj cov nyhuv ntawm kev ua rau concentration of serotonin uas suppresses excitation hauv lub lub hlwb.

Serotonin feem ntau reabsorbed ntawm lub synapse, tab sis los ntawm kev noj cov tshuaj dapoxetine nws inhibits reabsorption thiab suppresses serotonin.
Serotonin suppresses dopamine uas ua kom muaj kev txaus siab, kev ntxhov siab, thiab adrenaline uas tawm los thaum koj tseem poob siab, yog li koj tuaj yeem ua lub sijhawm ntev mus rau ejaculate.

Human ejaculation tsuas yog kho kom haum xeeb los ntawm cov kab mob sympathetic. Txoj kev ua kom tiav ntawm txoj haujlwm ejaculation yog muab los ntawm tus txha nqaj nruab nrab ntawm qhov chaw mos, uas yog kho los ntawm brainstem, uas yog thawj zaug tau los ntawm ntau lub hlwb nuclei (medial preoptic nucleus thiab hypoventrricular paraventricular nucleus).

Dapoxetine HCL Pharmacokinetics

Tom qab txoj kev noj haus ntawm qhov ncauj, dapoxetine sai absorbed thiab mus txog qhov siab tshaj plasma concentration (Cmax) tom qab cov xNUMX-1 teev. Qhov bioavailability tsis yog 2% (range 42-15%). Tom qab ib qho kev qhia ntawm 176 mg thiab 30 mg ntawm dapoxetine nyob rau hauv qhov kev yoo mov, ncov plasma concentrations (60 ng / ml thiab 297 ng / ml, feem ntau) tau ntsib tom qab 498 thiab 1.01 teev, feem. Kev noj cov zaubmov uas muaj roj ntau tuaj yeem txo qis Cmax (1.27%) ntawm dapoxetine thiab mob qis qis AUC (10%), qee zaum kuj txo qis qis ntawm dapoxetine; Txawm li cas los xij, roj rog kom tsawg Noj cov zaub mov tsis tuaj yeem ua rau lub cev tsis haum. Cov kev hloov no tsis muaj ib qhov kev ntsuam xyuas. Bentley tuaj yeem pab nrog lossis tsis noj mov.

Tom qab kev tswj hwm ntawm tib neeg lub cev los ntawm kev txhaj cov tshuaj intravenous, qhov kev kwv yees thaum ntxov, nruab nrab, thiab qhov xaus ntawm lub cev ntawm dapoxetine yog 0.10, 2.19, thiab 19.3 cov sijhawm.

Cov metabolites ntawm cov kabmob uas tawm hauv cov kabmob no tsuas yog tso meej los ntawm cov zis hauv qhov teebmeem no. Tsis muaj tus cwj pwm ua si nyob hauv cov zis. DAPoxetine sai sai, thiab cov pov thawj yog lub hauv qab ntawm cov ntshav concentration 24 cov xuab moos tom qab noj tshuaj (tsawg dua 5% ntawm lub ncov concentration). Txhua hnub koob tshuaj dapoxetine me heev. Lub davhlau ya nyob twg ib nrab ntawm lub cev ntawm qhov ncauj yog kwv yees li 19 cov xuab moos. Ib nrab ntawm lub neej ntawm desmethyl dapoxetine yog zoo ib yam li ntawm dapoxetine.

Siv Dapoxetine

Kev kho cov txiv neej uas muaj ejaculation ntxov ntxov (PE)

Dapoxetine hydrochloride ntsiav tshuaj tau zoo txhim khu kev muaj peev xwm ejaculation; ho txhim kho kev sib deev lub neej; ua zoo tsis ntev los no ejaculation latency.

Thaum siv tshuaj kho, cov neeg mob tseem tuaj yeem siv qee cov kev ntsuas me ntsis los txhim kho cov tsos mob thaum ntxov ntxov, kho kom zoo, sib zog sib txuas lus ntawm tus txiv thiab tus poj niam, noj zaub mov, ua rau lub cev qoj ib ce, ua txhua hnub, thiab koom kev ua si txhua lub lim tiam. Nws yog ib qho tseem ceeb xaiv los ua si football thiab ua si basketball kom muaj kev noj qab nyob zoo thiab txo kev ntxhov siab.

