Cov yam ntxwv yooj yim

khoom npe	Nicotinamide riboside chloride
CAS Number	23111-00-4
molecular Formula	C11H15ClN2O5
Mis Lub Cev	290.7
Synonyms	23111-00-4 Nicotinamide riboside chloride Nicotinamide riboside (chloride) 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride Nicotinamide ribose tshuaj dawb
tsos	Dawb hmoov
Cia thiab Ua Haujlwm	0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli).

 

Nicotinamide riboside chloride Cov lus piav qhia

Nicotinamide Riboside Chloride (NIAGEN) yog chloride ntsev daim ntawv ntawm nicotinamide riboside (NR) .NR yog ib daim ntawv tshiab pyridine-nucleoside ntawm cov vitamins B3 uas ua haujlwm ua lub zog ua ntej rau nicotinamide adenine dinucleotide (NAD) lossis NAD + .NIAGEN feem ntau pom tias muaj kev nyab xeeb. (GRAS) Tebchaws Asmeskas rau kev siv hauv cov khoom lag luam. Nicotinamide riboside chloride yog cov qauv siv lead ua ntawm Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride nce qib NAD [+] thiab ua kom SIRT1 thiab SIRT3, ua kom lub cev muaj zog oxidative metabolism thiab tiv thaiv cov rog rog rog kom ua rau cov roj ntsha tsis zoo. Nicotinamide riboside chloride hmoov yog siv rau hauv kev noj tshuaj pab rau neeg mob.

 

Nicotinamide riboside chloride Cov Kev Ntsuas Ntawm Kev Ua

Nicotinamide Riboside Chloride (NIAGEN) yog chloride ntsev tsim cov nicotinamide riboside (NR). NR yog pyridine-nucleoside daim ntawv ntawm cov vitamin B3 uas ua haujlwm ua lub hauv paus rau nicotinamide adenine dinucleotide lossis NAD +. NR cov kev cuam tshuam los ntawm kev phais mob sib cais dorsal cag ganglion neurons ex vivo thiab tiv thaiv lub suab tsis hnov ​​lus zoo nyob hauv cov nas. Nicotinamide riboside hmoov tiv thaiv cov leeg, neural thiab melanocyte qia cell senescence. Ua kom cov nqaij ntshiv nce ntxiv hauv cov nas tau raug pom tom qab kho nrog nicotinamide riboside, ua rau muaj kev cia siab tias nws yuav txhim kho kev ua kom rov ua haujlwm ntawm cov nruab nrog xws li lub siab, raum, thiab plawv. Nicotinamide riboside kuj txo qis cov ntshav qabzib thiab rog lub siab nyob rau hauv kev mob ntshav qab zib thiab hom 2 ntshav qab zib qauv thaum tiv thaiv kev txhim kho kev mob ntshav qab zib peripheral neuropathy. Lus Cim: Nicotinamide Riboside chloride yog kev sib xyaw α / β

 

Nicotinamide riboside chloride Ua Ntawv Thov

Nicotinamide riboside chloride hmoov yog sau npe nrog CAS naj npawb 23111‐00‐4 thiab EC naj npawb 807‐820‐5. Nws lub npe IUPAC yog 1 - [(2R, 3R, 4S, 5R) ‐3,4 ‐ dihydroxy ‐ 5‐ (hydroxymethyl) oxolan ‐ 2 ‐ yl] pyridin ‐ 1 ‐ ium ‐ 3 ‐ carboxamide; chloride. Cov tshuaj molecular ntawm nicotinamide riboside chloride yog C11H15N2O5Cl, thiab nws cov molecular hnyav 290.7 g / mol. Nicotinamide Riboside Chloride (NIAGEN) yog chloride ntsev daim ntawv ntawm nicotinamide riboside (NR) .NR yog ib daim ntawv tshiab pyridine-nucleoside ntawm cov vitamins B3 uas ua haujlwm ua lub hauv paus rau nicotinamide adenine dinucleotide (NAD) lossis NAD +. Lub cev xav tau NAD + ua haujlwm ib txwm. Qes ntawm NAD Qes + tuaj yeem ua rau muaj mob. Kev noj cov nicotinamide riboside tuaj yeem pab tsa cov qib NAD qis no +.

 

kev pab cuam ntawm Nicotinamide riboside chloride

Nicotinamide riboside Chloride, qhov ncauj ntawm NAD + txheej txheem ua ntej, nce NAD + qib thiab ua rau SIRT1 thiab SIRT3. Nicotinamide riboside Chloride hmoov yog qhov ua kom muaj vitamin B3 (niacin) thiab siv Nicotinamide riboside Chloride hmoov tuaj yeem txhim kho oxidative metabolism, tiv thaiv lub cev rog rog los ua kom cov roj ntsha tsis zoo. Nicotinamide riboside Cov tshuaj Chloride txo cov kev paub kev tsis zoo hauv lub zog transgenic mouse qauv ntawm Alzheimer tus kab mob.

 

reference

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[6] Kato M, Lin SJ. Kev cai ntawm NAD + kev siv metabolism, kev taw qhia thiab sib txuam hauv cov poov xab Saccharomyces cerevisiae. Kev Kho DNA (Amst). 2014 Nov; 23: 49-58. doi: 10.1016 / j.dnarep.2014.07.009. Ntsuam Xyuas. PubMed PMID: 25096760; PubMed Central PMCID: PMC4254062.

[7] Cantó C, li al. NAD (+) tus txheej txheem ua ntej nicotinamide riboside txhim kho cov kab mob oxidative thiab pab tiv thaiv kev rog rog ua rau cov rog rog. Cell Metab. 2012 Jun 6; 15 (6): 838-47.

[8] Bing Gong, li al. Nicotinamide Riboside Txum Rov Tsum Paub Txog Kev Ua Kom Zoo dua ntawm kev nce qib ntawm Proliferator-Txais Receptor-γ Coactivator 1α Kev tswj hwm β-Secretase 1 Kev Txo Txim thiab Mitochondrial Gene Qhia Hauv Alzheimer Tus Qauv Nas. Neurobiol Kev Laus. 2013 Jun; 34 (6): 1581-8.

[9] Collin D Heer, li al. Coronavirus thiab PARP Tshaj Tawm Dysregulate rau NAD Metabolome: Ib qho Txiaj Ntsig Zoo Nkaus Ib Ntus ntawm Innate Immunity. bioRxiv. 2020 Plaub Hlis Ntuj Tim 30; 2020.04.17.047480.

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