AASraw tsim NMN thiab NRC hmoov hauv qhov ntau!

Ibrutinib

  1. Cov Tshuaj Txhuas Tshuaj Ibrutinib (CAS: 936563-96-1)
  2. Ibrutinib Kev Siv Tes Haujlwm ntawm Kev Ua
  3. Cas Ibrutinib Siv Rau
  4. Ibrutinib Txiaj Ntsig / Zoo
  5. Peb Yuav Tsum Txais Ibrutinib Li Cas
  6. Ibrutinib Sab Sij Phim
  7. Ibrutinib Cia

Hom Phiaj Tshuaj Ibrutinib(CAS: 936563-96-1)

Ntau dua cov kev kho tshiab rau cov mob lymphoma yog cov hom phiaj tshuaj. Cov tshuaj phiaj tsom tua cov hom cell uas tau hloov mus ua qog ntshav lossis nres cov cim uas ua rau cov qog nqaij hlav loj tuaj lossis faib. Hauv cov qog ntshav, cov cell uas yuav mob loj yog hu ua “lymphocyte” (ib hom qe ntshav dawb uas tawm tsam sib kis). Muaj ob peb hom lymphocyte tuaj yeem ua rau mob nyuv. Ibrutinib lub hom phiaj B lymphocytes (B hlwb) thiab yog li siv los kho B-cell lymphomas.

Cov xov tooj ntawm tes xa thiab txais cov cim qhia rau lwm lub hlwb. Qee yam ntawm cov cim no ua rau lub hlwb nyob thiab ua rau lawv faib. Muaj ntau lub teeb liab ntawm cov phiajcim thiab cov cim taw qhia raug xa raws ib lossis ntau ntawm cov hau kev no. Ibrutinib yog lub xov tooj ntawm tes blocker uas lub hom phiaj ntawm cov protein hu ua 'Bruton's tyrosine kinase' (BTK). BTK yog ib feem ntawm txoj hauv kev uas pab cov B hlwb kom muaj sia nyob thiab sib faib. Kev thaiv BTK tuaj yeem ua rau cov hlwb B tuag lossis tiv thaiv lawv faib. Qhov kev kho no tuaj yeem ua rau kom tsis txhob muaj cov kabmob B hlwb mob loj.

 

Ibrutinib Mechanism of Action

Ibrutinib (936563-96-1) tsis yog siv tshuaj kho mob, tiam sis yog ib qhov hu ua "hom phiaj kho." Cov hom phiaj kho yog qhov tshwm sim ntawm xyoo ntawm kev tshawb fawb los ua kom nkag siab qhov sib txawv ntawm cov qog nqaij hlav cancer thiab cov qe ntshav kom zoo. Txog niaj hnub no, kev kho mob cancer tau tsom feem ntau rau kev tua cov cov hlwb tawg sai vim ib qho ntawm kev mob qog nqaij hlav cancer yog qhov lawv faib sai sai. Hmoov tsis zoo, qee qhov ntawm peb lub hlwb ib txwm faib nrawm dhau, ua rau muaj kev cuam tshuam ntau yam.

Targeted therapy yog hais txog kev txheeb xyuas lwm yam kev mob hlwb. Cov kws tshawb fawb nrhiav kev txawv ntawm cov kabmob kheesxaws thiab cov qe ntshav dawb. Cov ntaub ntawv no yog siv los tsim kev tsom kab mob los mus tua cov kabmob kheesxaws uas tsis muaj kev puas tsuaj ntawm cov qe ntshav, yog li ua rau muaj kev phiv ntau dua. Txhua hom kev kho mob yuav ua haujlwm txawv me ntsis tiam sis txhua yam cuam tshuam nrog kev muaj peev xwm ntawm kabmob kheesxaws ntawm tes kom loj hlob, sib faib, kho thiab / lossis sib txuas lus nrog lwm lub hlwb.

Ibrutinib inhibits qhov ua haujlwm ntawm Bruton tyrosine kinase (BTK). BTK yog lub teeb meem tseem ceeb tshaj ntawm cov B-cell receptor signaling complex uas ua lub luag haujlwm tseem ceeb hauv kev muaj sia nyob ntawm malignant B cell. Ibrutinib muaj cov cim taw qhia uas ua rau cov hlwb B muaj qhov tsis zoo thiab loj hlob thiab sib faib tsis tau. Kev tshawb fawb txuas ntxiv mus txheeb xyuas seb qhov twg mob qog nqaij hlav tuaj yeem kho tau zoo tshaj plaws nrog kev kho mob hom phiaj thiab kom paub cov hom phiaj ntxiv rau ntau hom qog nqaij hlav.

