Tebchaws Meskas Tuaj Tebchaws, Tebchaws Thoob Plaws Hauv Tebchaws Asmeskas, Lub Tebchaws Thoob Plaws Tebchaws Thoob Plaws Tebchaws

Lub 7 Zoo Tsis Nootropics (Ntse Tshuaj) nyob rau hauv kev ua lag luam ntawm Armodafinil

Amodafinil yog ib qho kev tsim tshuaj los ntawm Celphalon Pharmaceuticals thiab tau txais kev pom zoo los ntawm FDA rau lub Rau Hli 15, 2007. Amodafinil yog (-) - (R) -enantiomer ntawm cov khoom muaj nyob rau hauv cov tshuaj yeeb yaj kiab modafinil. Armodafinil yog lub isomer ntawm lub tshuaj modafinil (Progivil)

Armodafinil hmoov, xws li modafinil, muaj peb lub ntsiab siv:

• Txhawb kom sawvdaws pom zoo thaum muaj kev tsaug zog ntau dua thiab ua rau tsis muaj pa taws
• Nws yog ib qho yeeb tshuaj siv rau kev kho kom muaj kev txhawj xeeb rau cov menyuam yaus thiab cov laus
• Nws yog siv rau hauv cov neeg uas yuav tsum tau ua kom hloov, txij li thaum nws tso cai rau kom tsis txhob pw tsaug zog uas tuaj yeem ua rau cov sij hawm hloov hauv lub sij hawm lom ntawm tib neeg.
• Nws yog siv los ntawm qee cov menyuam kawm ntawv los txhim kho cov concentration.
Lub tuam txhab Cephalon tseem xav thiab npaj cov kev kawm nrog lub hom phiaj ntawm kev ntsuam xyuas armodafinil (Nuvigil) rau kev kho mob ntawm lwm cov mob xws li kev puas siab puas ntsws bipolar, schizophrenia, thiab pw tsaug zog thiab qaug zog hauv cov mob xws li Parkinson's thiab cancer.

Armodafinil Cov kev taw qhia ua ke

Armodafinil yog ib qho enantiomeric compound ntawm eugeroidal modafinil (Provigil). Nws tsuas yog ntawm (R) - (-) - enantiomer ntawm racemic modafinil.

Lub npe hu ua Nuvigil
Cov roj formula: C 15 H 15 TSIS 2 S
CAS Naj Npawb: 112111-43-0
Molecular phaus: 273.35000
PSA: 79.37000
LogP: 3.57600
Zoo zoo: 273.008200

Physicochemical thaj chaw

Lub cev muaj zog: dawb tawv
Qhov Ceev: 1.283g / cm 3
Lub pob taw: 559.1oC ntawm 760mmHg
Lub teeb nyem: 292oC
Melting point: 156-158oC
Vapor siab: 1.56E-12mmHg ntawm 25 C
Refractive Performance index: 1.645

Cov tshuaj no tau pom zoo nyob rau hauv Tebchaws Meskas rau kev kho mob ntawm cov neeg mob hnub nyoog ntau tshaj 18 xyoos nrog rau obstructive pw tsaug zog apnea Syndrome (OSAS), narcolepsy, los yog tus neeg mob ua haujlwm.

Kev piav qhia yooj yim ntawm Armodafinil hmoov

Qhov kev cim rau armodafinil zoo ib yam li modafinil. Lub Teb Chaws Asmeskas FDA lees almodafinil raws li kev kho mob rau narcolepsy, pw tsaug zog apnea syndrome thiab ua haujlwm tsis zoo ua haujlwm, Alzheimer's, kev loj hlob mob.

