Cov Tshuaj Qib 7 Hauv Kev Kho Mob Rau Cov Mob Hlwb Mob Cancer-Pom Zoo los ntawm FDA
AASraw ua rau Cannabidiol (CBD) hmoov thiab Hemp Roj tseem ceeb hauv qhov ntau!

Mob ntsws Cancer

    1. Mob ntsws yog dab tsi?
    2. Hom Mob Kauj Mob Hlwb Yog Dab Tsi?
    3. Cov tsos mob zoo li cas Thaum Koj Muaj Mob ntsws Cancer?
    4. Yuav Ua Li Cas Kuv thiaj Paub Tias Kuv Muaj Mob Qog Cancer?
    5. Dab tsi yog Ntu Ntawm Kuv Mob ntsws?
    6. Vim Li Cas Kuv Thiaj Muaj Mob Cancer?
    7. Yuav kho koj cov mob ntsws kom zoo li cas?

 

Mob ntsws yog dab tsi?

Kab mob khees xaws tuaj yeem pib txhua qhov chaw hauv lub cev. Kab mob khees xaws pib hauv lub ntsws yog hu ua mob qog noj ntshav. Nws pib thaum cov cell nyob hauv lub ntsws loj tuaj mus rau txoj kev tswj hwm thiab cais tawm cov qe ua ib txwm muaj. Qhov no ua rau nws nyuaj rau lub cev ua haujlwm txoj kev uas nws yuav tsum tau.

Cov kabmob kheesxaws tuaj yeem kis mus rau lwm qhov ntawm lub cev. Kab mob khees xaws hauv lub ntsws qee zaum tuaj yeem mus ncig rau lub hlwb thiab loj hlob nyob ntawd. Thaum cov qog nqaij hlav cancer ua qhov no, nws hu ua metastasis. Cov kws kho mob, cov qog nqaij hlav cancer nyob rau hauv qhov chaw tshiab zoo li tsuas yog cov ntawm cov ntsws.

Mob cancer yog ib txwm muaj npe rau qhov chaw uas nws pib. Yog li thaum mob ntsws kis mus rau lub hlwb (lossis lwm qhov chaw), nws tseem tseem hu ua mob ntsws. Nws tsis hu ua mob hlwb tshwj tsis yog tias nws pib los ntawm cov kab mob hauv lub hlwb.

Sau cia: Lub ntsws muaj 2 daim txhuam cev-zoo li cov kabmob hauv lub hauv siab. Txoj cai ntsws muaj 3 ntu hu ua lobes. Lub ntsws sab laug muaj 2 lub lobes. Lub ntsws ua pa tawm rau hauv thiab tawm ntawm lub cev. Lawv nyob rau hauv oxygen thiab rhuav tshem cov pa roj carbon dioxide, uas yog cov khoom pov tseg.

Kev txoj pa lossis txoj pa me me, coj cua mus rau hauv lub ntsws. Nws faib rau 2 leeg hu ua bronchi (ib txoj hlab hu ua bronchus).

 

Mob ntsws Cancer

Hom Mob Kauj Mob Hlwb Yog Dab Tsi?

Kab mob khees xaws pib hauv lub ntsws yog hu ua mob ntsws thawj. Mob kheesxaws uas kis mus rau lub ntsws los ntawm lwm qhov chaw hauv lub cev hu ua cancer mob ntsws thib ob. Nplooj ntawv no yog hais txog tus mob ntsws thawj zaug.

Nws muaj ob hom mob tseem ceeb ntawm cov qog ua cancer. Cov no tau faib raws cov qauv hlwb uas cov qog nqaij hlav pib loj zuj zus. Lawv yog:

Cov kab mob ntsws uas tsis mob me meNSCLC) - - daim foos tshaj plaws, tso nyiaj rau ntau dua 87% ntawm cov teeb meem. Nws tuaj yeem yog ib ntawm peb hom: squamous cell carcinoma, adenocarcinoma lossis loj-cell carcinoma.

Cov kab mob ntsws me-cell (SCLC) - ib daim ntawv dua uas feem ntau kis sai dua li cov mob ntsws uas tsis yog-me-hlwb.

