AASraw tsim NMN thiab NRC hmoov hauv qhov ntau!

Lorcaserin (Belviq) hmoov

Rating: SKU: 616202-92-7. Qeb:

AASraw yog nrog synthesis thiab muaj peev xwm ua tau los ntawm cov gram kom loj li ntawm Lorcaserin (Belviq) hmoov (616202-92-7), raws li CGMP kev tswj thiab kev tswj cov kev tswj qhov system.

dawb paug

Hauj lwm yam khoom

 

Qhia Sau Ntawv

Kev tsim tshuaj muaj yees thiab tsis zoo phom sij yog qhov kev ua tsis zoo. Cov kev sim yav dhau los tau muaj ntau yam xws li mob plawv. Luckily, ib txoj kev tshawb xyuas tshiab hais tias lorcaserin poob ntsiav tshuaj tuaj yeem pab koj tawm ntawm qhov hnyav tshaj uas tsis tas yuav txi kev noj qab haus huv ntawm koj lub siab. Lorcaserin yog ib qho kev xav appetite suppressant ntsiav tshuaj, uas tau pom zoo los ntawm FDA hauv 2012. Tab sis dab tsi yog lorcaserin? Zoo, hauv qab no yog ib qho kev qhia tob txog kev siv tshuaj, nws cov qauv thiab cov khoom siv, kev siv, kev siv, kev tiv thaiv, thiab ntau yam ntxiv.

Khoom npe: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

 

Lorcaserin (Belviq) hmoov duab yeeb yaj kiab

 

 


 

I.Lorcaserin (Belviq) hmoov theem pib cim:

 

Lub npe: Lorcaserin (Belviq) hmoov
CAS: 616202-92-7
Cov mis qauv:  C11H14ClN
Lub cev nyhav: 195.692
Melt Point: 212 ° C
Cia Temp: RT
xim: Dawb rau hmoov zoo dawb

 


 

Qhia Sau Ntawv

Kev tsim tshuaj muaj yees thiab tsis zoo phom sij yog qhov kev ua tsis zoo. Cov kev sim yav dhau los tau muaj ntau yam xws li mob plawv. Luckily, ib txoj kev tshawb xyuas tshiab hais tias lorcaserin poob ntsiav tshuaj tuaj yeem pab koj tawm ntawm qhov hnyav tshaj uas tsis tas yuav txi kev noj qab haus huv ntawm koj lub siab. Lorcaserin yog ib qho kev xav appetite suppressant ntsiav tshuaj, uas tau pom zoo los ntawm FDA hauv 2012. Tab sis dab tsi yog lorcaserin? Zoo, hauv qab no yog ib qho kev qhia tob txog kev siv tshuaj, nws cov qauv thiab cov khoom siv, kev siv, kev siv, kev tiv thaiv, thiab ntau yam ntxiv.

Khoom npe: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

 

Hauv qab no yog cov qauv tshuaj ntawm lorcaserin hauv 3-D kev sib hloov.

Lorcaserin (Belviq) hmoov

 

Cov Khoom Siv Tshuaj Lom Neeg ntawm Lorcaserin (belviq) (CAS 616202-92-7)

Hauv qab no yog cov tshuaj lom neeg thaj chaw ntawm Lorcaserin (belviq); lawv tau nthuav tawm hauv cov lus hauv qab no nrawm nrawm.

 

Khoom Npe Tus Nqi Khoom
Suav Cov Npoo Thaj Teb 1
Isotope Atom suav 0
Cov Nyiaj Txiag Lo Lus Uas Tsis Tau Undefined 0
Cov Nyiaj Txiag Lo Lus Stereocenter 0
Cov Npe Atop Stereocenter Suav 0
Hais txog Atom Stereocenter Suav 1
Hnyav Atom hnyav 13
Lub Nqi Them 0
Compound Is Canonicalized muaj tseeb
XLogP3-AA 2.7
Loj Loj 195.081 g / mol
Monoisotopic pawg 195.081 g / mol
Topological Polar Deg Cheeb Tsam 12 IB ^ 2
complexity 172
Cov Nyiaj Txiaj Ntsim Uas Tshaj Tawm 0
Hydrogen Bond Acceptor Suav 1
Hydrogen Nyiaj Donor Suav 1
molecular Nyhav 195.69 g / mol
Dissociation Constants

 

pKa = 9.98 (yog)

 

Ib qho lus qhia yooj yim ntawm Lorcaserin HCL hmoov

Lorcaserin (Belviq) yog lub tshuaj tiv thaiv kev noj qab haus huv uas tsim los ntawm Arena Tshuaj. Nws belongs rau chav kawm ntawm cov tshuaj raug xa mus ua serotonin receptor agonists. Nws tau tsim los pab koj kom koj siab nyob tom qab koj noj tsawg dua cov zaub mov. Nws tshem tawm kev qab los noj mov los ntawm kev ua kom lub 5-HT2C receptors, uas yog hom tshuaj serotonin hauv thaj tsam ntawm lub hlwb (hypothalamus) uas tswj kev qab los noj mov. Thaum lawv kos koj lub cev kom zoo, koj tau noj tsawg dua, yog li xaus poob phaus ntev ntev.

Belviq, nws lub npe tshuaj yog (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3 - benzazepine hydrochloride hemihydrate, txhais tau tias yuav tsum tau hais lus. Nws cov nyhuv molecular yog 241.16 g / mol, thiab nws cov mis nyuj tov yog C11H15Cl2N • 0.5H2O. Nws cov qauv hauv qab no yog:

 

Lorcaserin (Belviq) hmoov

 

Kev daws teeb meem ntawm Lorcaserin hydrochloride hemihydrate hauv dej yog siab dua 400 mg / mL. Ib lub ntsiav tshuaj Belviq muaj 10.4 milligrams ntawm crystalline lorcaserin hydrochloride hemihydrate (lub hmoov dawb mus rau hmoov-dawb), uas yog sib npaug li 10.0 milligrams anhydrous lorcaserin hydrochloride. Nws tseem muaj lwm cov khoom xyaw, suav nrog magnesium stearate NF, talc USP, FD&C Xiav # 2 txhuas lub pas dej, titanium dioxide USP, polyethylene glycol NF, polyvinyl cawv USP, colloidal silicon dioxide NF, croscarmellose sodium NF, silicified microcrystalline cellulose thiab hydroxypropyl cellulose NF.

 

Qhov kev txiav txim ntawm txoj cai ntawm Lorcaserin

Raws li kev tswj hwm cov khoom noj haus (2007), Lorcaserin muaj peev xwm pab cov laus ua tiav qhov kev poob phaus. Qhov hnyav no yog hais tias yuav tsum ua haujlwm zoo thaum muaj kev sib koom tes nrog kev noj qab haus huv thiab kev noj zaub mov qis tsawg. Nws tuaj yeem pab nrog tswj kev mob hnyav, tshwj xeeb tshaj yog cov neeg uas rog dhau (tsawg kawg 27 kg / m2), lossis rog (BMI tsawg kawg 30 kg / m2). Cov tshuaj no tuaj yeem pab cov neeg uas muaj teebmeem txog ib los sis ntau dua, xws li hom 2 Diabetes, dyslipidemia, lossis hypertension.

Lorcaserin yog ib qho kev noj qab haus huv suppressant ntsiav tshuaj uas ua tau xyua xim ua 5-HT2C receptor agonist nyob rau hauv cov hypothalamus nrog kev xaiv selectivity ntawm kaum tsib lub sij hawm ntau affinity rau 5-HT2C  receptors tshaj rau 5-HT2A  thiab xoom xoom 100 ntau dua kev xaiv kom zoo dua rau 5-HT2C receptors tshaj rau 5-HT2B.