Nco tseg: Peb xav kom koj nrog koj tus kws kho mob tham txog koj tej kev mob thiab kev kho mob. Cov ntaub ntawv muaj nyob hauv lub vev xaib no yog txhais tau tias muaj txiaj ntsig zoo thiab kev kawm, tab sis tsis hloov cov lus qhia kev kho mob.

AASraw yog lub chaw tsim khoom muaj txuj ci ntawm Ibrutinib.

Thov nyem ntawm no rau cov ntaub ntawv hais: dawb paugHu rau peb

 

Cas Ibrutinib Siv Rau

❶ Txhawm rau kho cov neeg mob mantle cell lymphoma (MCL; mob qog nqaij hlav loj sai uas pib hauv cov qe ntshav ntawm lub cev tiv thaiv kab mob) uas twb tau kho mob tsawg kawg yog ib lwm txoj kev kho tshuaj kho mob.

❷ Txhawm rau kho cov neeg mob nrog mob ntsws lymphocytic (CLL; ib hom mob cancer uas pib hauv cov qe ntshav dawb) thiab cov qog ntshav me me (SLL; ib hom mob cancer uas feem ntau pib ua rau cov qog ntshav).

❸ Txhawm rau kho cov neeg mob Waldenstrom's macroglobulinemia (WM; ua rau muaj mob qog nqaij hlav qeeb uas pib muaj qee cov qe ntshav dawb hauv koj cov pob txha pob txha).

❹ Txhawm rau kho cov tib neeg muaj mob qog nqaij hlav cancer loj (MZL; tus kabmob qeeb zuj zus uas pib ntawm cov qe ntshav dawb uas feem ntau sib ntaus sib tua kabmob) uas twb tau txais kev kho mob los ntawm qee yam tshuaj khomob.

❺ Txhawm rau kho cov neeg mob pob txha caj mob nrog tus neeg mob (cGVHD; ib qho kev hloov ntawm txoj kev hloov ntshav ntawm txoj hlab ntsha [HSCT; tus txheej txheem uas hloov cov pob txha mob uas muaj mob hlwb pob txha zoo] uas yuav pib lub sijhawm tom qab hloov ntshav thiab kav ntev ) tomqab siv tsis tiav nrog 1 lossis ntau yam tshuaj kho.

Ibrutinib nyob hauv chav kawm ntawm cov tshuaj hu ua kinase inhibitors. Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm cov protein tsis txaus ntseeg uas ua teeb liab rau cov cell mob qog hlav. Qhov no yuav pab kom tsis txhob kis mob hlwb.

Ibrutinib

Ibrutinib cov kev pab cuam/ Teebmeem

Ibrutinib tau suav hais tias los ntawm ntau tus kws tshaj lij yog 'kev hla kev kho mob' rau qee hom qog ntshav. Nws muab cov lus teb tau zoo dua piv nrog lwm cov kev kho rau tib hom mob cancer. Qhov kev sim loj uas ua rau pom zoo ibrutinib yog qhia luv luv hauv qab no.

 

(1) Muaj txiaj ntsig hauv mantle cell lymphoma

Mantle cell lymphoma uas tau rov mob lossis tsis teb rov qab kho thawj zaug tuaj yeem nyuaj rau kev kho mob. Txawm li cas los xij, kev kawm tseem ceeb hauv thaj chaw no tau qhia tias ntau tshaj li ob feem peb ntawm 111 tus neeg kho nrog ibrutinib teb kev kho mob (lawv lub qog ua kom poob lossis ploj mus).

Qhov kev tshawb nrhiav thib ob hauv 280 tus neeg piv rau ibrutinib nrog lwm cov tshuaj mob qog nqaij hlav cancer, temsirolimus, rau cov neeg mob rov huam mob lossis tso ntshav tawm lub hlwb lymphoma. Cov tib neeg muaj txoj sia nyob thaj tsam li 15 lub hlis yam tsis muaj mob rau cov qog uas mob hnyav thaum kho nrog ibrutinib piv nrog kwv yees li ntawm 6 lub hlis thaum kho nrog temsirolimus.

 

(2) Cov muaj txiaj ntsig rau kev mob qog ua ntshav (CLL)

Cov lus teb ncua ntev tau pom hauv cov neeg mob CLL raug kho nrog ibrutinib. Hauv kev sim tseem ceeb cuam tshuam nrog 391 tus neeg uas rov mob lossis rov ua kom zoo ib yam ntawm CLL, ibrutinib piv nrog ofatumumab, uas feem ntau siv rau cov neeg nrog CLL uas tau rov qab los. Ib xyoos tom qab pib kho mob, kwv yees li ntawm 66 nyob rau hauv 100 tus neeg uas siv ibrutinib muaj CLL uas nyob hauv kev tswj hwm (qhov no hu ua 'tsis muaj mob-ciaj sia taus') piv nrog nyob ib ncig ntawm 6 hauv 100 tus neeg kho nrog ofatumumab.

Hauv kev tshawb fawb zaum ob muaj txog 269 tus neeg uas tseem tsis tau txais ib qho kev kho rau lawv li CLL, ibrutinib piv nrog cov tshuaj chlorambucil. Tom qab 1.5 xyoo ntawm kev kho mob, nyob ib ncig ntawm 90 hauv 100 tus neeg noj ibrutinib muaj CLL uas nyob rau hauv kev tswjfwm piv nrog nyob ib ncig ntawm 52 hauv 100 tus neeg kho chlorambucil.

Ntxiv rau ibrutinib rau bendamustine thiab rituximab rau cov neeg uas rov huam dua lossis rov ua haujlwm tau zoo CLL kuj tseem muaj txiaj ntsig zoo ntawm kev tshawb fawb uas muaj 578 tus neeg. Txoj kev pheej hmoo ntawm CLL kev nce qib tau raug txo los ntawm kev noj ibrutinib hloov ntawm cov placebo (kev kho mob dummy).

 

(3) Cov txiaj ntsig hauv Waldenström' s mob macroglobulinaemia (WM)

Tus lej teb tau zoo kuj tau pom hauv cov neeg nrog WM - txog 9 ntawm 10 tus neeg nrog WM teb kev kho mob ibrutinib hauv kev sim hauv 63 cov neeg. Qhov kev sim no yog kev daws teeb meem tseem ceeb rau WM vim tias nws tsis txawv txav ntawm cov qog ntshav thiab yog vim li ntawd nws nyuaj los nrhiav neeg coob txaus los koom nrog kev sim kho mob. Qhov kev sim no ua rau kev pom zoo ntawm ibrutinib rau WM hauv Tebchaws Europe.

 

Peb Yuav Tsum Coj Li Cas Ibrutinib 

Koj yuav muab ibrutinib ua cov ntsiav tshuaj. Nws yuav muab nrog lwm cov tshuaj rau kev kho mob thiab kev siv tshuaj kho mob. Thaum lub sijhawm kho koj feem ntau ntsib tus kws kho mob cance¬r, tus kws tu neeg mob cancer lossis tus kws tu neeg mob tshwj xeeb, thiab kws tshaj lij tshuaj. Nov yog tus uas peb tau txhais thaum peb hais txog tus kws kho mob, tus kws tu neeg mob lossis kws tshuaj hauv cov ntaub ntawv no.

Ua ntej lossis nyob rau hnub kho mob, tus kws saib xyuas neeg mob lossis tus neeg kawm qhia kom noj ntshav (phlebotomist) yuav coj cov ntshav ntawm koj. Nov yog txhawm rau kuaj kom koj cov ntshav nyob rau hauv ib qib nyab xeeb rau koj kom tau txais kev kho mob.

Koj yuav ntsib kws kho mob lossis kws saib xyuas neeg mob ua ntej koj muaj kev kho mob. Lawv yuav nug seb koj nyob li cas lawm. Yog tias koj cov txiaj ntsig tau los ntshav thaum mus tau zoo, tus kws tshuaj yuav npaj cov tshuaj kho koj. Koj tus kws saib xyuas neeg mob yuav qhia koj thaum twg txoj kev kho koj lub siab yuav npaj txhij.

Tus neeg tu mob lossis tus kws muab tshuaj yuav muab cov tshuaj ibrutinib rau koj nqa mus tsev. Yuav tsum coj raws nraim li tau piav qhia. Qhov no tseem ceeb kom paub tseeb tias lawv ua haujlwm zoo li ua tau rau koj. Koj tuaj yeem raug muab ntsiav tshuaj ntawm qhov ua tau zoo sib txawv. Koj ib txwm khaws noj ibrutinib txhua hnub ntev li ntev tau kom nws tswj tus kabmob mus. Koj tus kws tu neeg mob lossis kws tshuaj muaj peev xwm muab cov tshuaj tiv thaiv kev mob rau koj thiab lwm yam tshuaj coj los tsev. Noj tag nrho koj cov ntsiav tshuaj raws nraim li tau piav qhia rau koj.

AASraw yog lub chaw tsim khoom muaj txuj ci ntawm Ibrutinib.

Thov nyem ntawm no rau cov ntaub ntawv hais: dawb paugHu rau peb

 

Ua kom sov ntawm Kev Tu Yus Tus Kheej

♦ Thaum haus ibrutinib, haus tsawg kawg yog ob mus rau peb khob dej txhua 24 teev, tshwj tsis yog koj hais ua lwm yam.

♦ Ntxuav koj ob txhais tes kom ntau thiab tom qab noj txhua koob tshuaj ibrutinib.

Koj yuav muaj kev pheej hmoo kis mob yog li sim ua kom tsis txhob muaj neeg coob coob lossis neeg mob khaub thuas, thiab ceeb toom qhia kev kub taub hau lossis lwm yam cim ntawm kev kis mob sai rau koj tus kws kho mob.

♦ Txhawm rau pab kho / tiv thaiv qhov ncauj tawm ntawm qhov ncauj thaum noj ibrutinib, siv tus txhuam hniav muag muag, thiab yaug peb zaug ib hnub nrog 1 diav ntawm cov dej qab zib tov nrog 8 ooj dej.

Siv cov pas ntsuas hluav taws xob thiab daim txhuam hniav muag muag txhawm rau kom los ntshav tsawg.

♦ Zam kev sib tw kis las lossis cov kis las uas yuav ua rau raug mob.

♦ Txhawm rau txo qhov xeev siab, noj tshuaj tiv thaiv xeev siab raws li koj tus kws kho mob tau qhia, thiab noj zaub mov me me thaum noj ibrutinib.

♦ Noj cov khoom noj uas yuav pab txo tau qhov raws plab - saib xyuas Cov Sab Hauv Lub Cev - Cawv plab

♦ Ua raws li kev qhia paub txog kev tiv thaiv mob zawv plab raws li kws kho mob koj hais.

♦ Zam kev tshav ntuj. Hnav SPF 15 (lossis siab dua) tiv thaiv tshav thiab tiv thaiv khaub ncaws. Ibrutinib yuav ua rau koj nkag siab ntau rau lub hnub thiab koj tuaj yeem ziab ntau dua.

General Feem ntau, kev haus dej haus cawv yuav tsum khaws tsawg kawg los yog zam kom txog thaum koj noj ibrutinib. Koj yuav tsum tham qhov no nrog koj tus kws kho mob.

♦ So kom txaus.

♦ Tswj kev noj zaub mov zoo thaum tab tom kho nrog ibrutinib.

♦ Yog tias koj muaj cov tsos mob lossis phiv thaum kho nrog ibrutinib, nco ntsoov nrog lawv tham nrog koj pab neeg saib xyuas kev noj qab haus huv. Lawv tuaj yeem sau tshuaj noj thiab / lossis muab lwm cov lus qhia uas ua haujlwm zoo los tswj cov teeb meem zoo li no.

 

Ibrutinib Skev xav Entxuav kab mob

Tau txais kev pabcuam thaum muaj kev kub ntxhov yog tias koj muaj tej yam tshwm sim ntawm kev tsis haum tshuaj: khaus; ua pa nyuaj; o ntawm koj lub ntsej muag, di ncauj, nplaig, lossis caj pas.

 

Tsum tsis txhob siv ibrutinib thiab hu rau koj tus kws kho mob tam sim yog tias koj muaj:

Cov cim ntawm kev kis tus mob – ua npaws, ua daus no, qaug zog, qhov ncauj tawm tsam, hnoos nrog hnoos qeev, ua tsis taus pa;

Cov cim ntawm los ntshav hauv koj lub cev izz kiv taub hau, tsis muaj zog, tsis meej pem, muaj teeb meem hais lus, mob taub hau ntev, tso quav dub los ntshav, tso zis liab lossis daj, lossis hnoos tawm ntshav lossis ntuav uas zoo li thaj chaw kas fes;

Diarrhea Mob plab zawv heev lossis txuas ntxiv mus;

Pain Mob hauv siab, txhaws lub hauv siab lossis lub ntsws hauv koj lub hauv siab, hnov ​​zoo li koj yuav dhau mus;

Headache Mob taub hau heev, qhov muag plooj, ua pob rau hauv koj lub caj dab lossis pob ntseg;

B Ua pob yooj yim, tsis los ntshav, ntshav lossis xim liab tshwm hauv koj cov tawv nqaij;

Skin Tawv tawv nqaij, txias tes thiab taw;

Problems Mob raum – me me los yog tsis tso zis, o rau koj txhais taw lossis pob taws; lossis

Cov cim ntawm qog nqaij hlav rau lub cev – tsis meej pem, tsis muaj zog, mob nqaij ntshiv, xeev siab, ntuav, lub plawv dhia ceev lossis qeeb, tso zis tsawg, txhawm rau hauv koj txhais tes thiab taw lossis ncig koj lub qhov ncauj.

 

Cov kev mob tshwm sim muaj xws li:

Iarrhea Mob plab zawv, xeev siab;

Ua npaws, hnoos, muaj teeb meem ua pa;

♦ Cov di ncauj lossis mob rau hauv koj lub qhov ncauj;

Hnov nkees;

Doog tawv, xoo pob; lossis

♦ Mob leeg mob, mob pob txha.

Qhov no tsis yog sau tag nrho cov kev mob tshwm sim thiab lwm tus yuav tshwm sim. Hu rau koj tus kws kho mob txog kev kho mob txog kev mob tshwm sim. Koj tuaj yeem qhia cov kev mob tshwm sim rau FDA ntawm 1-800-FDA-1088.

AASraw yog lub chaw tsim khoom muaj txuj ci ntawm Ibrutinib.

Thov nyem ntawm no rau cov ntaub ntawv hais: dawb paugHu rau peb

 

Ibrutinib Snkauj

Khaws Ibrutinib rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm lub teeb, tshaj cua sov thiab noo noo tsis nyob hauv chav dej.

Tsis siv tshuaj Ibrutinib pov tseg rau hauv cov hauv kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug qhov Ibrutinib hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA Kev Nyab Xeeb Kev Pov Tseg

Nws yog ib qho tseem ceeb rau kev noj txhua yam tshuaj kom tsis txhob pom thiab ncav cov menyuam yaus kom ntau lub thawv (xws li cov ntsiav tshuaj rau lub limtiam thiab cov neeg rau qhov muag tshuaj, cream, plhaw, thiab nqaum pa) tsis yog menyuam yaus thiab cov menyuam yaus tuaj yeem qhib tau yooj yim. Txhawm rau tiv thaiv cov me nyuam yaus kom txhob raug mob, nco ntsoov kaw lub hau kev ruaj ntseg thiab muab qhov chaw tso rau hauv qhov chaw nyab xeeb - ib qho uas tawm thiab deb thiab tawm ntawm lawv qhov muag thiab ncav cuag.

 

reference

[1] Xim av JR, Hillmen P, O'Brien S, li al. Ncua kev soj qab taug ntxiv thiab qhov cuam tshuam los ntawm qhov muaj feem pheej hmoo soj ntsuam los ntawm Ntu 3 RESONATE kev kawm rau cov neeg mob uas tau kho yav dhau los CLL / SLL [luam tawm online ua ntej luam tawm 8 Lub Rau Hli 2017]Cov. Mob ntshav siab.

[2] Byrd JC, Brown JR, O'Brien S, li al; SOJ NTSUAM Tus neeg tshawb xyuas. Ibrutinib tiv thaiv ofatumumab nyob rau yav tas los kho tus mob lymphoid leukemia. N Engl J Med. Xyoo 2014; 371 (3): 213-223.

[3] Byrd JC, Furman RR, Coutre SE, li al. Peb-xyoos taug qab kev kho mob-qhov quav thiab yav tas los kho cov neeg mob CLL thiab SLL tau txais tshuaj ibrutinib ib leeg. Ntshav. Xyoo 2015; 125 (16): 2497-2506.

[4] Mato AR, Toj Siab BT, Lamanna N, li al. Qib zoo sib xws ntawm ibrutinib, idelalisib, thiab venetoclax hauv kev mob qog mob ntshav ntws: tau los ntawm kev tshawb nrhiav ntau ntawm cov neeg mob 683. Ann Oncol. 2017; 28 (5): 1050-1056.

