Cov Lus Nquag Nug Txog Sunitinib Malate-AASraw
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Sunitinib Malate

 

  1. Sunitinib Malate Txheej txheem cej luam
  2. Peb Yuav Siv Dab Tsi Sunitinib Malate Rau?
  3. Sunitinib Malate Ua Haujlwm Li Cas?
  4. Yuav Ua Li Cas Noj Sunitinib Malate?
  5. Yuav Ua Li Cas Cia Sunitinib Malate?
  6. Peb Yuav Paub Qhov Ntau Npaum Cas Los Ntawm Sunitinib Malate?
  7. Lwm Yam Tshuaj Dab Tsi Yuav cuam tshuam rau Sunitinib Malate?
  8. FDA pom zoo Sunitinib Malate Yog Qhov Tsim Kho Kho Mob Quav Tshuaj Cell Hlawv Mob
  9. Kuv Yuav Yuav Sunitinib Malate Online Qhov Twg?

 

Sunitinib Malate (CAS:341031-54-7) tau tshawb pom ntawm SUGEN, lub tuam txhab biotechnology uas tau tsim cov kinase protein inhibitors. Nws yog qhov thib peb hauv kev sib txuas ua ke xws li SU5416 thiab SU6668. Lub tswv yim yog ntawm ATP mimic uas yuav sib tw nrog ATP rau kev sib khi rau catalytic site ntawm receptor tyrosine kinases. Cov ntsiab lus no coj mus rau qhov tsim muaj ntawm ntau yam me-molecule tyrosine kinase inhibitors, suav nrog Gleevec, Sutent, Tarceva thiab lwm yam.

 

Sunitinib Malate Txheej txheem cej luam

Sunitinib Malate yog daj daj rau txiv kab ntxwv hmoov. Sunitinib Malate yog ib hom roj me-molecule ntau lub hom phiaj receptor tyrosine kinase (RTK) inhibitor. Lub Ib Hlis 26, 2006, tus neeg sawv cev tau pom zoo los ntawm US FDA rau kev ntsuas ntawm kev kho mob raum cell carcinoma (RCC) thiab imatinib-resistant gastrointestinal stromal hlav (GIST). Rau cov laj thawj no, Sunitinib Malate feem ntau muaj raws li cov kev cai hais qhia tawm. Sunitinib Malate inhibits cov kev taw qhia ntawm tes los ntawm kev tsom mus rau ntau yam RTK. Cov no suav nrog tag nrho cov platelet-derived kev loj hlob tau receptors (PDGF-R) thiab vascular endothelial kev loj hlob yam receptors (VEGF-R). Sunitinib Malate tseem inhibits KIT (CD117), lub RTK uas tsav lub GIST feem ntau. Ntxiv rau, Sunitinib Malate inhibits lwm RTKs suav nrog RET, CSF-1R, thiab flt3.

 

Peb Yuav Siv Dab Tsi Sunitinib Malate Rau? 

Sunitinib Malate yog siv los kho cov neeg laus uas muaj mob raum tsis tau kis (hauv zos) thiab leej twg muaj feem yuav raug RCC rov qab los dua tom qab tau phais lub raum.

Sunitinib Malate yog siv los kho kev mob qog nqaij hlav hauv hlwb (qib siab lub raum cell carcinoma lossis RCC).

Sunitinib Malate yog siv los kho mob qog nqaij hlav hauv lub plab, plab hnyuv lossis hlab pas hu ua lub plab zom mov qog nqaij hlav (GIST) thiab thaum koj tau noj cov tshuaj imatinib mesylate thiab nws tsis txwv qhov mob qog nqaij hlav loj tuaj lossis koj tsis tuaj yeem noj cov tshuaj imatinib mesylate. Gleevec yog cov npe ua lag luam ntawm Novartis Pharmaceuticals Corporation.

Sunitinib Malate yog siv los kho hom mob qog nqaij hlav cancer hu ua pancreatic neuroendocrine hlav (pNET) uas tau muaj kev vam meej thiab tsis tuaj yeem raug kho nrog kev phais mob.

