Tebchaws Meskas Tuaj Tebchaws, Tebchaws Thoob Plaws Hauv Tebchaws Asmeskas, Lub Tebchaws Thoob Plaws Tebchaws Thoob Plaws Tebchaws

Nomegestrol Acetate hmoov

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 58652-20-3. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom huab hwm coj ntawm Nomegestrol acetate hmoov (58652-20-3), raws li CGMP kev tswj thiab kev tswj xyuas qhov system zoo.

Nomegestrol acetate hmoov , cov npe tshuaj 17-Hydroxy-6-Methyl-19-norpregna-4,6-diene-3,20-dione, yog ib qho muaj zog, feem ntau xaiv tau progestogen, ib tus agonist nyob ntawm progesterone receptor, tsis muaj los yog tsawg tsawm rau lwm cov tshuaj steroid.

Hauj lwm yam khoom

Nomegestrol Acetate hmoov yees duab


Nomegestrol Acetate hmoov theem pib

Lub npe: Nomegestrol Acetate hmoov
CAS: 58652-20-3
Molecular Formula: C21H28O3
Molecular phaus: 328.45
Melt Point: 177-180 ℃
Cia Temp: txias cia khoom
xim: Dawb los yog hmoov av dawb


Nomegestrol Acetate hmoov voj voog

npe

Cov npe tshuaj: Nomegestrol Acetate hmoov
Hom Npe: Lutenyl thiab Zoely, thiab lwm tus, 19-Normegestrol hmoov, Nomegestrol (INN) hmoov, 58652-20-3

Nomegestrol Acetate hmoov pab

Nomegestrol Acetate hmoov (CAS 58652-20-3) yog ib qho muaj zog, lub ncauj lus cuam tshuam rau lub ncauj lus nrog ib qhov kev sib haum xeeb thiab cov yeeb yam tsis zoo. Tsis zoo li feem ntau cov progestogens, uas yog 19-nortestosterone derivatives synthesized feem ntau rau lawv cov tshuaj tiv thaiv antigonadotropic ua ib feem ntawm hormonal contraception ua ke nrog estrogen, Nomegestrol Acetate hmoov yog ib 19-norprogesterone derivative tsim los khi tshwj xeeb rau lub progesterone receptor, thiab yog ib qho tsis nyob hauv affinity rau lwm cov tshuaj steroid. Nomegestrol Acetate hmoov siv zis muaj zog los ntawm cov tshuaj tua kab mob hauv lub cev thiab cov tshuaj ua kom muaj zog, tab sis tsis muaj cov kev txwv thiab cov khoom glucocorticoid. Thaum noj tshuaj 1.25 mg / hnub, Nomegestrol Acetate hmoov txhaws tawm thaum tsim tawm kev loj hlob hauv kev loj hlob, txawm yog npaum li cas ntawm 2.5 los 5 mg / hnub, kev tsim tawm ntawm ovulation thiab follicle yog kev txhawb zog. Cov tshuaj tiv thaiv antigonadotropic ntawm Nomegestrol Acetate hmoov yog kho kom haum, zoo li lwm yam progestins, nyob rau ntawm hypothalamic thiab pituitary theem. Ntxiv mus, Nomegestrol Acetate hmoov muaj ib qho kev ua haujlwm tawm tsam. Kev Nqus Ntawm Nomegestrol Acetate hmoov yog sai tom qab lub qhov ncauj tswj hwm, mus cuag lub ncov siab tshaj plaws hauv 4 cov xuab moos, nrog lub davhlau ya nyob twg ib nrab ntawm lub sij hawm 50.

Nomegestrol Acetate hmoov (19-Normegestrol hmoov) tau siv rau kev kho qee yam mob qog nqaij hlav ntws (cev ntu, mob plab hnyuv taum, mob plab hnyuv, thiab lwm yam mob) thiab ua ib feem ntawm HRT ua ke nrog estradiol rau cov kev mob ntawm menopausal tsos mob; nws tau raug pom zoo nyob rau cov teb chaws Europe ua rau kev kho tus mob menopausal syndrome, uterine kab mob thiab menorrhagia, thiab nrog cov tshuaj estrogen rau cov kev kho mob ntawm menopausal. Hauv vitro cov ntaub ntawv hais tias Nomegestrol Acetate cov hmoov preserves cov haemostatic lig los ntawm cov tshuaj no; tsis tas li ntawd, Nomegestrol Acetate hmoov muaj ib qho txiaj ntsim zoo los yog kev ua haujlwm ntawm cov lipid profiles, thiab tsis cuam tshuam rau cov ntshav qab zib lossis cev nqaij. Nomegestrol Acetate hmoov tau qhia tau hais tias tsis muaj kev ua ub ua no hauv cov qe ntshauv thiab mob cancer mis, thiab tsis muaj cov nyhuv ntawm cov pob txha. Cov tshuaj tiv thaiv kab mob antigonadotropic, thiab lwm yam khoom siv metabolic thiab pharmacological, qhia tias Nomegestrol Acetate hmoov yuav ua tau zoo progestogen rau kev siv nrog ib qho tshuaj estrogen hauv kev siv tshuaj thiab cov pojniam tawm hauv HRT, thaum nws tseem muaj qee cov kev pabcuam uas tsis yog kev tiv thaiv rau cov poj niam txoj kev noj qab haus huv.

