AASraw tsim NMN thiab NRC hmoov hauv qhov ntau!

Afatinib

Afatinib, muag nyob rau hauv lub npe lag luam Gilotrif nrog rau lwm tus, yog cov tshuaj siv los kho mob tsis-me me lub ntsws mob carcinoma (NSCLC) .Nws yog los ntawm tyrosine kinase inhibitor tsev neeg ntawm cov tshuaj noj.Nws yog noj hauv qhov ncauj.

Hauj lwm yam khoom

Cov yam ntxwv yooj yim

khoom npe Afatinib
CAS Number 439081-18-2
molecular Formula C24H25ClFN5O3
Mis Lub Cev 485.9
Synonyms Afatinib;

439081-18-2;

850140-72-6;

BIBW2992;

Tovok.

tsos Dawb crystalline hmoov
Cia thiab Ua Haujlwm Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo.

 

Afatinib Hauj lwm

Afatinib, muag nyob rau hauv lub npe lag luam Gilotrif nrog rau lwm tus, yog cov tshuaj siv los kho mob tsis-me me lub ntsws mob carcinoma (NSCLC) .Nws yog los ntawm tyrosine kinase inhibitor tsev neeg ntawm cov tshuaj noj.Nws yog noj hauv qhov ncauj.

Afatinib feem ntau yog siv los kho tus mob ntawm NSCLC uas muaj kev cuam tshuam kev hloov pauv hauv cov kab mob loj hlob ntawm tus kabmob (epidermal growth factor receptor) (EGFR).

 

Afatinib Kev Txom Nyem Ntawm Kev Ua

Zoo li lapatinib thiab neratinib, afatinib yog protein kinase inhibitor uas tseem tso tsis taus tib neeg txoj kev loj hlob qhov ua kom haum receptor 2 (Her2) thiab epidermal kev loj hlob yam receptor (EGFR) kinases. Afatinib tsis yog tsuas yog ua haujlwm tiv thaiv EGFR kev hloov pauv tau tsom los ntawm thawj tiam tyrosine-kinase inhibitors (TKIs) zoo li erlotinib lossis gefitinib, tab sis kuj tawm tsam tsawg dua kev hloov pauv uas tiv taus cov tshuaj no. Txawm li cas los xij, nws tsis muaj txiaj ntsig tawm tsam T790M hloov uas feem ntau yuav tsum tau cov tshuaj thib peb xws li osimertinib.Because ntawm nws cov haujlwm ntxiv tiv thaiv Her2, nws tseem tab tom tshawb fawb txog mob qog noj ntshav mis thiab lwm yam mob qog nqaij hlav EGFR thiab Her2.

 

Daim Ntawv Thov Afatinib

Afatinib tau txais kev cai pom zoo rau kev siv ua kev kho mob rau cov qog nqaij hlav ntsws tsis yog mob ntsws, txawm hais tias muaj pov thawj los txhawb nws txoj kev siv hauv lwm cov qog nqaij hlav cancer xws li mob cancer mis.

 

Afatinib Sab Sij Huam & Ceeb Toom

Heev ntau (> 10% zaus)

Zawv plab (> 90%)

▪ Ua pob khaus / dermatitis

▪ Stomatitis

▪ Paronychia

Tsis qab los noj mov

▪ Ntshav los ntshav

Ch Khaus

Skin Qhuav ntawm daim tawv nqaij

 

Ntau yam (1–10% qhov muaj)

Hyd Lub cev qhuav dej, Cov hloov pauv saj, qhov muag qhuav

Cystitis, Cheilitis, Ua npaws

Nose Mob ntswg / txhaws ntswg

▪ Cov piam thaj hauv cov ntshav tsawg tsawg

J Mob pob txha

AL Ntxiv ALT

Ased Ntau AST

Ndrome Kev Mob Tes Taw

As Qaug Zog pob

▪ Lub raum tsis zoo thiab / lossis tsis ua haujlwm

 

Tsis tshua muaj tshwm sim (0.1-1% zaus)

▪ Keratitis

Lung Mob ntsws sib kis

 

reference

[1] "Gilotrif (afatinib) ntsiav tshuaj, zaj duab xis coated". Txhua Hnub. Boehringer Ingelheim Cov Tshuaj Kho Mob, Inc. 18 Lub Kaum Hli 2019. Tshawb Dua 4 Lub Kaum Ib Hlis 2020.

[2] Spreitzer H (13 Tej zaum 2008). “Neue Wirkstoffe - Tovok”. Österreichische Apothekerzeitung (hauv German) (10/2008): 498

[3] Minkovsky N, Berezov A (Lub Kaum Ob Hlis 2008). "BIBW-2992, muaj dual receptor tyrosine kinase inhibitor rau kev kho cov qog ua haujlwm". Cov tswvyim Tam Sim No Hauv Kev Tshuaj Yeeb. 9 (12): 1336–46. PMID 19037840.

[4] “Afatinib”. Asmeskas Cov Khoom Noj thiab Tshuaj Yeeb Tshuaj. 12 Lub Xya hli ntuj 2013. [tuag txuas] [5] “Giotrif Afatinib (as afatinib dimaleate)” (PDF). TGA eBusiness Cov Kev Pab Cuam. Boehringer Ingelheim Pty Txwv. 7 Kaum Ib Hlis Ntuj 2013. Tshawb Dua 28 Lub Ib Hlis 2014.

[6] Vavalà T (2017). "Lub luag haujlwm ntawm afatinib hauv kev kho mob ntawm kev mob siab ntsws txhaws taus cell carcinoma". Cov Chaw Tshuaj Kho Mob. 9: 147–157. doi: 10.2147 / CPAA.S112715. PMC 5709991. PMID 29225480.