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LCZ696 hmoov (936623-90-4)

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 936623-90-4. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom huab hwm coj ntawm LCZ696 hmoov (936623-90-4), raws li CGMP kev tswj thiab kev tswj cov kev tswj qhov system.

LCZ696 hmoov (sacubitril / valsartan hmoov) yog ib tug tswv cuab ntawm ib chav tshiab ntawm cov neeg sawv cev hu ua angiotensin reseptor-neprilysin inhibitors (ARNIs) uas muab cov neprilysin inhibitor thiab angiotensin receptor blocker (ARB). LCZ696 hmoov yog tam sim no qhia rau kev kho mob rau cov neeg mob uas mob plawv tsis ua hauj lwm nrog txo ejection feem (HFrEF) hloov qhov angiotensin converting enzyme (ACE) inhibitor los yog ARB ib leeg. Lub npe pauv rau LCZ696 hmoov yog Entresto.

Hauj lwm yam khoom

LCZ696 hmoov yees duab


LCZ696 hmoov theem pib

Lub npe: LCZ696 hmoov
CAS: 936623-90-4
Molecular Formula: C24H29N5O3.C24H29NO5.5/2H2O.3Na
Molecular phaus: 915.98
Melt Point: 137-140 ° C
Cia Temp: tom-20 ° C 3 xyoo hmoov
xim: Dawb hmoov


LCZ696 hmoov nyob hauv kev pheej hmoo ntawm plawv tuag thiab lub plawv

npe

LCZ696 hmoov, sacubitril hmoov, valsartan, LCZ 696, LCZ-696

Raw LCZ696 hmoov pab

LCZ696 hmoov (sacubitril / valsartan hmoov) yog ib tug tswvcuab ntawm ib chav tshiab ntawm cov neeg sawvcev hu ua angiotensin reseptor-neprilysin inhibitors (ARNIs) uas yog muab cov neprilysin inhibitor thiab angiotensin receptor blocker (ARB). LCZ696 hmoov yog tam sim no qhia rau kev kho mob rau cov neeg mob uas mob plawv tsis ua hauj lwm nrog txo ejection feem (HFrEF) hloov qhov angiotensin converting enzyme (ACE) inhibitor los yog ARB ib leeg. LCZ696 hmoov (sacubitril / valsartan hmoov) tau pom zoo los ntawm FDA nyob rau lub Xya hli ntuj 2015 los txo qhov kev pheej hmoo ntawm kev tuag los ntawm kev mob plawv thiab tsev kho mob rau lub plawv tsis ua hauj lwm hauv cov neeg mob uas mob plawv tsis ua hauj lwm, NYHA chav kawm II-IV, thiab txo tsawg feem ntau. Ua ke ntawm neprilysin inhibition thiab renin-angiotensin aldosterone system (RAAS) tau pom tias yuav tsum tau ua kom zoo dua rau cov neeg ntawm ACE inhibitor. Lub npe pauv rau LCZ696 hmoov yog Entresto.

Tus qauv pib txhaj yog 49 / 51 mg ob zaug ib hnub.
Ib koob txo koob tshuaj LCZ696 hmoov (xiav / valsartan hmoov) 24 / 26 mg ob zaug txhua hnub yog pom zoo rau cov neeg mob nram no:

• ACE Inhibitor lossis ARB naive
• Tsis tshua muaj kab mob ACE inhibitor lossis ARB txoj kev kho: tsis tshua muaj dose ACE inhibitor sib npaug: enalapril <= xNUMX mg txhua hnub, tsawg koob tshuaj ARB: valsartan <= xNUMXmg txhua hnub
• Kev ua haujlwm loj heev (GFR <30ml / min / 1.73m 2)
• Kev puas siab puas (hepatitis B)

Ceeb toom rau raw LCZ696 hmoov

LCZ696 hmoov (tshuaj dawb (sacubitril / valsartan hmoov) yog qhia kom txo kev mob plawv thiab kev kho mob plawv tsis ua haujlwm rau cov neeg mob uas muaj mob HFrEF, NYHA hoob II-IV. LCZ696 nyoos hmoov (sacubitril / valsartan hmoov) yuav tsum tau siv nrog lwm tus GDMTs qhov chaw ntawm ACE inhibitor lossis ARB.

Contraindications muaj xws li:
• Mob siab rau ib yam ntawm cov khoom.
• Siv cov tshuaj ACE inhibitor: LCZ696 hmoov (sacubitril / valsartan hmoov) yuav tsum tsis txhob muab rau hauv 36 cov xoob moos tau txais ACE inhibitor.
• Siv cov tshuaj aliskiren hauv cov neeg mob uas muaj ntshav qab zib mellitus.
• Keeb kwm ntawm angioedema ntsig txog kev kho mob yav dhau los nrog ACE inhibitor lossis ARB kev kho.

Undesirable teebmeem

(1) Fetal toxicity: Txhua yam tshuaj uas ua haujlwm hauv RAAS tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab thaum uas cev xeeb tub. Lawv tuaj yeem txo tus mob hauv plab hauv ob peb lub hlis thiab zaum peb ntawm cev xeeb tub thiab ua kom cov me nyuam hauv plab thiab me nyuam yaus tuaj yeem ua lub siab. LCZ696 nyoos hmoov (sacubitril / valsartan hmoov) yuav tsum tsis ua haujlwm yog tias muaj menyuam hauv plab.

