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2-Methoxyestradiol (362-07-2)

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 362-07-2. Qeb:

AASraw yog nrog kev sib txuas thiab kev tsim muaj peev xwm los ntawm gram mus rau qhov kev txiav txim ntau ntawm 2-Methoxyestradiol (362-07-2), raws li CGMP cov kev cai thiab cov khoom tsim kev tswj xyuas tau zoo.

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2-Methoxyestradiol (362-07-2) video


2-Methoxyestradiol (362-07-2) Specification:

Tshuaj Txheem: khoom npe: 2-Cov Methoxyestradiol
Yuav 2-Methoxyestradiol (362-07-2) hplc≥98% | AASraw Cas Tsis: 362-07-2
molecular Formula: C19H26O3
molecular Nyhav: 302.4
txhais: 2-Cov Methoxyestradiol

362-07-2

Panzem

2-Methoxyestradiol-17beta

2-Hydroxyestradol 2-methyl ether

cia: Qhuav, tsaus nti
Cov ntaub ntawv (COA & HPLC thiab lwm yam): Qhov

2-Methoxyestradiol (362-07-2) Description:

methoxyestradiol hmoov, tseem hu ua 2-ME, yog qhov ncauj ntawm bioavailable estradiol metabolite nrog cov haujlwm antineoplastic muaj peev xwm, yog li nws yog angiogenesis inhibitorIt tseem ua raws li vasodilator.

2-Methoxyestradiol inhibits angiogenesis los ntawm kev txo endothelial cell proliferation thiab inducing endothelial cell apoptosis. Tus neeg sawv cev no tseem cuam tshuam rau cov qog cell loj hlob los ntawm khi rau tubulin, ua rau muaj kev ua rau antimitotic, thiab los ntawm kev ua kom cov tub ntxhais ua haujlwm, ua rau lub voj voog ntawm tes raug ntes hauv G2 theem, DNA tawg, thiab apoptosis.

reference:

  • 1: Perez-Sepulveda A, EspaÃ-a-Perrot PP, Norwitz ER, Illanes SE. Metabolic txoj hauv kev koom nrog 2-methoxyestradiol synthesis thiab lawv lub luag haujlwm hauv preeclampsia. Reprod Sci. 2013 Sep; 20 (9): 1020-9. doi: 10.1177 / 1933719113477483. Epub 2013 Mar 1. Rov los saib. PubMed PMID: 23456663; PubMed Central PMCID: PMC3745713.
  • 2: Machado-Linde F, Pelegrin P, Sanchez-Ferrer ML, Leon J, Cascales P, Parrilla JJ. 2-methoxyestradiol nyob rau hauv pathophysiology ntawm endometriosis: tsom rau angiogenesis thiab kev kho mob lub peev xwm. Reprod Sci. 2012 Oct; 19 (10): 1018-29. doi: 10.1177 / 1933719112446080. Epub 2012 Lub Yim Hli 8. Rov Ntsuam Xyuas. PubMed PMID: 22875846.
  • 3: Peyrat JF, Brion JD, Alami M. Khoom cua 2-methoxyestradiol derivatives: qauv-kev sib raug zoo. Curr Med Chem. 2012; 19 (24): 4142-56. Ntsuam Xyuas. PubMed PMID: 22709003.
  • 4: Verenich S, Gerk PM. Kev cog lus rau kev kho mob ntawm 2-methoxyestradiol thiab nws txoj kev sib tw cov tshuaj. Mol Pharm. 2010 Dec 6; 7 (6): 2030-9. doi: 10.1021 / mp100190f. Epub 2010 Oct 21. Tshawb Xyuas. PubMed PMID: 20831190; PubMed Central PMCID: PMC3059899.
  • 5: Mueck AO, Seeger H. 2-Methoxyestradiol – biology thiab lub tswv yim ntawm kev ua. Steroids. Xyoo 2010 Oct; 75 (10): 625-31. doi: 10.1016 / j.steroids.2010.02.016. Epub 2010 Mar 7. Tshawb Xyuas. PubMed PMID: 20214913.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

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Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations