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Mitoxantrone HCL hmoov

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 70476-82-3. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom huab hwm coj ntawm MIToxantrone HCL hmoov (70476-82-3), raws li CGMP kev tswj thiab kev tswj xyuas qhov system zoo.

Mitoxantrone hydrochloride hmoov yog ib hom kab mob khees xaws uas cuam tshuam nrog txoj kev loj hlob thiab kis mob qog nqaij hlav hauv lub cev. Tshuaj Mitoxantrone HCL yog siv los kho cov mob cancer hauv prostate thiab qee yam mob ntshav dawb. Cov tshuaj Mitoxantrone HCL kuj tseem siv los kho cov tsos mob ntawm kev rov qab ntau tus kab mob sclerosis. Cov tshuaj no yuav tsis kho cov sclerosis ntau.

Hauj lwm yam khoom

Mitoxantrone hydrochloride hmoov yees duab


Mitoxantrone hydrochloride hmoov theem pib

Lub npe: Mitoxantrone hydrochloride hmoov
CAS: 70476-82-3
Molecular Formula: C22H30Cl2N4O6
Molecular phaus: 517.4
Melt Point: 160-162 ° C
Cia Temp: tub yees
xim: Dawb los yog tua dawb Crystalline hmoov


Mitoxantrone hydrochloride hmoov nyob hauv kev siv

npe

Hom Lub Npe: Novantrone
Tshuaj Npe: 1,4-dihydroxy-5,8-bis [[2- [2-hydroxyethyl) amino] ethyl] amino] 9,10-anthracenedione dihydrochloride

Mitoxantrone hydrochloride hmoov pab

Tus mob Myeloid Leukemia

Ib feem ntawm cov kws khomob ntau txoj haujlwm rau kev tshem tawm ntawm kev mob plawv (myelogenous, nonlymphocytic) leukemia (AML, ANLL). AML muaj xws li mob promyelocytic, monocytic, myelomonocytic, megakaryoblastic, thiab erythroid leukemias.

Siv nrog lwm tus antineoplastic cov neeg ua haujlwm nyob hauv kev kho cov tshuaj kho kom haum raws li nram qab no qhov kev tshem tawm tag nrho.

Prostate Cancer
Siv raws li lwm txoj kev tswj hwm rau thawj palliative kho mob siab tshaj plaws, symptomatic (xws li, mob) hormone-refractory prostate cancer (nrog prednisone). Xav tias thawj zaug kho ntawm txoj kev kho rau hormone-refractory metastatic prostate cancer yog docetaxel nrog prednisone.

Ntau Sclerosis (MS)
Kev kho kab mob qis dua (mob ntev), hnyav hnyav, lossis rov huam mob ntxiv rov qab-MS. Kev siv los txo cov kev tsis paub txog kev puas hlwb thiab / lossis kev rov qab mob dua.

Twb tau kawm nyob rau hauv cov neeg mob uas muaj cov kab mob nram qab no: Mob qeeb zuj zus ntxiv los yog tsis muaj mob khees xaws rov qab tuaj ntxiv (qib ob ntxiv thiab mob hnyav ntxiv) thiab kev mob rov qab ua rau kauj ruam nce ntxiv hauv kev xiam oob qhab, nrog rau qhov xwm txheej tsis tshua muaj teeb meem txog kev nyuab siab dua ntawm kev rov mob dua ( kho kab mob).

Tsis pom zoo rau kev siv rau hauv cov neeg mob uas muaj tus qauv loj hlob zoo MS.

Yuav tsum tsis txhob siv rau kev kho mob ntawm MS rau cov neeg mob uas muaj lub hauv paus LVEF <50% (pomMyocardial Toxicity nyob rau hauv Boxed Ceeb toom). Feem ntau tsis pom zoo siv rau hauv cov neeg uas muaj kev puas siab puas ntsws (saib Hepatic Tsis zoo hauv Ceev Faj) lossis hauv cov uas suav neutrophil <1500 / mm3.

Non-Hodgkin's Lymphoma
Siv raws li kev tivthaiv kev siv tshuaj tua kabmob ua ke rau kev kho cov qes tsis-Hodgkin's lymphoma †.

Tshuaj npaum li cas ntawm Mitoxantrone hydrochloride hmoov

Muaj li Mitoxantrone hydrochloride hmoov; cov tshuaj siv ntau npaum li cov tshuaj mitoxantrone HCL.