(2) Angioedema: Angioedema tau tshaj tawm tias 0.5% nrog LZC696 (sacubitril / valsartan hmoov) thiab 0.2% nrog enalapril thaum lub sij hawm qhib ob lub qhov muag hauv PARADIGM-HF. Muaj kuj nce nqi nyob rau hauv Blacks vs. non-Blacks thiab cov neeg uas muaj keeb kwm yav dhau los ntawm angioedema. Yog tias muaj tus mob angioedema, LCZ696 hmoov (sacubitril / valsartan hmoov) yuav tsum tau txiav thiab tsis txhob rov ua dua. LCZ696 nyoos hmoov (sacubitril / valsartan hmoov) yuav tsum tsis txhob siv rau cov neeg uas muaj keeb kwm ntawm angioedema ntsig txog ACE inhibitor yav dhau los los yog ARB txoj kev kho. Yog tias hloov mus lossis los ntawm ACE inhibitor, yuav tsum tau siv tshuaj 36-teev ib zaug ntawm kev siv tshuaj.

(3) Hypotension: LCZ696 nyoos hmoov (sacubitril / valsartan hmoov) txo cov ntshav siab los ntawm nws kev tiv thaiv ntawm RAAS thiab tuaj yeem ua rau cov neeg mob hypotension. Nyob rau hauv ob zaug-dig muag lub sij hawm ntawm PARADIGM-HF, 18% ntawm cov neeg mob nyob rau LCZ696 nyoos hmoov (sacubitril / valsartan hmoov) qhia qhov teeb meem nyom ntawm hypotension vs. 12% rau cov neeg mob nyob rau hauv enalapril. Txij li muaj ib qho kev pheej hmoo loj dua rau cov neeg mob uas muaj mob RAAS, nws raug pom zoo kom kho ntsev los yog ntim kom tsis txhob pib ua ntej pib. Yog tias kev mob hypotension tshwm sim, kho cov tshuaj diuretics thiab lwm yam tshuaj antihypertensives, thiab kho lwm yam ua rau ntawm lub ntsws hypovolemia thiab txo cov koob tshuaj LCZ696 hmoov (sacubitril / valsartan hmoov). Yog tias symptomatic hypotension persist txawm tias txo qis hauv LCZ696 hmoov (sacubitril / valsartan hmoov), cov tshuaj yuav tsum nres.

(4) Lub cev tsis muaj zog: LCZ696 hmoov (sacubitril / valsartan hmoov) yog ib tus neeg saib xyuas RAAS thaiv; Yog li ntawd, txo cov kev ua haujlwm hauv lub raum kuj yuav raug rau cov tib neeg muaj kev pheej hmoo siab xws li cov neeg uas muaj tus kab mob rectal stenosis. Nyob rau hauv ob zaug-dig muag lub sij hawm ntawm PARADIGM-HF, 5% ntawm cov neeg kho nrog LCZ696 nyoos hmoov (sacubitril / valsartan hmoov) thiab tus kab mob enalapril tau qhia tias lub raum tsis ua hauj lwm raws li kev phom sij. Tsis tas li ntawd, nce hauv Scr> = 50% tau pom nyob rau hauv 16% ntawm cov neeg kho nrog LCZ696 hmoov (cov hmoov xiav dawb / valsartan hmoov) thiab cov tshuaj tua kab mob enalapril. Kev kho mob ntawm lub cev yuav tsum raug saib xyuas zoo thiab LCZ696 hmoov (sacubitril / valsartan hmoov) koob tshuaj yuav tsum tau qis dua los yog txiav tu vim qhov kev txo kab mob hauv plab.

(5) Hyperkalemia: Los ntawm nws cov teebmeem ntawm RAAS blockade, LCZ696 hmoov (sacubitril / valsartan hmoov) muaj peev xwm ua rau mob hyperkalemia. Nyob rau hauv ob zaug-dig muag lub sij hawm ntawm PARADIGM-HF, 12% ntawm cov neeg mob kho nrog LCZ696 nyoos hmoov (sacubitril / valsartan hmoov) qhia txog cov nyhuv rau cov hyperkalemia. Tsis tas li ntawd, potassium ntau> 5.5 mEq / L tau pom hauv 16% ntawm cov neeg tau kho nrog ob lub LCZ696 hmoov (cov hlab xauj dawb / valsartan hmoov) thiab cov tshuaj tua kab mob enalapril. Kaw saib xyuas yog qhia rau cov neeg mob uas muaj feem cuam tshuam loj xws li mob raum tsis zoo, ntshav qab zib mellitus, hypoaldosteronism, los yog cov kab mob potassium. Koob tshuaj txiav los sis discontinue ntawm cov tshuaj tej zaum yuav tsim nyog rau cov kev kho mob hnyav ntxiv hauv cov potassium.

Raws li cov qauv tsim ntawm PARADIGM-HF uas cov neeg mob yuav tsum tau tso siab rau ob lub phom enalapril thiab LCZ696 nyoos hmoov (sacubitril / valsartan hmoov) thaum muaj qhov muag tsis pom nyob rau theem, nws yuav hais tias cov kev mob tshwm sim nyob rau hauv qhia thiab tej zaum yuav siab dua nyob rau hauv kev kho mob kev xyaum.

Cov lus qhia ntxiv

LCZ696 hmoov ua rau BP txo qis dua valsartan hauv SHR tsis hais txog cov dej ntsev kom tsawg, uas yog txuam nrog ib yam li hauv urinary sodium excretion thiab kev txhawb nqa kev ua haujlwm. Tsis tas li ntawd, ib qho khoom ntxiv BP txo cov nyhuv ntawm LCZ696 nyoos hmoov coj mus rau ntau dua kev tiv thaiv plawv nyob rau hauv hypertensive nas tsuag.

LCZ696 Raw Hmoov

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nyiaj.

LCZ696 hmoov li

Kom muab rau yav tom ntej tom ntej.


Yuav ua li cas yuav LCZ696 hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


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COA

COA 936623-90-4 LCZ696 hmoov AASRAW

HNMR

Zaub mov txawv

LCZ696 Raw Powder Recipes

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations