AASraw tsim NMN thiab NRC hmoov hauv qhov ntau!

Coluracetam

Racetam Tsev Neeg Nootropic– Coluracetam

Coluracetam (BCI-540, lossis MKC-231) yog qhov tsis muaj roj-soluble nootropic hauv racetam-chav kawm sib txuas. Coluracetam muaj ntau zog ntau dua li cov thawj racetam, PiracetamCov. Coluracetam tau raug daim ntawv tso cai los ntawm Mitsubishi Tanabe Pharma ntawm Nyij Pooj xyoo 2005. Ua rau nws ua ib qho tshiab tshaj plaws racetam-based nootropics.

Tus Patent rau Coluracetam tom qab muag rau BrainCells, Inc. hauv San Diego, California. BrainCells yog lub tuam txhab me me, tus kheej ntiag tug tuav biopharmaceutical tshwj xeeb hauv kev tsim cov khoom sib txuas rau kev kho mob ntawm qhov tsis txaus siab (MDD), kev kho mob tiv thaiv kev nyuaj siab (TRD), thiab Alzheimer's Kab Mob.

Coluracetam zoo sib xws hauv cov qauv rau Piracetam. Thiab zoo li txhua yam racetam nootropics, muaj lub pyrrolidone nucleus ntawm nws cov tub ntxhais. Cov kev tshawb fawb soj ntsuam kawg qhia tau tias muaj peev xwm kho kev mob siab tsis zoo, thiab rov qab thiab cov leeg puas tsuaj.

Coluracetam yog cov muaj zog heev choline tsom ntsoov rau supplementCov. Nws ua rau koj lub hlwb hloov choline hloov pauv rau acetylcholine (ACh) los ntawm cov txheej txheem zoo siab choline uptake (HACU) txheej txheem. Uas ua rau kom muaj kev ceeb toom, ua rau kom paub meej thiab nco.

Qee cov kev tshawb fawb, thiab kev paub ntawm tus kheej qhia Coluracetam tuaj yeem cuam tshuam AMPA receptors. Ua nws lub peev xwm ampakine nootropic. Qhov no tuaj yeem piav qhia cov hom-xav li tus yam ntxwv yam tsis muaj kev phiv los ntawm cov tshuaj stimulants. Coluracetam tseem qhia tau qee qhov kev mob siab (los tiv thaiv kev ntxhov siab) zoo los pab txhim kho kev mob siab thiab ntsiag to ntxhov siab.

 

Yuav ua li cas Cmamacetam Tej hauj lwm(Mechanism ntawm Kev Ua)

Zoo li feem ntau racetam tebchaw, coluracetam (CAS:135463-81-9) ua haujlwm tshwj xeeb los ntawm kev nce qib ntawm cov neurotransmitter acetylcholine, uas muaj kev cuam tshuam nrog kev kawm, cim xeeb, thiab kev paub.

Txawm li cas los xij, txoj kev uas coluracetam kho cov qib acetylcholine ntau ntau yog qhov tsis zoo. Feem ntau, racetams ua rau acetylcholine ntau lawm los ntawm kev ua kom cov txiaj ntsig tsim nyog, tab sis coluracetam ua li ntawd los ntawm kev ua kom zoo siab choline uptake, lossis HACU. Lub HACU system txiav txim siab tus nqi uas choline raug kos rau neurons rau hloov mus rau hauv acetylcholine.

Los ntawm nce tus nqi uas choline raug twv rau hauv cov hlab ntsha, coluracetam txhawb cov acetylcholine ntau lawm thiab ua rau lub hlwb ntawm qhov tseem ceeb ntawm cov neurotransmitter nce siab ntxiv. rau qhov sai muaj ntawm choline rau kev khaws.

Ua ke cov kev ua no ua rau ntau dua ntawm cov acetylcholine, uas cuam tshuam nrog txhim kho kev txawj ntse thiab kev nco qab.

Coluracetam

cov kev pab cuam thiab los Of Coluracetam

 Coluracetam Txhim kho lub Cim xeeb thiab Kev Kawm

Cov txiaj ntsig Coluracetam ua pov thawj ua haujlwm hauv tswj hwm kev txawj ntse thiab cim xeeb ua haujlwm hauv cov nas thiab cov teebmeem zoo sib xws rau tib neeg. Brain Cells Inc. tau ua qhov kev tshawb fawb uas qhia txog kev txhim kho lub hlwb hauv cov nas tom qab tau txais AF64A rau yim hnub. Txoj kev tsim kho tau txuas mus ntxiv ntev dua li kev kho mob. Tus kab mob Alzheimer ua rau muaj qis dua ntawm acetylcholine. Los ntawm kev loj hlob acetylcholine nyob rau hauv hippocampus, coluracetam yuav nce cov tsos mob ntawm Alzheimer tus kab mob xws li kev kawm tsis zoo thiab nco tsis zoo.

 

 Coluracetam Txo txo ​​Cov Kev Kho Mob-Thaum Muaj Kev Nyuaj Siab

Hauv kev tshawb fawb ntawm 101 tus tib neeg muaj kev nyuaj siab, uas tsis ua tiav cov txiaj ntsig kho nrog kev tiv thaiv kev ntxhov siab, nws muaj qhov cuam tshuam rau kev txhim kho qhov pom kev txhim kho hauv lub neej muaj txiaj ntsig ntawm 80 mg 3 zaug hauv ib hnub. Txawm li cas los xij, qhov no tsuas yog kawm ntawm tib neeg. Lub peev xwm nws tuav txhawm rau txo glutamate tsis muaj dej num tuaj yeem tsim nyog rau nws qhov kev cuam tshuam zoo hauv kev kho kev nyuaj siab.

 

 Coluracetam Txo Cov Kev Ntxhov Siab

Hauv kev soj ntsuam cov nas, txhaj tshuaj 21 hnub ntawm coluracetam qhia pom muaj 20% txhim kho hauv kev ntxhov siab, uas yog siab dua 12% cov nyhuv valium cuam tshuam rau hauv ib zaug hauv tib txoj kev tshawb nrhiav.

 

 Coluracetam Txhawb nqa Neurogenesis

Qee cov kev tshawb fawb tau hais tias nws pab nrog neurogenesis. Thawj qhov kev ua haujlwm tseem tsis meej, tab sis nws cuam tshuam rau kev tswj hwm ntawm nws rau ob peb lub lis piam, uas nce hauv acetylcholine hauv thaj chaw hippocampus. Lub tshuab tsis paub txog, tseem xav tias muaj feem cuam tshuam nrog qhov nce ntawm hippocampal acetylcholine thaum coluracetam yog hnub dosed txhua hnub rau ob peb lub lis piam. ''

 

 Coluracetam Pab nrog Schizophrenia

Coluracetam tsub kom ntau ntxiv cov haujlwm ntawm ChAT nyob rau hauv cov nas uas muaj cov hlab ntsha puas tsuaj. Qhov nce no qhia tias nws yuav muaj txiaj ntsig zoo rau cov neeg mob schizophrenia los ntawm tib qho enzyme no. Tshawb nrhiav ntau ntxiv ncaj qha rau cov neeg muaj tus mob schizophrenia.

 

 Coluracetam Txhim kho Lub Qhov Muag

Coluracetam tau qhia nws cov kev ua zoo tshaj plaws xws li kev txhim kho xim paub, pom kev, thiab pom tseeb. Tshwj xeeb, nws txhawb txoj kev loj hlob hlab ntsha rau cov kab mob sib kis. Ntau cov kev tshawb fawb hais txog xim pom kev zoo dua thiab pom tseeb ntawm lub qhov muag pom, tab sis tsis muaj kev tshawb fawb txog kev tshawb fawb tau lees paub cov teebmeem no.

AASraw yog lub chaw tsim khoom tshaj lij ntawm Coluracetam.

Thov nyem ntawm no rau cov ntaub ntawv hais: dawb paugHu rau peb

 

Yuav ua li cas Coluracetam Ua Haujlwm hauv Lub Hlwb?

Coluracetam pab txhawb nqa lub hlwb kev ua haujlwm thiab ua haujlwm nyob rau ntau txoj hauv kev. Tab sis ob qho tshwj xeeb sawv.

Coluracetam txhawb koj lub hlwb's choline uptake los ntawm phiaj thiab ua haujlwm nrog lub siab affinity choline uptake (HACU) cov txheej txheem hauv lub hlwb cov leeg hlwb.

Acetylcholine (ACh) yog ua los ntawm choline thiab acetate. Cov no yuav tsum muaj rau cov khoom hauv Neuron lub sijhawm txhua lub sijhawm. Yog li ntawd ACh tuaj yeem raug coj los ua ke thaum twg xav tau.

Dawb choline ncig hauv cov ntshav hla ntshav-hlwb teeb meem. Thiab tau coj los ntawm cholinergic neuron terminals. Nws tau coj mus rau hauv lub neuron los ntawm qhov muaj siab affinity choline uptake (HACU) system. Cov synthesis ntawm ACh tshwm sim nyob rau hauv synaptic cleft. Qhov chaw ntawm cov neurons thaum nws taug kev mus rau hauv neuron.

HACU system yog kub-, zog-, thiab sodium-tos. Qhov system no yog qhov tseem ceeb yog qhov uas choline xav tau rau qhov kev coj los ua ke ntawm ACh thauj mus rau hauv lub neuron. Thiab yog tus nqi-txiav cov kauj ruam hauv kev tsim cov tshuaj no neurotransmitter tseem ceeb heev.Thaum cov kab ke no tawg lossis tsis ua haujlwm zoo npaum li nws tau tsim, koj ntsib teeb meem nrog nco, kawm thiab hlwb huab.

Coluracetam ua haujlwm rau cov txheej txheem no thiab pab nws ua haujlwm tau zoo dua. Qhov tseeb, nws zoo li txhawb HACU cov txheej txheem. Txawm nyob hauv puas cov neurons. Nce acetylcholine nyob rau hauv neurons pab txhim kho kev nco, boosts cognition thiab muab kev txiav txim siab zoo dua qub.

Coluracetam kuj zoo li txhim kho AMPA kev ua kom muaj zog. AMPA receptors cuam tshuam los ntawm glutamate. Uas ua haujlwm hauv lub hlwb thiab lub hauv nruab siab hauv lub hlwb txhawm rau txhawm rau txhim kho kev paub meej thiab kev nco qab.

Coluracetam ua haujlwm nrog ob qho AMPA potentiation thiab choline ua kom zoo ntxiv. Qhov kev sib xyaw no zoo li yuav pab txhim kho kev mob siab ntsws yam tsis muaj kev cuam tshuam rau qib serotonin.

Serotonin Selective Reuptake Inhibitors (SSRIs) yog cov kev kho mob niaj hnub tam sim no rau kev daws cov teeb meem kev xav thiab kev nyuaj siab. Lawv tuaj nrog cov npe teev cov kev mob tshwm sim uas tsis zoo. Tsis txhob ua haujlwm rau txhua tus neeg mob ntxhov siab.

Cov kws tshawb nrhiav tau tshaj tawm tias Coluracetam tau muaj txiaj ntsig zoo rau kev kho mob loj hauv kev kho mob thiab kev ntxhov siab. Tsis tas cuam tshuam rau qib serotonin hauv lub hlwb. Thiab tsis muaj cov kev mob tshwm sim uas mus nrog cuam tshuam nrog serotonin.

Coluracetam

Coluracetam Kev Siv: Dosage Thiab Tshooj Rau Siv Tsuas

Coluracetam yog qhov sib txuas uas tsis pom nyob hauv cov zaub mov thiab peb lub cev tsis tuaj yeem tsim nws. Li no, tsuas yog txoj hauv kev los tso tawm cov txiaj ntsig ntawm cov qauv no yog los ntawm kev txhawb ntxiv.

Coluracetam feem ntau yog muag hauv cov hmoov lossis tshuaj ntsiav thiab tuaj yeem noj ntawm qhov ncauj. Koob tshuaj kuj tseem tuaj yeem coj sublingually (nyob rau hauv tus nplaig) kom nrawm dua thiab muaj kev nqus zoo.

Txij li coluracetam yog qhov tshwj xeeb tshaj yog tus sawv cev, nws tau tawm tswv yim kom pib nrog kev siv tshuaj qis dua. Yog tias koj pom koj yuav tsum tau nce koob tshuaj kom hnov ​​qab cov txiaj ntsig, qhov no yuav tsum ua kom maj mam thiab yuav tsum tsis pub ntau dua 80mg.

Coluracetam yog tsis muaj tshuaj lom thiab suav tias yog kev nyab xeeb thiab zoo-tau txais txiaj ntsig.Yuav tsuas muaj qee qhov kev phiv tsis zoo cuam tshuam nrog kev sib txuas, xws li ntxhov siab, mob taub hau, nkees thiab xeev siab. Cov kev mob tshwm sim no tsis tshua muaj thiab feem ntau tsuas yog tshwm sim thaum tsis muaj qhov loj txaus ua ntej ntawm choline siv rau cov tshuaj acetylcholine synthesis. Qhov no yog vim li cas peb pom zoo kom pib cov synthesis-nce coluracetam nrog choline qib txhim kho xws li citicoline.

Coluracetam tuaj yeem cuam tshuam nrog qee cov tshuaj, tshwj xeeb yog cov uas cuam tshuam nrog NMDA receptor. Qhov no suav nrog kev siv tshuaj tua kab mob hnoos thiab tshuaj loog. Lwm yam tshuaj uas cuam tshuam nrog cholinergic system, xws li kev siv tshuaj tiv thaiv kab mob glaucoma thiab nicotine, kuj tseem tuaj yeem cuam tshuam nrog cov teebmeem ntawm coluracetam. Coluracetam tuaj yeem tiv thaiv qhov cuam tshuam rau tshuaj tiv thaiv cholinergic (xws li qee tus Benadryl, qee cov tshuaj tiv thaiv tshuaj thiab tshuaj Parkinson).

Ib yam li lwm yam ntxiv, yog tias koj noj tshuaj lossis muaj qhov mob hauv qab, nws yog ib qho zoo uas koj nrog koj tus kws kho mob tham ua ntej pib ib qho ntxiv tsoom fwv.

 

 Yuav ua li cas Kev sib tsoo Well Wimp Lwm Cov Tshuaj

Ura Coluracetam yog cov roj uas zom cov roj, yog li nws yog qhov zoo tshaj plaws muaj cov roj hauv kev noj qab haus huv zoo xws li roj txiv ntoo lossis roj MCT.

Ura Coluracetam kuj yuav tsum tau txiav nrog ib a choline ntxiv xws li citicoline. Citicoline nce rau pas ntawm cov choline muaj rau kev sib txuas. Cov pawg tuaj yeem tsim cov teebmeem muaj zog los ntawm kev muaj choline ntau dua (citicoline) thiab muaj peev xwm coj los ua nws rau hauv acetylcholine (coluracetam).

 

 Koob tshuaj: 5-80mg ib hnub

Peb pom zoo ntawm 5-80mg ntawm coluracetam ib hnub.

Kev nyab xeeb sab saud hnyav rau coluracetam yog 80mg ib hnub. Txawm li cas los xij, peb pom zoo nyob nrog 35mg ib hnub vim qhov kev rau txim ntau dua tseem tsis tau muaj kev soj ntsuam txhua tus tib neeg.

Nws zoo dua rau faib cov tshuaj no ua ib tag kis sawv ntxov lossis yav tav su. Piv txwv, noj 20mg ntawm 10mg thaum sawv ntxov thiab ib qho ntxiv 10mg thaum tav su.

Raws li tau hais dhau los, koj yuav tsum pib ntawm qhov qis kawg ntawm qhov teev koob tshuaj. Pib ntawm kev siv tshuaj qis qis qis tshaj plaws yuav txo qhov muaj feem ntawm cov kev phiv tsis zoo.

 

Qhov tshuaj tiv thaiv sab Coluracetam

Coluracetam yog non-toxic. Yog li tau muab txiav txim siab zoo thiab nyab xeeb. Ntau thawj zaug cov neeg siv ntawm Coluracetam qhia txog kev qaug zog uas feem ntau yog tshwm sim los ntawm kev pib nrog ntau dhau ib koob.

Nco ntsoov, Coluracetam ua haujlwm los ntawm kev txhim kho choline uptake hauv koj lub hlwb. Choline yog qhov ua ntej rau kev tsim cov tshuaj acetylcholine. Yog tias tsis muaj choline txaus hauv koj lub cev, koj yuav xav tias muaj cov kev mob tshwm sim.

Cov kev mob tshwm sim muaj tsawg tab sis muaj xws li kev ntxhov siab, qaug zog, mob taub hau, muaj siab thiab xeev siab. Ntxiv dua thiab, cov kev mob tshwm sim muaj feem ntau ntawm cov koob tshuaj tiv thaiv kab mob siab tsis zoo.

Mob taub hau los ntawm kev siv Coluracetam feem ntau tshwm sim thaum koj tsis nco qab los ua ke nws nrog choline zoo ntxiv. Cov mob taub hau feem ntau yog cov tsos mob choline tawm hauv koj lub hlwb.

 

Txheej txheem cej luam– Coluracetam

Coluracetam yog ib qho ntawm cov tshiab dua thiab tsis paub dua cov tswv cuab ntawm chav kawm racetam ntawm nootropics, tab sis nws yog qhov nyiam nrog ntau cov neeg siv.

Nws nce qib ntawm '' kev kawm neurotransmitter '' acetylcholine, uas yuav ua rau muaj kev paub txog, thiab cov kev tshawb fawb tsiaj pom tias nws tuaj yeem ua rau cov kev nco tsis txaus yam tsis muaj kev cuam tshuam loj. Txawm hais tias muaj ntawv sau me ntsis txog tib neeg tshawb fawb txog coluracetam, cov kev tshawb fawb muaj nyob ntawd qhia tias nws yuav yog txoj kev kho mob rau kev ntxhov siab thiab kev ntxhov siab.

Ntau cov neeg siv suav nws yog kev txhim kho kev tso siab kev xav thiab cim xeeb txhim kho uas muab rau lawv ua kom zoo dua thiab ua kom pom tseeb. Lwm tus hais tias nws muab lawv qhov sib npaug ntawm "HD lub zeem muag", ua rau cov xim ci, qhov sib txawv ntau khaus, thiab cov teeb ci ntau dua.

Coluracetam yog qhov muaj peev xwm sib tov, yog li qhov ntau npaum li cas cov tshuaj tsawg, thiab nws paub tias yuav ua haujlwm nrawm. Nws raug muag raws li kev noj haus ntxiv hauv Asmeskas thiab tuaj yeem raug cai nkag rau tebchaws Canada thiab UK hauv tus nqi tsawg.

Tseem tshuav ntau yam uas yuav tsum tau kawm txog coluracetam, tab sis nws zoo li muaj kev nyab xeeb rau feem ntau cov neeg siv thaum coj lub luag haujlwm. Yog tias koj txaus siab ntxiv qhov tshiab thiab txawv rau koj nootropic pawg, coluracetam tuaj yeem yog ib qho yuav tau xav txog.

Coluracetam tsis muaj qhov kev tshawb fawb ntau, cov kev tshawb fawb muaj qhia muaj lub peev xwm zoo rau nws siv. Nws yog ib qho ntawm kev hloov tshiab tshaj-mus-mainstream racetams, ib sab ntawm sab nrog FasoracetamCov. Txawm li cas los xij, tsis ntev los no, FDA tau pom zoo ib daim ntawv "txhim kho" Fasoracetam rau kev kho mob ntawm ADHD.

AASraw yog lub chaw tsim khoom tshaj lij ntawm Coluracetam.

Thov nyem ntawm no rau cov ntaub ntawv hais: dawb paugHu rau peb

 

reference

[1] Brauser D. "Neurogenesis-Stimulating Compounds Qhia Cog Lus rau Kev Kho Tus Mob Loj Tshaj Plaws" Medscape Medical News Lub Cuaj Hli 21, 2009

[2] Murai S., Saito H., Abe E., Masuda Y., Odashima J., Itoh T. Phau ntawv Journal neural kis General Feem. Xyoo 231; 1994 (98): 1-1.

[3] Takashina K., Bessho T., Mori R., Eguchi J., Saito K. Phau ntawv Journal neural kis (Vienna). 231 Jul; 2 (64): 2008-115.

[4] Bessho T., Takashina K., Eguchi J., Komatsu T., Saito K. Phau ntawv Journal neural kis (Vienna). 231 Jul; 1 (64): 2008-115.

[5] Akaike A., Maeda T., Kaneko S., Tamura Y. Japanese Phau Ntawv Teev Cov Tshuaj. 231 Lub Ob Hlis; 1998 (76): 2-219

[6] Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R (Cuaj hlis 2007). "Tom qab kis tau tus kab mob choline uptake enhancer MKC-231 antagonizes phencyclidine-induced tus cwj pwm tsis txaus thiab txo qis hauv septal cholinergic neurons hauv nas". European Neuropsychopharmacology. 17 (9): 616–26.

[7] Tsim Nyog Ua Rau Kho Kev Tshawb Fawb Txog Kev Tshawb Nrhiav Cov Nyiaj Pab rau Xeev California, IRS.gov.

[8] Malykh, AG, & Sadaie, MR (2010). Piracetam thiab Piracetam-Zoo li Cov Tshuaj. Cov Tshuaj, 70 (3), 287–312.

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