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Alprostadil, (PGE1), Prostaglandin E1

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5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 745-65-3. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm gram los ntawm kev txiav txim siab txog Alprostadil, (PGE1), Prostaglandin E1 (745-65-3), raws li CGMP cov cai tswj thiab kev tswj xyuas qhov system.

Prostaglandin E1 (PGE1), kuj hu ua alprostadil, yog ib qho uas tshwm sim los ntawm prostaglandin uas yog siv tshuaj. Hauv cov menyuam mosliab uas muaj teebmeem ntawm lub plawv, nws siv los ntawm kev hnoos qeev mus rau hauv lub qhov ncauj kom qhib ductus arteriosus txog thaum kev phais mob. Los ntawm kev txhaj tshuaj mus rau hauv chaw mos lossis qhov chaw nyob hauv qhov zis, nws yog siv los kho erectile kawg.

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Alprostadil, (PGE1), Prostaglandin E1 video


Alprostadil, (PGE1), Prostaglandin E1 Basic Cim

Lub npe: Alprostadil, (PGE1), Prostaglandin E1
CAS: 745-65-3
Molecular Formula: C20H34O5
Molecular phaus: 354.48
Melt Point: 115-116 ° C
Cia Temp: 2 ° -8 ° C
xim: Dawb hmoov


Alprostadil, (PGE1), Prostaglandin E1 (745-65-3) siv nyob rau hauv steriods kho

npe

Alprostadil, (PGE1), Prostaglandin E1 (CAS 745-65-3), kuj hu ua Avastin thiab Mvasi.

Alprostadil, (PGE1), Prostaglandin E1 Siv

Bevacizumab los ua ib qho kev daws teeb meem los maj mam ua tus voos. Bevacizumab isadministered los ntawm ib tus kws kho mob lossis tus nais maum nyob rau hauv ib lub chaw kho mob, chaw mos, los yog tsev kho mob. Bevacizumab feem ntau yog muab thaum txhua lub lim tiam 2 lossis 3.

Nws yuav tsum noj 90 feeb rau koj kom tau txais thawj koob tshuaj ntawm bevacizumab. Tus kws kho mob lossis tus nais maum yuav saib xyuas koj kom pom zoo li cas koj lub cev reacts rau bevacizumab. Yog tias koj tsis muaj teebmeem loj thaum koj tau txais thawj koob tshuaj Bevacizumab, nws yuav siv 30 rau 60 feeb kom koj tau txais txhua yam ntawm koj cov tshuaj ntxiv.

Kev txhaj tshuaj Bevacizumab tuaj yeem ua rau muaj kev cuam tshuam loj heev thaum noj tshuaj. Yog tias koj muaj cov tsos mob nram qab no, qhia koj tus kws kho mob sai li sai tau: ua pa nyuaj los yog ua tsis taus pa, ua daus no, tshee, tawm hws, mob taub hau, mob hauv siab, kiv taub hau, tsis muaj zog, ntxhuav, khaus, pob khaus, lossis khaus. Koj tus kws kho mob yuav tsum tau qeeb koj lub plab, los yog ncua lossis kho koj cov kev kho mob yog tias koj muaj cov tshuaj los yog lwm cov kev mob tshwm sim.

