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Pyridoxal-5-phosphate Monohydrate

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5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 41468-25-1. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm gram kom loj npaum li Pyridoxal-5-phosphate Monohydrate (41468-25-1), raws li CGMP kev tswj thiab kev tswj xyuas qhov kev tswj kom zoo.

Pyridoxal-5-phosphate Monohydrate hmoov, Vitamin B6 metabolite uas ua raws li kev sib tsoo hauv kev cuam tshuam kev sib tsoo los ntawm kev sib koom tes ntawm Schiff-base linkage nrog lysine pawg ntawm aminotransferase. Kuj pab tau ua ib coenzyme hauv qee qhov decarboxylation thiab deamination tshua. Hloov tau lysyl thiab valyl seem nyob rau hauv cov nqaijrog. Muaj peev xwm ua kom tsis txhob muaj ntshav qab zib purpergic receptors thiab intracellular influx ntawm Ca2 +.

Hauj lwm yam khoom

Pyridoxal-5-phosphate Monohydrate video


Pyridoxal-5-phosphate Monohydrate basic Characters

Lub npe: Pyridoxal-5-phosphate Monohydrate
CAS: 41468-25-1
Molecular Formula: C8H12NO7P
Molecular phaus: 265.16
Melt Point: 2-8 ° C
Cia Temp: Chav Tsev Kub
xim: Ntsuab daj Crystalline


Pyridoxal-5-phosphate Monohydrate cycle

1. Npe:
Cov npe tshuaj: Pyridoxal-5-phosphate monohydrate, 3-Hydroxy-2-methyl-5 - ([phosphonooxy] methyl) -4-pyridinecarboxaldehyde
Codecarboxylase
Lwm Npe: Vitamin B6, Pyridoxal Phosphate, PLP

Pyridoxal-5-phosphate Monohydrate Siv

Vitamin B6 metabolite uas ua raws li coenzyme hauv kev cuam tshuam kev sib tsoo los ntawm kev sib koom tes nrog Schiff-base linkage nrog lysine pawg ntawm aminotransferase. Kuj pab tau ua ib coenzyme hauv qee qhov decarboxylation thiab deamination tshua. Hloov tau lysyl thiab valyl seem nyob rau hauv cov nqaijrog. Muaj peev xwm ua kom tsis txhob muaj ntshav qab zib purpergic receptors thiab intracellular influx ntawm Ca2 +.

Qhov kev siv tshuaj Pyridoxal-5-phosphate Monohydrate yog npaum li cas

PLP yog pab rau kev kho cov lysyl thiab valyl residues thiab ua haujlwm ua ib coenzyme hauv kev cuam tshuam kev txeeb los ntawm kev sib koom tes ntawm Schiff-base linkage nrog lysine pawg ntawm aminotransferase
PLP yog ib daim ntawv uas muaj vitamin B6
Kuj pab tau ua ib coenzyme hauv qee qhov decarboxylation thiab deamination tshua

Yuav ua li cas Pyridoxal-5-phosphate Monohydrate ua haujlwm

Pyridoxal phosphate (PLP, Pyridoxal 5'-phosphate, P5P), yog hom tshuaj vitamin B6, yog ib coenzyme nyob rau ntau yam kev hloov tshuaj enzymatic. Lub koom haum Enzyme tau qhia ntau dua 140 PLP-kev ua ub no, sib nug txog ~ 4% ntawm tag nrho cov dej num ua dej num. Lub versatility ntawm PLP tshwm sim los ntawm nws lub peev xwm los mus khi khawm lub substrate, thiab ces ua raws li tus electrophilic catalyst, ua li no stabilizing ntau hom carbanionic cov tshuaj tiv thaiv intermediates.

PLP ua raws li kev coenzyme hauv txhua txoj kev xav tshuaj, thiab nyob rau hauv qee qhov decarboxylation, deamination, thiab racemization reactions ntawm cov amino acids. Cov pab pawg neeg plum hauv plhis (PLP) tau sib txuas ntawm Schiff-base linkage (Internal aldimine) nrog lub ε-amino pawg ntawm ib hom lysine ntawm aminotransferase enzyme. Cov α-amino pawg ntawm cov amino acid substrate displaces cov ε-amino pawg ntawm qhov chaw dhia-lysine seem hauv cov txheej txheem hu ua transaldimination. Cov sab nrauv uas tau txais yuav tsis muaj proton, carbon dioxide, los yog cov amino acid sidechain los ua quinoid intermediate, uas tig tau ua ib qho nucleophile hauv ntau txoj hau kev.