5-HT2C receptors muaj nyob rau yuav luag txhua yam hauv tib neeg lub hlwb thiab tuaj yeem pom nyob hauv thalamus, hypothalamus, cortex, hippocampus, choroid plexus, cerebellum, thiab amygdala. Kev loj hlob ntawm 5-HT2C receptors nyob rau hauv hypothalamus ua rau POMC (proopiomelanocortin) ntau lawm thiab yog li ntawd txhawb qhov hnyav txo los ntawm kev ua kom txaus. Qhov kev sib cav no tau txais kev txhawb nqa los ntawm cov pov thawj hauv tsev kuaj mob thiab lwm yam kev tshawb fawb. Thaum nws ib txwm xav tias 5-HT2C receptors pab tswj kev ua kom qab los noj mov, kev tso tshuaj rau endocrine, thiab mus ob peb vas siab, hom qhia kiag ntawm kev txiav txim siab hauv qhov qab los noj mov tsis paub.

 

receptor EC50 [NM] Ki[NM]
5-HT2C 39 13
5-HT2B 2380 147
5-HT2A 553 92

 

Kev siv ntawm Lorcaserin HCL hmoov

Yog tias peb xav txog qhov tseeb Lorcaserin rov tawm muaj, ces qhov no yog qhov zoo tshaj qhov ceeb thawj ntsiav tshuaj ntawm lub khw hnub no. Cov neeg rog uas hnyav dhau lawm, xws li, cov neeg muaj mob hnyav los sis cov neeg uas muaj rog yuav pab tau los ntawm cov khoom no.

Thaum siv nrog ua haujlwm nrog kws kho mob pom zoo, kev pabcuam txo qis, thiab kev hloov hauv txoj kev ua neej, Lorcaserin tuaj yeem pab ua ib qho ntau ntau tshaj qhov poob xwb - nws tuaj yeem txo qee yam kev phom sij uas muaj feem rau kev rog, nrog rau ntshav siab, ntshav qab zib, mob plawv, thiab tuag ntxov.

Raws li Lub Chaw Tswj Xyuas Kab Mob, tsuas yog 5 rau 10 feem pua ​​ntawm tag nrho lub cev qhov hnyav tuaj yeem nthuav qee qhov kev pab cuam xws li kev txhim kho hauv cov ntshav qab zib, cov ntshav siab, thiab ntshav siab.

 

 Kev noj tshuaj ntawm Lorcaserin HCL hmoov

Cov laus yuav tsum tau noj ob lub tshuaj ib hnub twg. Koj yuav tsum tau noj tshuaj 60 ib lub hlis twg. Raws li FDA, ib tug yuav tsum tau siv cov tshuaj thaum lub sij hawm so ntawm nws lub neej kom txhawb nqa kev noj qab nyob zoo.

Nws yog ib qho tseem ceeb kom nco ntsoov tias cov txiaj ntsig zoo yuav tsum pom tom qab 12 lub lis piam. Yog tias koj yuav tsis tau poob qis tsawg kawg ntawm 5 feem pua ​​ntawm koj lub cev hauv lub cev thaum lub sij hawm ntawd, koj yuav tsum qhia kom tsis txhob siv lub ntsiav tshuaj. Txawm tias siv txuas ntxiv, nws tsis tshua xav tias koj yuav ua tiav thiab ceev nrhav lub cev tsis muaj zog.

 

Lorcaserin HCL Precautions

Nws yog qhov zoo uas yuav tsum nco ntsoov tias koj tus kws saib xyuas kev noj qab haus huv tau qhia cov tshuaj no vim tias lawv tau txiav txim siab tias qhov zoo uas koj tau txais yog siab dua qhov kev pheej hmoo ntawm kev phiv. Feem ntau cov neeg uas siv cov tshuaj no tsis pom muaj kev phiv loj heev.

Ua ntej koj noj cov tshuaj lorcaserin, qhia rau koj tus kws muag tshuaj lossis tus kws kho mob paub tias koj muaj kev fab tshuaj dabtsi; lossis seb koj puas muaj lwm yam ua xua. Lorcaserin muaj cov khoom xyaw uas tsis muaj zog uas tuaj yeem ua rau ua xua tuaj yeem ua rau tsis haum lossis lwm yam teebmeem. Nug koj tus kws muag tshuaj kom muab cov ntsiab lus ntxiv rau koj.

