AASraw tsim NMN thiab NRC hmoov hauv qhov ntau!

Cabozantinib

Cabozantinib, muag nyob hauv cov npe lag luam Cometriq thiab Cabometyx, yog cov tshuaj siv los kho kev mob qog nqaij hlav cancer, ua rau lub qog cell carcinoma, thiab mob hepatocellular carcinoma. Nws yog cov tshuaj loog me me ntawm lub zog tyrosine kinases c-Met thiab VEGFR2, thiab tseem inhibits AXL thiab RET. Nws tau tshawb pom thiab tsim los ntawm Exelixis Inc.

Hauj lwm yam khoom

Cov yam ntxwv yooj yim

khoom npe Cabozantinib
CAS Number 849217-68-1
molecular Formula C28H24FN3O5
Molar loj 501.514
Synonyms XL184, BMS907351;

Cabometyx;

Cometriq;

Cabozanix.

tsos Dawb crystalline hmoov
Cia thiab Ua Haujlwm Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo.

 

CabozantinibHauj lwm

Cabozantinib, muag nyob hauv cov npe lag luam Cometriq thiab Cabometyx, yog cov tshuaj siv los kho kev mob qog nqaij hlav cancer, ua rau lub qog cell carcinoma, thiab mob hepatocellular carcinoma. Nws yog cov tshuaj loog me me ntawm lub zog tyrosine kinases c-Met thiab VEGFR2, thiab tseem inhibits AXL thiab RET. Nws tau tshawb pom thiab tsim los ntawm Exelixis Inc.

Thaum Lub Kaum Ib Hlis 2012, cabozantinib (Cometriq) hauv nws cov qauv tshuaj ntsiav tau pom zoo los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj (FDA) raws li lub npe Cometriq rau kev kho mob rau cov neeg mob qog nqaij hlav cancer. Daim foos xav tau kev pom zoo nyob hauv European Union rau tib lub hom phiaj hauv 2014.

Lub Plaub Hlis 2016, FDA tau pom zoo rau kev lag luam cov ntsiav tshuaj tsim tawm (Cabometyx) ua cov kab thib ob rau kev kho mob raum [8] [9] thiab tib yam kev pom zoo hauv European Union thaum lub Cuaj Hli xyoo ntawd.Qhov hom Cometriq thiab Cabometyx muaj cov qauv sib txawv thiab tsis sib hloov.

 

Cabozantinib Kev Siv Tes Haujlwm ntawm Kev Ua

Cabozantinib inhibits cov nram qab no receptor tyrosine kinases: MET (hepatocyte qhov zoo tshaj yuav receptor protein) thiab VEGFR, RET, GAS6 receptor (AXL), KIT), thiab Fms-zoo li tyrosine kinase-3 (FLT3).

 

CabozantinibDaim ntawv thov

Cabozantinib yog siv ua ob hom. Daim ntawv tshuaj ntsiav yog siv txij li xyoo 2012 los kho cov qog ntshav qog nqaij hlav cancer thawm xyoo thiab daim ntawv ntsiav tshuaj tau siv txij li xyoo 2016 los ua kev kho kab mob thib ob rau lub raum cell carcinoma.

 

CabozantinibSab sij huam & Lus Ceeb Toom

Cabozantinib tsis tau raug kuaj hauv cov poj niam cev xeeb tub; nws ua rau mob plab mus rau nas hauv nas. Cov poj niam thaum cev xeeb tub yuav tsum tsis txhob noj cov tshuaj no, thiab cov poj niam yuav tsum tsis txhob cev xeeb tub thaum noj nws. Nws tsis paub yog tias cabozantinib raug tawm hauv cov kua mis niam.Qhov tshuaj yuav tsum tau siv nrog ceev faj hauv cov neeg muaj keeb kwm muaj teeb meem plawv, nrog rau QT sib nrug ntev.

Hauv Teb Chaws Asmeskas, tshuaj ntsiav tsim (Cometriq) nqa lub thawv dub ceeb toom ntawm qhov kev pheej hmoo ntawm qhov ua rau lub plab lossis plab hnyuv nrog rau kev tsim cov fistulas (tunnels ntawm GI huam thiab tawv nqaij). Lub thawv dub kuj tseem ceeb toom tawm tsam qhov tsis muaj ntshav tsis tuaj yeem los ntshav.Qhov tsim cov ntsiav tshuaj (Cabometyx) ceeb toom txog cov teebmeem no thiab.

Cov ntawv cim tseem ceeb toom txog kev pheej hmoo ntawm clog tsim thiab ua rau mob plawv lossis mob hlab ntsha tawg, ntshav siab nrog rau kev kub siab, osteonecrosis ntawm lub puab tsaig, mob plab zawv plab, tawv nqaij plam tawm ntawm xib teg thiab cov hauv plab, ib qho kev mob siab nrog mob taub hau, tsis meej pem, tsis pom kev , thiab qaug dab peg, thiab cov protein tshwm sim hauv koj cov zis

Cov kev mob tshwm sim ntau (ntau dua 10% ntawm tib neeg) suav nrog kev qab los noj mov; Tsis muaj calcium, potassium, phosphate, thiab qib magnesium; siab bilirubin ntau ntau; distorted siab ntawm saj, mob taub hau, thiab kiv taub hau; ntshav siab; distorted siab hnov, hnov ​​pob ntseg thiab mob caj pas; raws plab, xeev siab, cem quav, ntuav, mob plab thiab mob plab, thiab mob ntawm lub qhov ncauj thiab daim di ncauj thiab hnov ​​cov nqaij hauv qhov ncauj; daim tawv nqaij tawm ntawm xib teg thiab xib taws, plaub hau xim hloov thiab plaub hau hle, pob, tawv nqaij qhuav, thiab tawv nqaij liab; mob tej pob txha thiab mob pob txha; qaug zog thiab qaug zog; poob phaus, txhawb siab hloov ntshav siab, kom cov roj (cholesterol) siab dua, thiab poob cov qe ntshav liab thiab ntshav dawb.

 

reference

[1] “Cabozantinib Siv Thaum Cev Xeeb Tub”. Drugs.com. 30 Lub Peb Hlis 2020. Tshawb Dua 23 Lub Cuaj Hli 2020.

[2] “Ntsiav tshuaj Cabometyx- cabozantinib”. Txhua Hnub. 21 Lub Xya Hli 2020. Tshawb Dua 23 Lub Cuaj Hli 2020.

[3] “Cometriq- cabozantinib pob Cometriq- cabozantinib tshuaj ntsuab”. Txhua Hnub. 11 Lub Ob Hlis 2020. Tshawb Dua 23 Lub Cuaj Hli 2020.

[4] “Cometriq EPAR”. Lub Chaw Saib Xyuas European Tshuaj (EMA). Tshawb Fawb 23 Lub Cuaj Hli 2020.

[5] “Cabometyx EPAR”. Lub Chaw Haujlwm Tshuaj Noj European. 17 Lub Cuaj Hli Ntuj 2018. Rov Tuaj Txog 23 Lub Cuaj Hli 2020.

[6] "FDA pom zoo Cometriq los kho yam tsis tshua muaj mob qog nqaij hlav" (Tso tawm). Meskas cov Khoom Noj thiab Tshuaj (FDA). 29 Kaum Ib Hlis 2012. Tawm los ntawm daim tseem ntawm Lub Xya hli ntuj 7, 2014.