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Monomethyl auristatin E (MMAE) hmoov

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 474645-27-7. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram los ntawm kev txiav txim siab Monomethyl auristatin E (MMAE) hmoov (474645-27-7), raws li CGMP kev tswj thiab kev tswj xyuas qhov kev tswj kom zoo.

Hauj lwm yam khoom

Monomethyl auristatin E (MMAE) hmoov yees duab


Monomethyl auristatin E (MMAE) hmoov theem pib

Lub npe: Monomethyl auristatin E (MMAE) hmoov
CAS: 474645-27-7
Molecular Formula: C39H67N5O7
Molecular phaus: 717.97858
Melt Point: 238-240 ° C
Cia Temp: Khaws cia rau hauv lub khob thawv, ntawm 36 rau 46 degrees F
xim: Dawb hmoov


Monomethyl auristatin E cov hmoov ua cov tshuaj tiv thaiv antimitotic

npe

Brentuximab vedotin, MMAE hmoov

Monomethyl auristatin E hmoov Siv

• Cov neeg laus
Monotherapy, 1.8 mg / kg (tsis pub tshaj 180 mg / koob) IV txhua lub lim tiam 3; nrog chemotherapy, 1.2 mg / kg (tsis pub dhau 120 mg / koob) IV txhua lub lim tiam 2.

• Tshaj Backatric
Monotherapy, 1.8 mg / kg (tsis pub tshaj 180 mg / koob) IV txhua lub lim tiam 3; nrog chemotherapy, 1.2 mg / kg (tsis pub dhau 120 mg / koob) IV txhua lub lim tiam 2.

Monomethyl auristatin E hmoov (MMAE hmoov, vedotin) yog ib qho tshuaj tiv thaiv antimitotic heev uas cuam tshuam rau cell division by thaiv cov polymerisation ntawm tubulin.The tsev neeg ntawm auristatins yog hluavtaws analogues ntawm cov khoom antineoplastic Dolastatin 10, ultrapotent cytotoxic microtubule inhibitors uas yog clinically siv raws li payloads nyob rau hauv antibody-yeeb tshuaj conjugates. Monomethyl auristatin E hmoov los yog MMAE hmoov yog 100-1000 lub sijhawm muaj zog dua doxorubicin (Adriamycin / Rubex) thiab tsis tuaj yeem siv los ua ib qho tshuaj. Txawm li cas los, raws li ib feem ntawm cov tshuaj antibody-conjugate los yog ADC, hmoov MMAE yog txuas rau ib qho monoclonal antibody (mAb) uas pom tau tias muaj cov cim kev qhia hauv cov qog nqaij hlav thiab qhia MMAE hmoov mus rau ib hom qog hlwb.

Lub linker txuas MMAE hmoov rau lub monoclonal antibody yog ruaj khov nyob rau hauv extracellular kua, tab sis yog cleaved los ntawm cathepsin thaum antibody-yeeb tshuaj-conjugate tau ua txhua yam rau cov kab mob cancer cell antigen thiab nkag mus rau cov kab mob cancer ntawm tes, tom qab uas lub ADC nthuav tawm cov tshuaj lom MMAE hmoov thiab activates lub hwj chim los tiv thaiv txoj kev ntsuas. Antibody-drug conjugates txhawb cov antitumor cov teebmeem ntawm cov tshuaj tiv thaiv thiab txo cov txheej txheem cov teebmeem ntawm cov kab mob muaj zog cytotoxic.

Ceeb toom rau Monomethyl auristatin E hmoov

• Mob ntsws (Pneumonitis), kab mob ntsws (pulmonary syndrome), ua pa nyuab
Cov tshuaj lom neeg tsis muaj zog toxicity (xws li, pneumonitis, kab mob ntsws kua ntaiv hauv tus kabmob, mob ntsws mob nyuab siab) tau qhia nrog kev kho mob brentuximab; qee cov neeg raug tuag. Saib xyuas cov neeg mob rau cov cim thiab cov tsos mob ntawm cov tshuaj toxicity xws li hnoos thiab dyspnea. Soj ntsuam cov neeg mob uas tsim muaj cov tsos mob ntawm cov kab mob ntsig tshiab lossis mob ntxiv; tuav brentuximab kom txog rau thaum cov tsos mob. Kev siv sib xyaw nrog brentuximab nrog bleomycin-chemotherapy (off-label), xws li ABVD (adriamycin, bleomycin, vinblastine, dacarbazine), tiv thaiv vim muaj kev phom sij ntawm cov tshuaj tsis muaj kab mob ntsws toxicity. Cov kab mob intestinal infiltration thiab inflammation (nyob hauv siab xoo hluav taws xob lossis tomographic computed tomography) tshwm sim ntau dua hauv Hodgkin lymphoma cov neeg mob uas tau txais brentuximab ntxiv rau ABVD hauv qhov chaw kuaj mob piv nrog cov keeb kwm tswj cov neeg mob uas tau txais ABVD ib leeg. Feem ntau cov tshuaj txiav txim tom qab kho cov kab mob corticosteroid.