Ua ntej yuav siv cov tshuaj no, qhia rau koj tus kws muag tshuaj lossis kws kho mob txog koj li keeb kwm kev kho mob, tshwj xeeb yog cov raum muaj teeb meem, ntshav qab zib, mob siab, mob plawv (suav nrog lub plawv thaiv, mob plawv nres, ua kom lub plawv dhia, plawv tsis ua hauj lwm) uas yuav ua rau muaj kev pheej hmoo ntxiv mob siab / ntev li erections hauv tus txiv neej (suav nrog cov leeg tsis ua haujlwm, Peyronie's kab mob, ntau yam mob myeloma, ntshav ntawm lub ntsej muag ntshav, ntshav daj).

Cov tshuaj noj paum ntxaum no tuaj yeem ua rau koj qeeb koj txoj kev xav lossis kiv taub hau. Cov maj xas lossis dej cawv tuaj yeem ua rau cov teebmeem no tsis zoo. Tsis txhob siv cov tshuab, tsav tsheb, lossis ua txhua yam uas xav tau kev soj ntsuam kom txog thaum koj tuaj yeem ua zoo. Txwv txiav cov dej cawv thiab tham nrog kws kho mob yog tias koj siv yeeb tshuaj xas.

Yog tias koj tau mus phais mob, nws yog ib qho zoo uas koj qhia koj tus kws kho hniav lossis kws kho mob txog txhua yam khoom koj noj (suav nrog tshuaj tsis siv tshuaj, tshuaj ntsuab, thiab tshuaj siv).

Yog tias koj nyob nrog ntshav qab zib, cov ntsiav tshuaj poob phaus no yuav cuam tshuam koj cov ntshav qab zib. Nco ntsoov tias koj txheeb xyuas koj cov ntshav qab zib kom ntshav nyob sib nrug raws li qhia thiab qhia koj kev soj ntsuam nrog kws kho mob. Qhia rau koj tus kws kho mob paub yog tias koj muaj cov ntshav qab zib hauv lub cev tsawg. Koj tus kws saib xyuas kev noj qab haus huv yuav xav kho koj txoj kev tawm dag zog, kev noj zaub mov noj lossis noj tshuaj ntshav qab zib.

Cov tshuaj no yuav tsum tsis txhob noj thaum cev xeeb tub vim nws tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab. Nug koj tus kws kho mob txog kev siv hom kev tiv thaiv tsis pub muaj menyuam. Yog tias koj xeeb tub los yog cev xeeb tub, qhia koj tus kws kho mob kom sai.

Txog tam sim no, tseem tsis tau paub meej tias cov tshuaj no kis mus rau leej niam mis li cas. Yuav kom tiv thaiv tau kev pheej hmoo rau kev pheej hmoo rau menyuam mos, noj niam mis thaum siv cov tshuaj no tsis pom zoo. Nco ntsoov tias koj sab laj nrog koj tus kws kho mob ua ntej koj pub mis rau menyuam.

Nyeem Cov Ntawv Qhia Rau Cov Neeg Siv kom raug yog tias muaj los ntawm koj tus kws kho mob ua ntej koj pib siv lorcaserin thiab txhua lub sijhawm koj tau txais daim ntawv rov ntxiv. Yog tias koj muaj lus nug, nug koj tus kws muag tshuaj lossis kws kho mob.

Noj cov tshuaj noj tshuaj no uas ntsuas qhov ncauj noj nrog lossis tsis tau noj mov raws li koj tus kws muag tshuaj qhia, feem ntau ob zaug ib hnub. Siv cov tshuaj no tsis tu ncua kom tau tshaj tawm. Txhawm rau pab koj nco qab, noj tshuaj ntsiav tib lub sijhawm txhua hnub.

Lorcaserin yog ib hom kev tsim tshuaj. Tsis txhob nce lub koob tshuaj los yog noj cov tshuaj no ntau dua li cov tshuaj. Tus mob uas koj muaj ntawd yuav tsis txhim kho sai sai, thiab qhov kev pheej hmoo ntawm cov kev mob tshwm sim tuaj yeem nce.