Hom mob ntsws uas koj tau txiav txim siab txog yam kev kho mob twg pom zoo.

 

Cov tsos mob zoo li cas Thaum Koj Muaj Mob ntsws Cancer?

Cov neeg muaj mob ntsws yuav tsis muaj cov tsos mob kom txog qib tom qab. Yog tias pom cov tsos mob tshwm sim, lawv tuaj yeem zoo li cov pa ntawm tus neeg muaj kab mob ua pa.

 

Qee cov tsos mob tshwm sim Source:

▪ hloov pauv mus rau lwm tus neeg lub suab, xws li txhaws qa

▪ nquag mob hauv siab, xws li mob ntsws lossis mob ntsws

▪ mob rau ntawm cov qog ntshav hauv plawv

Cough qhov hnoos ntev uas yuav pib mob heev dua

▪ mob hauv siab

Breath txog siav ua pa thiab hawb pob

 

Hauv lub sijhawm, tus neeg kuj yuav pom cov tsos mob hnyav ntxiv, xws li:

Chest mob hauv siab ceev heev

Mob mob pob txha thiab pob txha tawg

Aches mob taub hau

Hnoos tau ntshav

Ots cov ntshav txhaws

▪ qab los noj mov thiab poob ceeb thawj

▪ qaug zog

 

Mob ntsws Cancer

 

Yuav Ua Li Cas Kuv thiaj Paub Tias Kuv Muaj Mob Qog Cancer?

Tus kws kho mob nug koj txog koj li kev noj qab haus huv thiab kuaj lub cev. Yog tias cov cim qhia tau tias mob qog noj ntshav, yuav kuaj ntxiv.

Nov yog qee qhov kev sim uas koj xav tau:

Xoos xoo fais fab: Qhov no feem ntau yog thawj qhov sim ua los saib rau pob rau koj lub ntsws. Yog tias qhov hloov pauv tau pom, koj yuav tsum tau kuaj ntxiv.

CT scan: Qhov no tseem hu ua CAT scan. Nws yog qhov tshwj xeeb xoo hluav taws xob uas siv cov duab ntxaws ntxaws ntawm koj sab hauv. Kev thaij duab CT kuj tseem siv tau los pab ua qhov nqus (saib hauv qab).

Tus tsiaj scan: Hauv qhov kev ntsuas no, koj tau muab hom qab zib uas tuaj yeem pom sab hauv koj lub cev nrog lub koob yees duab tshwj xeeb. Yog tias nws muaj mob qog nqaij hlav, qab zib qhia tias yog “pob kub” qhov chaw muaj kabmob qog. Nws tuaj yeem pab tau thaum koj tus kws kho mob xav tias mob cancer tau kis, tab sis tsis paub qhov twg.

Bronchoscopy: Ib qho thin, lighted, saj zawg zog raj tau dhau los ntawm koj lub qhov ncauj mus rau hauv lub bronchi. Tus kws kho mob tuaj yeem saib ntawm txoj yas kom pom cov qog. Lub raj kuj tseem siv tau los ua qhov thev me.

Kev kuaj ntshav: Kev kuaj ntshav tsis yog siv los kuaj mob ntsws, tab sis lawv tau ua rau qhia tus kws kho mob ntxiv txog koj li kev noj qab haus huv.

 

Mob ntsws Cancer

 

Dab tsi yog Ntu Ntawm Kuv Mob ntsws?

Yog tias koj muaj mob qog nqaij hlav cancer hauv lub hnab me, tus kws kho mob yuav xav nrhiav pom tias nws kis tau mus ntev npaum li cas. Qhov no hu ua staging. Koj yuav tau hnov ​​lwm tus neeg hais tias lawv cov mob cancer yog “theem 2” lossis “theem 3.” Koj tus kws kho mob yuav xav nrhiav qhov theem ntawm koj mob cancer los pab txiav txim siab seb hom kev kho mob twg thiaj zoo rau koj.

Cov theem piav qhia txog kev kis mob qog nqaij hlav mus thoob ntsws. Nws tseem qhia tau tias yog tias mob cancer kis mus rau cov kabmob lossis cov kabmob uas nyob deb dua.

Koj theem yuav yog theem 1, 2, 3, lossis 4. Tsawg dua tus naj npawb, tsawg tus kabmob kis tau. Cov lej ntau dua, xws li theem 4, txhais tau hais tias yog mob qog noj ntshav hnyav dua uas tau kis tawm sab nraud koj lub ntsws. Nco ntsoov nug tus kws kho mob txog koj qhov mob qog noj theem thiab txhais tau li cas.

 

(1) Qib Ntawm Cov Neeg Mob Tsis Yog Cov Kuaj Cell Kuaj

Cov kws kho mob feem ntau siv cov qog loj thiab sib kis los piav qhia txog cov theem ntawm cov mob ntsws uas tsis yog cov noob qes, raws li nram no

Ntau, lossis zais rau: Tus kab mob cancer tsis tshwm sim los ntawm kev soj ntsuam, tab sis cov qog nqaij hlav cancer yuav tshwm sim hauv lub hnoos qeev lossis hnoos qeev.

theem 0: Muaj cov qe ntshav tsis zoo tsuas yog cov txheej txheej sab saum toj ntawm cov kab ua txoj hlab pa.

theem 1: Cov qog tawm nyob rau hauv lub ntsws, tab sis nws yog 4 centimeters (cm) lossis hauv qab thiab tsis kis mus rau lwm qhov ntawm lub cev.

 theem 2: Cov qog nqaij hlav 7 cm lossis qis dua thiab tej zaum yuav kis rau cov nqaij thiab cov qog ntshav nyob ze.

theem 3: Tus kabmob tau kis mus rau cov qog ntshav thiab mus txog rau lwm qhov chaw ntawm lub ntsws thiab ib puag ncig thaj tsam.

theem 4: Tus kabmob tau kis mus rau lub cev deb, xws li cov pob txha lossis mob hlwb.

 

(2) xyaum Of Skhw Cell LUng Ctus muab tshuaj

Tus kab mob ntsws me ntawm lub ntsws muaj nws cov pawg. Cov theem uas peb paub muaj tsawg thiab dav heev, thiab lawv hais txog seb puas mob cancer tau kis mus rau sab hauv lossis sab nraud lub ntsws.

Hauv theem qee, tus kabmob tsuas cuam tshuam rau ib sab ntawm lub hauv siab xwb, txawm hais tias tej zaum nws tsuas muaj qee qhov hnoos qog nyob ib puag ncig. Nyob ib ncig ntawm ib feem peb ntawm cov neeg uas muaj hom no pom tias lawv muaj mob qog noj ntshav thaum nws nyob hauv theem qis. Cov kws kho mob tuaj yeem kho nws nrog kho hluav taws xob raws li thaj chaw xwb.

Hauv cov theem uas dav, mob cancer kis tau dhau ntawm ib sab ntawm lub hauv siab. Nws yuav cuam tshuam rau lwm lub ntsws lossis lwm qhov ntawm lub cev. Nyob ib ncig ntawm ob feem peb ntawm cov neeg uas muaj cov mob ntsws me me ntawm lub ntsws tau tshawb pom tias lawv muaj nws thaum nws twb nyob hauv theem loj.

 

Vim Li Cas Kuv Thiaj Muaj Mob Cancer? 

Kab mob khees-xaws tshwm sim tom qab kev tshuaj ntsuam kev puas tsuaj rau DNA thiab epigenetic hloov. Cov kev hloov pauv cuam tshuam rau lub cell ua haujlwm ib txwm, suav nrog kev nthuav tawm ntawm tes, kev tuag ntawm tes (apoptosis), thiab kho DNA. Raws li kev puas tsuaj ntau ntxiv, qhov kev pheej hmoo rau mob qog noj ntshav nce zuj zus.

Cov laj thawj no ua rau lub ntsws mob manily:

Vim Li Cas Kuv Thiaj Muaj Mob Cancer

 

 

Kev haus luam yeeb

Tsis yog txhua tus haus luam yeeb yuav mob qog noj ntshav, thiab tsis yog txhua tus neeg uas mob qog noj ntshav yog haus luam yeeb. Tab sis tsis muaj ib qho tsis txaus ntseeg tias kev haus luam yeeb yog qhov muaj kev phom sij loj tshaj plaws, ua rau 9 tawm ntawm 10Trusted Tau qhov twg los mob qog nqaij hlav. Ntxiv rau luam yeeb, luam yeeb loj thiab haus luam yeeb yeeb kuj tseem cuam tshuam rau cov ntsws mob ntsws. Koj haus luam yeeb ntau thiab ntev koj haus luam yeeb, koj yuav muaj feem mob cancer qog ntau dua.

Koj tsis tas yuav yog tus neeg haus luam yeeb yuav raug cuam tshuam. Kev ua pa rau lwm tus neeg haus luam yeeb ua rau muaj feem mob ntsws. Raws li Lub Chaw Tiv Thaiv Kab Mob thiab Tiv Thaiv CDC) Lub Chaw Cia Siab, neeg haus luam yeeb muaj lub luag haujlwm rau txog 7,300 tus neeg mob cancer tuag txhua xyoo hauv Tebchaws Meskas.

Cov khoom luam yeeb muaj ntau tshaj 7,000 tshuaj, thiab tsawg kawg 70 paub tias ua rau mob qog nqaij hlav.

Thaum koj nqus tau cov pa luam yeeb, cov tshuaj sib tov no xa ncaj qha rau koj lub ntsws, uas tam sim ntawd pib ua kev puas tsuaj.

Lub ntsws feem ntau tuaj yeem kho kev puas tsuaj thaum xub thawj, tab sis cov kev txuas ntxiv txuas ntxiv rau cov ntaub so ntswg tau nyuaj los tswj hwm. Yog thaum lub hlwb tsis zoo tuaj yeem hloov pauv thiab loj hlob ntawm txoj kev tswj hwm. Cov tshuaj uas koj nqus tau nkag rau hauv koj cov hlab ntshav thiab nqa mus thoob koj lub cev, ua kom muaj kev pheej hmoo lwm yam mob qog ntshav ntau. Cov neeg haus luam yeeb yav dhau los tseem muaj feem yuav mob qog nqaij hlav cancer, tab sis kev txiav luam yeeb tuaj yeem txo qis qhov kev pheej hmoo ntawd ntau heev. Tsis pub dhau 10 xyoo txiav tawm, txoj kev pheej hmoo ntawm kev tuag los ntawm ntsws cancer poob ib nrab.

 

Radon roj

Radon yog cov xim tsis muaj ntxhiab thiab tsw ntxhiab roj los ntawm kev tawg ntawm cov xov tooj cua radium, uas nyob rau hauv lem yog cov khoom puas ntawm uranium, pom hauv ntiaj teb ua kaub puab. Cov hluav taws xob zom khoom hluav taws xob ionize cov khoom siv hauv caj ces, ua rau kev hloov pauv uas qee zaum ua rau neeg mob. Radon yog qhov muaj feem thib ob ntawm cov mob ntsws nyob hauv Asmeskas, ua rau muaj txog 21,000 tus neeg tuag txhua xyoo. Qhov kev pheej hmoo nce 8-16% rau txhua 100 Bq / m³ nce rau hauv radon concentration.Radon qib roj sib txawv los ntawm thaj chaw thiab cov lus sib xyaw ntawm qhov pib av thiab pob zeb. Kwv yees li ib ntawm 15 lub tsev hauv Teb Chaws Asmeskas muaj radon theem siab tshaj cov lus qhia pom zoo ntawm 4 picocuries rau ib litre (pCi / l) (148 Bq / m³).

 

Asbestos

Asbestos tuaj yeem ua rau ntau yam mob ntsws xws li mob ntsws. Kev haus luam yeeb thiab cov pa luam yeeb ob leeg puav leej muaj txiaj ntsig zoo rau kev tsim mob qog nqaij hlav cancer.Thaum cov neeg haus luam yeeb ua haujlwm nrog asbestos, kev pheej hmoo ntawm kev mob qog noj ntshav nce ntxiv 45-npaug piv rau cov pej xeem. qhov tiag yog txawv ntawm mob ntsws.

 

Cov pa phem

Cov pa phem nyob sab nraum zoov, tshwj xeeb yog cov tshuaj tawm los ntawm qhov hlawv cov roj pob txha, ua rau muaj kev pheej hmoo mob ntsws ntsws.Fine particulates (PM2.5) thiab sulfate aerosols, uas yuav raug tso tawm hauv cov pa hluav taws tso pa, cuam tshuam nrog kev pheej hmoo me ntsis. Rau cov pa roj carbon dioxide, nce ntau ntxiv ntawm 10 ntu ib nphom ua rau muaj kev pheej hmoo mob ntsws ntau dua 14% .Ntawm huab cua huab cua nyob sab nraud tau kwv yees ua rau 1–2% ntawm mob ntsws.

Cov ntaub ntawv pov thawj txhawb nqa kev pheej hmoo ntawm mob ntsws los ntawm cov pa phem hauv tsev muaj feem cuam tshuam nrog kev hlawv cov ntoo, hluav ncaig, hmoov av, lossis qoob loo rau kev ua noj thiab cua sov.Women uas tau raug cov pa luam yeeb hauv tsev muaj qee yam kev pheej hmoo ob zaug, thiab ntau ntau cov khoom lag luam tawm ntawm kev hlawv cov roj ntsha biomass tau paub lossis xav tias yog cov carcinogens.Qhov kev pheej hmoo no cuam tshuam txog 2.4 txhiab tus neeg thoob ntiaj teb, thiab ntseeg tau tias 1.5% ntawm kev tuag mob ntsws.

 

noob caj noob ces

Txog 8% ntawm mob ntsws yog los ntawm cov keeb caj ces.Qhov cov txheeb ze ntawm cov neeg uas tau kuaj pom tias muaj qog mob ntsws ntsws, qhov kev pheej hmoo yog ob npaug, tej zaum vim yog kev sib xyaw ntawm cov noob.Polymorphism ntawm cov keebkwm 5, 6, thiab 15 paub tias cuam tshuam rau kev pheej hmoo ntawm mob ntsws cancer.Single-nucleotide polymorphisms (SNPs) ntawm cov noob encoding nicotinic acetylcholine receptor (nAChR) - CHRNA5, CHRNA3, thiab CHRNB4 - yog ntawm cov cuam tshuam nrog kev pheej hmoo ntawm mob ntsws, nrog rau RGS17 - ib caj tswj hwm G-protein cov paib.

 

lwm yam yog vim li cas

Ntau ntau lwm yam tshuaj, cov haujlwm thiab ib puag ncig kev sib kis tau cuam tshuam txog mob ntsws. Lub Koom Haum International rau Kev Tshawb Nrhiav Kab Mob Cancer (IARC) hais tias nws muaj qee qhov "pov thawj txaus" los qhia tias cov hauv qab no yog cov kabmob tua kabmob hauv lub ntsws:

Qee cov hlau ua (cov khoom txhuas, cadmium thiab cadmium tebchaw, chromium (VI) tebchaw, beryllium thiab beryllium tebchaw, hlau thiab hlau pom, nickel tebchaw, arsenic thiab inorganic arsenic compounds, thiab underground hematite mining)

Qee cov khoom siv ntawm kev sib txuas (cov kev sib txuas tsis tiav, cov roj zeb (cov pa tawm sab hauv tsev los ntawm cov tsev neeg hlawv cov roj), cov roj av ua haujlwm, cov txhab roj av ntxig, coke ntau lawm, cov pa roj av, thiab lub tshuab hluav taws xob diesel roj)

Kev ntsuas hluav taws xob (X-ray thiab gamma).

Qee qhov muaj kuab lom (methyl ether (technical qib), thiab bis- (chloromethyl) ether, sulfur mustard, MOPP (vincristine-prednisone-nitrogen mustard-procarbazine sib xyaw) thiab pa taws los ntawm kev pleev xim)

Cov roj hmab ntau lawm thiab crystalline silica hmoov av.

Muaj feem me me ntawm kev pheej hmoo mob ntsws mob ntsws rau cov neeg uas raug cuam tshuam los ntawm cov kab mob sclerosis.

 

Yuav kho koj cov mob ntsws kom zoo li cas? 

Muaj ntau txoj hauv kev los kho tus mob ntsws. Kev phais mob thiab hluav taws xob tau siv los kho qog nqaij hlav xwb. Lawv tsis cuam tshuam rau lwm tus lub cev. Chemo siv yeeb tshuaj, tsom kev kho, thiab txhaj tshuaj mus rau tag nrho lub cev. Lawv tuaj yeem mus txog rau cov kab mob cancer yuav luag txhua qhov chaw hauv lub cev.

 

Kev kho mob qog noj ntshav tuaj yeem suav nrog kev phais mob, hluav taws xob, tshuaj khomob, phiaj xwm kho, thiab tiv thaiv kab mob. Qhov kev npaj khomob uas zoo tshaj plaws rau koj yuav yog nyob ntawm:

Theem mob cancer

Muaj caij nyoog tias hom kev kho mob yuav pab tau

▪ Koj lub hnub nyoog

▪ Lwm yam teeb meem kev noj qab haus huv koj muaj

Koj cov kev xav txog kev kho mob thiab cov kev mob tshwm sim uas yuav los nrog nws.

 

Mob ntsws Cancer

 

Ntau tus neeg mob uas mob ntsws xaiv tshuaj kho mob hauv cov theem thaum ntxov, vim tias nws yog txoj kev tshaj thiab yooj yim los tswj kev kis tus mob qog noj ntshav. Cov tshuaj hauv qab no feem ntau siv los kho mob ntsws (SCLC thiab NSCLC):

 

❶ AZD-3759 (CAS: 1626387-80-1)

AWM-3759 yog ib qho muaj zog loj qhov ua kom mob loj ntxiv receptor (EGFR) inhibitor, nrog rau kev muaj peev xwm ua haujlwm antineoplastic. AZD-3759 muab khi rau thiab txwv tsis pub muaj kev ua haujlwm ntawm EGFR nrog rau qee yam kev hloov pauv ntawm EGFR.Qhov no tiv thaiv EGFR-mediated cov paib, thiab tuaj yeem ua rau ob leeg tawm ntawm cell tsis zoo thiab kev txwv ntawm qog loj hlob hauv EGFR-overexpressing hlwb.

Cov ntsws mob ntsws AZD 3759

 

❷ Gefitinib (CAS: 184475-35-2)

Gefitinib yog ib qho tyrosine kinase inhibitor siv los ua thawj txoj kev kho los kho cov kabmob tsis muaj kabmob me rau cov leeg mob ntsws carcinoma (NSCLC) uas tau ntsib qee yam kev hloov caj ces.

Gefitinib yog ib qho inhibitor ntawm qhov chaw loj hlob ntawm tus kabmob (EGFR) tyrosine kinase uas khi rau adenosine triphosphate (ATP) -binding qhov chaw ntawm enzyme. EGFR feem ntau pom tias muaj ntau dhau heev nyob rau qee cov qog nqaij hlav cancer neeg, xws li mob ntsws thiab mob qog mis. Overexpression ua rau kev ua kom zoo dua ntawm cov anti-apoptotic Ras teeb liab transduction cascades, tom qab ntawd ua rau kom muaj sia nyob ntawm cov qog nqaij hlav cancer thiab tswj tsis tau ntawm tes. Gefitinib yog thawj qhov kev xaiv tshuaj loog ntawm EGFR tyrosine kinase uas tseem hu ua Her1 lossis ErbB-1. Los ntawm inhibiting EGFR tyrosine kinase, cov nqes dej uas tsis muaj kev cuam tshuam tseem ceeb raug cuam tshuam, uas ua rau muaj kev cuam tshuam tsis zoo rau cov kab mob ntawm tes.

 

AWM-9291(CAS: 1421373-65-0)

AZD-9291 tseem tseem hu ua Osimertinib uas yog tyrosine kinase inhibitor siv nyob rau hauv kev kho qee yam mob uas tsis yog me me ntawm lub ntsws mob carcinoma.

AWM-9291 yog ib qho kev loj hlob nthuav dav receptor (EGFR) tyrosine kinase inhibitor (TKI) uas khi rau qee yam mob ntawm EGFR (T790M, L858R, thiab exon 19 tshem tawm) uas ua ntej cov mob ntsws tsis mob qog nqaij hlav (NSCLC) cov qog tom qab kho nrog thawj zaug -line EGFR-TKIs. Raws li lub koob thib peb ntawm tyrosine kinase inhibitor, AZD-9291 yog tshwj xeeb rau lub rooj sib tw-keeper T790M hloov uas nce ATP khi kev ua haujlwm rau EGFR thiab ua rau muaj kev soj ntsuam tsis zoo rau tus kab mob lig-theem. Tsis tas li ntawd, AZD-9291 tau pom tias yuav tso tseg cov tsiaj qus hom EGFR thaum kho, yog li txo qhov tsis khi thiab khi muaj cov kuab lom.

Cov ntsws mob ntsws AZD 9291

 

Ac Dacomitinib (CAS: 1110813-31-4)

Dacomitinib yog cov tshuaj siv los kho tsis mob qog nqaij hlav cancer me me nrog EGFR exon 19 tshem tawm ntawm exon 21 L858R hloov chaw. Dacomitinib, tsim raws li (2E) -N-16-4- (piperidin-1-yl) tab sis-2-enamide, yog qhov ncauj xaiv tau zoo quinazalone ib feem ntawm tiam thib ob tiam tyrosine kinase inhibitors uas tau pom los ntawm qhov tsis muaj kev cuam tshuam ntawm ATP sau ntawm phaum epidermal kev loj hlob tau receptor tsev neeg kinase puav. Dacomitinib yog ib qho tshuaj rau kev kho mob uas tsis yog-tus me-cov ntsws mob ntsws carcinoma (NSCLC). Nws yog qhov xaiv xaiv thiab tsis hloov pauv ntawm EGFR.

 

Er Ceritinib (CAS: 1032900-25-6)

Ceritinib tseem hu ua LDK378 uas yog antineoplastic kinase inhibitor siv los kho anaplastic lymphoma kinase (ALK) -positive metastatic tsis-me me cell mob ntsws (NSCLC) hauv cov neeg mob uas tsis muaj qhov tsis txaus hauv chaw kho mob lossis tsis nkag rau hauv crizotinib.

Ceritinib yog siv rau kev kho mob ntawm cov neeg laus uas muaj cov kab mob tsis haum rau lub cev (ALK) -positive metastatic tsis yog mob qog nqaij hlav hauv hlwb tsawg (NSCLC) tom qab tsis ua tiav (theem nrab ntawm kev tawm tsam lossis tsis nkag siab) ntawm kev kho mob ua ntej crizotinib. Kwv yees li 4% ntawm cov neeg mob NSCLC muaj cov roj teeb rov qab uas tsim cov fusion caj nruab nrab ntawm EML4 (echinoderm microtubule-txuam cov protein zoo li 4) thiab ALK (anaplastic lymphoma kinase), uas ua rau muaj kev ua haujlwm ntawm kinase uas ua rau carcinogenesis thiab zoo li tsav cov malignant phenotype. Ceritinib tshaj tawm nws txoj kev kho mob tshwm sim los ntawm kev ua kom tsis txhob muaj kabmob autophosphorylation ntawm ALK, ALK-mediated phosphorylation ntawm cov roj ntsha qis hauv cov pa roj ntsha STAT3, thiab kev loj hlob ntawm ALK-qog mob hlwb. Tom qab kho nrog crizotinib (thawj cov tshuaj ALK inhibitor), cov qog feem ntau tsim tshuaj tiv thaiv vim muaj kev sib hloov hauv cov tseem ceeb ntawm "tus neeg zov me nyuam" cov seem ntawm cov enzyme. Qhov tshwm sim no tau coj mus rau kev tsim kho tshiab ntawm lub cim thib ob-tiam ALK inhibitors xws li ceritinib kom kov yeej crizotinib tsis kam. FDA tau pom zoo ceritinib thaum Lub Plaub Hlis 2014 vim tias muaj qhov txawv txav ntawm qhov lus teb siab (56%) ntawm crizotinib-thaum cov qog ua kom zoo thiab tau xaiv nws nrog cov xwm txheej tsis zoo rau cov menyuam yaus.