Yuav ua li cas Alprostadil, (PGE1), Prostaglandin E1 (745-65-3) ua haujlwm

Rau cov kev kho mob ntawm erectile kawg (ED), alprostadil relaxes cov leeg nqaij ntawm cov corpus cavernosum; Txawm li cas los xij, lub tswv yim ntawm qhov kev txiav txim tsis paub. Nws pom tias cov teebmeem no yog vim ua rau kom cov pob yawm suab ntawm AMP muaj zog. Alprostadil ua ke nrog ib lub zuaj zis ntawm cov zis uas ua rau cov adenylate cyclase thiab ua kom txhawb zog AMP, ua rau kev ua kom muaj protein kinase thiab ua kom muaj zog ntawm cov nqaij ntshiv. Qhov kev txiav txim no yog nyob rau qhov sib txawv ntawm papaverine uas tsis cuam tshuam rau oxidative phosphorylation kho tau ntawm inactivation ntawm cyclic cyclic thiab cuam tshuam nrog calcium mobilization thaum cov nqaij contraction. Alprostadil kuj tseem tuaj yeem tiv thaiv kev ua rau vasthiab tsis sib haum xeeb ntawm kev tsis ua haujlwm ntawm norepinephrine los ntawm kev tiv thaiv cov neuronal tawm ntawm norepinephrine thiab yuav txhim khu cov kev ua ntawm nonadrenergic, noncholinergic vasodilatory neurotransmitters. Hauv kev kho ED, alprostadil induces erection los ntawm relaxing trabecular du nqaij thiab dilating cavernosal hlab ntsha thiab lawv cov ceg ntoo. Kev tua ntawm cov hlab ntsha cavernosal yog los ntawm kev nce kab mob hauv cov hlab ntsha ntau ntxiv thiab nce cov kab mob ua kom tsis muaj zog. Vim li ntawd, qhov chaw txhab nyiaj nthuav dav thiab cov ntshav ua rau nws tuaj yeem ua rau lub nruab nrab ntawm lub venules tiv thaiv qhov tunica albuginea. Yuav ua kom tiav cov tumescence thiab rigidity, tunica albuginea yuav tsum tau txaus txhav kom nruj rau cov hlab ntsha mus rau nws thiab yog li thaiv block outflow. Txoj kev no yog hu ua veno-occlusive mechanism. Alprostadil tsis ncaj qha rau ejaculation lossis orgasm.

Hauv kev kho mob ntawm ductus arteriosus-dependent congenital heart defects, alprostadil tswj ductal patency los ntawm relaxing cov nqaij ntshiv ntawm ductus arteriosus. Alprostadil tsuas yog siv tau yog tias ua ntej ua ntej anatomic closure ntawm ductus arteriosus. Kev tswj hwm ntawm cov tshuaj tua kabmob (alprostadil) rau neonates nrog cyanotic congenital heart defects (txwv pulmonary ntshav ntws) ua rau nce ntshav pulmonary ntws thiab nce siab ntawm cov kev sib xyaw ua mob thiab pulmonary uas ua rau ib ntus nce nyob rau hauv cov pa ib nrab siab (PaO2) thiab cua txias. Cov lus teb ntawm qhov cyanotic neonate rau qhov kev kho mob alprostadil kuj yog hais txog kev ua ntej PO2. Cov lus teb loj tshaj tshwm rau hauv cov neonates uas tsis tshua muaj ua pa PaO2 (<20 torr), qis zis ductus arteriosus, thiab leej twg yog 4 hnub nyoog lossis hluas dua. Neonates nrog PaO2 qhov tseem ceeb ntawm 40 torr los yog ntau dua feem ntau muaj me ntsis lus teb rau alprostadil.

Hauv cov neonates uas txwv tsis pub muaj ntshav khiav, kev tswj hwm ntawm cov tshuaj tua kab mob yuav ua rau kev tiv thaiv lossis kev kho mob ntawm acidemia, ntxiv cov kab mob plawv uas muaj ntshav siab, ntxiv femoral pulse ntim, muaj zog ntxiv ntshav xoob thiab kev ua haujlwm, tsawg dua qhov kev tuaj yeem txo nqis mus rau ascending aortic blood pressure (nyob rau hauv neonates nrog coarctation ntawm aorta), thiab / los sis tsawg ntawm qhov ntsig txog ntawm cov hlab ntsws mus rau qhov siab (hauv neonates nrog cuam tshuam ntawm aortic arch). Tsis zoo li hauv cyanotic neonates, qhov ua tau ntawm alprostadil hauv acyanotic neonates tsis yog nyob ntawm seb muaj hnub nyoog lossis ua ntej Pa cua.

Cov lus qhia ntxiv

Alprostadil (Prostglandin E1) yog siv los kho erectile kawg (ED) rau cov txiv neej laus. Kev ua tau zoo ntawm alprostadil hauv kev kho ED nws txawv nrog qhov ua rau; cov lus teb feem ntau yog qis dua rau cov neeg mob ED vim kev sib xyaw sib txawv xws li cov neeg uas muaj ED vim yog cov kev ua rau lub hlwb, paj hlwb, los yog vasculogenic. Ob hom ntaub ntawv tau siv rau kev kho mob ED: ib qho khoom siv transurethral (Muse) uas siv cov tshuaj pellet siv rau hauv txoj hlab pas thiab kev txhaj tshuaj (Caverject lossis Edex) uas yog ncaj qha mus rau hauv lub corpus cavernosa. Lwm cov ntawv khom nqi xws li cov tshuaj pleev xim gel thiab cov liposomal tub tsis muaj tus kabmob yog nyob hauv kev tshawb xyuas. Raws li txoj cai ED kev kho mob, qhov ncauj phosphodiesterase hom 5 inhibitors (PDE5 inhibitor) yog suav hais tias yog thawj txoj kev kho. Cov kev kho kab mob thib ob muaj xws li kev txhaj tshuaj tiv thaiv thiab kev kho mob hauv tsev kho mob. Intracavernous injection therapy yog qhov kev kho mob zoo tshaj plaws rau ED, nrog kev paub tseeb thiab kev pab teb. Txawm li cas los xij, nws yog ib qho mob thiab ua rau lub npe tsis zoo xws li priapism thiab penile fibrosis. FDA approvals yog raws li nram no: Caverject nyob rau lub Xya hli ntuj 1995, MUSE nyob rau lub kaum hli 1996, thiab Edex hauv lub Xya hli ntuj 1997.

Alprostadil thiab lwm yam prostaglandins hauv E series yog tam sim no nyob rau hauv lub tsho me thiab plab zawv hauv lub plab. Tus E-type prostaglandins vasodilate kev kho mob ntawm kev ncaj nraim ntawm vascular tus leeg mob. Lwm yam tshuaj ua lag ua luam muaj xws li nce rau hauv cov hlwv plawv, qhov ua rau cov hlab ntsha thiab cov hlab ntsws, kev mob plab zawv plawv, kev tiv thaiv platelet aggregation, relaxation ntawm bronchial leeg, nce hauv lub raum ntshav khiav, thiab qeeb lub sij hawm pub dawb. Cov hlab ntsha hauv kev siv roj ntsha yog siv rau hauv cov hlab ntaws nrog cov hlab ntaws ntawm sab xis los yog sab laug qhov ntswg kom muaj kev tiv thaiv ntawm tus cwj pwm ductus arteriosus txog thaum lub sij hawm kho los yog palliative phais. Alprostadil feem ntau zoo dua rau cov neonates uas tsis tshua tsim ua ntshav PO2 thiab leej twg yog 4 hnub qub lossis tsawg dua. Hauv cov neonates hnub nyoog tshaj 4 hnub, nws muaj qhov txo ntawm cov nqaij ntshiv pob txaig vim muaj kev hloov pauv tom qab ntawm phab ntsa ntawm ductus arteriosus. Alprostadil intravenous yuav tsum tau ua pa xyuas thaum lub sij hawm saib xyuas vim hais tias apnea muaj nyob rau hauv 10-12% ntawm neonates. Alprostadil yog FDA pom zoo nyob rau hauv cov neeg mob hauv cov menyuam yaus li cov menyuam yaus. Prostin VR Cov kab mob raug tso cai los ntawm FDA hauv 1981.


Yuav ua li cas yuav Alprostadil, (PGE1), Prostaglandin E1 los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.


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References & cov khoom citations