Cov tshuaj yeeb dej caw loj heev tuaj yeem siv thaum siv cov tshuaj siv nrog lorcaserin ntsiav tshuaj. Qhia rau koj tus kws kho mob txog txhua yam tshuaj uas koj siv tam sim no, thiab lwm yam tshuaj uas koj pib los yog siv tsis tau.

Lorcaserin ntsiav tshuaj tsis tau yog tsis tau kev tso cai los ntawm cov neeg yau dua 18 xyoo.

 

Kuv yuav noj cov tshuaj Lorcaserin HCL li cas?

Txhob pub noj mov, so, los yog maj mam muab ntsaws tshuaj ntsaws. Cia li nqos nws tag nrho.

Lorcaserin noj qab haus huv suppressant yog ib feem ntawm txoj kev kho mob uas yuav tsum tau muaj xws li qoj, hnyav tswj, noj haus, thiab ib txwm kuaj ntshav koj cov ntshav qab zib. Ua raws li koj cov tshuaj noj, kev noj haus, thiab kev ua hauj lwm txhua hnub kom nruj heev.

Khaws cov tshuaj noj nyob rau hauv chav tsev kub tawm ntawm tshav kub thiab noo noo.

Khaws cov ntaub ntawv ntawm cov tshuaj siv los ntawm txhua lub hwj. Kev ntses tshuaj tua ntses Lorcaserin yog ib qho yeeb tshuaj ntawm kev tsim txom, thiab koj yuav tsum nco ntsoov paub yog tias ib tug neeg siv koj cov tshuaj tsis muaj ntaub ntawv los yog tsis tsim nyog.

Tsis txhob pub cov tshuaj lorcaserin nrog lwm tus noj. Khaws cov tshuaj nyob hauv ib qho chaw uas tsis muaj leej twg tuaj yeem tau txais.

 

Yuav ua li cas yog tias koj tsis nco qab Lorcaserin koob?

Tsuas siv cov tshuaj uas tsis tuaj yeem tam sim ntawd koj nco qab. Koj yuav tsum hla cov tshuaj uas tsis tuaj yeem yog lub sijhawm rau kev txhaj tshuaj tom ntej yuav luag. Tsis txhob noj tshuaj ntxiv kom tsim tau ib qho tshuaj tsis tuaj.

 

Yuav ua li cas yog tias koj dhau ntawm Lorcaserin?

Nrhiav kev pabcuam thaum muaj mob ceev lossis hu rau Poison Help line ntawm 1-800-222-1222.

 

Kuv yuav tsum tsis txhob noj thaum uas nyob rau lorcaserin?

Tsis txhob noj lwm yam khoom uas yuav tom khw los yog cov khoom poob-tshuaj uas tsis tau tso cai yam tsis tau kev pab ntawm koj tus kws kho mob. Tsis tas li, tsis txhob noj tshuaj los yog hnoos thaum noj cov tshuaj lorcaserin.

 

Lwm cov tshuaj dab tsi yuav cuam tshuam rau lorcaserin?

Cov tshuaj hauv qab no tej zaum yuav cuam tshuam li cas lorcaserin ua haujlwm:

  • Ib qho "triptan" uas yog mob taub hau mob taub hau xws li Maxalt, Zomig almotriptan, rizatriptan, sumatriptan, frovatriptan, zolmitriptan, Imitrex, thiab lwm yam.
  • Cabergoline;
  • linezolid;
  • txhua yam ntawm kev tiv thaiv kev antidepressant
  • lithium;
  • John lub wort;
  • erectile dysfunctiondrugs– Levitra, Viagra avanafil, Cialis, sildenafil, tadalafil, thiab lwm tus;
  • tramadol;
  • tryptophan (tseem hu ua L-tryptophan);
  • hnoos lossis tshuaj txias uas muaj dextromethorphan; los yog
  • tshuaj kho mob hlwb, khaus khaus lossis ntxhov siab.

Daim ntawv teev saum toj no tsis tag. Lwm yam tshuaj yuav cuam tshuam rau lorcaserin, thiab tsis tag nrho cov kev sib tshuam tau tshwm sim nyob hauv phau ntawv qhia txog tshuaj kho mob.

 

Cov Ntawv Tshaj Tawm BBC Txog Kev Nyab Xeeb thiab Kev Ua Tau Zoo ntawm Lorcaserin HCL (CAS 616202-92-7)

Muaj ob peb BBC cov lus ceeb toom ntawm Lorcaserin hais txog kev tsis tsuas yog cov txiaj ntsig, tiam sis tseem muaj kev nyab xeeb ntawm cov tshuaj. Raws li cov BBC, txoj kev tshawb nrhiav tsis ntev los no, luam tawm hauv New England Journal of Medicine, qhia tias cov neeg siv cov lorcaserin nqos cov kua tshuaj tua tau ntses poob qhov nruab nrab ntawm ib puag ncig 8.8lb (4kg) ntau dua li peb thiab ib nrab xyoo. Cov txiaj ntsig ntawm txoj kev tshawb fawb no tau ua pov thawj tias lorcaserin yog ib qho ntawm ib qho kev poob phaus zoo tshaj plaws.

Daim ntawv ceeb toom kuj hais tias cov tshuaj no txij thaum nws ua hauj lwm los ntawm kev txo hwj chim, tsis txhob muab cov neeg siv ntxig rau kev mob plawv. Qhov kev tshawb fawb tau ua raws li kev xoom xoom 12,000 rog los yog cov neeg mob rog dhau ntawm 40 lub hlis.

Tom qab peb thiab ib nrab xyoo, cov neeg laus tau noj cov tshuaj lorcaserin muaj peb zaug ntau dua li tsis tau txo qis tshaj li tsib feem kaum ntawm lawv lub cev ntau dua cov uas tau txais cov placebo, raws li ib qho kev soj ntsuam ntawm kev tshawb fawb, Dr. Erin Bohula.

Kev ntsuam xyuas ntawm lub plhaub plawv tsis pom qhov txawv ntawm qhov sib txawv ntawm lub plawv ntawm cov neeg uas siv cov placebo. Nco ntsoov hais tias qhov no yog thawj qhov kev txhawj xeeb thaum nws los txog kev ruaj ntseg ntawm lwm cov tshuaj slimming, lorcaserin yuav muaj qhov zoo tshaj plaws yuag poob ntsiav tshuaj.

Cov neeg laus noj tshuaj kuj tseem muaj feem kis mob ntshav qab zib hom 2 qis dua. Tus nqi tshuaj ntsiav nyob ib ncig ntawm -155 225-220 ($ 290-XNUMX) ib hlis ib zaug hauv Asmeskas. Lorcaserin muab lwm txoj hauv kev zoo rau cov txheej txheem ua kom yuag hnyav zoo li kev phais tus mob plab phais ntawm lwm tus.

Lwm tsab ntawv xov xwm BBC nthuav tawm txoj kev tshawb nrhiav los ntawm cov kws tshawb fawb ntawm University of Aberdeen's Rowett lub koom haum uas ua qhov kev tshawb fawb txog kev qab los noj mov. Cov kws tshawb fawb tau hais tias lawv txoj kev tshawb fawb txog kev qab los noj mov tau ua rau lawv muaj qee yam hauv lub hlwb.

Lawv pom hais tias los ntawm kev cuam tshuam cov hlwb uas muaj qee cov tshuaj uas lawv tau noj qis dua. Txij li thaum lorcaserin ua haujlwm los ntawm lub tswv yim no, cov ntsiab lus ntawm qhov kev tshawb fawb no tsis tsuas qhib cov qhov rooj rau cov tshuaj tshiab xws li lorcaserin, tab sis kuj txhawb cov kws txawj ntseeg txog lorcaserin-nws qhov kev nyab xeeb thiab kev ua haujlwm.