Dosage ntawm Dapoxetine

Cov tshuaj ntawm dapoxetine hydrochloride ntsiav tshuaj yog qhov ncauj, thiab cov ntsiav tshuaj yuav tsum tau nqos tau; cov neeg mob yuav tsum tau siv tsawg kawg yog ib lub khob dej rau noj tshuaj; cov neeg mob yuav tsum sim tsis txhob raug mob los ntawm prodromal cov tsos mob xws li syncope los yog kiv taub hau.

Tus nqi ntawm dapoxetine hydrochloride lub ntsiav tshuaj pom zoo rau tag nrho cov neeg mob hauv cov laus cov txiv neej (18 rau 64 xyoo) yog 30 mg thiab yuav tsum tau npaum li cas txog 1 rau 3 cov xuab moos ua ntej kev sib deev. Yog tias cov nyhuv tsis zoo tom qab kev noj tshuaj 30mg thiab cov kev mob tshwm sim tseem nyob hauv qhov kev ntsuas, xam qhov ntau ntxiv yuav tau ntxiv rau 60mg ntawm qhov tshuaj tiv thaiv ntau tshaj plaws.

Qhov hnyav ntau tshaj yog siv txhua xuab moos 24.
Cov neeg laus (cov laus 65 thiab cov laus) Cov khoom no tsis tau raug tshuaj xyuas nyob rau hauv 65 xyoo thiab kev nyab xeeb thiab ua haujlwm rau cov neeg mob uas siv ntau tus neeg, qhov tseem ceeb rau cov ntaub ntawv ntawm cov khoom no rau kev siv hauv cov pejxeem no tsis tshua muaj kev txwv rau cov neeg mob lub raum tsis zoo los sis cov neeg mob nrog lub raum puas tsuaj tsis tas yuav kho lub koob tshuaj thaum noj cov khoom no, tab sis yuav tsum nqa nrog ceev faj. Cov khoom no tsis pom zoo rau cov neeg mob uas raug mob hnyav heev.

Cov Kev Ntsuas Dapoxetine:

Cov khoom no yog tsim rau kev kho mob ntawm cov txiv neej uas muaj hnub nyoog ejaculation (PE) ntawm cov hnub nyoog ntawm 18 thiab 64 uas ua tau raws li tag nrho cov nram qab no: tus noov ntxiv mus txog thaum nws tau muab tso rau hauv qhov chaw mos, thaum lub sij hawm los yog sai tom qab tso quav, thiab ua ntej qhov kev sib deev kev sib deev yog ua tiav, tsuas yog vim muaj kev sib txis tsawg. Los yog rov qab ejaculation; thiab teeb meem loj rau tus kheej los yog tus neeg tsis sib haum vim yog ntxov ntxov ejaculation (PE); thiab kev tswj xyuas tsis tau ejaculation.

(1) Cov poj niam laus (18 rau 64 xyoo)

Pom kom thawj koob tshuaj 30 rau txhua tus neeg mob thiab yuav tsum tau noj txog 1 rau 3 cov xuab moos ua ntej sib deev. Yog tias cov nyhuv tsis zoo tom qab kev noj tshuaj 30mg thiab cov kev mob tshwm sim tseem nyob hauv qhov kev ntsuas, xam qhov ntau ntxiv yuav tau ntxiv rau 60mg ntawm qhov tshuaj tiv thaiv ntau tshaj plaws. Qhov hnyav ntau tshaj yog siv txhua xuab moos 24. Cov khoom no tuaj yeem noj ua ntej lossis tom qab noj mov.

