AASraw tsim NMN thiab NRC hmoov hauv qhov ntau!

Urolithin Ib Pab Pawg Rov Qab

Pomegranate lub plawv muaj txiaj ntsig tau ua rau cov kws tshawb fawb soj ntsuam seb cov txiv hmab txiv ntoo liab no tuaj yeem ua rau peb noj qab haus huv li cas. Hauv kev tshawb pom tsis ntev los no, Swiss cov kws tshawb nrhiav tau txheeb xyuas cov qauv tshiab uas tshwm sim los ntawm kev zom ob lub tebchaw nyob hauv pomegranates: punicalagins thiab ellagitannins. Qhov tshwj xeeb molecule, hu ua urolithin A, pab ua kom mitochondria, peb lub tsev tsim hluav taws xob. Urolithin A qhib qhov rooj rau cov kev kho mob tshiab los tiv thaiv kev cuam tshuam txog lub hnub nyoog, suav nrog kev ua kom tsis muaj zog, uas yog qhov phom sij rau kev xiam oob qhab, pw hauv tsev kho mob, thiab kev tuag.

Urolithin Ib Txheej txheem cej luam

Urolithin A yog cov tshuaj sib xyaw ua ke, uas yog pawg kawm ntawm cov organic sib txuas hu ua benzo-coumarins. Nws yog qhov kawg khoom tsim tawm los ntawm kev noj zaub mov uas muaj ellagitannins (polyphenols) thiab metabolized los ntawm lub cev muaj kab mob plab. Hauv lwm lo lus, Urolithin A yog tsim thaum ib tus neeg noj cov khoom noj muaj cov ellagitannins.

Urolithin A tsis tshwm sim ib txwm muaj nyob hauv nws daim foos kawg. Ellagitannin cov khoom noj muaj txiaj ntsig, zoo li qee yam ntawm cov txiv ntoo thiab pomegranate, yuav tsum muaj lub cev nrog cov kab mob hauv plab txhawm rau tsim. Txhawm rau kom cov compound kom muaj cov ntawv thov siv tau, nws yuav tsum tau tsim hauv chav kuaj, lossis ua lwm yam lus, dag Urolithin A yuav tsum tau tsim kom nws siv tau.

Kev tshawb fawb pom tau hais tias Urolithin A muaj cov khoom coj los tiv thaiv kev laus. Nws tau hais los pab hauv kev tsim cov leeg nqaij, ua cov yam ntxwv tiv thaiv lub cev, thiab nws tseem qhia tau tias yuav pab txhim kho kev txawj ntse hauv cov laus lub cev.

Urolithin Ib Txheej Txheem Ntawm Kev Ua

Urolithin A ua haujlwm li cas? Ellagic acids thiab Ellagitannins yog Urolithin Ib yam khoom siv ua ntej.

Ellagitannins yog hydrolyzed los ntawm txoj hnyuv mus rau tso tawm Ellagic acid, thiab qhov no tau ua tiav los ntawm lub plab microflora rau urolithins los ntawm kev nce zuj zus hauv 1 ntawm nws ob lactones cov kev tshem tawm hydroxyl pawg txuas ntxiv. Thaum Nws tau noj nyob rau hauv cov hnyuv, tom qab ntawd Urolithin Ib cov hmoov nkag mus rau Qhov Txaus Tshaj ntawm lub plab hnyuv no.

Mitophagy, raws li Wikipedia txhais, yog qhov kev xaiv degradation ntawm koj mitochondria los ntawm autophagy. Nws feem ntau tshwm sim rau cov mitochondria uas muaj kev puas tsuaj lossis kev ntxhov siab. Txawm li cas los xij, raws li peb hnub nyoog, Mitophagy kev ua haujlwm ua tau tsawg dua. Muaj hmoov kawg, Urolithin A tau pom zoo kom txhawb nqa mitophagy yam uas tau pom zoo nyob rau ntau hom sib txawv.

Cov Txiaj Ntsig / Zoo Los Ntawm Urolithin A

Rol Urolithin Ib Pab Tau Mob Cancer

Txawm hais tias yuav tsum tau mus kuaj phais mob thiab siv tshuaj kho, yuav luag li 50% ntawm cov neeg mob qog nqaij hlav hlav hlav muaj hlav hlav tuaj. Qhov no tuaj yeem yog ib feem rau kev muaj sia nyob ntawm cov qog nqaij hlav nyuv-mob qia hlwb uas tiv taus cov kev kho mob ib txwm muaj thiab ua raws li '' noob '' rau cov qog nqaij hlav tom ntej
Hauv kev tshawb pom tseem ceeb, cov kws tshawb nrhiav nthuav tawm qog-mob qog nqaij hlav hlwb los ntawm tus neeg mob uas muaj mob plab hnyuv rau ib qho sib xyaw uas muaj 85% urolithin A lossis 30% urolithin A. Cov txiaj ntsig tau zoo kawg nkaus. Lub siab dua urolithin Ib cov ntsiab lus sib xyaw ua ke tau zoo tshaj plaws ntawm kev txwv tsis pub muaj pes tsawg thiab qhov loj ntawm cov nyuv-mob qog nqaij hlav hlwb thiab inhibiting cov kev ua ntawm aldehyde dehydrogenase, lub cim ntawm chemoresistance.
Qhov kev kho mob kom zoo siab no zoo siab heev vim tias kev kho mob ib txwm tiv thaiv qog noj ntshav tsis muaj peev xwm tua lossis tso tseg kev loj hlob ntawm cov qog hlwb. Cov kev tshawb pom tshiab no txhawb nqa cov kev xav tias cov khoom noj muaj txiaj ntsig zoo tuaj yeem ua pov thawj muaj txiaj ntsig zoo li lwm txoj kev kho mob lossis kev tiv thaiv kev tiv thaiv rau lub hom phiaj ntawm cov kab mob no.

Rol Urolithin A - Cov Teeb Meem Neuroprotective

Cov kev sib txuas ntawm pomegranate thiab nws cov neuroprotective cuam tshuam tiv thaiv Alzheimer tus kab mob tau tsim tau zoo hauv kev tshawb fawb tsiaj.
Alzheimer tus kab mob yuav raug rau ntau dua 115 lab tus neeg thoob ntiaj teb los ntawm xyoo 2050.A pawg neeg tshawb fawb tau saib kev tshawb nrhiav tsiaj dhau los uas tau tshaj tawm txog cov teebmeem kev tiv thaiv Alzheimer ntawm pomegranate extract cov qauv.
Pab pawg tau soj ntsuam qhov muaj peev xwm ntawm cov feem no los hla cov ntshav-hlwb teeb meem thiab pom tias methylated daim ntawv ntawm urolithin A (mUA), muab tau los ntawm pomegranate, nrog rau lwm yam urolithins muaj peev xwm ua tau.
Thiab, txawm hais tias yuav tsum muaj kev tshawb fawb ntxiv, cov sau phau ntawv xaus lus tias urolithins yog cov sib txuas uas yuav muaj lub luag haujlwm los tiv thaiv Alzheimer cov teebmeem uas suav nrog kev tiv thaiv neurotoxicity thiab b-amyloid fibrillation. Cov txiaj ntsig tau tshwm sim muaj kev cia siab, thiab qhia txog qhov xav tau los tshawb nrhiav lwm qhov kev noj haus zoo rau kev tiv thaiv kev tiv thaiv lossis txo qis kev nce ntawm Alzheimer.
Cov txiaj ntsig thiab cov ntaub ntawv los ntawm cov kev tshawb fawb no ntxiv txhawb qhov tseem ceeb ntawm polyphenol metabolite sib txuas zoo li urolithin A los ntawm pomegranate thiab lawv lub luag haujlwm hauv kev tawm tsam mob nyuv thiab mob neurodegenerative.
Cov kev tshawb fawb kuj tau qhia tias Urolithin A tuaj yeem txhim kho cov leeg pob txha thiab lub zog ntawm cov neeg laus. Cov kev tshawb fawb tsis ntev los no qhia tau hais tias cov ntawv pov thawj ua ntej nthuav tawm lwm cov txiaj ntsig ntawm Urolithin A, uas suav nrog hauv qab no:

-Anti-mob
-Anticarcinogenic
-Cov tshuaj tiv thaiv zoo
-Antiglycative
-Antimicrobial


Urolithin A kuj tseem pom tau hais tias ntxiv rau cov khoom muaj protein txhawm rau txhim kho cov txiaj ntsig ntawm kev qoj ib ce, nrog rau txo kev rog.

Urolithin Qhov Teeb Meem Zoo

Hauv cov ntsiab lus hais txog tib neeg kev sim tshuaj, tsis muaj kev phiv tshuaj dab tsi. Hauv kev tshawb nrhiav ntau dua ntawm cov kev kawm ua ntej thiab kev soj ntsuam, pom tau muaj pov thawj txhawb rau kev nyab xeeb ntawm Urolithin A siv.

Tsis muaj kev qhia txog kev mob toxicological, txawm tias nyob rau hauv kev tshawb fawb uas koom nrog qhov siab tshaj plaws muab rau cov nas nyob hauv kev tshawb fawb.

Urolithin A tau tsim los hloov txoj kev lag luam tiv thaiv kev laus. Cov kev tshawb fawb soj ntsuam tseem nyob rau lawv thaum ntxov tab sis feem ntau ntawm kev sim qhia pom cov txiaj ntsig tau zoo uas tsis muaj kev phiv tshuaj. Los ntawm cov khoom noj rau cov tshuaj ntxiv, Urolithin A yog khi rau kev nrhiav noj tshiab superfood zoo uas txhua tus neeg yuav tsum tau noj.

Urolithin Qhov Chaw Khoom Noj Khoom Noj

Raws li tau hais, Urolithin A hauv nws daim foos kawg tsis pom zoo. Kuj tsis paub muaj nyob hauv tej chaw nrhiav khoom noj. Txawm li cas los xij, tus ua ntej rau cov kev sib txuas tuaj yeem pom nyob hauv qee cov txiv hmab txiv ntoo thiab txiv ntoo. Cov khoom noj khoom haus uas muaj ellagitannins xws li pomegranate, txiv pos nphuab, txiv pos nphuab, pos huab, thiab walnuts yog qee qhov ua piv txwv.

Cov ellagitannins hauv cov txiv hmab txiv ntoo thiab noob txiv yog hydrolyzed nyob rau hauv lub plab los tsim ellagic acid, uas yog ntxiv tom qab ua tiav ntawm lub plab thiab metabolized nrog lub plab microflora rau hauv Urolithin A.

Nws yog ib qho tseem ceeb kom nco ntsoov tias Urolithin A tsis pheej tshwm sim thaum noj. Qee tus neeg lub siab tsis muaj cov khoom noj zoo ntawm microflora xav tau los hloov ellagic acid rau hauv Urolithin A. Qhov no txhais tau hais tias tsis yog txhua tus yuav tsim Urolithin A hauv lawv lub plab yog tias lawv noj pomegranate, walnuts, lossis berries. Txhua yam nws nyob ntawm tus kab mob plab tshwm sim hauv koj lub cev.

Urolithin Kev Tsim Khoom Siv Khoom

Urolithin A yog tsim los ntawm cov tshuaj syntheses siv ib qho ntawm ob txoj kev piav qhia hauv qab no. Ob qho txheej txheem koom nrog Ullmann coupling cov tshuaj tiv thaiv, tom qab los ntawm Kev Kho Mob Lewis acid kom paib urolithin A ntshiab cov khoom lag luam.

Cov khoom kawg yog ua kom huv los ntawm cov txheej txheem los ntawm kev kho mob hauv cov kuab tshuaj, lim, ntxuav thiab ziab kom tau txais urolithin A. Cov khoom tom qab raug yuam kev txo qhov loj me.

Raws li cov txheej txheem ua tau zoo, Urolithin Ib cov hmoov yog cov khoom tsim hluavtaws tsim thiab ua kom huv huv nyob rau hauv ntau kauj ruam loj mus rau kev ua kom pom tseeb huv si 99%. Cov Khoom Siv Raw thiab cov txheej txheem ua haujlwm koom nrog hauv kev sib xyaw ua ke ntawm urolithin A suav nrog 2-Bromo-5-methoxy benzoic acid, 2-Bromo-5-hydroxy benzoic acid, Resorcinol, 50% sodium hydroxide, Copper sulfate pentahydrate, Methanol, Aluminium chloride, Toluene , DMSO, Methanol, Acetic Acid, thiab TBME (tert-butyl-methyl ether).

Khoom cua Urolithin A VS Ntuj Urolithin A

Raws li tau hais los saum toj no, Urolithin A yog lub plab git-derived bacterial metabolite ntawm ellagitannins (ET) lossis ellagic acid (EA). Yog tias koj xav tau ntau qhov ntau ntawm Urolithin A, koj yuav tsum xub noj cov txiv ntoo loj heev, thiab tom qab ntawd tos kom lawv hloov ntawm ellagitannins thiab ellagic acid rau Urolithin A. Cov txheej txheem no ntev, thiab nws qhov kev coj dawb huv tsawg, thiab tseem ceeb tshaj , nws yuav kim heev kom ua li ntawd.

Tsis yog txhua tus muaj cov microflora txoj cai uas tuaj yeem ua rau cov metabolite. Ntxiv rau, cov txheej txheem no tsis tuaj yeem siv rau huab hwm coj ntau hauv chaw tsim khoom GMP-raws chaw.

Qhov xov xwm zoo yog tias, raws li ib qho kev tshaj tawm tshiab, Urolithin A yog thaum kawg ua lag luam hauv 2019 los ntawm Cima Science. Tam sim no tuaj yeem raug tsim nyob rau hauv chav kuaj thiab koom xwm. Cov khoom siv hluavtaws urolithin A yog qhov zoo ib yam hauv cov qauv rau ntuj urolithin A. Cov khoom tsim muaj peev xwm nce txog 3000 kgs lossis 2.5 tons / hli.

Urolithin Qhov Kev Nyab Xeeb

Urolithin A pom zoo los ntawm European Union yog tus ua zaub mov noj tshiab.

Tebchaws Asmeskas Cov Khoom Noj thiab Tshuaj Yeeb Tshuaj (FDA) xyoo 2018 tau tso cai urolithin A nws cov GRAS xwm txheej siv hauv cov mis ntxiv. GRAS txhais tau hais tias Urolithin A feem ntau suav tias yog qhov muaj kev nyab xeeb nrog kev noj ntau npaum li 500mg rau 1 gram ib zaug ua haujlwm.

Urolithin Kev tshawb xyuas kev nyab xeeb tau raug tshawb fawb ntawm qhov kev sim ua ntej thiab kev kuaj mob, uas txhawb nws txoj kev nyab xeeb kev noj qab haus huv rau nws cov kev siv. Rov qab siv dua 28-hnub thiab 90-hnub kev tshawb fawb ntawm urolithin A hauv cov nas tsis tau ua kom pom kev cuam tshuam tshuaj lom nyob hauv qee qhov ntsuas tau ntsuas txhua txoj kev ntsuas.

Kev txhawb ntxiv mus txog 90 hnub nrog urolithin A tsis ua rau muaj cov tsos mob ntawm lub paj hlwb lossis lub cev muaj tshuaj lom nyob rau hauv kev txheeb xyuas lub sijhawm ntawm kev rov tshawb dua ib zaug ntxiv xws li kev ntsuam xyuas cov phevatogenesis lossis oestrus cov voj voog, kev kuaj xyuas ophthalmoscopic, kev soj ntsuam lub roj teeb ua haujlwm, thiab kev ua haujlwm lub cev cov kev ntsuas.

Txais tos Yuav Urolithin A / Urolithin A 8-Methyl Ether Bulk Hmoov los ntawm AASraw!

Kev tshawb pom ntawm urolithin A, uas tshwm sim los ntawm punicalagins thiab ellagitannins sib txuas pom hauv pomegranates, muab cov hauv kev tshiab los tawm tsam lub hnub nyoog ntsig txog kev ua haujlwm ntawm mitochondrial thiab qhov ua rau lub cev tsis muaj zog thiab poob ntawm cov leeg.

Los ntawm pab cov hlwb rov ua lawv tus kheej thiab ua kom cov leeg ua tau zoo, pomegranate extract thiab nws qhov khoom noj tshiab tau metabolite, urolithin A-tuaj yeem ua tiav.

Nrog rau cov kev tshawb pom no, muaj cov pov thawj txhawb nqa ntawm cov muaj txiaj ntsig zoo uas urolithin A muaj kev tiv thaiv kab mob Alzheimer thiab mob qog nqaij hlav, muab lwm cov cuab yeej los tawm tsam cov kev mob no uas cuam tshuam rau ntau tus neeg laus.

Qhov kev noj haus kom mus zoo li qhib tau qhov ib txwm siv tshuaj ib txwm tsis tau tshawb nrhiav. Yog tias koj xav yuav Urolithin A hmoov / Urolithin A 8-Methyl Ether hmoov, AASraw tej zaum zoo xaiv.

Urolithin B Lus Qhia

Urolithin B yog urolithin, ib hom phenolic tebchaw tsim hauv tib neeg lub plab tom qab nqus cov ellagitannins-uas muaj cov zaub mov xws li pomegranate, txiv pos nphuab, liab raspberries, walnuts lossis oak-hnub nyoog liab. Urolithin B yog pom nyob hauv cov zis hauv daim ntawv ntawm urolithin B glucuronide.

Urolithin B kuj yog ib yam khoom ntuj nrog antiproliferative thiab antioxidant kev ua ub no. Urolithin B yog tsim los ntawm cov metabolism los ntawm polyphenols pom nyob rau hauv qee cov txiv ntoo thiab txiv hmab txiv ntoo, tshwj xeeb yog pomegranates. Urolithin B tau pom tias hla cov ntshav tiv thaiv lub hlwb, thiab tej zaum yuav muaj neuroprotective tiv thaiv Alzheimer Tus Kab Mob.

Urolithin B Cov Kev Ua Haujlwm ntawm Kev Ua

Nws txo qis cov protein degradation thiab ua rau cov leeg ntshav tsis zoo. Urolithin B inhibits kev ua ntawm aromatase, ib qho enzyme uas sib cuam tshuam cov tshuaj estrogen thiab testosterone.

Urolithin B yog cov khoom siv ntuj tsim nrog antiproliferative thiab antioxidant kev ua haujlwm. Urolithin B yog tsim los ntawm cov metabolism los ntawm polyphenols pom nyob rau hauv qee cov txiv ntoo thiab txiv hmab txiv ntoo, tshwj xeeb yog pomegranates. Urolithin B tau pom tias hla cov ntshav tiv thaiv lub hlwb, thiab tej zaum yuav muaj neuroprotective tiv thaiv Alzheimer Tus Kab Mob.

Urolithin B inhibits NF-activityB kev ua haujlwm los ntawm kev txo phosphorylation thiab degradation ntawm IκBα, thiab suppresses phosphorylation ntawm JNK, ERK, thiab Akt, thiab txhim kho phosphorylation ntawm AMPK. Urolithin B kuj tseem yog tus tsim txoj cai pob txha pob txha pob txha.Urolithin B yog ib ntawm lub plab hnyuv plab zom zaub mov ntawm ellagitannins, thiab muaj cov kev ua los tiv thaiv kev tiv thaiv thiab ua kom muaj zog.

Urolithin B Daim Ntawv Thov

Thaum kawm txog lub zog tiv thaiv kev tiv thaiv thiab tshuaj tua kab mob ntawm urolithins A thiab B, UCL cov kws tshawb nrhiav tau tshwm sim pom tias tom kawg muaj qhov cuam tshuam rau cov leeg. 'Nqaij hlav hlwb hauv kab lis kev cai uas tau sib cuag nrog urolithin B tau loj dua cov uas tsis tau ua. Peb xav paub vim li cas.

Ua ntej, lawv tau kawm cov tshuaj hauv vitro thiab pom urolithin B muaj cov txiaj ntsig zoo: nws ua kom cov nqaij mos ua kom cov nqaij hluavtaws ua kom tsis tshua muaj zog thiab ua rau cov kev ua kom tsis tshua pom.

Thib ob, cov kws tshawb nrhiav tau kawm txog cov txiaj ntsig ntawm urolithin B hauv vivo, rau ntawm cov nas. 'Nws nce lawv cov leeg kev loj hlob', Prof. Francaux hais. 'Peb kuj tau muab nws tso rau cov nas nrog lub pob txha loj sciatic hlab ntsha ua rau txhawm rau txhawm rau txhawm rau, thiab cov leeg mob tom qab tau tshwm sim 20 mus rau 30% tsawg dua sai sai thiab ua rau muaj qhov qis dua.'

Qhov zoo ntawm Urolithin B

Urolithin B yog ib lub plab microbial metabolites ntawm ellagitannins, thiab muaj cov anti-inflammatory thiab antioxidant cuam tshuam. Urolithin B inhibits NF-activityB kev ua haujlwm los ntawm kev txo phosphorylation thiab degradation ntawm IκBα, thiab suppresses phosphorylation ntawm JNK, ERK, thiab Akt, thiab txhim kho phosphorylation ntawm AMPK. Urolithin B kuj tseem yog tus tsim txoj cai pob txha leeg pob txha.

(1). Urolithin B txo cov uas ua kom cov leeg leeg tsis rog los ntawm kev lees paub
(2). Urolithin B-ntxias cov leeg pob txha hauv cov leeg ntshav ntau ntau hauv cov nas
(3). Cov nyhuv anabolic ntawm urolithin B yog kev sib kho los ntawm lub androgen receptor
(4). Urolithin B stimulates protein synthesis hauv C2C12 myotubes los ntawm kev ua kom mTORC1 taw qhia
(5). Urolithin B inhibits protein ntawm kev ua kom tsis zoo los ntawm kev ua kom txoj kab ubinin – proteasome txoj hauv kev
(6). Urolithin B txhim kho kev sib txawv ntawm C2C12 myotubes

reference:

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