Cov neeg laus
Tus mob Myeloid Leukemia
Qhov Kev Kho Mob Induction
IV
12 mg / m2 txhua hnub rau hnub 1-3 nrog rau cytarabine 100 mg / m2 txhua txhua hnub (raws li tus kab IV txuas mus ntxiv 24 cov sijhawm) rau hnub 1-7.

Yog tias qhov tshuaj tiv thaiv antileukemic mus rau thawj chav kawm tsis tiav, qhov thib ob yog qhov kev kawm ntawm 2 hnub ntawm mitoxantrone HCL hmoov (12 mg / m2 txhua hnub) thiab 5 hnub ntawm cytarabine (100 mg / m2 txhua hnub).

Yog tias tsis muaj teeb meem loj los yog tsis muaj teeb meem ua rau lub cev tsis muaj teeb meem, thaum lub sijhawm pib ua kom tsis muaj teeb meem, tsis txhob ua kom tsis txhob muaj teeb meem txog thaum toxicity.

Consolidation Therapy
IV
12 mg / m2 txhua hnub rau hnub 1 thiab 2 nrog rau cytarabine 100 mg / m2 txhua hnub (raws li ib qho kev xaus IV qhov kev ua haujlwm dhau 24 cov sijhawm) rau hnub 1-5. Tiv thaiv kev pib kawm thawj zaug txog 6 lub lis piam tom qab kawg kev kawm; tswj kev kawm ob feem sib xyaw feem ntau 4 lub lis piam tom qab pib kawm.

Prostate Cancer
IV
12-14 mg / m2 ib zaug txhua hnub 21; muab raws li kev kho mob corticosteroid (xws li, prednisone 5 mg lus qhauj ob zaug txhua hnub, hydrocortisone 40 mg txhua hnub). Qee cov kws kho mob pom zoo kom tsis txhob tso cov tshuaj mitoxantrone HCL (thiab txuas ntxiv ntawm corticosteroid therapy ib leeg) rau cov neeg mob uas tseem ua haujlwm tom qab ib qho tshuaj mitoxantrone HCL hmoov tshuaj ntawm 140 mg / m2 vim muaj kev mob plawv toxicity.

Multiple Sclerosis
IV
12 mg / m2 ib zaug txhua 3 lub hlis.

Sau Cov Txwv Txwv
Cov neeg laus
Multiple Sclerosis
IV
Qhov hnyav tshaj plaws hauv lub cev: 140 mg / m2.

Cov Pej Xeem Tshwj Xeeb
Hepatic Tsis Zoo
Txwv tsis pub dhau; Yuav tsum tau kho npaum li cas, tab sis, tsis muaj kev tawm tswv yim ntau npaum li cas. (Saib Hepatic Impairment hauv Ceev Fwm.)

Raum tsis zoo
Kev txo qhov hnoos qeev tsis tau.

Ceeb toom

Kev paub txog kev soj ntsuam cov kws kho mob

Tsuas pub ua tus saib xyuas ntawm cov kws kho mob uas tau txais kev pom zoo hauv kev siv cytotoxic therapy.

Kev Ceeb Toom Tseg
Ua kom maj mam muab mus rau txoj kev ywj pheej ncaj ncees IV. Tsis txhob siv cov tshuaj hu ua IM, sub Q, intra-arterial, lossis intrathecal txhaj tshuaj.

Cov ntaub so ntswg loj hauv zos necrosis yog tias extravasation tshwm sim. (Saib Cov Kev Los Ntawm Lub Zog Hauv Qab Zov Hais Kom Cuam Tshuam.)

Mob hnyav thiab qee zaum irreversible neurotoxicity qhia tom qab intrathecal administration. (Saib Neurotoxicity hauv Ceev Fwm.)

Myelosuppression
Qis heev myelosuppression yuav tshwm sim. Feem ntau tsis txhob siv rau cov neeg mob uas muaj lub hauv paus neutrophil suav <1500 / mm3, tshwj tsis yog kev kho mob ntawm cov mob myeloid (myelogenous, nonlymphocytic) leukemia. Saib xyuas seb puas tsim nyog hematologic. (Saib Hematologic Teebmeem hauv Tsiaj Txhaum.)

Myocardial Toxicity
Quaj mob plawv thiab tuag taus CHF thaum lub sijhawm lossis lub hlis mus rau lub xyoo tom qab kho tas; txoj kev pheej hmoo siab nrog nce kab ntxiv.