peripheral neuropathy
Peripheral neuropathy, feem ntau cov kev hnov ​​mob neuropathy, tau raug mob nrog brentuximab vedotin therapy; peripheral neuropathy yog cumulative. Saib xyuas cov neeg mob rau cov tsos mob ntawm neuropathy (xws li, hypoesthesia, hyperesthesia, paresthesia, tsis xis nyob, kub nyhav, mob paj hlwb, lossis tsis muaj zog). Kev kho kev cuam tshuam, txo qhov kev txo qis, lossis kev txiav ntxiv lawm yuav tsim nyog rau cov neeg mob uas tsim muaj lub hlwb tshiab los yog qhov kev puas tsuaj.

• Kev mob ntshav qab zib, rov qab plab, hlab ntsws, thrombocytopenia
Cov tshuaj lom neeg mob hnyav heev (piv txwv, ntshav dawb, thrombocytopenia, neutropenia) thiab cov neeg mob tuag taus thiab mob hnyav ntawm febrile neutropenia tau qhia nrog kev kho mob brentuximab vedotin; neutropenia tuaj yeem muab lub sijhawm ntev (ntev 1 lub lim tiam lossis ntev dua). Geriatric cov neeg laus uas muaj hnub nyoog 65 thiab laus dua nrog Hodgkin lymphoma uas tau txais brentuximab vedotin nrog cov kws khomob tau ntsib ntau dua ntawm febrile neutropenia piv nrog cov neeg mob hluas. Ua kom tiav cov ntshav ntsuas ua ntej txhua hom mob brentuximab thiab ntau zaus yog tias qib 3 los yog 4 neutropenia tshwm sim; saib xyuas tag nrho cov neeg mob rau kub cev. Kev kho kev cuam tshuam, txo kev noj tshuaj, lossis kev txiav ntxiv lawm yuav tsim nyog rau cov neeg mob uas tsim qib 3 lossis 4 neutropenia; xav txog qhov sib ntxiv ntawm prophylactic granulocyte-colony stimulating factor (G-CSF) nrog cov koob ntxiv tom ntej. Tso G-CSF pib nrog 1 ncig rau cov neeg mob uas tau txais brentuximab vedotin nrog cov kws khomob.

• Tus kab mob hnyuv lysis syndrome (TLS)
Tumor lysis syndrome (TLS) tau raug tshaj tawm hauv cov neeg mob uas tau txais brentuximab vedotin. Cov neeg mob uas muaj cov hlav sai sai thiab / los yog lub siab hnyav tuaj yeem ua rau muaj kev pheej hmoo siab ntawm kev tsim cov TLS. Saib xyuas cov neeg mob rau cov cim ntsig txog TLS (xws li, cov ntsha roj ntsha electrolytes, uric acid, serum creatinine) ua ntej thiab thaum txoj kev kho; ua raws li cov lus hais haum thiab kev kho mob (xws li, co, kev txo qis tshuaj uric acid) raws li tsim nyog.

• Cov kab mob plawv (multifocal leukoencephalopathy)
Kev tuag ua rau cov neeg mob plawv dhau los (PML), tshwm sim los ntawm John Cunningham tus kab mob (JC virus), tau qhia txog kev kho mob brentuximab; qee cov neeg tshwm sim hauv thawj 3 lub hlis pib kev kho mob. Cov neeg mob uas muaj kev tiv thaiv kab mob ua ntej immunosuppressive lossis kab mob hauv immunosuppressive tej zaum yuav muaj kev pheej hmoo siab ntawm tus kab mob JC thiab PML. Soj ntsuam cov neeg mob uas tsim muaj cov kev qhia tshiab, lub hlwb, lossis kev coj cwj pwm xws li hloov pauv lossis kev coj tus cwj pwm; tsis meej pem; nco tsis tau; kev hloov hauv kev hais lus, kev hais lus, lossis kev taug kev; thiab / lossis tsis muaj zog lossis qaug zog ntawm ib sab ntawm lub cev. Tuav kev khomob yog tias PML raug xav; txhob ncua brentuximab rau cov neeg mob uas paub tseeb tias PML.

