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Sunifiram (DM235) hmoov

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 314728-85-3. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom huab hwm coj ntawm Sunifiram (DM235) hmoov (314728-85-3), raws li CGMP cov kev tswj thiab kev tswj cov kev tswj qhov system.

Hauj lwm yam khoom

Sunifiram (DM235) hmoov video


Sunifiram (DM235) cov ntsiab lus tsim cov roj

Lub npe: Sunifiram (DM235) hmoov
CAS: 314728-85-3
Molecular Formula: C15H13F2NO2S
Molecular phaus: 309.33
Melt Point: 57-58 ° C
Cia Temp: Khaws ntawm chav kub thiab txias
xim: Dawb los yog hmoov dawb


Sunifiram (DM235) hmoov hauv lub hlwb boost pab

npe

Sunifiram hmoov, DM235 hmoov yog nrog lub npe hu ua BisfluoroModafinil, Flmodafinil.

DM235 hmoov pab

DM235 hmoov yog ib qho tshiab, co tsis muaj zog thiab tsis zoo li AMPAkine nrog cognition-enhancing cov teebmeem hauv cov qauv tsiaj.

Sunifiram hmoov yog ib tug piperazine uas muaj qee qhov sib thooj sib luag rau piracetam. Piracetam yog tsim los rau kev tsim kabmob neurodegenerative xws li Alzheimer's disease, thiab Sunifiram hmoov yog paub txog kev paub txog kev ua haujlwm ntawm qee yam kev coj cwj pwm. Nyob rau hauv receptor ruaj kev tshawb fawb, Sunifiram nyoos hmoov tsis pom affinity rau feem ntau cov neurotransmitter receptors los yog channels (tsis muaj affinity ntawm 1μM rau serotoninergic, dopaminergic, muscarinic, nicotinic, adrenergic, glutamatergic, histaminergic, opioid, los yog GABAergic receptors), tseem txhawb cov kev tso tawm ntawm acetylcholine ntawm cov paj hlwb cirrhosis, yuav zoo los ntawm kev ua haujlwm ntawm AMPA tus txais tos.

Sunifiram hmoov tiv thaiv amnesia vim li cas los ntawm scopolamine, tom qab tus IP thiab cov neeg ua haujlwm hauv kev siv tshuaj tiv thaiv kabmob tsis zoo ntawm 0.01 mg / kg po Cov tshuaj tiv thaiv Antiamnesic ntawm Sunifiram hmoov yog piv rau cov uas tau siv los ntawm cov tshuaj tsis pom zoo xws li tshuaj piracetam (30 mg / kg ip), aniracetam (100 mg / kg po) thiab rolipram (30 mg / kg po), tab sis nrog lub zog 1,000 - 10,000 zaug dua.

Ceeb toom rau DM235 hmoov phiv

Sunifiram hmoov (DM-235) yog piperazine derived kev tshawb fawb tshuaj uas muaj kev cuam tshuam los tiv thaiv cov kab mob hauv cov tsiaj txhu nrog cov neeg muaj peev xwm siab dua piracetam. Sunifiram nyoos hmoov yog ib qho yooj yim molecular ntawm unifiram. Raws li nyob rau hauv vitro thiab kev tshawb fawb tsiaj, nws pom tias Sunifiram hmoov ua ntawm AMPA-receptor qhib rua.

Sunifiram nyoos hmoov ua hauj lwm los ntawm activating AMPA receptors; uas yog, cov neeg txais kev pabcuam uas muaj feem xyuam rau kev kho kom haum xeeb ntawm kev sib kis ntawm cov kab mob hauv nruab nrab. Nws mechanics kuj tau nce phosphorylation ntawm AMPAR thiab NMDAR los ntawm protein kinase activation, uas ua rau cov tub ntxhais muaj peev xwm ua tau ntev - uas yog, ib qho hauv cov teeb meem kev sib kis ntawm ob lub paj hlwb uas ua rau simultaneous stimulation.

Qhov kev ua kom muaj kev ntxub ntxaug kinase los ntawm Sunifiram hmoov kuj pab txhawb kev paub lub hauv paus. Ntxiv thiab, Sunifiram nyoos hmoov ua haujlwm nyob rau hauv lub paj hlwb cortex ntawm cov tsiaj kuaj los ntawm kev pab nyob rau hauv kev tso tawm acetylcholine, cov organic molecule uas ua raws li neurotransmitter nyob rau hauv ib lub party ntawm ntau yam kab mob. Cov tswv yim ua hauj lwm no pab kom Sunifiram cov hmoov kom ua rau cov khoom siv zog tiv thaiv kev ruaj ntseg.

Cov lus qhia ntxiv

Sunifiram hmoov kuj tseem tuaj yeem tiv thaiv kom tsis txhob muaj qhov ua rau lub cev tsis zoo los ntawm cov nicotinic antagonist mecamylamine, GABAB agonist baclofen, α2 agonist clonidine thiab AMPA receptor antagonist NBQX nyob rau hauv txoj kev kuaj tsis zoo.

