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MMAF (Hydrochloride) (1415246-68-2)

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 1415246-68-2. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram rau huab hwm coj ntawm MMAF (Hydrochloride) (CAS 1415246-68-2), raws li CGMP kev tswj thiab kev tswj xyuas qhov system zoo.

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Hauj lwm yam khoom

MMAF (Hydrochloride) yees duab


MMAF (Hydrochloride) Cov Cim Tseem Ceeb

Lub npe: MMAF (Hydrochloride)
CAS: 1415246-68-2
Molecular Formula: C39H66ClN5O8
Molecular phaus: 768.42
Melt Point: 314.3 ° C ntawm 760 mmHg (Yam raug)
Cia Temp: Hmoov-20 ° C 3 xyoo
4 ° C 2 xyoo
Hauv solvent-80 ° C 6 lub hlis
-20 ° C 1 lub hlis
xim: Dawb crystalline hmoov


MMAF (Hydrochloride) siv nyob rau hauv kev hloov tho txawv

npe

MMAF (Hydrochloride) (1415246-68-2) kuj hu ua Monomethylauristatin F Hydrochloride, MMAF HCL

MMAF (Hydrochloride) Pab

Tus kws tshawb fawb kho mob ua ntau heev ntawm MMAF, hauv qab no yog qee qhov lus qhia rau kev siv:
Hauv Vitro: MMAF qhia hauv vitro cytotoxicity tiv thaiv lub vaj huam sib luag ntawm cov kab ntawm tes. Qhov tseem ceeb IC50 rau Karpas 299, H3396, 786-O thiab Caki-1 yog 119, 105, 257, thiab 200 nM, feem. Targeted MMAF yog tus muaj peev xwm ntau dua cov tshuaj dawb, thiab tias cAC10 conjugates ntawm MMAF cov lus qhia tau hais ua si. Ntawm lub qhov cag, lub cAC10-L1-MMAF4 yog nruab nrab ntawm ntau tshaj 2200-quav ntau zog tshaj MMAF dawb thiab khiav tawm ntawm tag nrho cov CD30 zoo cell kab xeem

Nyob rau hauv Vivo: Qhov siab tshaj plaws cov tshuaj tiv thaiv kab mob hauv MMAF (1415246-68-2) (> 16 mg / kg) ntau dua MMAE (1 mg / kg). CAC10-L1-MMAF4 muaj ib qho MTD ntawm 50 mg / kg hauv cov nas thiab 15 mg / kg hauv nas. Qhov sib thooj cAC10-L4-MMAF4 ADC yog qhov muaj mob tsawg, muaj MTDs hauv cov nas thiab cov nas> 150 mg / kg thiab 90 mg / kg hauv nas, feem

Ceeb toom rau MMAF (Hydrochloride)

Rau kev tshawb fawb siv xwb

Cov lus qhia ntxiv

Nws tau sau tseg tias Monomethylauristatin F Hcl (MMAF Hcl) yog ib tus neeg saib xyuas tus kab mob antitubulin uas cuam tshuam kev sib faib ntawm cell los ntawm kev thaiv lub polymerization ntawm tubulin; thiab thecytotoxic kev ua si yog qis dua MMAE; thiab nws yog ib qho tshuaj antibody cytotoxin.

Cell Assay
Hlwb yog kho nrog cov kua luaj li kev kuaj ntawm cov qauv kev kuaj thiab cov kab 4-6 hnub nyob ntawm seb kab ntawm tes. Kev soj ntsuam ntawm kev loj hlob ntawm tes thiab cov ntaub ntawv txo los tsim cov IC50 qhov tseem ceeb yog siv Alamar Blue dye txo assay
MCE tsis tau muaj kev ywj siab hais txog qhov tseeb ntawm cov txheej txheem no. Lawv tsuas yog siv rau xwb.

Animal Administration
Hneev: Kev tshawb pom pom tias thaum tus kabmob Karpas 299 tumor ncav cuag 300 mm3, peb cov tsiaj tau txais ib qhov kev txhaj tshuaj 10 mg antibody tivthaiv / kg lub cev ntawm qhov cAC10-L1-MMAF4 lossis cBR96-L1-MMAF (1415246-68-2 ) 4 intravenously. Cov pob txha tom qab raug muab tshem tawm thiab muab tso rau hauv qhov ntsuas siab, thiab 5 μm-thin frozen cov ntaub so ntsig yog siv los siv kev ntsuam xyuas kev txhaj tshuaj tiv thaiv kabmob (immunohistochemistry)
MCE tsis tau muaj kev ywj siab hais txog qhov tseeb ntawm cov txheej txheem no. Lawv tsuas yog siv rau xwb.


Yuav ua li cas yuav MMAF; muas Hydrochloride los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

Zaub mov txawv

References & cov khoom citations