Yog tias tus kws kho mob xaiv qhov khoom no rau kev kho mob ntxov ntxov, nws yuav tsum soj ntsuam qhov kev pheej hmoo thiab tus neeg mob tau txais txiaj ntsig rau thawj 4 lub lis piam tom qab siv tshuaj, los yog ntsuas tus neeg mob qhov txiaj ntsig kev pab tom qab siv tshuaj 6 sij hawm thiab txiav txim siab seb puas yuav siv cov khoom ntxiv.

(2) Cov neeg laus (65 xyoo thiab laus dua)

Kev tshawb nrhiav tseem tsis tau soj ntsuam qhov kev nyab xeeb thiab ua haujlwm ntawm cov khoom no rau cov neeg mob hnub nyoog 65 thiab tshaj. Lub ntsiab tseem ceeb rau qhov no yog tias cov ntaub ntawv ntawm kev siv cov khoom no hauv cov pejxeem no tsis tshua muaj txwv.

(3) Cov me nyuam thiab cov tub ntxhais hluas

Cov khoom no tsis yog siv rau cov neeg uas muaj hnub nyoog hauv 18.

Ib ntsiav tshuaj ntawm ib lub sij hawm yuav tsum tau noj sijhawm tas li. Cov tshuaj yuav tsum tau noj rau ntawm lub plab tas. Nws zoo dua rau haus dej tshuaj yej ua ntej siv tau zoo ua ntej cov tshuaj no yog qhov zoo tshaj plaws los ua ib qho kev tshuaj ntsuam xyuas, nyob ntawm lawv cov kab mob hauv tus kws kho mob los yog tus kws muag tshuaj qhia thiab kev ruaj ntseg npaj rau cov tshuaj kom tsis txhob siv cov tshuaj phem, tab sis tsis nce qhov uas siv tshuaj ntau zaus thaum koj yuav tsum tau ua raws li tus kws kho mob npaj thiab txaj muag.

DAPoxetine Overdose

Feem ntau, cov tsos mob ntawm tus kabmob tsos mob ntawm tus kabmob txiav xoos no yog muaj xws li cov kev mob ntses xws li qaug zog, mob plab hnyuv, xws li xeev siab thiab ntuav, muaj kev ntxhov siab, qaug zog, kiv taub hau thiab tachycardia. Yog hais tias dhau ntawm overdose, yuav tsum tau siv cov txheej txheem kev them nyiaj yug raws li xav tau. Muaj tam sim no tsis muaj antidote rau cov khoom no.

Dapoxetine HCL Precautions

1. General ceev faj. Dapoxetine tsuas yog siv rau txiv neej cov poj niam uas muaj quag ntxov ntxov. Kev nyab xeeb ntawm Dapoxetine rau cov txiv neej uas tsis muaj qhov ejaculation ntxov ntxov tsis meej. Tib lub sij hawm, tsis muaj cov ntaub ntawv hais txog DP rau Dapoxetine ntawm kev ncua ntawm ejaculation hauv cov pejxeem no. Nws raug nquahu tias cov neeg mob yuav tsum tsis txhob siv Beverly thiab "tshuaj lom ze" tib lub sijhawm vim tias qhov tshwm sim tsis paub thiab muaj kev phom sij heev.

2. Cov neeg mob raug qhia kom tsis txhob noj cov tshuaj psychotropic thaum noj nws.

3. Txhob haus dej cawv thaum noj Dapoxetine.

4. Siv cov tshuaj Dapoxetine ua rau ua kom muaj zog lossis kiv taub hau

5. Tsis tas li ntawd, siv cov kab mob cytochrome P450 3A4 ua kom tsis zoo xws li erythromycin, clarithromycin, fluconazole, verapamil thiab diltiazem.

6. Noj tshuaj cytochrome P450 2D6 inhibitor los yog paub cytochrome P450 2D6 Cov neeg mob uas muaj cov metabolism hauv lub cev tsis muaj zog yuav tsum ceev faj thaum ntxiv cov koob tshuaj rau 60 mg, vim qhov no yuav ua rau muaj kev raug mob ntxiv, uas ua rau tuaj yeem ua rau muaj kev phom sij ntau dua thiab mob hnyav.

7. Txoj kev tsis zoo yuav tsum tsis txhob siv rau kev mob siab / Mob rau cov keeb kwm ntawm hypomanic los yog kev puas siab puas ntsws bipolar, tib lub sij hawm, txhua tus neeg mob uas muaj cov tsos mob ntawm tus kab mob hais saum toj no yuav tsum tsis siv nrog Dapoxetine.

8. Vim hais tias selective serotonin reuptake inhibitor yuav txo qhov pib ntawm qaug dab peg Tus nqi, txhua tus neeg mob nrog qaug dab peg yuav tsum tau txiav, thiab cov neeg mob uas tsis ruaj tsis khov yuav tsum tsis txhob siv Dapoxetine.

9. Dapoxetine yuav tsum tsis txhob siv rau cov neeg muaj hnub nyoog hauv 18.

10. Tsis pom zoo Rau cov neeg mob hnyav ua rau lub raum tsis zoo, cov neeg mob uas muaj qhov tsis sib xws me ntsis los yog mob nruab nrab yuav tsum tau siv nrog ceev faj. Ib yam li lwm cov xim serotonin reuptake inhibitors, kev siv Dapoxetine yog txuam nrog qee qhov muag. Piv txwv, tub ntxhais kawm dilation thiab qhov muag mob. Cov neeg mob uas mob siab rau lub hauv siab los sis muaj feem yuav raug mob ntawm lub qhov ntsws yuav tsum siv nrog ceev faj.

Dapoxetine HCL hmoov Txwv tsis pub

1. Dapoxetine raug txwv rau cov neeg mob uas paub tias yog tshuaj tsis haum rau dapoxetine hydrochloride los yog ib tus neeg tau tshuaj.

2. Dapoxetine raug txwv rau cov neeg mob uas muaj kev mob plawv hauv lub plawv [xws li NYHA II-IV), tsis muaj kev hloov tsis tu ncua nrog pacemaker therapy (qib 2 lossis 3 atrioventricular block los yog mob plawv mob xaj), tseem ceeb hauv cov leeg hu ua myocardial ischemia and valvular disease]

3. Dapoxetine tsis yog nrog cov tshuaj monoamine oxidase (MAOIs)) Nws yuav tsum tsis txhob siv ua ke hauv 14 hnub tom qab kho cov tshuaj monoamine oxidase lawm. Tsis tas li ntawd, tsis txhob siv cov tshuaj monoamine oxidase nyob rau hauv 7 hnub ntawm kev ua tsis tiav ntawm Bili (saib kev sib hloov tshuaj).

4. Dapoxetine yuav tsis siv nrog thioridazine los yog tom qab kho thiodazine lawm. Siv hauv ib hnub. Tsis tas li ntawd, thioridazine yuav tsum tsis txhob noj nyob rau hauv 7 hnub tom qab discontinuation ntawm Dapoxetine (saib cov seem kev sib txuas tshuaj).

5. Dapoxetine txwv tsis pub noj tshuaj ketoconazole, itraconazole, ritonavir, saquin Cov neeg mob uas muaj zog cytochrome P450 3A4 inhibitors xws li nave, telithromycin, nefazodone, naffenavir, thiab atazanavir.

6. Dapoxetine raug txwv rau cov neeg mob uas muaj mob hnyav thiab mob hnyav heev.

Dapoxetine HCL hmoov xaus

Thaum siv dapoxetine hydrochloride cov ntsiav tshuaj, nws yuav tsum raug ua raws li kev taw qhia ntawm ib tus kws kho mob, uas yuav pab tau cov tsos mob ntawm tus kab mob thiab tib lub sij hawm zoo dua rau kev siv tshuaj.


Yuav ua li cas yuav Dapoxetine hydrochloride hmoov (129938-20-1) los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

CAS 129938-20-1 Dapoxetine hydrochloride HNMR

Zaub mov txawv

References & cov khoom citations