Amodafinil yog L-mododafin thiab yog lub ntsiab yam khoom muaj nyob rau hauv modafinil. 200 mg ntawm modafinil nyob rau hauv tus laug-tes laug thiab cov cai-tso modafinil txhua tus accounted rau ib nrab, tab sis tus cai-tso modafinil yog noj rau 4 teev, noj tau txo, modafinil noj 2 teev Cov nyhuv yog tias qhov siab tshaj plaws ncov ntawm ntshav yog mus txog hauv 4 teev. Ntawm lub siab tshaj plaws, L-mododa nyiaj rau 90%, thiab txoj cai ntawm kev cai-tsuas yog tawm 10%. Tom qab plaub teev, Moda ua txoj haujlwm tseem ceeb. Nws yog L-mododafin. Cov nyhuv ntawm amodafinil yog muaj zog heev. Yog hais tias Moda sim ua kom tsaug zog, ces Amoda tuaj yeem tsom thiab rub siab, ua tib zoo saib xyuas, thiab muaj feem xyuam tsis zoo. Thaum kawg, nws yuav hloov lub teeb meem modafinil. Amoda muaj peb zaug qhov affinity rau cov ntshav proteins, yog li nws tuaj yeem khi tau cov ntshav proteins kom zoo dua. Yog li ntawd, qhov kev xav ntawm amateur uas nkag mus rau lub hlwb nrog ntshav yog siab heev. Amoda qhov affinity rau lub hlwb yog peb lub sijhawm ntawm Moda.

Ib nrab ntawm lub neej ntawm amodafinil yog 13-15 teev. Cov kev mob tshwm sim tsawg heev.
Kev noj tshuaj hauv kev ua haujlwm ntawm amodafinil, qhov concentration ntawm cov tshuaj nyob rau hauv cov ntshav yuav mus txuas ntxiv, vim hais tias cov laus cov tshuaj yeeb tshuaj tsis tau raug pov thawj, cov tshuaj tshiab tau nkag mus rau hauv cov ntshav, kev siv cov tshuaj amodafinil yuav ncua cov sij hawm tuaj txog ntawm cov tshuaj ntshav siab.

Lub 7 Zoo Tsis Nootropics (Ntse Tshuaj) nyob rau hauv kev ua lag luam ntawm Armodafinil

Armodafinil Pharmacology

Mechanism ntawm kev txiav txim

Armodafinil ua kom muaj kev vam meej hauv cov neeg mob uas raug kev txom nyem ntau heev. Nws siv nws cov txiaj ntsig los ntawm kev siv qee cov neurotransmitter receptors thiab ua rau lub cev khov kho siab. Lub tswv yim ntawm kev txiav txim, nrog Modafinil, yog tsis paub. Nyob rau hauv vitro, tsis yog ib tug ncaj qha los yog ib qho tsis ncaj nraim li α 1 -adrenoceptor - los yog dopamine receptor agonist yuav tau kuaj. Qhov kev muaj peev xwm ntawm armodafinil kom muaj kev vam meej yog zoo ib yam li ntawm amphetamine, tab sis nws txawv ntawm nws nyob rau hauv nws cov tshuaj pharmacological.

metabolism hauv

Ib nrab ntawm lub sij hawm ntawm ob enantiomers ntawm modafinil txawv ntawm ib qho ntawm 3 los ntawm txhua lwm. Cov tshuaj pharmacokinetics ntawm Armodafinil yog dose-independent thiab linear hauv 50 rau 400 mg ntau. Cov tshuaj siv sai sai thiab metabolised nyob rau hauv lub siab mus rau ob lub metabolites loj. Armodafinil thiab nws cov metabolites yog khiav tawm feem ntau ntawm ob lub raum. Rau cov neeg mob uas muaj kab mob tsis zoo los sis lub plab tsis zoo, cov koob tshuaj yuav tsum txo kom tsawg.

Armodafinil Siv:

Armomafinil yog ib qho tshuaj ncauj. Hauv kev ua lag luam, raws li txoj cai, qhov kev meej meej yog 50 mg, 150 mg, 200 mg, 250 mg. Rau cov neeg uas muaj lub hli, lawv yuav tsum tau ua ntawm 150-250 mcg ib hnub.

Qhov kev cim rau armodafinil zoo ib yam li modafinil. Lub Teb Chaws Asmeskas FDA lees almodafinil raws li kev kho mob rau narcolepsy, pw tsaug zog apnea syndrome thiab ua haujlwm tsis zoo ua haujlwm, Alzheimer's, kev loj hlob mob.

sib tshuam

Armodafinil hmoov yog metabolised los ntawm cytochrome P450 3A4 thiab tseem inhibits tej subtypes ntawm cytochrome P450 enzyme tsev neeg. Muaj ib qho peev xwm rau kev sib raug zoo nrog ntau lwm cov tshuaj, uas yog tig los yog ua rau cov tib lub cytochrome P450 subtypes los yog ua rau hauv. Cov no muaj xws li cov tshuaj tiv thaiv qhov ncauj, tshuaj rau kev kho mob chua leeg (anticonvulsants), anticoagulants (anticoagulants), antidepressants los yog immunosuppressant cyclosporine.

Sab los

Cov kev mob tshwm sim feem ntau tshwm sim yog: mob taub hau, xeev siab, kiv taub hau, pw tsis taus. Armodafinil tej zaum yuav ua rau tsis haum me ntsis xws li ua pob khaus los yog kub taub hau. Cov kev tsis haum rau cov tawv nqaij, xws li cov neeg tau pom nrog daim ntawv ntxim nyiam Modafinil, nrog rau Stevens-Johnson syndrome, tsis raug tshem tawm thiab xav tau kev txiav kiag tam sim ntawd.

Armomafinil VS Modafinil

1.Armodafinil thiab Modafinil yog non-amphetamine cov tshuaj uas txhawb kev vam meej thiab pab tib neeg tau pw tsaug zog apnea, narcolepsy los yog ntev li ntawm nkees nkees tseem nyob ruaj khov. ... Pib, Modafinil yog siv los kho tshuaj narcolepsy thiab ua kom muaj kev vam meej

2. Armomafinil muaj nyob rau hauv daim ntawv ntawm 50 mg / 150 mg / 200 mg / 250 mg. Modafinil muaj tsuas yog 100 / 200 mg.

3. Armodafinil lub neej txoj haujlwm yog 15 teev, whereas Modafinil hmoov yog xNUMX teev. Cov nyhuv ntawm Armodafinil yog 12 teev, qhov twg Modafinil kav 8 rau 6 cov xuab moos.

4. Farmafinil ncav nws cov concentration peak tom qab, vim li cas rau kev tsim muaj lub cev mus ntev dua, thiab lub sijhawm ntev tshaj li Modafinil. Tsis tas li, yog tias koj noj 150 mg ntawm Armodafinil, yuav tsum tau 200 mg ntawm Modafinil. Vim hais tias ntawm kev ua haujlwm ntev, Armodafinil hmoov yog qhov zoo tshaj plaws ntawm ob, tab sis cov kws kho mob hais tias lawv yog ob qho tib si, thiab cov kev tshwm sim feem ntau yog tib yam.

Ua ntej siv

Kev txiav txim siab txog kev siv cov tshuaj, cov txiaj ntsig ntawm kev siv nws yuav tsum yog ntau tshaj qhov tsim txom, thiab koj thiab koj tus kws kho mob yuav tsum txiav txim seb puas yuav siv cov tshuaj los yog tsis.

Koj yuav tsum xav txog:

cov me nyuam

Cov kev tshawb fawb tsis tsim nyog tau ua rau kev sib raug zoo ntawm hnub nyoog thiab cov nyhuv ntawm armodafinil rau cov me nyuam yau dua 17 xyoo nyoog. Kev nyab xeeb thiab ua tau ntawm cov tshuaj no tau tsis tau tsim.

Cov laus

Txawm hais tias tsis muaj kev tshawb fawb los ntawm txoj kev sib raug zoo ntawm hnub nyoog thiab cov nyhuv ntawm cov neeg ua haujlwm ntawm cov neeg laus, cov teeb meem uas muaj feem cuam tshuam nrog kev laus tsis xav kom txwv tsis pub siv cov tshuaj armodafinil rau cov neeg laus. Txawm li cas los xij, cov neeg mob laus tuaj yeem muaj kev tshem tawm ntawm txoj kev siv tshuaj no los ntawm lub cev, uas tej zaum yuav xav tau kev kho rau cov neeg mob uas tau txais cov tshuaj tiv thaiv.

Cev xeeb tub thiab pub niam mis

Cev xeeb tub

Qhov kev faib tawm ntawm armodafinyl thaum cev xeeb tub yog (C). Cov kev tshawb fawb tsiaj pom muaj qhov tsis zoo thiab tsis muaj kev tshawb fawb txog tib neeg kev xeeb tub. Tsis muaj kev tshawb nrhiav tsiaj thiab tsis muaj kev tshawb fawb txog tib neeg kev xeeb tub.

Mis Pub Mis

Ceev faj, nws tsis paub tias qhov tshuaj no puas tawm hauv tib neeg cov kua mis.

Cov kev sib tshuam thiab kev siv yeeb tshuaj

Txawm hais tias qee cov tshuaj yuav tsum tsis txhob siv sab ib ntus los ntawm sab nqaij daim tawv, lwm tus neeg siv ob yam tshuaj siv tau ua ke txawm tias lawv muaj kev sib thiav tshuaj. Thiab qhov no, koj tus kws kho mob yuam kom hloov qhov tshuaj, lossis lwm yam kev tiv thaiv uas tsim nyog. Thaum noj cov tshuaj no, nws tseem ceeb heev uas koj tus kws kho mob paub yog tias koj noj cov tshuaj hauv qab no. Cov kev sib tham hauv qab no tau raug xaiv los ntawm lawv qhov tseem ceeb Muaj peev xwm, uas tsis tas yuav tag nrho-suav txhua tus.

Siv cov tshuaj txuam nrog Armodafinil hmoov

Lwm cov kev sib tshuam

Qee cov tshuaj yuav tsum tsis txhob siv nyob rau los sis ib ncig ntawm lub sijhawm noj mov los yog noj tej hom zaub mov vim hais tias kev sib cuam tshuam ntawm kev noj tshuaj thiab qee hom khoom noj yuav tshwm sim tau. Kev siv cawv lossis luam yeeb yuav ua tau rau kev siv yeeb tshuaj. Nrog tus kws kho mob tham nrog kev siv cov tshuaj no nrog zaub mov los yog dej cawv, los yog luam yeeb.

Lwm yam mob

Muaj lwm yam teeb meem kev noj qab haus huv tej zaum yuav cuam tshuam rau kev siv cov tshuaj no:

Kev nyuaj siab los yog muaj keeb kwm ntawm nws, los yog ntshav siab, kev xav, los yog psychosis: siv cov tshuaj nrog ceev faj. Cov mob no yuav ua rau tuaj yeem mob ntxiv.

Sab nraud hypertrophy, los yog mitral valve poob: yuav tsum tsis txhob siv rau cov neeg mob uas muaj cov mob no.

Mob ntshav qab zib (mob heev): siv nrog ceev faj. Cov teebmeem ntawm cov tshuaj yuav tuaj yeem nce vim nws qhov kev tshem tawm qis ntawm lub cev.

Kom siv

Noj cov tshuaj no raws li koj tus kws kho mob qhia. Tsis txhob nce cov tshuaj ntawm cov tshuaj, thiab tsis ntxiv cov sij hawm siv tshuaj, thiab tsis siv nws ntev dua li tus kws kho mob tau txiav txim siab.
Cov tshuaj no tuaj nrog Phau Ntawv Neeg Mob Cov Lus Qhia (Internal Bulletin). Nws yog ib qho tseem ceeb heev uas koj nyeem thiab to taub cov ntaub ntawv no. Nco ntsoov nug koj tus kws kho mob yog tias koj muaj lus nug.
Yog tias koj raug kev txom nyem los ntawm kev pw tsaug zog apnea thiab siv kev siab ntev ntawm kev hnoos siab thaum hmo ntuj, siv txuas ntxiv nrog rau kev siv tshuaj.
Noj cov tshuaj no tib lub sijhawm txhua hnub. Tsis txhob hloov lub sijhawm ntawm kev noj tshuaj yam tsis tau tham nrog koj tus kws kho mob ua ntej.
Koj tuaj yeem noj cov tshuaj no nrog lossis tsis noj mov.

Cov kev mob tshwm sim

Ua ke nrog cov kev kho mob ntawm cov tshuaj, cov tshuaj no yuav ua rau muaj qee qhov tsis zoo. Txawm hais tias tsis tag nrho cov kev mob tshwm sim no, tab sis yog tias koj ua, koj yuav tsum tau kev kho mob.

Nrog koj tus kws kho mob tham sai li sai tau yog tias muaj ib yam kev mob tshwm sim nram no rau koj:

Tsawg dua

Cov hlwv, hlawv, khaus plawv, khaus, lossis tawv nqaij
Khaus, ua tsis taus pa, los yog tingling
ua pa nyuaj
Lub plawv dhia ceev ceev los sis tsis sib haum
npaws
nquag tso zis
Mob taub hau hnyav nrog mob siab
Nce tus nqi tso zis
Khaus, lossis hnyav liab, lossis caj dab, lossis tawv nqaij o
Cov tawv nqaij ua pob liab liab
Ib qho kev kub ntxhov ntawm ob txhais ceg, caj npab, ob txhais tes los yog ko taw
Txog siav ua tsis taus pa

Ceev faj

Nws yog ib qho tseem ceeb uas koj tus kws kho mob kuaj xyuas koj txoj kev kho mob nrog cov tshuaj hauv kev mus ntsib kws kho mob kom paub tseeb tias cov tshuaj ua haujlwm zoo thiab kom paub tseeb tias tsis muaj teeb meem dab tsi.

Cov tshuaj no tsis hloov chaw kom pw txaus. Cov tshuaj no yuav tsum tau siv yog hais tias tus kab mob no tau pom tias yog obsessive-compulsive disorder, obstructive pw tsaug zog apnea (tseem hu ua apnea syndrome), los yog teeb meem pw tsaug zog los ntawm psoriasis.

Cov tshuaj no yuav ua rau muaj kev phiv loj, xws li mob siab thiab mob vascular.

Txhob siv cov tshuaj no thiab xyuas nrog koj tus kws kho mob tam sim ntawd yog tias koj muaj cov tsos mob nram qab no: mob plab, paug, tawv muag, ua daus no, hnoos, raws plab, ua npaws, lossis mob leeg lossis mob nqaij. Lossis liab tawv nqaij. Los yog mob caj pas; qhov nqaij, los yog cov pob dawb dawb hauv qhov ncauj los yog daim di ncauj. Los yog qaug zog lossis qaug zog.

Tsis txhob tsav lub tsheb, tsis txhob siv cav, tsis txhob ua lwm yam uas yuav tsim kev puas tsuaj yog tias koj tsis ceev faj, yog li koj paub yuav teb li cas rau cov tshuaj no.

Tej zaum nws yuav ua rau qee tus neeg tau npau taws, npau taws, lossis muaj lwm yam cwj pwm txawv. Tej zaum kuj ua rau qee tus neeg xav tua tus kheej los yog yuav ua rau muaj kev nyuaj siab ntau dua.

Ua ntej ua kev kuaj mob, qhia rau tus kws kho mob paub tias koj noj cov tshuaj no. Cov txiaj ntsim ntawm qee yam kev kuaj kuj yuav muaj kev cuam tshuam los ntawm cov tshuaj no.

Tsis txhob noj lwm yam tshuaj tshwj tsis yog nrog koj tus kws kho mob tham. Qhov no suav nrog cov tshuaj los yog cov tshuaj tsis yog kws kho mob (OTCs), tshuaj ntsuab los yog cov vitamins.

cia

Khaws cov tshuaj rau hauv ib lub thawv uas muab ntim cia rau hauv qhov chaw sov, kom deb ntawm cov cua sov, cov av noo thiab cov teeb ci ncaj nraim.

Tam sim ntawd los ntawm kev khov.

Khaws cov tshuaj tawm ntawm cov menyuam yaus.

Tsis txhob khaws cov tshuaj los yog cov tshuaj uas tsis siv sij hawm ntev lawm.

Nug koj tus kws kho mob kom tshem tawm cov tshuaj uas koj tsis siv.


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