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IDFP (615250-02-7)

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 615250-02-7. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom loj npaum li kev cai ntawm IDFP (615250-02-7), raws li CGMP kev tswj thiab kev tswj cov kev tswj qhov system.

Hauj lwm yam khoom

IDFP video


IDFP theem pib:

Lub npe: IDFP
CAS: 615250-02-7
Molecular Formula: C15H32FO2P
Molecular phaus: 294.391
Melt Point:
Cia Temp: -20 ° C
xim:


IDFP (615250-02-7) lub voj voog

npe

Kws tshuaj npe: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Synonym:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

IDFP (615250-02-7) Pab

IDFP yog ib qho kev mob ntsig txog cov hlab ntsws sarin. Zoo li sarin, IDFP yog ib qho kev ua rau tsis muaj zog nyob rau hauv ntau hom kev sib txawv ntawm cov roj ntsha hauv cov dej khov kho, tab sis ntev npaum li cas los ntawm IDFP ua rau nws muaj zog zuj zus li ntawm cov tshuaj acetylcholinesterase (AChE), nrog rau IC50 ntawm 6300nM nws yog lub hwj chim inhibitor ntawm ob hom kab mob hauv lub cev monoacylglycerol lipase (MAGL), tus thawj enzyme lub luag hauj lwm rau thuam qhov endocannabinoid 2-arachidonoylglycerol (2-AG), thiab fatty acid amide hydrolase (FAAH), thawj lub enzyme uas ua rau lwm qhov endocannabinoid anandamide . IC50 ntawm IDFP yog 0.8nM ntawm MAGL, thiab 3.0nM ntawm FAAH. Kev tiv thaiv ntawm ob hom kev enzymes no ua rau muaj ntau ntxiv ntawm ob leeg anandamide thiab 2-AG hauv lub hlwb, uas ua rau tsis muaj peev xwm tshwm sim ua rau cov tsiaj txhu tsis sib haum xeeb nyob hauv cov kev tshawb fawb tsiaj, thaum nws tsis muaj peev xwm ntawm AChE txhais tias tsis muaj cov tsos mob cholinergic. ] [1] [2] [3] Txawm tias nws zoo ib yam li cov tshuaj qauv mus rau lub txwv paj agents, qhov ntev alkyl saw ntawm IDFP ua rau nws rau lub caij nplooj zeeg sab nraum lub ntsiab txhais ntawm "tej chemical tshuaj lom" nyob rau hauv lub tshuaj lom neeg Riam phom Convention, [4] thiab txij li thaum nws kuj tsis muaj lub hwj chim AChE inhibition ntawm lwm yam kab mob hauv nruab nrog cev, IDFP tsis raug rau tib txoj cai tswj kav.

Qhov ntau npaum li cas ntawm IDFP

Ntev ntev cia, peb xav hais tias IDFP muab cia li nkag ntawm-20 ℃. Nws yuav tsum ruaj khov rau tsawg kawg ib xyoos.
IDFP yog muab los ntawm cov tshuaj methyl acetate. Hloov cov xim hnyav, tsuas ua kom cov methyl acetate nyob rau hauv ib kwj deg ntawm nitrogenand tam sim ntawd ntxiv qhov hnyav ntawm xaiv. Cov neeg xws li ethanol, DMSO, thiab dimethyl formamide purged nrog cov roj hauv inertible yuav siv tau. Kev txhim kho ntawm IDFP hauv cov dej no yog kwv yees li 10mg / ml.
Yog hais tias aqueous Tshuag ntsiab yog yuav tsum tau rau lom thwmsim, lawv yuav zoo tshaj plaws yuav npaj los ntawm diluting cov organic kuab rau hauv aqueous buffers los yog isotonic saline.Ensure hais tias cov residual nyiaj ntawm organicsolvent yog insignificant, txij li thaum organic solvents yuav muaj sia los thaum uas tsis muaj concentrations.We ua tsis xav kom kho kom zoo dua qub rau ntau tshaj ib hnub.

Yuav ua li cas IDFP ua haujlwm

IDFP yog ib qho kev tiv thaiv tsis muaj zog rau ntau hom kev enzymes uas nquag siv los rhuav tshem neurotransmitters, txawm li cas los ntev alphs ntawm IDFP ua rau nws tsis zoo li qhov inhibitor ntawm acetylcholinesterase (AChE), thaum nws yog lub hwj chim inhibitor ntawm ob enzymes monoacylglycerol lipase ( MAGL), cov thawj enzyme lub luag hauj lwm rau qhov dev qhov endocannabinoid 2-arachidonoylglycerol (2-AG), thiab fatty acid amide hydrolase (FAAH), cov thawj enzyme uas degrades rau lwm mainendocannabinoid anandamide. Lub cev organic organism uas dually inhibits MAGL thiab FAAH nrog IC50 qhov tseem ceeb ntawm 0.8 thiab 3 nM. 1 Ntawm 10 mg / kg, IDFP nce siab lub hlwb ntawm 2-AG thiab AEA ntau dua 10-fold, thiab txo theem ntawm arachidonic acid los ntawm 10-fold.

Ceeb toom

Cov khoom no tsis yog siv rau cov tib neeg los sis tus kws kho tsiaj, kev ceeb toom ntxiv tseem nyob hauv kev tshawb nrhiav. Tsis txhob kov cov tawv nqaij, qhov muag, kev ua pa, qhov tsis xis nyob, hu rau koj tus kws kho mob tam sim ntawd.

IDFP (615250-02-7) Nqaij Hmoov

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Kev txiav txim loj dua tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nqi.

IDFP Kev Ua Lag Luam

Kom muab rau yav tom ntej tom ntej.

Puas muaj IDFP Muaj Tej Teebmeem

Lub raum medulla, xam tau tias yog ib qho tseem ceeb rau cov kev cai ntawm ntsev thiab dej tshuav nyiaj li cas thiab ntev-lub sij hawm cov ntshav siab tswj, yog enriched nyob rau hauv anandamide thiab ob ntawm nws loj metabolizing enzymes, cyclooxygenase-2 (COX-2) thiab fatty acid amide hydrolase (FAAH) . Txoj hlab ntsha ntawm anandamide (15, 30, thiab 60 nmol · min-1 · kg-1) mus rau hauv lub plawv ntawm C57BL / 6J cov kab mob ua kom muaj zog thiab cov kab ntsev hauv COX-2 - tab sis tsis yog COX-1. Yuav kom txiav txim xyuas seb endogenous endocannabinoids nyob rau hauv lub raum medulla yuav niamtxiv txojkev zoo xws li cov teebmeem, qhov teebmeem ntawm cov intramedullary isopropyl dodecyl fluorophosphate (IDFP), uas cheeb qhov uas cov ob tug loj endocannabinoid hydrolases, tau kawm. Kev kho IDFP tau nce cov zis ntawm qhov tso zis thiab sodium excretion hauv COX-2 - tab sis tsis yog COX-1-raws li. Tsis muaj leej twg anandamide los yog IDFP tau cuam tshuam txog glomerular filtration rate. Tsis pub muaj ntsev (0.625 mg · kg-1 · 30 min-1 iv) los yog intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) IDFP ua ntej ua ntej intramedullary anandamide (15-30 nmol · min-1 · kg-1) nruj me ntsis teebmeem ntawm anandamide, tawm tswv yim tias hydrolysis ntawm anandamide tsis tsim nyog rau nws cov diuretic nyhuv. Intramedullary IDFP twb tsis muaj cov kab mob hauv lub raum tab sis kev ua kom cov ntshav liab mus tsis tau. Qhov teebmeem ntawm IDFP txog kev tso zis thiab cov ntshav cov ntshav nce hlwb yog FAAH-raws li qhia tau tias siv cov nas FAA knockout nas. Kev soj ntsuam ntawm cov tsom iav ntawm PGE2 ntau ntawm HPLC-electrospray ionization tandem huab hwm coj spectrometry pom tias IDFP kho tsis tso zis PGE2 Cov ntaub ntawv no muaj raws nraim nrog FAAH thiab endogenous anandamide los ntawm COX-2-dependent metabolite los tswj kev noj haus thiab kev ua kom tsis muaj zog mousekidney.


Yuav ua li cas yuav cov hmoov HMF IDFP (615250-02-7) los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

Zaub mov txawv

IDFP Nqaij Khoom Noj Hmoov Noj:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations

IDFP (615250-02-7): Teebmeem, Ua Yeeb Yam, Xyuas