Tej yam teeb meem (keeb kwm ntawm los yog kab mob plawv, ua ntej los sis sib thooj ntawm qhov chaw kho mob mediastinal / pericardial, kev kho mob yav dhau los nrog lwm yam anthracyclines lossis anthracenediones, los yog siv cov tshuaj lwm yam tshuaj muaj yees) yuav ua rau kom muaj kev pheej hmoo txog kev mob plawv (cardiotoxicity). Txawm li cas los xij, txoj kev mob toxicity kuj yuav tshwm sim tsis hais seb puas muaj cov kev mob plawv. (Saib Cardiotoxicity nyob rau hauv Faj seeb.)

Txoj kev pheej hmoo ntawm CHF tsim rau cov neeg mob khees xaws tau kwv yees li 2.6% ntawm qhov hnyav ntxiv txog 140 mg / m2.

Ua ntej pib kho, kuaj xyuas tag nrho cov neeg mob rau cov kev mob plawv / cov tsos mob ntawm keeb kwm thiab kev kuaj lub cev thiab txiav txim siab raws li sab laug plunging vial feem (LVEF) los ntawm echocardiogram lossis multigated radionuclide angiography (MUGA).

Tsis txhob pib kev kho mob rau cov neeg mob uas muaj ntau yam tshuaj sclerosis yog tias LVEF yog lub ntsiab yog <50%.

Hauv cov neeg mob uas muaj ntau yam kab mob sclerosis, ntsuas LVEF los ntawm echocardiogram lossis MUGA ua ntej txhua koob; tsis txhob siv cov tshuaj ntxiv yog tias LVEF txo rau <50% lossis yog tias qhov kev txo qis qis hauv LVEF tshwm sim.

Cov neeg mob uas muaj ntau yam kab mob sclerosis yuav tsum tsis txhob txais cov tshuaj hnyav> 140 mg / m2.

Kev mob qog nqaij hlav tshuaj Myelogenous Leukemia (AML)
Secondary AML qhia rau cov neeg mob kho mob mitoxantrone HCL hmoov; qhov kev pheej hmoo ntawm cov roj ntsha tuaj yeem tsub ntxiv thaum cov anthracyclines muaj nrog lwm cov DNA ua rau cov tshuaj antineoplastics, tom qab nws kis tau rau cov tshuaj cytotoxic, lossis thaum anthracycline doses tau nce lawm (Saib Carcinogenicity hauv Cautions.)

Mitoxantrone hydrochloride Nyoos Hmoov Noj

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Kev txiav txim loj dua tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nqi.

Mitoxantrone hydrochloride hmoov muag

Kom muab rau yav tom ntej tom ntej.

Mitoxantrone HCL hmoov puas muaj lwm cov teebmeem

Feem ntau qhia txog cov kev mob tshwm sim ntawm mitoxantrone xws li: kis kab mob rau lub cev, mob ua kom mob caj pas, mob cov hlab ntaws, kab mob hauv lub plab, mob fungal, sepsis, alopecia, amenorrhea, cardiac arrhythmia, constipation, mob ntshav qab zib, mob ntshav qab zib, mob ntshav qab zib, mob ntshav siab, mob plab, mob plab, mob plab, mob plab, mob ntsws, hyperglycemia, hypocalcemia, hypocalcemia, ntau dua ntshav qab zib, lymphocytopenia, mucositis, pharyngitis, rhinitis, mob plab, thrombocytopenia, ntuav, hnyav nce, tsis txawv txav neutrophil suav, anorexia, tsis zoo, thiab nailbedchanges. Lwm cov kev mob tshwm sim muaj xws li: mob ntsws tsis ua hauj lwm, mob plab tsis ua hauj lwm, qaug dab peg, mob plawv, mob plawv, mob plawv, mob taub hau, mob ntsws, ntxhov siab, mob nyhav, ntxhov siab, kev nyuab siab, mob hnyav, ntshav siab, ntshav siab, ntshav siab, alanine aminotransferase, mob ntsws aspartate aminotransferase, mob qog nqaij hlav plawv, tshuaj pleev plab, mob, petechia, proteinuria, muaj peev xwm, nqaij tawv, ua daus no, diaphoresis, thiab ecchymoses. Saib nram qab no rau daim ntawv teev cov kev phiv tshuaj.


Yuav ua li cas yuav Mitoxantrone hydrochloride hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

COA 70476-82-3Mitoxantrone HCL hmoov AASRAW

HNMR

Peb yog Mitoxantrone hydrochloride hmoov tshuaj, Mitoxantrone HCL hmoov cia, muag Mivoxantrone HCL hmoov supplie (70476-82-3) hplc = 98% | AASraw

Zaub mov txawv

Mitoxantrone hydrochloride Raw Powder Recipes

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations