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Alfaxalone

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Alfaxalone yog ib qho neuroactive steroid molecule nrog cov yam ntxwv ntawm ib qho tshuaj loog. Alfaxalone tau hais qhia txog tshuaj yog li 3-α-hydroxy-5-α-cev xeeb tub-11, 20-dione, thiab muaj lub cev hnyav ໂມ lis 332.5…

Hauj lwm yam khoom

Cov yam ntxwv yooj yim

khoom npe Alfaxalone
CAS Number 23930-19-0
molecular Formula C21H32O3
Mis Lub Cev 332.48
Synonyms Alphaxalone;

Alfaxalone;

23930-19-0;

5alpha-Pregnan-3alpha-ol-11,20-dione;

Alfaxalonum.

tsos Dawb hmoov
Cia thiab Ua Haujlwm Khaws nyob ntawm chav tswj qhov kub thiab txias-20 ° C

 

Alfaxalone Hauj Lwm

Alfaxalone yog ib qho neuroactive steroid molecule nrog cov yam ntxwv ntawm ib qho tshuaj loog. Alfaxalone tau hais qhia txog tshuaj yog li 3-α-hydroxy-5-α-cev xeeb tub-11, 20-dione, thiab muaj lub cev hnyav li 332.5. Lub tswv yim ua ntej rau kev ua kom loog ntawm alfaxalone yog kev hloov kho ntawm neuronal cell membrane chloride ion thauj, ntxias los ntawm khi ntawm alfaxalone rau GABAA (gamma-aminobutyric acid) cell deg receptors.

 

Alfaxalone Mechanism ntawm kev ua

Alfaxalone ua rau tsis nco qab los ntawm kev ua yeeb yam ntawm gamma aminobutyric acid subtype A (GABAA) receptors hauv nruab nrab lub paj hlwb (CNS). Cov receptors yog ionotropic ligand-gated channels, thiab GABA yog lawv cov ligand ua rau. GABA yog lub ntsiab tshuaj tiv thaiv neurotransmitter hauv CNS. Tom qab cov receptor tshuab txais, cov channel qhib thiab txhawb chloride conduction rau hauv lub cell, ua rau hyperpolarization ntawm cov postsynaptic membrane. Thaum tsis tshua muaj ntau, alfaxalone zoo hloov kho chloride tam sim no los ntawm chloride channel; tab sis ntawm kev muaj peev xwm ntau dua, nws ua haujlwm ua GABA agonist, zoo ib yam li barbiturates. Qhov kawg tshwm sim yog kev ntxias lossis kev ua kom tsis hnov ​​tsw, nyob ntawm koob thiab txoj kev khiav.

 

Alfaxalone Daim Ntawv Thov

Alfaxalone, tseem hu ua alphaxolone lossis alphaxalone thiab siv nyob rau hauv lub npe kev lag luam Alfaxan, yog neuroactive steroid thiab dav dav tshuaj loog siv hauv cov dev thiab miv. Nws tuaj yeem raug siv los ua tus sawv cev induction lossis rau kev siv tshuaj loog.

 

Alfaxalone Cov Kev Pom Zoo & Cov Tsis Zoo

  • Zoo:

Alfaxalone ua rau muaj kev hloov pauv hauv lub plawv tsawg kawg lossis ntshav siab thaum cov chaw txhaj tshuaj uas tau muab rau cov neeg mob noj qab haus huv. Alfaxalone muaj lub siab ntsuas kho qhov siab, yog qhov kev coj ua luv luv, thiab tsis yeem. Cov cwj pwm no ua rau alfaxalone zoo tagnrho rau siv ua tus sawv cev induction lossis rau kev muab tshuaj loog rau kev txhaj tshuaj.

Alfaxalone tseem tuaj yeem siv tshuaj intramuscularly, yog li nws tuaj yeem siv los ua rau qaug tshuaj mob rau cov neeg mob. Thaum alfaxalone yog siv los ua kom loog tus neeg mob yog koob tshuaj 1-3mg / kg IM thiab nws feem ntau yog sib koom tes nrog ib qho opioid rau kev ua kom zoo.

Thaum alfaxalone siv rau kev phais mob ntawm cov menyuam dev muaj ntau yam meej meej thiab muaj siab dua nrog cov qhab nia AGPAR zoo dua piv rau propofol.

 

  • tsis zoo:

Alfaxalone ua rau cov tshuaj tiv thaiv kev mob ua pa nyuaj siab, nrog kev ua pa nyuaj yuav tshwm sim tom qab txhaj tshuaj IV sai sai. Npaj kom tsim tawm, muab kev txhawb nqa oxygen, thiab ua kom muaj pa tawm thaum siv alfaxalone rau kev sib cais lossis kev tawm tsam.

Kev tswj fwm ntau dhau ntawm alfaxalone tuaj yeem ua rau cov tshuaj tiv thaiv kev cia siab ntawm lub plawv, nrog qhov kev txo qis hauv ob qho tib si kev mob plawv thiab ntshav siab. Cov koob tshuaj ntawm alfaxalone yuav tsum ua tib zoo them rau hauv cov neeg mob uas tau txo qis cov hlab plawv cov ntshav cia lossis yog hemodynamically tsis khov.

Alfaxalone tsis muaj kev ua kom loog, yog li nws yuav tsum tau siv nrog kev siv opioid tsim nyog rau cov txheej txheem mob.

Thaum alfaxalone raug tswj hwm intramuscularly qhov ntau ntawm qhov kev txhaj tshuaj tuaj yeem yog qhov loj, uas muaj peev xwm ua rau mob ntawm kev txhaj tshuaj. Lub ntim loj kuj tseem tuaj yeem ua rau kev tswj hwm nyuaj thaum muaj qhov txwv tsawg rau kev txhaj tshuaj vim yog tus neeg mob lub siab. Alfaxalone kev tswj hwm tuaj yeem muaj peev xwm ua rau cov kev txom nyem tsis zoo los ntawm kev ua kom txawv txav ntawm cov paddling, suab, thiab / lossis myoclonus.

 

reference

[1] Whittem T, Pasloske KS, Heit MV li al. (2008) Cov khw muag tshuaj thiab chaw muag tshuaj ntawm alfaxalone hauv cov miv tom qab ib leeg thiab ntau txoj kev tswj hwm ntawm Alfaxan ntawm kev siv tshuaj thiab qib siab supraclinical. J Vet Pharmacol Ther 31 (6), 571-579.

[2] Ferre PJ, Pasloske K, Whittem T li al. (2006) Plas pharmacokinetics ntawm alfaxalone hauv cov dev tom qab kev tso ntshav tawm ntawm Alfaxan-CD. Vet Anaesth Analg 33, 229–236.

[3] Muir W, Lerche P, Wiese A li al. (2009) Txoj kev mob plawv thiab tshuaj loog ntawm kev kho mob thiab cov tshuaj supraclinical ntawm alfaxalone hauv miv. Vet Anaesth Analg 36, 42-54.

[4] Clarke KW, Luas CM, Hall LW, eds. (2014). “Tshooj 15: Kev ua kom loog ntawm tus dev”. Veterinary tshuaj loog (11th ed.). Oxford: WB Saunders. pp. 135–153.

[5] Varga M (2014). “Tshooj Lus 4: Kev Ua Tshuaj Loog thiab Analgesia”. Phau Ntawv ntawm luav Tshuaj (2nd ed.). Butterworth-Heinemann. pp. 178–202.

[6] Nieuwendijk H (Lub Peb Hlis 2011). “Alfaxalone”. Veterinary Tshuaj loog & Pabcuam Analgesia Pab Pawg. Tshawb Fawb Lub Xya Hli 14, 2017.

[7] Zeltzman P (Kaum Ib Hlis 17, 2014). "Vim li cas Kev Tswj Alfaxalone Yuav Tsum Tau Kawm Ntawv Me Me". Veterinary Xyaum Xov Xwm. Tshawb Fawb Lub Xya Hli 14, 2017.