• Kev puas tsuaj dua
Tsis txhob siv cov brentuximab vedotin hauv cov neeg mob uas muaj kev puas tsuaj loj heev (creatinine clearance (CrCl) tsawg dua 30 mL / min). Cov xwm txheej ntawm qib 3 los yog ntau dua cov teeb meem kev phom sij thiab kev tuag yog siab dua rau cov neeg mob uas muaj mob xiam oob qhab loj dua piv rau cov neeg mob uas ua rau lub cev tsis zoo (CrCl ntau dua 80 mL / min) hauv kev tshawb nrhiav me me, ib leeg xwb.

• Mob kabmob siab
Tsis txhob siv cov brentuximab vedotin hauv cov neeg mob uas muaj ntsis (Child-Pugh B) lossis loj (Child-Pugh C) hepatic disease / impairment; kev txo cov koob tshuaj tiv thaiv kom tsawg yog pom zoo rau cov neeg mob uas muaj kev sib txawv me ntsis (Child-Pugh A). Cov xwm txheej ntawm qib 3 los yog muaj teeb meem phom sij thiab kev tuag ntau dua rau cov neeg mob uas muaj mob loj los sis mob hnyav tsis zoo los ntawm cov neeg mob uas muaj tus kabmob ua rau lub cev me me, ib leeg ib txwm tshuaj. Hepatotoxicity (xws li hepatocellular raug mob, hepatic enzymes, thiab hyperbilirubinemia) tau raug qhia nrog brentuximab vedotin therapy. Qee cov neeg tshwm sim tom qab thawj koob tshuaj los yog raws li tshuaj yeeb dawb; Hepatotoxicity hais txog kev tuag tau raug tshaj tawm. Saib xyuas kev ua haujlwm hauv lub siab (LFTs), suav nrog bilirubin, ua ntej thiab thaum kho. Kev kho kev cuam tshuam, txo kev txo qis, lossis kev txiav ntxiv lawm yuav tsim nyog rau cov neeg mob uas tsim muaj kab mob siab tshiab, tsis zoo, lossis rov qab tuaj yeem rov los dua. Cov neeg mob uas muaj kab mob tsis muaj zog tiv thaiv kab mob los yog ua kom LFT nce siab thiab cov neeg mob uas tau txais cov tshuaj noj tsis zoo yuav ua rau muaj feem yuav mob siab rau tus kab mob hepatotoxicity.
• Kev kis mob, sepsis
Kab mob kis tau zoo thiab lwm yam kab mob loj, nrog rau kev mob ntsws, kab mob bacteremia, thiab sepsis (qee zaum ua rau tuag taus), tau qhia nrog brentuximab vedotin therapy. Ua tib zoo saib cov neeg mob thaum kho mob rau cov tsos mob thiab cov tsos mob ntawm kab mob bacterial, fungal, los yog kis tus kab mob.

• Txoj kev quav tshuaj tiv thaiv kab mob
Txoj kev tuaj yeem tiv thaiv kev quav tshuaj muaj xws li tshuaj anaphylaxis tau qhia nrog kev kho mob brentuximab vedotin; yog li ntawd, saib xyuas cov neeg mob nyob ze rau cov tsos mob ntawm qhov tshuaj tiv thaiv thaum muaj tus kab mob brentuximab. Tam sim ntawd thiab txiav tsis tu ncua yog tias anaphylaxis tshwm sim. Txhob muab qhov Infusion thiab kho cov kev kho mob tsim nyog rau cov neeg mob uas tsim muaj cov tshuaj tiv thaiv kab mob. Premedicate (xws li, acetaminophen, antihistamine, thiab / los yog corticosteroid) ua ntej infusions tom ntej rau cov neeg mob uas tau pom txog cov tshuaj tiv thaiv kab mob yav dhau los.

• Colitis, GI ntshav, Kab mob GI, GI rhuav, GI perforation, nrogus, peptic ulcer disease
Mob nyhav (GI) muaj xws li GI perforation, GI ntshav, GI erosion, kab mob peptic ulcer, GI obstruction, neutropenic colitis, enterocolitis, thiab ileus tau raug qhia nrog brentuximab vedotin therapy; qee cov neeg tau raug tuag. Tuaj soj ntsuam thiab kho cov teeb meem GI hauv cov neeg mob uas tsim muaj cov tsos mob GI tshiab lossis mob ntxiv. Siv brentuximab nrog ceev faj rau cov neeg mob uas muaj keeb kwm mob GI. Cov neeg mob uas muaj keeb kwm ntawm cov qog ntshav hauv nrog GI kev koom tes yuav muaj kev pheej hmoo siab ntawm GI qhov tobhau.

• Cev xeeb tub
Brentuximab vedotin yuav ua rau me nyuam raug mob yog tias ua rau thaum cev xeeb tub raws li nws txoj kev ua haujlwm thiab cov ntaub ntawv los ntawm kev tshawb fawb tsiaj. Cov poj niam ntawm kev muaj peev xwm yuav tsum qhia kom tsis txhob cev xeeb tub thaum uas tau txais brentuximab. Yog tias ib tug poj niam cev xeeb tub thaum noj cov tshuaj no, nws yuav tsum tau paub txog qhov tsim kev puas tsuaj rau tus me nyuam hauv plab. Nyob rau hauv kev tshawb fawb tsiaj, embryo-fetal toxicities nrog rau congenital malformations tau pom ntawm brentuximab koob tshuaj uas ua rau menyuam muaj mob uas zoo tib yam rau tib neeg kev kis tus kab mob thaum txhaj tshuaj.

• Kev tiv thaiv kev tsis sib haum xeeb, kev noj tshuaj ntxiv, kev mob txiv neej, kev xeeb tub, kev xeeb tub,
Cov neeg mob ntuas txog kev pheej hmoo loj thiab kev xeebtub yuav tsum tau ua thaum muaj kev kho mob brentuximab vedotin. Kev xeeb tub cev xeeb tub yuav tsum tau ua ua ntej yuav pib brentuximab rau cov poj niam uas muaj peev xwm ua me nyuam. Cov neeg mob no yuav tsum siv tshuaj tiv thaiv zoo thiab tsis txhob muaj menyuam hauv plab thiab rau tsawg kawg 6 lub hlis tom qab kev kho mob brentuximab. Cov poj niam uas cev xeeb tub thaum tau txais brentuximab yuav tsum tau paub txog qhov tsim kev puas tsuaj rau tus me nyuam hauv plab. Tsis tas li ntawd, txiv neej cov poj niam nrog tus poj niam koom tes ntawm kev ua me nyuam yuav tsum siv tshuaj tiv thaiv zoo thaum siv tshuaj kho thiab tsawg kawg ntawm 6 lub hlis tom qab kho vim qhov kev pheej hmoo ntawm txiv neej-mediated teratogenicity. Raws li kev tshawb fawb tsiaj, brentuximab yuav ua tau rau cov txiv neej yob ntxiv.

• Kev pub niam mis
Tsis muaj xov xwm qhia txog kev muaj tus kab mob brentuximab vedotin nyob rau hauv tib neeg cov mis, cov teebmeem ntawm niam mis, lossis cov teebmeem ntawm cov kua mis. Vim tias muaj peev xwm ua rau muaj kev phom sij rau tus me nyuam mos liab (piv txwv li, cytopenias thiab paj hlwb los yog mob plab hnyuv), kev pub niam mis tsis pom zoo thaum lub caij tu mob brentuximab. Xav txog cov txiaj ntsig ntawm kev pub mis rau me nyuam, kev pheej hmoo ntawm cov me nyuam mos liab raug mob, thiab kev pheej hmoo ntawm kev tsis kho lossis tsis zoo. Yog tias tus me nyuam mos pub mis rau me nyuam yaus muaj kev cuam tshuam txog kev siv yeeb tshuaj, cov kws kho mob yuav tsum tau qhia tawm qhov kev cuam tshuam rau FDA.

Cov lus qhia ntxiv

Monomethyl auristatin E hmoov (MMAE hmoov) yog muab tso tawm los ntawm SGN-35 hauv CD30 + mob hlwb thiab, vim nws cov ntaub ntawv permeability, muaj peev xwm siv cov kev ua si cytotoxic ntawm cov hlwb bystander. MMAE hmoov tshuaj ua kom muaj xim nqaij tawv thiab mob qog pancreatic hlwb mus rau IR hauv cov sij hawm thiab koob tshuaj raws li sib txheeb nrog mitotic ntes. Radiosensitization yog evidenced los ntawm kev noj qab haus huv clonogenic thiab nce DNA ob chav strand so hauv cov hlwb irradiated.

Monomethyl auristatin E Khaub Ncaws Hmoov

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nyiaj.

Monomethyl auristatin E Raw Hmoov Noj Txawv Noj

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

Monomethyl auristatin E hmoov muag

Kom muab rau yav tom ntej tom ntej.


IV. Yuav ua li cas yuav Monomethyl auristatin E hmoov; muas MMAE hmoov los ntawm AASraw?

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

COA 474645-27-7 Monomyl auristatin E (MMAE) AASRAW

HNMR

Peb yog monomethyl auristatin e hmoov tshuaj, MMAE hmoov muag, Monomethyl auristatin E (MMAE) hmoov (474645-27-7) ≥98% | AASraw

Zaub mov txawv

Monomethyl auristatin E Raw Khoom Noj Cov Khoom Noj:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations

Antineoplastic Agent Monomethyl auristatin E (MMAE)