Hauv transamination, tom qab deprotonation quinoid intermediate lees txais cov proton ntawm lwm txoj hauj lwm los ua ib tug ketimine. Lub kittenine resulting yog hydrolysed kom cov amino pawg nyob rau hauv cov complex. Tsis tas li ntawd, PLP yog siv los ntawm aminotransferases (los yog transaminases) uas ua raws li cov suab thaj tsis zoo xws li perosamine thiab desosamine. Hauv cov kev tshwm sim no, PLP reacts nrog glutamate, uas hloov nws cov alpha-amino pawg rau PLP kom pyridoxamine phosphate (PMP). PMP ces hloov nws cov nitrogen mus rau cov piam thaj, ua rau cov kua qab qab zib.

PLP tseem muaj feem xyuam rau cov kev sib txawv ntawm kev sib txawv ntawm beta-xws li cov kev ntsuam xyuas ua los ntawm serine dehydratase thiab GDP-4-keto-6-deoxymannose-3-dehydratase (ColD).

Nws kuj tseem ua haujlwm nyob rau hauv kev sib haum xeeb hauv kev sib cav sib ceg. PLP plays lub luag hauj lwm hauv kev hloov ntawm levodopa rau hauv dopamine, tswj qhov kev hloov ntawm cov excitatory neurotransmitter glutamate mus rau qhov ua kom tsis muaj zog neurotransmitter GABA, thiab tso cai rau SAM yuav decarboxylated rau propylamine, uas yog ib qho kev cob qhia rau cov khoom siv.

Ceeb toom

Qhov no yog daim npav ntawm VITAMIN B 6 ua ib coenzyme rau synthesis ntawm amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Thaum siv cov amino acids, pyridoxal phosphate yog transiently hloov mus ua pyridoxamine phosphate (PYRIDOXAMINE).
los ntawm MeSH
Pyridoxal Phosphate yog hom kab mob vitamin B6 thiab ib coenzyme rau ntau yam pyridoxal phosphate (PLP) -tsis muaj zog ntawm cov enzymes. PLP muab kev koom tes hauv ntau hom kev hloov pauv ntawm enzymatic, decarboxylation thiab deamination reactions; nws yog qhov tsim nyog rau cov synthesis ntawm cov amino acids thiab amino acid metabolites, thiab rau cov synthesis thiab / lossis catabolism ntawm cov neurotransmitters, nrog rau kev hloov cov glutamate hauv gamma-aminobutyric acid (GABA) thiab levodopa rau hauv dopamine. PLP tuaj yeem siv raws li kev noj haus ntxiv rau cov neeg muaj vitamin B6 deficiency. Txo cov qib PLP hauv lub hlwb tuaj yeem ua rau lub hlwb tsis ua haujlwm.
Pharmacology los ntawm NCIt
Qhov no yog lub cev rau cov vitamin B6 ua hauj lwm raws li ib coenzyme rau synthesis ntawm amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Thaum lub sij hawm transaminating cov amino acids, pyridoxal phosphate yog transiently hloov mus ua pyridoxamine phosphate (pyridoxamine). - Pubchem; Pyridoxal-phosphate (PLP, pyridoxal-5'-phosphate) yog ib qho cofactor ntawm ntau cov tshuaj enzymatic. Nws yog lub cev rau cov vitamin B6 uas muaj peb cov organic organic txuas, pyridoxal, pyridoxamine thiab pyridoxine.

Pyridoxal-5-phosphate Monohydrate Raw Recipes

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Pyridoxal Phosphate yog hom kab mob vitamin B6 thiab ib coenzyme rau ntau yam pyridoxal phosphate (PLP) -tsis muaj zog ntawm cov enzymes. PLP muab kev koom tes hauv ntau hom kev hloov pauv ntawm enzymatic, decarboxylation thiab deamination reactions; nws yog qhov tsim nyog rau cov synthesis ntawm cov amino acids thiab amino acid metabolites, thiab rau cov synthesis thiab / lossis catabolism ntawm cov neurotransmitters, nrog rau kev hloov cov glutamate hauv gamma-aminobutyric acid (GABA) thiab levodopa rau hauv dopamine. PLP tuaj yeem siv raws li kev noj haus ntxiv rau cov neeg muaj vitamin B6 deficiency. Txo cov qib PLP hauv lub hlwb tuaj yeem ua rau lub hlwb tsis ua haujlwm.


Yuav ua li cas yuav Pyridoxal-5-phosphate Monohydrate los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

Zaub mov txawv

Pyridoxal-5-phosphate Monohydrate Raw Zaub mov txawv

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Kev txiav txim loj dua tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nqi.

References & cov khoom citations