 

Sunitinib Malate Ua Haujlwm Li Cas?

Sunitinib Malate yog cov tshuaj tiv thaiv me-molecule inhibitor ntawm ntau yam receptor tyrosine kinases, qee qhov cuam tshuam rau cov qog loj hlob, pathologic angiogenesis, thiab metastatic hloov kho mob qog nqaij hlav. Tus neeg sawv cev inhibits platelet-derived kev loj hlob tau receptors - (PDGFRα thiab PDGFRβ), vascular endothelial kev loj hlob yam receptors (VEGFR1, VEGFR2, thiab VEGFR3), qia cell factor receptor (KIT), FMS-zoo li tyrosine kinase 3, colony-stimulating factor receptor hom 1, thiab lub ntsej muag glial cell-line muab tau neurotrophic factor receptor (RET). Sunitinib Malate inhibition ntawm cov kev ua thiab kev ua haujlwm ntawm cov receptor tyrosine kinases tau pom nyob rau hauv biochemical thiab cellular assays thiab cell proliferation assays. Tus thawj metabolite ntawm Sunitinib Malate kev nthuav qhia potency zoo ib yam li cov niam txiv sib txuas hauv biochemical thiab cellular assays.

Sunitinib Malate inhibits phosphorylation ntawm ntau yam receptor tyrosine kinases (PDGFRβ, VEGFR2, KIT) hauv cov qog xenografts qhia txog receptor tyrosine kinase cov hom phiaj hauv vivo thiab inhibits qog loj hlob thiab metastasis hauv qee cov qauv sim. Tus neeg sawv cev txwv tsis pub muaj kev loj hlob ntawm cov qog qog hais tawm dysregulated phiaj yam receptor tyrosine kinases (PDGFR, RET, lossis KIT) hauv vitro thiab PDGFRβ-thiab VEGFR2-dependant mob qog angiogenesis hauv vivo.

 

Sunitinib Malate

 

Yuav Ua Li Cas Noj Sunitinib Malate?

Lub Sunitinib Malate ntau npaum koj tus kws kho mob sau yuav yog nyob ntawm ntau yam. Cov no suav nrog:

Type hom thiab mob hnyav uas koj siv tshuaj Sunitinib Malate kho

❷ Lwm yam mob uas koj yuav muaj

❸ Lwm yam tshuaj koj siv

Koj tus kws kho mob yuav muab tshuaj kom tsawg tshaj plaws uas qhia txog yam xav tau.

Cov ntaub ntawv hauv qab no piav qhia txog kev noj tshuaj uas feem ntau siv lossis pom zoo. Txawm li cas los xij, nco ntsoov siv qhov ntau npaum koj tus kws kho mob sau rau koj. Koj tus kws kho mob yuav txiav txim siab muab qhov zoo tshaj plaws kom haum koj cov kev xav tau.

 

Forms Daim ntawv tshuaj thiab qhov ua tau zoo

Sunitinib Malate los ua tshuaj ntsiav uas koj nqos. Nws muaj nyob hauv cov kev ua tau zoo no: 12.5 milligrams (mg), 25 mg, 37.5 mg, thiab 50 mg.

 

Os Qhov koob tshuaj rau lub plab zom mov

Kev noj tshuaj li ib txwm ntawm Sunitinib Malate rau kev mob plab txoj hnyuv hlav (GISTs) yog 50 mg ib hnub ib hnub rau 4 lub lis piam. Qhov no yog ua raws li 2 lub lis piam tsis muaj tshuaj kho mob. Tom qab ntawd, koj mam li rov ua lub voj voog.

Koj yuav noj cov tshuaj Sunitinib Malate kom txog thaum koj mob qog tuaj lossis koj lub cev tsis tuaj yeem tiv thaiv kev kho mob nrog tshuaj. Koj tus kws kho mob yuav txiav txim siab thaum koj yuav tsum tsis txhob noj Sunitinib Malate. Yog xav paub meej txog yuav ua li cas Sunitinib Malate siv los kho GISTs, saib qhov link raws li hauv qab no.

