Yuav hwm Spermidine Hmoov raug cai chaw tsim tshuaj paus lub Hoobkas
AASraw ua rau Cannabidiol (CBD) hmoov thiab Hemp Roj tseem ceeb hauv qhov ntau!

Spermidine Hmoov Nqe lus piav qhia

Spermidine hmoov yog qhov ua kom txaus nyiam thiab nws yog qhov ua ntej ntawm spermine. ntau yam khoom noj muaj spermidine, xws li nceb, taum pauv, txiv ntseej, thiab tshwj xeeb tshaj yog cov noob nplej.Qhov muaj nyob hauv txhua tsob ntoo thiab tsiaj txhu thiab ze li ntawm txhua lub cell ntawm koj lub cev. Hauv peb lub cev, nws tuaj yeem noj tau los ntawm kev noj zaub mov -sib xyaw hauv plab microbiome lossis ua ke hauv cov cell.Spermidine hmoov ua lub luag haujlwm tseem ceeb hauv cov kab mob, zoo li tib neeg thiab txawm tias nroj tsuag. Ib qho ntawm spermidine qhov loj tshaj thiab muaj txiaj ntsig tshaj plaws, los ntawm lwm qhov kev ua haujlwm los ntawm, yog lub peev xwm los tiv thaiv kev laus thiab txhawb kev mob qog noj ntshav.

Spermidine Mechanism of Action

Spermidine yog aliphatic polyamine. Spermidine synthase (SPDS) catalyzes nws tsim los ntawm putrescine. Nws yog qhov ua ntej ntawm lwm cov polyamines, xws li spermine thiab nws cov qauv isomer, kub spermine.

Spermidine yog tus neeg sawv cev muaj sia nyob ntev hauv cov tsiaj vim muaj ntau yam txheej txheem ntawm kev nqis tes ua, thiab cov txheej txheem no tsuas yog pib nkag siab. Autophagy yog lub hauv paus tseem ceeb ntawm qib molecular, tab sis muaj pov thawj rau lwm cov txheej txheem tau pom, suav nrog txo qhov mob, lipid metabolism, thiab kev tswj hwm ntawm kev loj hlob ntawm tes, nthuav tawm, thiab tuag.

Benifits ntawm Spermidine Hmoov

Spermidine yog qhov tseem ceeb hauv cov txheej txheem rov ua haujlwm ntawm tes. Raws li cov cell qub tuag, lwm lub hlwb ua rau lawv sib txawv thiab siv cov lwg me me los tsim cov cell tshiab. Raws li peb muaj hnub nyoog, qib ntuj ntawm spermidine hauv peb lub cev yuav txo qis, yog li txo qhov peev xwm ntawm cov cell txuas hnub nyoog thiab kho lawv tus kheej.

Spermidine kuj tau pom tias txo qis kev pheej hmoo ntawm qee hom mob qog noj ntshav, thiab yog tias siv sijhawm ntev txaus, nws tuaj yeem ua lub neej ntev. Thiab tuaj yeem txhim kho kev tiv thaiv tshuaj tiv thaiv rau cov neeg laus.

Thiab spermidine ua lub luag haujlwm tseem ceeb hauv kev tswj hwm cov peev txheej ntawm tes thiab tswj hwm intracellular pH thiab ntim. Cov kev tshawb fawb tseem tau qhia tias nws tuaj yeem txo qhov kev pheej hmoo ntawm kab mob plawv thiab txhim kho kev paub. Spermidine muaj cov tshuaj tiv thaiv kab mob tiv thaiv kab mob hauv lub cev los ntawm kev mob o, ischemia thiab oxidative kev nyuaj siab.

Cov teebmeem ntawm Spermidine Hmoov

Vim muaj ntau yam txheej txheem ntawm kev nqis tes ua, spermidine yog tus neeg muaj sia nyob ntev rau cov tsiaj, suav nrog txo qhov mob, lipid metabolism, thiab kev tswj hwm ntawm tes kev loj hlob, loj hlob, thiab tuag. Spermidine tuaj yeem tiv thaiv daim siab fibrosis thiab kab mob siab hepatocellular carcinoma uas yog ib qho ua rau mob qog noj ntshav ntau tshaj plaws. Nws nquag siv hauv cov tshuaj uas, thaum noj, tsis tu ncua, tuaj yeem muaj kev cuam tshuam loj rau kev ua neej nyob ntev.

Spermidine trihydrochloride Hmoov Nqe lus piav qhia

Spermidine trihydrochloride hmoov kuj tseem yog polyamine uas txwv tsis pub muaj cov neuronal nitric oxide synthase (nNOS) thiab khi thiab ua kom cov DNA nce. Nws tuaj yeem siv los ua kom cov DNA khi rau cov protein. Ib qho ntxiv, spermidine ua rau T4 polynucleotide kinase ua haujlwm. Nws tau koom nrog hauv kev loj hlob, kev txhim kho, thiab kev ntxhov siab hauv cov nroj tsuag.

Spermidine trihydrochloride Mechanism of Action

Spermidine trihydrochloride yog ntuj polyamine uas tsim los ntawm putrescine thiab decarboxylated S-adenosylmethionine (dcSAM) los ntawm spermidine synthase, yog tus tshiab autophagy inducer thiab hloov pauv tsis zoo N-methyl-d-aspartate (NMDA).

Ribs rau polyamine modulatory site ntawm NMDA receptor thiab tau piav raws li agonist raws li nws lub peev xwm los txhim kho txoj kev khi ntawm [3H] -MK801.

Spermidine trihydrochloride Hmoov Thov

Spermidine trihydrochloride tau siv nyob rau hauv plaub qhov kev hloov pauv infrared spectroscopy (FTIR) tus yam ntxwv thiab hauv kev ntsuas zeta.

Spermidine hydrochloride tau pom dav hauv qhov thiab tseem ceeb rau kev loj hlob ntawm cov nqaij; Nws feem ntau siv los ua cov cuab yeej hauv kev tshawb fawb biochemical; Spermidine hydrochloride yog cov tshuaj polyamine, C7H22Cl3N3, pom hauv ribosomes thiab cov nqaij nyob thiab muaj ntau yam kev ua haujlwm hauv lub cev.

Cov teebmeem ntawm Spermidine trihydrochloride Hmoov

Spermidine trihydrochloride hmoov yog Inhibits neuronal nitric oxide synthase (nNOS). Nws khi thiab precipitates DNA; Spermidine trihydrochloride hmoov tuaj yeem siv rau kev ua kom huv ntawm DNA khi cov protein thiab ua kom lub sijhawm T4 polynucleotide kinase ua haujlwm.

Qhov Yuav Yuav Cov Phem Spermidine Hmoov?

AASraw yog cov chaw tsim khoom lag luam thiab cov khoom lag luam ntawm ntau cov tshuaj spermidine hmoov rau muag. Yog tias koj xav yuav spermidine hmoov ntau ntau, thov xa lus nug rau peb ncaj qha.Qhov zoo tshaj speridine hmoov nrog tus nqi zoo tshaj yuav muab los ntawm peb!

reference:

[1] American Heritage Dictionary Retrieved 2014-11-18.
[2] Minois, Nadège (28 Lub Ib Hlis 2014). "Molecular Basis of the" Anti-Aging "Effect of Spermidine thiab Lwm Yam Ntuj Polyamines-Mini-Review". Gerontology. 60 (4): 319-326. doi: 10.1159/000356748. PIB 24481223.
[3] Madeo F, Eisenberg T, Pietrocola F, Kroemer G (2018). "Spermidine hauv kev noj qab haus huv thiab kab mob". Kev tshawb fawb. 359 (6374): yog 2788. doi: 10.1126/science.aan2788. PIB 29371440.
[4] [4] Ramot, Yuval; Tiede, Stephan; Bíró, Tamás; Abu Bakar, Mohd Hilmi; Sugawara, Koji; Philpott, Michael P.; Harrison, Wesley; Pietilä, Marko; Paus, Ralf (27 Lub Xya Hli 2011). "Spermidine txhawb tib neeg cov plaub hau kev loj hlob thiab yog tus tshiab Modulator ntawm tib neeg epithelial qia tes haujlwm". PLOS IB. 6 (7): e22564. doi: 10.1371/journal.pone.0022564. ISSN 1932-6203. PMC 3144892. PMID 21818338.
[5] Munir li al (1993) Polyamines hloov kho cov teebmeem neurotoxic ntawm NMDA hauv vivo. Lub paj hlwb. 616 163 PMID: 8358608.
[6] Williams li al (1989) Cov teebmeem ntawm polyamines ntawm kev khi ntawm [3H] -MK801 rau N-MthD.-aspartate receptor: cov ntaub ntawv pov thawj tshuaj rau lub neej ntawm polyamine paub qhov chaw. Mol.Pharmacol. 36 375 PMID: 2554112

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