Qhov ntau npaum li cas ntawm Nomegestrol Acetate hmoov

COV LUS QHIA NO YOG RAU COV NEEG TSO NPE THOV NTSUAB XWB THIAB TSIS TXHOB SIV LOS YOG TUS NEEG SIV RAU KEV QHIA LOSSIS LWM TUS KHO TSHUAJ TIV THAIV KAB MOB.

Nomegestrol Acetate hmoov (NOMAC) yog muaj ob leeg nyob ib leeg thiab nrog estrogens.The following formulations muaj:

NOMAC 3.75 mg thiab 5 mg cov ncauj ntsiav tshuaj (Lutenyl) - qhia rau kev kho tus mob menopausal hormone thiab gynecological disorders

NOMAC 3.75 mg thiab estradiol 1.5 mg cov ncauj ntsiav tshuaj (Naemis) - qhia tau rau cov tshuaj menopausal hormones

NOMAC 2.5 mg thiab estradiol 1.5 mg qhov ncauj ntsiav tshuaj (Zoely) - qhia rau kev tiv thaiv kev tiv thaiv

Qhov muaj ntawm cov formulations txawv ntawm lub teb chaws

Yog tias koj tau ncua lub sijhawm
Yog tias koj tau noj tag nrho koj cov ntsiav tshuaj thaum lub sijhawm, thiab koj tsis ntuav, los yog mob plab heev lossis siv lwm yam tshuaj ces koj tsis tshua muaj kev xeeb tub. Mus nqa Nomegestrol Acetate hmoov (NOMAC) li qub.
Yog tias koj tsis nco qab koj lub sijhawm ob zaug ua ke, koj yuav xeeb tub. Tsis txhob pib lub pob ntim tom ntej ntawm Nomegestrol Acetate hmoov (NOMAC) kom txog rau thaum koj tus kws kho mob tau tshawb xyuas tias koj tsis xeeb tub.

Yog tias koj noj ntau dhau (dhau ntawm overdose)
Tsis muaj cov ntaub ntawv qhia txog teeb meem loj los ntawm kev siv ntau cov Nomegestrol Acetate hmoov (NOMAC) ntawm ib zaug. Yog tias koj noj ntau dhau lawm Nomegestrol Acetate hmoov (NOMAC) koj yuav hnov ​​mob, ntuav lossis muaj ntshav los ntawm qhov chaw mos.
Yog tias koj pom tias tus menyuam tau noj cov tshuaj Nomegestrol Acetate (NOMAC), nug koj tus kws kho mob kom nws pab tswv yim

Yuav ua li cas Nomegestrol Acetate hmoov ua haujlwm

NOMAC yog ib qho kev tiv thaiv kab mob hauv lub cev, feem ntau hu ua "Kev Yug Menyuam Yaus" los yog "Tus Kua Ntsiav" uas tau muab rau kom tiv thaiv tsis pub koj cev xeeb tub.
NOMAC txwv tsis pub cev xeeb tub rau ntau txoj hauv kev:
-Nws txwv tsis pub lub qe tso tawm los ntawm kev siv ceev xwmphem nws.
-Huab lub ncauj tsev menyuam hnyav ua rau nws nyuaj rau cov phev kom mus txog ntawm lub qe.
-Yog sab caj npab ntawm lub tsev menyuam ua rau nws tsis haum rau implantation.

Zoo li ntau lwm cov kev progestogens, NOMAC tau raug txheeb xyuas thiab pom nyob rau hauv vitro rau inhibit conversion ntawm estrone sulfate rau estrone (ntawm inhibition of steroid sulfatase) thiab estrone rau estradiol (ntawm inhibition of 17β-HSD) ntawm cov concentrations siab (0.5-50 μM) thiab ua kom muaj kev sib hloov ntawm estrone rau hauv estrone sulfate (ntawm kev ua kom muaj cov tshuaj sulfotransferase) ntawm qis concentrations (0.05-0.5 μM), uas tsis cuam tshuam cov aromatase ua ntawm txhua qhov kev soj ntsuam (txog 10 μM) .Cov dej num no tshwm rau PR -dependent, raws li NOMAC muaj peev xwm ua rau lawv nyob rau hauv PR-nplua nuj ntawm tes (piv txwv, T47-D thiab MCF-7) thiab lawv tuaj yeem raug thaiv los ntawm PR antagonist mifepristone (RU-486) .Txawm tias qhov kev soj ntsuam ntawm cov kev ua no tsis paub thiab lawv tseem tsis tau paub tseeb hauv vivo lossis soj ntsuam xyuas cov kev tshawb fawb soj ntsuam, nws tau raug pom tias NOMAC thiab lwm yam kev ua hauj lwm progestins yuav pab tau kho tus mob ER-positive breast cancer los ntawm kev txo qis Cov tshuaj tsw qab ntawm lub mis ntawm cov kua mis ntawm lub mis kuj ua rau lub cev tsis muaj zog ntawm cov kua mis, ntawm NOMAC, tsis muaj cov teebmeem ntawm cov kua ntswg, tsis txhob ua lub suab qis ntawm lub hlwb ntawm PGRMC1 (piv rau progesterone), thiab txo cov kev loj hlob ntawm estradiol lub mis thaum ntxiv rau nws nyob hauv nruab nrab

Ceeb toom

Tsis txhob noj cov tshuaj Nomegestrol Acetate hmoov (NOMAC) yog tias koj muaj kev fab rau:
-tshaj tshuaj muaj Nomegestrol Acetate hmoov los yog estradiol
-nws cov khoom xyaw uas teev rau tom kawg ntawm phau ntawv no.

Qee cov tsos mob ntawm kev tsis haum tshuaj muaj xws li:
-qhov kev ua pa
-hoob lossis ua pa nyuab heev
-qhia txog lub ntsej muag, di ncauj, nplaig lossis lwm qhov ntawm lub cev
- khaus, khaus lossis khaus ntawm daim tawv nqaij.

Nomegestrol Acetate hmoov (CAS 58652-20-3)

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Kev txiav txim loj dua tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nqi.

Nomegestrol Acetate hmoov muag

Kom muab rau yav tom ntej tom ntej.

Nomegestrol Acetate hmoov puas muaj lwm yam mob

Zoo ib yam li tag nrho cov tshuaj, Nomegestrol aceate (NOMAC) tau muaj kev mob tshwm sim. Qee zaum lawv loj heev, feem ntau lawv tsis yog.

Cov kev mob tshwm sim heev heev (tshwm sim hauv ntau tshaj ib tug neeg 10 cov neeg siv):
-cne
-pauv hauv kev phiv thaum cev ntas (xws li tsis ua poj niam los yog ntshav)

Cov kev mob tshwm sim (tshwm sim ntau dua ib qho ntawm 100 cov neeg siv, tab sis tsawg dua ib qho hauv 10 cov neeg siv):
-tsis txaus siab rau kev sib deev;
-qhov kev nyuaj siab / nyuaj siab ntxhov plawv;
-tshua hloov;
-hoob mob los yog migraine;
-qhov mob (xeev siab);
-qhov mob;
mob mob hlwb;
-au qhov nce.

Cov kev mob tshwm sim tsis tshua muaj tshwm sim (tshwm sim ntau dua ib qho ntawm ib tug 1000 cov neeg siv, tab sis tsis muaj ib yam hauv 100 cov neeg siv):
-cov tsis qab los;
-qluav tuav (edema);
-tsis dej yaug;
-nyob plab;
-nqe tawm hws;
-hlub poob;
-tej;
-qhov daim tawv nqaij;
-tawv nqaij tawv;
-txawm ntawm kev kub ntxhov;
-tsis tiamsis lub sijhawm luv luv;
-nyug mis;
-qhov pob lump;
-milk ntau lawm thaum tsis xeeb tub;
-tseem Syndrome;
-paub lub sijhawm thaum com;
-tsis nyob hauv qhov chaw mos lossis qhov chaw mos;
-spasm ntawm lub tsev menyuam;
-qhov kev ua haujlwm;
-tsis nyob rau theem ntawm daim siab enzymes.


Yuav ua li cas yuav Nomegestrol Acetate hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

Zaub mov txawv

Nomegestrol Acetate hmoov zaub mov txawv

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations