Tebchaws Meskas Tuaj Tebchaws, Tebchaws Thoob Plaws Hauv Tebchaws Asmeskas, Lub Tebchaws Thoob Plaws Tebchaws Thoob Plaws Tebchaws

J 147 hmoov

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 1146963-51-0. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm kab gram los ntawm kev txiav txim siab loj ntawm J 147 hmoov (1146963-51-0), raws li CGMP kev tswj thiab kev tswj xyuas qhov kev tiv thaiv.

J147 hmoov yog thawj tsim nyob hauv 2011, thiab cov neeg tshawb xyuas tau nqa ob peb cov kev tshawb fawb qhia tias nws yuav rov qab nco thiab qeeb Alzheimer's nyob hauv cov nas. Tab sis txog rau txoj kev tshawb no, lawv tsis paub tias nws ua haujlwm hauv hlwb. Lawv tau pom tias J147 hmoov ua hauj lwm los ntawm kev siv ATP, protein nyob hauv mitochondria thiab lub zog ntawm lub cev ntawm lub zog. Thaum J147 hmoov yog tam sim no, cov neurons tau raug tiv thaiv los ntawm cov tshuaj lom tiv thaiv kev laus. Lwm cov thwm sim tau qhia tias J147 hmoov ua rau cov qib ATP thiab txhawb kom muaj kev noj qab haus huv, ruaj khov mitochondria

Hauj lwm yam khoom

J 147 hmoov video


Nyoos J 147 cov hmoov av cim

Lub npe: J 147 hmoov
CAS: 1146963-51-0
Molecular Formula: C18H17F3N2O2
Molecular phaus: 350.3349896
Melt Point: 177-178 ° C
Cia Temp: 4 ° C
xim: Dawb los yog hmoov av dawb


Raw J 147 hmoov hauv kev txhim khu hlwb muaj nuj nqi thiab muaj kev tshaj tawm ntxiv mus

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J 147 hmoov

J 147 (1146963-51-0) Kev noj tshuaj

Siv lub tswv yim tshawb nrhiav kev kho mob rau Alzheimer's disease (AD) uas muaj raws li ntau yam pathologies ntawm cov laus muaj hnub nyoog, peb pom tias lub zog muaj zog nrog cov kev ua ub no nco txog cov tsiaj ntawv nco thiab AD tsiaj qauv. Txij li no compound, J-147 hmoov, yog ib phenyl hydrazide, muaj kev txhawj xeeb uas nws yuav tsum metabolized rau aromatic amines / hydrazines uas yog cov carcinogenic. Yuav kom tshawb tau qhov no, peb tau soj ntsuam cov metabolites ntawm J 147 hmoov hauv tib neeg thiab nas microsomes thiab nas ntshav. Nws pom tias J-147 (1146963-51-0) hmoov tsis metabolised rau cov ntxhuav amines los hydrazines, tias tus scaffold yog kws ruaj khov, thiab cov oxidative metabolites kuj yog neuroprotective. Nws yog xaus tias cov tshuaj metabolites hauv J 147 (1146963-51-0) hmoov pwm yuav ua rau nws cov khoom lom rau tsiaj.
J 147, muab tau los ntawm cov curcumin txuj lom tivthaiv, muaj tsawg toxicity thiab ua reverses puas nyob rau hauv neurons nrog Alzheimer's.

J 147 (1146963-51-0) yog tus mitochondrial protein hu ua ATP synthase, hais tias ATP5A, tus subunit ntawm cov protein. ATP synthase muab kev koom tes hauv lub cim mitochondrial ntawm ATP, cov hlwb siv zog.

Cov neeg tshawb xyuas pom tau hais tias los ntawm kev txo cov kev ua ntawm ATP synthase, lawv muaj peev xwm los tiv thaiv cov hlwb lub hlwb los ntawm ntau cov tshuaj toxicities nrog lub laus laus ntawm lub hlwb. Ib qho laj thawj rau cov nyhuv nyhuv no yog xav tias yog lub luag haujlwm ntawm excitotoxicity hauv kev puas hlwb neuronal.

Excitotoxicity yog tus txheej txheem ntawm cov kab mob neurons uas puas ntsoog thiab raug tua los ntawm lub overactivation ntawm receptors rau excitatory neurotransmitter glutamate. Xav tias nws yog me ntsis zoo li ib lub teeb ci taws tau qhib thiab tawm sai heev thaum nws ua rau lub teeb pom kev los tshuab.

Tsis ntev los no, lub luag hauj lwm ntawm ATP synthase inhibition rau neuroprotection tiv thaiv excitotoxic kev puas tsuaj tau pom nyob rau hauv kev kawm nas [4]. Qhov thib ob txoj kev tshawb no tau pom tias cov qauv siv tus qauv piav txog tib neeg daim ntawv qhia txog kev sib txig ntawm cov tsiaj tsis zoo nyob rau hauv XMUMX (hIF1), uas ua rau muaj kev tiv thaiv ntawm ATP synthase, muaj ntau lub zog rau kev tuag kev tuag tom qab tus mob excitotoxic. Cov ntaub ntawv no zoo ib yam li cov kev kawm tshiab J 1 hmoov, uas qhov nce hauv IF147 hauv cov nas tsuag txo cov kev ua ntawm ATP synthase (lawv ATP1A) thiab yog cov neuroprotective.

Ceeb toom rau Raw J 147 hmoov

Cov ntaub ntawv nthuav tawm ntawm no qhia tias J-147 hmoov muaj peev xwm cawm tau lub peev xwm ntawm kev paub thaum lub sijhawm dhau los ntawm tus kab mob. Lub peev xwm ntawm J-147 hmoov los txhim kho kev nco hauv cov laus AD cov tsiv yog correlated nrog nws cov induction ntawm lub paj hlwb NGF (paj hlwb loj hlob) thiab BDNF (lub hlwb derived neurotrophic factor) nrog rau ntau cov BDNF-responsive proteins uas tseem ceeb rau kev kawm thiab nco. Lub sib piv ntawm X-147 (1146963-51-0) hmoov thiab donepezil nyob rau hauv cov qauv scopolamine pom tias thaum ob lub tebchaw tau zoo nyob rau lub sijhawm luv luv nco, J-147 hmoov yog superior ntawm rescuing spatial nco thiab ua ke ntawm ob txoj haujlwm zoo tshaj plaws rau cov lus tseem ceeb thiab cim xeeb.

Cov lus qhia ntxiv

Alzheimer's disease yog ib lub plab hnyuv siab tsis meej, tsis ntev los no yog qhov thib peb uas ua rau kev tuag hauv Tebchaws Meskas thiab muaj kev cuam tshuam ntau tshaj tsib lab tus neeg Mis Kas. Nws tseem yog qhov ua rau kev mob ntshav qab zib rau cov laus laus, raws li National Institutes of Health. Txawm hais tias feem ntau cov tshuaj tsim los ntawm 20 xyoo dhau los npaj cov amyloid quav hniav tso rau hauv lub hlwb (uas yog ib qho kev qhia ntawm tus kab mob), tsawg leej tau muaj pov thawj zoo nyob hauv qhov chaw kho mob.

"Txawm hais tias feem ntau cov tshuaj tsim los ntawm 20 xyoo dhau los npaj cov pob nyiaj (amyloid plaque deposits) nyob rau hauv lub hlwb (uas yog lub cim ntawm tus kab mob), tsis muaj pov thawj zoo hauv chaw kho mob," hais Schubert, tus sau hais txog kev tshawb nrhiav.

Ntau xyoo dhau los, Schubert thiab nws cov npoj yaig pib ua rau kev kho mob ntawm tus kab mob los ntawm lub kaum ntse ntse tshiab. Tsis yog lub hom phiaj amyloid, qhov kev txiav txim siab txiav txim siab xoom rau ntawm qhov loj tshaj qhov muaj feem rau qhov kab mob-laus hnub nyoog. Kev siv cell-based cov tiv thaiv tawm tsam lub hlwb muaj hnub nyoog laus, lawv ua ke J 147 (1146963-51-0) hmoov.

Yav dhau los, pawg neeg pom tias J-147 hmoov yuav tiv thaiv thiab txawm rov nrawm nco thiab Alzheimer's pathology hauv nas uas muaj ib tug version ntawm tus kab mob los ntawm Alzheimer's, feem ntau yog siv mouse qauv. Txawm li cas los, daim ntawv ntawm tus kab mob no tsuas yog hais txog 1 feem pua ​​ntawm Alzheimer tus neeg mob xwb. Rau txhua leej txhua tus, hnub nyoog laus yog qhov tseem ceeb tshaj plaws, uas hais tias Schubert. Pawg neeg xav tau tshawb txog cov teeb meem ntawm cov neeg sib tw tshuaj rau ntawm ib hom tsiaj uas muaj hnub nyoog sai sai thiab muaj ib txoj kev dementia uas zoo li zoo li lub hnub nyoog txog tib neeg tsis meej.

J 147 Raw Hmoov

Min yuam 10grams.
Cov lus nug txog ntawm ntau npaum li cas (Hauv 1kg) tuaj yeem xa tawm hauv 12 teev tom qab them nyiaj.
Rau kev loj dua (Hauv 1kg) tuaj yeem xa tawm hauv 3 hnub ua hauj lwm tom qab them nyiaj.

Raw J 147 hmoov muag

Kom muab rau yav tom ntej tom ntej.


Yuav ua li cas yuav J 147 hmoov los ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.

PRECAUTION THIAB DISCLAIMER:

Cov Khoom Siv No Yog Muag Rau Kev Tshawb Xyuas Siv Xwb. Cov ntsiab lus ntawm kev muag khoom Thov. Tsis Yog Rau Tib Neeg Noj, Tsis Kho Mob, Kho Tsiaj, lossis Tsev Neeg Siv.


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COA

HNMR

Raw J-147 hmoov (1146963-51-0) hplc = 98% | AASraw SARMS hmoov

Zaub mov txawv

J 147 Raw Pluas Noj Cov Khoom Noj:

Yog xav paub txog peb Tus Neeg Sawv Cev Kev Nkag Siab (CSR) kom paub meej, rau qhov koj siv.

References & cov khoom citations

J-147 Powder Complete Combat Guide thiab Review

Yeeb Yam Tshuaj J147 (1146963-51-0) Alzheimer's Aging