 

❻ Afatinib (CAS: 439081-18-2)

Afatinib yog cov tshuaj tua kab mob antineoplastic siv rau kev kho mob hauv zos ua ntej lossis metastatic tsis yog mob qog nqaij hlav cancer hauv hlwb tsawg (NSCLC) nrog kev tsis hloov tshuaj tiv thaiv EGFR los yog kev ua kom mob platinum-tshuaj khomob.

Afatinib yog 4-anilinoquinazoline tyrosine kinase inhibitor nyob rau hauv daim ntawv ntawm cov dimaleate ntsev muaj li Boehringer Ingelheim lub npe lag luam Gilotrif. Rau kev siv qhov ncauj, afatinib ntsiav tshuaj yog thawj-kab (xub pib) kev kho mob rau cov neeg mob uas muaj metastatic tsis yog mob ntsws ntawm tes ntsws qog nqaij hlav (NSCLC) nrog cov kev sib kis mob feem ntau kis tau tus kabmob (EGFR) kev hloov pauv tau tshawb pom los ntawm FDA pom zoo kuaj 4. Gilotrif afatinib) yog thawj zaug pom zoo FDA oncology khoom los ntawm Boehringer Ingelheim.

 

❼ Erlotinib (CAS: 183321-74-6)

Erlotinib yog ib qho EGFR tyrosine kinase inhibitor siv los kho qee yam mob ntsws me me ntawm tes mob qog nqaij hlav cancer los yog ua nqaij hlav hlav tawm sai. Nws belongs rau chav kawm ntawm cov tshuaj hu ua tyrosine kinase inhibitors. Nws ua haujlwm los ntawm thaiv qhov ua haujlwm ntawm cov protein hu ua epidermal growth factor receptor (EGFR). EGFR yog pom nyob rau ntawm ntau cov qog nqaij hlav cancer ntshav nrog rau cov cell ua ib txwm muaj. Nws ua haujlwm zoo li "tus kav hlau txais xov," txais cov cim qhia los ntawm lwm lub hlwb thiab ib puag ncig uas qhia lub cell kom loj tuaj thiab faib. EGFR ua lub luag haujlwm tseem ceeb hauv kev loj hlob thiab kev loj hlob ua ntej yug menyuam thiab thaum menyuam yaus thiab pab tswj kev hloov qub chaw ntawm cov qub thiab puas hlwb hauv cov laus. Txawm li cas los xij, ntau cov kabmob kheesxaws muaj qhov tsis txaus ntawm EGFR ntawm lawv qhov chaw, lossis lawv cov EGFR tau hloov pauv los ntawm kev hloov pauv ntawm DNA uas nqa cov caj ces rau cov protein. Qhov tshwm sim yog tias cov cim taw qhia los ntawm EGFR muaj ntau dhau, ua rau muaj kev loj hlob ntawm tes thiab kev faib tawm ntau, yog qhov pom ntawm kev mob qog nqaij hlav.

Tag nrho cov tshuaj no tuaj yeem muab los ntawm Piv txwv nyob rau hauv daim ntawv ntshiab hmoov, uas yog rau kev tshawb fawb lub hom phiaj. Txais tos tiv toj nrog aasraw yog tias koj xav paub ntau ntxiv txog kev yuav tshuaj aganist ntsws mob qog ntshav!

 

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