[5] Woyach JA, Ruppert AS, Guinn D, li al. BTKC481S-mediated tsis kam mus rau ibrutinib nyob rau cov roj ntsha muaj mob lymphocytic. J Clin Oncol. 2017; 35 (13): 1437-1443.

[6] Winqvist M, Asklid A, Andersson PO, li al. Tiag tiag lub ntiaj teb cov txiaj ntsig ntawm ibrutinib hauv cov neeg mob uas rov huam mob dua lossis rov huam mob mus ntev: cov ntaub ntawv los ntawm 95 cov neeg mob sib law liag kho nyob rau hauv kev siv txoj kev hlub. Kev tshawb fawb los ntawm Swedish Kev Noj Qab Haus Huv Lymphocytic Leukemia Group. Haematologica. 2016; 101 (12): 1573-1580.

[7] Jones JA, Hillmen P, Coutre S, li al. Siv cov tshuaj tiv thaiv anticoagulants thiab antiplatelet hauv cov neeg mob uas mob lymphocytic mob ntshav qab zib kho nrog ib tus neeg sawv cev ibrutinib. Br J Haematol. 2017; 178 (2): 286-291.

[8] Kamel S, Horton L, Ysebaert L, li al. Ibrutinib inhibits collagen-mediated tab sis tsis ADP-mediated platelet aggregation. Mob ntshav siab. Xyoo 2015; 29 (4) 783-787.

[9] Rigg RA, Aslan JE, Healy LD, li al. Qhov ncauj tswj hwm ntawm Bruton tyrosine kinase inhibitors cuam tshuam GPVI-mediated platelet muaj nuj nqi. Am J Physiol Cell Physiol. 2016; 310 (5): C373-C380.

[10] Wang ML, Txoj Cai S, Martin P, li al. Hom phiaj BTK nrog ibrutinib hauv qhov rov ua mob lossis tso refractory mantle-cell lymphoma. N Engl J Med. 2013; 369 (6): 507-516.

[11] Treon SP, Tripsas CK, Meid K, li al. Ibrutinib hauv kev kho yav tas los Waldenström's macroglobulinemia. N Engl J Med. Xyoo 2015; 372 (15): 1430-1440.

[12] Lampson BL, Yu L, Glynn RJ, li al. Ventricular arrhythmias thiab kev tuag sai sai rau cov neeg mob noj ibrutinib. Ntshav. 2017; 129 (18): 2581-2584.

[13] Tedeschi A, Frustaci AM, Mazzucchelli M, Cairoli R, Montillo M. Puas yog HBV prophylaxis xav tau thaum kho CLL nrog ibrutinib? Leuk Lymphoma. 2017; 58 (12): 2966-2968.

[14] Tshav C, Tian X, Lee YS, li al. Ib nrab rov ua dua ntawm kev txo hwj chim hauv lub cev thiab tsawg dua kis mob hauv cov neeg mob uas muaj cov roj ntsha lymphocytic uas tau kho nrog ibrutinib. Ntshav. 2015; 126 (19): 2213-2219.

[15] Ruchlemer R, Ben Ami R, Lachish T. Ibrutinib rau mob qog mob ntshav qab zib. N Engl J Med. 2016; 374 (16): 1593-1594.

[16] Ahn IE, Jerussi T, Farooqui M, Tian X, Wiestner A, Gea-Banacloche J. Atypical Pneumocystis jirovecii mob ntsws rau cov neeg mob tsis tau txais kev kho mob nrog CLL ntawm ib tus neeg sawv cev ibrutinib. Ntshav. 2016; 128 (15): 1940-1943.

[17] Vitale C, Ahn IE, Sivina M, li al. Autoimmune cytopenias hauv cov neeg mob uas mob lymphocytic mob ntshav qab zib kho nrog ibrutinib. Haematologica. 2016; 101 (6): e254-e258.

[18] Daim di ncauj GY, Pan X, Kamble S, li al. Kev pheej hmoo los ntshav txaus ntawm cov neeg mob plawv tsis ua haujlwm rau cov neeg mob apixaban, dabigatran, rivaroxaban lossis warfarin: qhov kev kawm tshawb xyuas qhov tseeb hauv Asmeskas. Int J Clin Kev Xyaum. 2016; 70 (9): 752-763.

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