Nyob hauv tus nas Morris dej tshawb tshawb xyuas, kev tswj hwm ntawm scopolamine inhibits qhov txo ntawm txoj kev khiav ntawm lub qhov qub thiab kev tuav pov hwm retraining xeem. Tshem cov hmoov nplej, muab 20 min ua ntej txhua qhov kev kawm niaj hnub, muaj peev xwm tiv thaiv scopolamine induced nco qhov tsis taus ntawm 0.1 mg / kg ip

Sunifiram hmoov ua cov tshuaj tiv thaiv thiab ua kom tsis muaj teeb meem tsis pom muaj hauv cov cwj pwm ntawm cov nas lossis nas, thiab 0.1 mg / kg IP, Sunifiram hmoov txo lub sijhawm ntawm hypnosis vim yog pentobarbital hauv nas tsis hloov kho lub sijhawm hypnosis. Tsis tas li ntawd, cov nas tsuag kho nrog Sunifiram nyoos hmoov tuav lub cev sib haum xeeb hauv kev ntsuas ntawm rotarod. Lub cev ntom nti ntawm cov nas, ntsuas los ntawm Animex khoom siv, thiab kev tshawb xyuas tus cwj pwm, ntsuam xyuas los ntawm qhov kev ntsuam xyuas qhov kev sib tw, nyob twj ywm tom qab Sunifiram hmoov.

Tshem tawm ntawm cov hmoov hloov hmoov cholinergic kis tau rau hauv lub paj hlwb cortex ntawm cov nthwv dej dawb. Raws li pom ntawm microdialysis thwmsim, Sunifiram hmoov yog tau nce qhov kev tso tawm ntawm ACh ntawm ib koob tshuaj 0.01 mg / kg, nrog zog muaj zog dua li Unifiram.

Raug tshuaj nas hippocampal slices rau 100 μM NMDA yog ib qho kev nce ntxiv ntawm [3H] NE (48). Cov nyhuv ntawm NMDA yog kev tiv thaiv los ntawm 100 μM kynurenic acid (KYNA). Sib ntxiv ntawm nanomolar ntau ntau ntawm cov kua txig Sunifiram nyoos pauv nws cov kab mob KYNA kev sib nkag siab. Cov nyom ntawm Sunifiram hmoov yog concentration-dependent (EC50 0.1 μM) thiab yuav luag tiav ntawm 1 μM.

Kev koom tes ntawm AMPA receptors tuaj yeem soj ntsuam los ntawm kev thov ntawm AMPA tus neeg pleev phom antagonist NBQX. Thaum ua ntawv thov 5 μM, NBQX txwv tsis pub cov [3H] NE tso tawm los ntawm AMPA (100 μM), tiam sis tsis yog 100 μM NMDA-mediated tritium tawm ntawm nas hippocampal slices (48). NBQX, tsis vam nws tus kheej, ua rau lub Sunifiram rwa hmoov hloov ntawm KYNA antagonism ntawm NMDA-evoked tritium tawm, tawm tswv yim koom tes ntawm AMPA cov neeg txais khoom nyob rau hauv cov teebmeem ntawm Sunifiram hmoov.

Txaus siab rau, Cov kev kho cov tshuaj hu ua Sunifiram ntau dua PKCa (Ser-657) thiab Src tsev neeg (Tyr-416) cov kev ua si nrog tib lub voj voog uas tau txais kev kho mob raws li LTP, hla 10 nM. Qhov nce ntawm phosphorylation ntawm PKCa (Ser-657) thiab Src (Tyr-416) vim tias Sunifiram hmoov tau raug kho los ntawm kev kho 7-ClKN. Lub LTP li ntawm Sunifiram cov hmoov nyoos tau ua rau hauv PP2, hauv tsev neeg Src.

Thaum kawg, thaum pretreated nrog lub siab concentration ntawm glycine (300 lM), Sunifiram hmoov kho tsis tau ua rau lub zog LTP hauv cheeb tsam CA1.

Tawm ua ke, cov lus pov thawj saum toj no pom zoo tias Sunifiram nyoos hmoov stimulates tus glycine-binding site ntawm NMDAR nrog PKCa ua ke ntawm Src kinase. Li PKCa kev ua rau ua rau muaj zog ntawm Hippocampal LTP los ntawm CaMKII kom ua.

Sunifiram (DM235) Nqaij Hmaw

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua haujlwm tom qab them nqi.

DM235 hmoov muag

Kom muab rau yav tom ntej tom ntej.


Yuav ua li cas yuav DM235 hmoov: yuav Sunifiram hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


COA

HNMR

Sunifiram (DM235) hmoov (314728-85-3) hplc = 98% | AASraw lwm tus neeg HNMR

Zaub mov txawv

Sunifiram (DM235) Nqaij Khoom Noj Hmoov Noj:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations

Yuav ntse Drug Sunifiram hmoov hauv online

Lub 7 Zoo Tsis Nootropics (Ntse Tshuaj) nyob rau hauv kev ua lag luam ntawm Sunifiram