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Dolastatin 10 (110417-88-4)

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5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 110417-88-4. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom loj txog kev tswj hwm ntawm Dolastatin 10 (CAS 110417-88-4), raws li CGMP kev tswj thiab kev tswj cov kev tswj qhov system.

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Hauj lwm yam khoom

Dolastatin 10 video


I.Dolastatin 10 Basic Cim:

Lub npe: Dolastatin 10
CAS: 110417-88-4
Molecular Formula: C42H68N6O6S
Molecular phaus: 785.09g / mol
Melt Point: 94-95oC
Cia Temp: Khaws hauv qhov chaw txias thiab qhuav thiab tom 0 - 4 ℃ rau lub sij hawm luv luv (hnub rau lub lis piam) los yog -57 ℃ rau lub sij hawm ntev (hli mus rau xyoo)
xim: Dawb rau so-dawb sollid


II. Dolastatin 10 (110417-88-4) siv nyob rau hauv antitumor cycle

1. Npe:

Tshuaj lub npe:
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

2.Dolastatin 10 Siv:

Lub Hom Phiaj: Tus kws tshawb fawb txog kev soj ntsuam tshawb xyuas txog qhov ua tau zoo thiab toxicity ntawm tus tshiab tus neeg saib xyuas tus neeg mob microtubule dolastatin-10 rau cov neeg mob uas muaj mob cancer mis lawm.

Txoj kev: Nees nkaum-ib tus neeg uas muaj kabmob metastatic mis mob cancer tau raug kho nrog dolastatin-10 ntawm koob tshuaj 400 mcg / m2 los ntawm intravenous bolus thaum txhua txhua lub lim tiam 3.

Kev soj ntsuam: Ib qho ntawm 21 cov neeg mob (5%; 95% CI: 0-24%) ua tiav ib qhov kev tiv thaiv ib ntus rau 113 hnub. Plaub tus neeg mob cov kab mob ruaj khov rau nruab nrab ntawm 87 hnub. Cov neeg mob tau txais ib pawg nruab nrab ntawm ob kab ntawm dolastatin-10. Hematologic toxicity yog ib nrab, nrog 8 cov neeg mob tsim qib 4 neutropenia, thiab 5 nrog qib 3 neutropenia; ib qib 3 febrile neutropenia tau pom. Cov mob ntawm qib 3 thiab 4 neutropenia tau ntsib txog 36% ntawm kev kho mob. Tsis-hematologic toxicity yog tsis zoo.

Xaus: Txawm tias cov tshuaj lom neeg hu ua dolastatin-10 yog qhov tau txais, nws muaj qhov ua tau tsawg heev hauv qhov kev mob kheesxawj mis cancer no.

Hauv Vitro: Dolastatin 10 yog ib qho tshwj xeeb pentapeptide uas cais los ntawm hiav txwv hare Dolabella auricularia. Nws pom tau tias cov ntaub ntawv hauv vitro no kuj piv rau cov neeg ntawm Dolastatin 10 thiab Auristatin PE, txhua tus uas muaj GI50 qhov tseem ceeb ntawm 10-5-10-6 μg / mL (10-2-10-3 nM) minipanel ntawm tib neeg ntawm tes. Cov tshuaj antibody-conjugate (ADC) muaj cov tshuaj tua kab mob CD30 monoclonal antibody cAC10 conjugated rau cov neeg saib xyuas cytotoxic monomethyl auristatin E (MMAE), ib qho analog ntawm tubulin polymerization inhibitor Dolastatin 10 (110417-88-4).

3.Warning ntawm Dolastatin 10

Cov khoom no yog rau kev tshawb fawb siv xwb, tsis yog siv rau tib neeg los sis tus kws kho tsiaj.

Kev muab lub cev ntau dua, thov sov lub raj ntawm 37 ℃ thiab co nws nyob rau hauv lub ultrasonic da dej rau ib lub sijhawm. Kev daws teeb meem yuav muab cia hauv qab-20 ℃ rau ob peb lub hlis.

4.Xaiv cov lus qhia:

Dolastatin 10 synthesis
Total synthesis ntawm Dolastatin 10 (110417-88-4) tau ua tiav los tsim cov txheej txheem ntawm cov cim tseem ceeb ntawm amino acid, Dil (6) thiab Dap (11), thiab tom qab stepwise coupling tsib amino acid ntawm C-terminal .

Synthesis thiab kev ntsuam xyuas ntawm Dolastatin 10 Analogues Cov Heteroatoms nyob rau ntawm Amino Acid Sab Chains.
Synthetic analogues ntawm lub caij ntuj sov dolastatin 10 yog zoo txaus siab rau kev mob kheesxaws vim lawv muaj peev xwm nyob rau hauv vitro kev ua si thiab lawv siv raws li payloads nyob rau hauv antibody tshuaj conjugates (ADCs). Kev hloov kho ntawm tus tub ntxhais 10 1 tus tub ntxhais tau muaj feem tsim kho cov kev hloov ntawm P5, N-terminus, thiab P2, C-terminus, nrog rau kev pom tsawg heev rau PXNUMX subunit.

Hauv kev soj ntsuam ntawm cellular, Dolastatin 10 (110417-88-4) qhia tau hais tias muaj kev tiv thaiv qee tus neeg mob leukemia, lymphoma thiab cov qog ntawm tes (xws li OVCAR-3 thiab NSCLC) nrog IC50 qhov tseem ceeb xws li 0.1nM rau 10nM. Nws yog tam sim no tau sim nyob rau hauv kev soj ntsuam.


III. Dolastatin 10 (110417-88-4) HCML

Peb yog khoom noj khoom haus Aprepitant, Aprepitant hmoov muag, Raw Aprepitant hmoov (170729-80-3) hplc = 98% | AASraw R & D Reagents


IV. Yuav ua li cas mus yuav Dolastatin 10 ntawm AASraw?

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.