γ-Aminobutyric acid (GABA) hmoov - chaw tsim tshuaj paus Hoobkas Chaw tsim khoom
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acid-Aminobutyric acid (GABA)

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GABA noj los ntawm qhov ncauj rau daws kev ntxhov siab, txhim kho kev xav, txo cov tsos mob ntawm tus mob premenstrual syndrome (PMS), thiab kho kev saib xyuas qhov tsis txaus siab-cuam tshuam kev puas tsuaj (ADHD). Nws kuj yog siv rau kev txhawb cov nqaij ntshiv kev loj hlob, lub cev rog, ua kom lub cev ruaj khov, thiab txo tus mob.

Hauj lwm yam khoom

Cov yam ntxwv yooj yim

khoom npe acid-Aminobutyric acid (GABA)
CAS Number 56-12-2
molecular Formula C4H9NO2
Mis Lub Cev 103.12
Synonyms 4-aminobutyric acid

4-Aminobutanoic acid

gamma-aminobutyric acid

GABA

56-12-2

tsos Dawb hmoov
Cia thiab Ua Haujlwm Qhuav, tsaus thiab 0 - 4 C rau lub sijhawm luv, lossis -20 C rau lub sijhawm ntev.

 

acid-Aminobutyric acid (GABA)Hauj lwm

acid-aminobutyric acid, lossis gamma-Aminobutyric acid, lossis GABA, yog tus thawj cov tshuaj tiv thaiv neurotransmitter hauv txoj kev loj hlob mammalian lub hauv nruab nrog cev. Nws lub luag haujlwm tseem ceeb yog txo cov neuronal excitability thoob plaws hauv cov leeg hlwb.

GABA raug muag raws li kev pabcuam kev noj haus hauv ntau lub tebchaws. Nws tau ib txwm xav tias GABA exogenous (piv txwv li noj tshuaj ntxiv) tsis hla cov ntshav-hlwb teeb meem, txawm li cas los xij cov ntaub ntawv tau los ntawm kev tshawb fawb tam sim no qhia tau hais tias nws yuav ua tau.

 

γ-Aminobutyric acid (GABA) Kev Ntsuas Ntawm Kev Ua

Cov tshuaj uas ua raws li allosteric modulators ntawm GABA receptors (paub zoo li GABA analogues lossis GABAergic tshuaj), lossis nce qhov muaj nyiaj ntawm GABA, feem ntau muaj kev so, tiv thaiv kev ntxhov siab, thiab los tiv thaiv kev cuam tshuam. Ntau ntawm cov tshuaj hauv qab no paub tias ua rau anterograde amnesia thiab retrograde amnesia.

Feem ntau, GABA tsis hla cov ntshav barrier thaiv lub hlwb, txawm hais tias qee qhov chaw ntawm lub hlwb tsis muaj ntshav effective lub hlwb tseem ceeb, xws li lub hlwb ua kom tsis taus, tuaj yeem siv tau los ntawm cov tshuaj xws li txhaj tshuaj GABA. Tsawg kawg ntawm ib txoj kev tshawb nrhiav qhia tias qhov ncauj noj GABA nce tib neeg kev loj hlob hormone (HGH). GABA ncaj qha txhaj rau lub hlwb tau tshaj tawm tias muaj ob qho stimulatory thiab inhibitory cuam tshuam rau kev tsim khoom hauv kev loj hlob hormone, nyob ntawm tus physiology ntawm tus neeg. Qee yam tshuaj ntawm GABA (ex. Picamilon) tau tsim kho kom nkag siab cov ntshav – hlwb teeb meem, tom qab ntawd cais mus rau GABA thiab cov roj ntsha molecule ib zaug hauv lub hlwb.

GABA txhim kho qhov catabolism ntawm serotonin rau hauv N-acetylserotonin (tus npuaj npau suav ntawm melatonin) hauv nas. Nws yog li no xav tias GABA koom nrog hauv cov synthesis ntawm melatonin thiab yog li yuav ua rau muaj kev cuam tshuam zoo rau kev pw tsaug zog thiab kev ua me nyuam.

 

acid-Aminobutyric acid (GABA) Daim ntawv thov

Gamma-Aminobutyric Acid yog ib qho tshwm sim rau neurotransmitter nrog lub hauv nruab nrab cov hlab ntsha (CNS) inhibitory kev ua si. Gamma-aminobutyric acid (GABA), hloov pauv los ntawm tus thawj xibfwb excitatory neurotransmitter glutamate hauv lub hlwb, ua lub luag haujlwm hauv kev tswj neuronal excitability los ntawm khi rau nws cov receptors, GABA-A thiab GABA-B, thiab yog li ua rau ion channel qhib, hyperpolarization thiab nws thiaj li inhibition ntawm neurotransmission.

Gamma-aminobutyric acid yog gamma-amino acid uas yog butanoic acid nrog cov amino hloov chaw uas nyob ntawm C-4. Nws muaj lub luag haujlwm ua cim taw qhia txog molecule, tib neeg cov tshuaj tiv thaiv kab mob, Saccharomyces cerevisiae metabolite thiab neurotransmitter. Nws yog gamma-amino acid thiab monocarboxylic acid. Nws tawm los ntawm cov kua qaub butyric. Nws yog cov kua roj conjugate acid ntawm gamma-aminobutyrate. Nws yog lub tautomer ntawm gamma-aminobutyric acid zwitterion.

 

Cov txiaj ntsig ntawm γ-Aminobutyric acid (GABA)

GABA noj los ntawm qhov ncauj rau daws kev ntxhov siab, txhim kho kev xav, txo cov tsos mob ntawm tus mob premenstrual syndrome (PMS), thiab kho kev saib xyuas qhov tsis txaus siab-cuam tshuam kev puas tsuaj (ADHD). Nws kuj yog siv rau kev txhawb cov nqaij ntshiv kev loj hlob, lub cev rog, ua kom lub cev ruaj khov, thiab txo tus mob.

 

reference

1, Chapouthier G, Venault P (Lub Kaum Hli 2001). “Qhov txuas pharmacological sib cuam tshuam ntawm kev mob vwm thiab kev ntxhov siab?”. Tiam sis Tshuaj Kho Mob. Khej. 22 (10): 491–3. doi: 10.1016 / S0165-6147 (00) 01807-1. PMID 11583788.

2, Campagna JA, Miller KW, Forman SA (Tsib Hlis 2003). “Cov txheej txheem ntawm cov tshuaj txau qhov quav tshuaj”. N. Engl. J. Med. 348 (21): 2110–24. doi: 10.1056 / NEJMra021261. PMID 12761368.

3, Müller EE, Locatelli V, Cocchi D (Lub Plaub Hlis 1999). "Neuroendocrine tswj kev loj hlob hormone secretion". Physiol. Rev 79: 2 (511): 607–10.1152. doi: 1999.79.2.511 / physrev.10221989. PMID XNUMX.

4, Powers ME, Yarrow JF, McCoy SC, Borst SE (Lub Ib Hlis 2008). "Kev loj hlob hormone isoform cov lus teb rau GABA noj thaum so thiab tom qab ua exercise". Tshuaj thiab Science hauv Kev Ua Si thiab Qoj. 40 (1): 104–10. doi: 10.1249 / mss.0b013e318158b518. PMID 18091016.

5, Balemans MG, Mans D, Smith I, Van Benthem J (1983). "Cuam tshuam ntawm GABA ntawm kev sib txuas ntawm N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol thiab O-acetyl-5-methoxytryptophol nyob rau hauv lub caj pas pineal ntawm tus txiv neej Wistar nas". Kev Luam Tawm, Khoom Noj Khoom Haus, Kev Loj Hlob. 23 (1): 151–60. doi: 10.1051 / rnd: 19830114. PMID 6844712.

6, Sato S, Yinc C, Teramoto A, Sakuma Y, Kato M (2008). "Kev sib deev dimorphic ntawm GABA (A) cov khoom txais tam sim no los ntawm melatonin hauv cov nas gonadotropin" tso tawm cov leeg neurons ". J Physiol Sci. 58 (5): 317–322. doi: 10.2170 / physiolsci.rp006208. PMID 18834560.

7, Kuriyama K, Sze PY (Lub Ib Hlis 1971). "Ntshav – lub hlwb thaiv kom H3-γ-aminobutyric acid hauv cov tsiaj thiab cov amino oxygenacetic acid-kho tsiaj". Neuropharmacology. 10 (1): 103–108. doi: 10.1016 / 0028-3908 (71) 90013-X. PMID 5569303.

8, Foster AC, Kemp JA (Lub Ob Hlis 2006). “Glutamate- thiab GABA-based CNS kev kho”. Cov tshuaj Opin Pharmacol. 6 (1): 7–17. doi: 10.1016 / j.coph.2005.11.005. PMID 16377242.