 

Os Koob tshuaj rau mob raum

Sunitinib Malate kuj tseem siv los kho hom mob raum uas yog hu ua advanced raum cell carcinoma (RCC). Kev noj tshuaj li niaj zaus ntawm Sunitinib Malate rau RCC siab heev yog 50 mg ib zaug ib hnub rau 4 lub lis piam. Qhov no yog ua raws li 2 lub lis piam tsis tau noj tshuaj. Tom qab ntawd, koj mam li rov ua lub voj voog.

Koj yuav noj cov tshuaj Sunitinib Malate kom txog thaum koj mob qog tuaj lossis koj lub cev tiv thaiv tsis tau kev kho mob nrog tshuaj. Koj tus kws kho mob yuav txiav txim siab thaum koj yuav tsum tsis txhob noj Sunitinib Malate. Yog xav paub ntxiv txog yuav ua li cas Sunitinib Malate siv los kho qib siab RCC, saib cov kab ntawv hauv qab no.

 

Os Noj ntau rau qhov kev kho mob qog noj ntshav qog ntshav

Sunitinib Malate kuj tseem siv ua qhov kev txiav txim siab rau ib hom mob qog mob raum hu ua RCC tom qab kev kho mob rau lub raum (qhov kev phais lub raum tawm). Cov li ib txwm tsuas tshuaj ntawm Sunitinib Malate rau qhov kev siv no yog 50 mg ib hnub ib hnub rau 4 lub lis piam. Qhov no yog ua raws li 2 lub lis piam tsis tau noj tshuaj. Koj feem ntau yuav rov qab ua lub voj voog no mus txog cuaj zaug. Yog xav paub ntxiv txog yuav ua li cas Sunitinib Malate siv los ua kev kho mob rau RCC, saib qhov txuas raws li hauv qab no.

 

Koob tshuaj rau kabmob qog ntshav

Kev noj tshuaj li niaj zaus ntawm Sunitinib Malate rau kev mob siab dua ntawm necendocrine hlav (pNETs) yog 37.5 mg ib hnub ib zaug.

Koj yuav noj cov tshuaj Sunitinib Malate kom txog thaum koj mob qog tuaj lossis koj lub cev tsis tuaj yeem tiv thaiv kev kho mob nrog tshuaj. Koj tus kws kho mob yuav txiav txim siab thaum koj yuav tsum tsis txhob noj Sunitinib Malate.

 

Sau tseg: qhov tsuas yog tsuas siv, thov pab tshawb xyuas cov ntsiab lus ntxiv los ntawm lub vev xaib no:www.fda.gov .

 

 

Yuav Ua Li Cas Cia Sunitinib Malate?

Khaws cov tshuaj no rau hauv lub khob ntim nws tuaj, kaw nruj nreem, thiab tsis pub me nyuam yaus ncav cuag. Khaws nws ntawm chav kub thiab deb ntawm cov cua kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb rau kev noj txhua yam tshuaj kom tsis txhob pom thiab ncav cov menyuam yaus kom ntau lub thawv (xws li cov ntsiav tshuaj rau lub limtiam thiab cov neeg rau qhov muag tshuaj, cream, plhaw, thiab nqaum pa) tsis yog menyuam yaus thiab cov menyuam yaus tuaj yeem qhib tau yooj yim. Txhawm rau tiv thaiv cov me nyuam yaus kom txhob raug mob, nco ntsoov kaw lub hau kev ruaj ntseg thiab muab qhov chaw tso rau hauv qhov chaw nyab xeeb - ib qho uas tawm thiab deb thiab tawm ntawm lawv qhov muag thiab ncav cuag.

Cov tshuaj tsis tau siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj zej zog. Saib ntawm FDA Kev Nyab Xeeb Kev Pov Tseg Tshuaj lub vev xaib rau cov ntaub ntawv ntxiv yog tias koj tsis muaj txoj cai siv rov qab kev pab cuam.

 

Peb Yuav Paub Qhov Ntau Npaum Cas Los Ntawm Sunitinib Malate?

Sunitinib Malate qhov xwm txheej tsis zoo yog suav tias yog kev tswj hwm me ntsis thiab qhov xwm txheej ntawm qhov tshwm sim tsis zoo yog qhov tsawg.

Cov xwm txheej feem ntau cuam tshuam nrog Sunitinib Malate txoj kev kho yog nkees, zawv plab, xeev siab, mob ntshav qab zib, kub siab, ua kom tawv nqaij daj daj, ntxuav tes ntawm daim tawv nqaij, thiab mob plab. feem ntau nrog Sunitinib Malate dua li cov tshuaj placebo suav nrog zawv plab, tsis nco qab, tawv nqaij ua kom tawv nqaij, hnoos qeev / stomatitis, asthenia, hloov saj, thiab cem quav. Kev txo tus koob tshuaj yuav tsum nyob hauv 50% ntawm cov neeg mob tau kawm hauv RCC txhawm rau tswj hwm qhov muaj feem ua rau muaj kev phom sij ntawm tus neeg sawv cev no.

Cov mob hnyav (qib 3 lossis 4) muaj qhov tshwm sim tsis zoo tshwm sim hauv ≤10% ntawm cov neeg mob thiab suav nrog kev kub siab, qaug zog, mob asthenia, raws plab, thiab kev kho mob tshuaj lom neeg mob erythema. Cov kev tsis zoo hauv ntshav nrog txuam nrog Sunitinib Malate txoj kev kho muaj xws li lipase, amylase, neutrophils, lymphocytes, thiab platelets. Hypothyroidism thiab mob erythrocytosis thim rov qab kuj tseem cuam tshuam nrog Sunitinib Malate. Feem ntau cov xwm txheej tsis zoo tuaj yeem tswj hwm los ntawm kev pab txhawb nqa, cuam tshuam nrog koob tshuaj, lossis txo koob tshuaj.

Ib txoj kev tshawb nrhiav tsis ntev los no ua tiav ntawm MD Anderson Cancer Center piv cov txiaj ntsig ntawm cov neeg mob qog nqaij hlav metastatic uas tau txais Sunitinib Malate ntawm cov qauv sijhawm (50 mg / 4 lub lis piam rau 2 lub lis piam tawm) nrog cov uas tau txais Sunitinib Malate nrog ntau dua thiab luv hnub so tshuaj yeeb (lub sijhawm hloov). Nws tau pom tias tag nrho cov kev ua neej nyob, kev muaj sia nyob ywj pheej thiab kev quav yeeb tshuaj tau zoo dua rau cov neeg mob uas tau txais Sunitinib Malate ntawm lwm cov sijhawm kawm. Cov neeg mob kuj tau txais kev zam zoo dua thiab muaj qis dua qhov ua rau muaj kev phiv tshuaj uas feem ntau ua rau tsis cuam tshuam kev kho mob ntawm cov neeg mob qog nqaij hlav metastatic cell.

 

Sunitinib Malate

 

Lwm Yam Tshuaj Dab Tsi Yuav cuam tshuam rau Sunitinib Malate?

Sunitinib Malate tuaj yeem ua rau mob plawv heev. Tej zaum koj yuav muaj feem ntau yog koj tseem siv lwm cov tshuaj rau kab mob, hawb pob, mob plawv, ntshav siab, nyuaj siab, hlwb, mob hlwb, mob npaws, lossis HIV.

Qee lub sij hawm nws tsis tuaj yeem siv qee cov tshuaj tib lub sijhawm. Qee yam tshuaj tuaj yeem cuam tshuam rau koj cov ntshav ntawm lwm cov tshuaj koj noj, uas yuav ua rau muaj kev cuam tshuam ntau ntxiv lossis ua rau cov tshuaj tsis ua hauj lwm zoo.Qhov koj tus kws kho mob hais txog tag nrho koj lwm yam tshuaj, tshwj xeeb: tshuaj mob txha.

Cov npe no tsis tiav. Lwm cov tshuaj yuav cuam tshuam rau Sunitinib Malate, suav nrog cov tshuaj uas yuav thiab lub khw muag tshuaj, cov vitamins, thiab cov khoom siv tshuaj ntsuab. Tsis yog tag nrho cov tshuaj sib cuam tshuam tau muaj npe nyob ntawm no.

 

FDA pom zoo Sunitinib Malate Yog Qhov Tsim Kho Kho Mob Quav Tshuaj Cell Hlawv Mob

Thaum Lub Kaum Ib Hlis 16, 2017, Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj tau pom zoo Sunitinib Malate (Sunitinib Malate, Pfizer Inc) rau kev kho mob rau cov neeg mob cov neeg laus uas muaj kev pheej hmoo ntawm kev mob raum cell carcinoma tom qab nephrectomy.

Kev pom zoo yog txiav txim siab los ntawm ntau lub chaw, thoob ntiaj teb, ob lub qhov muag tsis pom kev, tshuaj placebo, sim (S-TRAC), hauv 615 cov neeg mob uas muaj kev pheej hmoo siab rov ua dua RCC tom qab nephrectomy. Cov neeg mob tau xaiv 1: 1 kom tau txais 50 mg Sunitinib Malate ib hnub ib zaug, 4 lub lis piam rau kev kho mob tom qab ntawd 2 lub limtiam tawm, lossis cov placebo. Kev tiv thaiv kab mob tsis muaj txiaj ntsig rau cov neeg mob noj tshuaj Sunitinib Malate yog 6.8 xyoo (95% CI: 5.8, tsis tau mus txog) piv nrog 5.6 xyoo (95% CI: 3.8, 6.6) rau cov neeg mob tau txais cov placebo (HR = 0.76; 95% CI: 0.59 , 0.98; p = 0.03). Thaum lub sijhawm DFS txheeb xyuas, tag nrho cov ntaub ntawv kev ciaj sia tsis tau paub tab.

Cov kev mob tshwm sim feem ntau (≥25%) rau Sunitinib Malate yog cov qaug zog / mob vwm, raws plab, mob plab / mob plab, xeev siab, tsis qab los noj mov / tsis nco qab, ntuav, mob plab, mob tes taw Syndrome no, kub siab, los ntshav, ua rau tsis txaus siab / saj tsis tau. , dyspepsia, thiab thrombocytopenia. Daim ntawv lo no muaj lub thawv ceeb toom rau ceeb toom cov kws kho mob thiab cov neeg mob txog kev pheej hmoo ntawm hepatoxicity, uas tuaj yeem ua rau daim siab tsis ua haujlwm lossis tuag.

Qhov koob tshuaj pom zoo ntawm Sunitinib Malate rau kev kho qhov mob ntawm RCC yog 50 mg ntawm qhov ncauj ib hnub ib zaug, nrog lossis tsis noj zaub mov, 4 lub lis piam ntawm kev kho mob tom qab ntawd 2 lub lis piam tawm rau cuaj 6 lub lis piam mus los.

 

Sau tseg: Cov ntawv qhia tag nrho muaj nyob rau ntawm:accessdata.fda.gov  PDF 

 

Kuv Yuav Yuav Sunitinib Malate Online Qhov Twg? 

Muaj ntau tus neeg muab khoom lag luam / cov neeg tsim khoom ntawm Sunitinib Malate hmoov hauv kev ua lag luam, nrhiav ib qho tseem ceeb heev rau txhua tus neeg uas xav tau cov khoom no sai. Thaum peb txiav txim siab yuav Sunitinib Malate hmoov hauv khw, peb yuav tsum kawm paub ntau ntxiv txog nws, paub siv nws thiab nws yog cov haujlwm ntawm kev coj ua, txhua yam kev pheej hmoo thaum peb noj Sunitinib Malate hmoov…. Ntxiv rau, nqe thiab qhov zoo yuav tsum yog peb qhov kev txhawj xeeb ua ntej yuav nws.

Tom qab peb tau soj ntsuam cov ntaub ntawv los ntawm kev ua lag luam, piv rau ntau tus neeg muab khoom, AASraw zoo li kev xaiv zoo rau cov neeg uas xav yuav ntau Sunitinib Malate hmoov, lawv cov khoom lag luam raug tswj hwm nruj me ntsis raws li cGMP, cov khoom zoo tuaj yeem taug qab txhua lub sijhawm thiab lawv tuaj yeem muab tag nrho cov ntawv xeem thaum koj xaj. Raws li rau Sunitinib Malate hmoov cov nqi / nqi, nws yuav tsum muaj qhov tsim nyog, hauv kuv qhov muag. Vim tias kuv tau txais ntau tus nqi los ntawm kev sib txawv Sunitinib Malate lwm tus neeg, piv nrog zoo, Kuv xav tias aasraw yuav tsis yog qhov kev xaiv tsis zoo.

 

reference

[1] Cov Tswj Xyuas Zaub Mov thiab Yeeb Tshuaj. Sunitinib (Sutent) Tshaj tawm cov ntaub ntawv. Xyoo 2015.

[2] CA Naranjo, U. Busto, thiab tus neeg muag khoom EM, "Ib txoj hauv kev kwv yees qhov tshwm sim ntawm qhov tshwm sim tsis zoo tshuaj yeeb tshuaj," Cov chaw tshuaj thiab Kho Mob, vol. 30, tsis muaj. 2, pp. 239–245, 1981.

[3] Z. Ansari thiab MK George, "Qhov muaj mob tshwm sim rau kev tiv thaiv cov tshuaj tiv thaiv kab mob thrombocytopenia lub tsev kawm ntawv qib siab mus rau sunitinib nyob rau hauv tus neeg mob nrog metastatic hlaus cell carcinoma: cov ntaub ntawv qhia," Journal of Medical Case Reports, vol. 7, tsab xov xwm 54, 2013.

[4] K. Sakai, K. Komai, D. Yanase, thiab M. Yamada, "Plasma VEGF yog qhov ua cim rau kev kuaj mob thiab kho tus mob vasculitic neuropathy," Phau Ntawv Tshaj Xo Tawm ntawm Neurology, Neurosurgery thiab Psychiatry, vol. 76, tsis muaj. 2, tsab xov xwm 296, 2005.

[5] Cov Chaw Kho Mob European Tshuaj. Sunitinib (TXUJ CI). Cov ntsiab lus ntawm Cov Khoom Muag Khoom. Xyoo 2015.

[6] Pajiab B, Torres E, Trigo JM li al. Tyrosine kinase inhibitors thiab tshuaj sib cuam tshuam: tshuaj xyuas nrog cov tswv yim pom zoo. Clin Txhais Oncol 2012; 14: 94-101.

[7] Teo YL, Ho HK, Chan A. Metabolism ntsig txog cov tshuaj-yeeb tshuaj sib cuam tshuam nrog tyrosine kinase inhibitors: kev nkag siab tam sim no, kev nyuaj thiab cov lus pom zoo. Br J Clin Pharmacol 2015; 79: 241-253.

[8] Jamie Dlugosch (2009-03-13). "Yuav biologics thiab Sutent txuag Pfizer?". Neeg twv lag luam.

[9] BMJ 31-Jan-2009 “NICE thiab cov kev sib tw ntawm cov tshuaj tua kab mob cancer” p271

[10] Blay JY, Reichardt P (Lub Rau Hli 2009). “Mob siab rau lub qog stromal nyob hauv cov teb chaws Europe: tshuaj xyuas cov tswv yim kho tshiab”. Cov Kws Muaj Txuj Rev Anticancer Ther. 9 (6): 831–8. doi: 10.1586 / era.09.34. PMID 19496720. S2CID 23601578.

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