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MMAD (Demethyldolastatin 10)

Rating:
5.00 tawm ntawm 5 raws li nyob rau 1 neeg ntsuam xyuas
SKU: 203849-91-6. Qeb:

AASraw yog nrog kev sib koom tes thiab kev tsim tawm los ntawm cov gram los ntawm kev txiav txim siab MMAD (Demethyldolastatin 10) (CAS 203849-91-6), raws li CGMP kev tswj thiab kev tswj cov kev tswj.

tas li ntawd, MMAD yog qhia tias yuav siv los tsim cov tshuaj tua kab mob sib kis (antibody drug conjugates) (NDCs). Hauv cov NDCs, MMAD ua ke nrog nrog anti-5T4 antibody los tiv thaiv Her2 antibody. Nws pom tau tias cov NDCs ua tau zoo dua qhov ua tau zoo thiab cov tshuaj noj tshuaj.

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Hauj lwm yam khoom

MMAD (Demethyldolastatin 10) yees duab


MMAD (Demethyldolastatin 10) cov Cim Tseem Ceeb

Lub npe: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Molecular Formula: C41H66N6O6S
Molecular phaus: 771.06
Melt Point: N / A
Cia Temp: Hmoov-20 ° C 3 xyoo
4 ° C 2 xyoo
Hauv solvent-80 ° C 6 lub hlis
-20 ° C 1 lub hlis
xim: Dawb kom tawm-dawb (khoom)


MMAD (Demethyldolastatin 10) (203849-91-6) kev siv nyob rau hauv kev hloov qis

npe

Cov ntsiab lus: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Ceeb toom rau MMAD (Demethyldolastatin 10)

Cov khoom tsis tau raug tso siab rau cov ntaub ntawv kho mob. Rau kev tshawb fawb siv xwb

Kev muab lub cev ntau dua, thov sov lub raj ntawm 37 ℃ thiab co nws nyob rau hauv lub ultrasonic da dej rau ib lub sijhawm. Kev daws teeb meem yuav muab cia hauv qab-20 ℃ rau ob peb lub hlis.

Cov lus qhia ntxiv

Hauv Vitro: MMAD (Demethyldolastatin 10) (203849-91-6) yog sib txuas los ntawm kev ruaj ntseg oxime-ligation txheej txheem kom muaj ntau hom tshuaj tiv thaiv hom tshuaj antibody-tshuaj conjugates (ADCs) nrog rau kev sib piv ntawm tshuaj yeeb-los-antibody txog ~ 2.0. Cov conjugates resulting ua kom pom cov khoom zoo hauv cov tshuaj, muaj peev xwm ua tau rau hauv vitro cytotoxic yam tawm tsam HER2 + mob hlwb. Thaum piv nrog ADCs npaj los ntawm cysteine ​​alkylation tom qab hauv zos interchain disulfide txo, qhov chaw tshwj xeeb tsis zoo-amino-acid-based ADCs pom tias tau nce hauv vitro cytotoxicity

Hauv Vivi: Cov tshuaj antibody-conjugates (ADCs) ua rau pom tus mob siab hloov hauv cov nas tsuag. Lawv kuj muaj kev txhim kho toxicology profile hauv cov kaus mom.


Yuav ua li cas thiaj yuav MMAD; yuav Demethyldolastatin 10 ntawm AASraw

1.To tiv tauj peb ntawm peb tus email nug qhov system, lossis hauv internettus sawv cev rau tus neeg sawv cev (CSR).
2.To muab peb nug koj qhov ntau thiab qhov chaw nyob.
3.Our CSR yuav muab nqe lus hais txog koj, qhov them nqi, tus lej nrhiav, kev xaib thiab kwv yees hnub uas tuaj txog (ETA).
4.Payment ua tiav thiab cov khoom xa tuaj rau 12 cov xuab moos (Rau kev txiav txim hauv 10kg).
5.Goods tau txais thiab muab tswv yim.


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COA

HNMR

Zaub mov txawv

References & cov khoom citations